TDMS Study 93020-07 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 06/30/04
EXPERIMENT: 93020 TEST: 07 TIME: 11:08:29
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: SKIN APPLICATION NTP: C93020D
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE DIISOPROPYLCARBODIIMIDE DATE: 06/30/04
EXPERIMENT: 93020 TEST: 07 TIME: 11:19:21
SPECIES: RATS, FISCHER 344
TEST TYPE: TWO YEAR ROUTE: DERMAL NTP: 93020D
CONT: N01-ES 05451 CAS: 693-13-0
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR DERMAL STUDY OF DIISOPROPYLCARBODIIMIDE
==========================================================================================================
WEEK 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 101.0 50 100.1 99.1 50 100.8 99.8 50 102.2 101.2 50
1 101.0 50 100.1 99.1 50 100.8 99.8 50 102.2 101.2 50
2 125.8 50 123.1 97.9 50 124.6 99.0 50 123.9 98.5 50
3 154.9 50 150.8 97.4 50 152.6 98.5 50 153.0 98.8 50
4 182.4 50 177.2 97.1 50 179.0 98.1 50 178.7 98.0 50
5 207.8 50 199.6 96.1 50 201.4 96.9 50 202.9 97.6 50
6 230.2 50 223.5 97.1 50 223.2 97.0 50 225.6 98.0 50
7 247.6 50 240.7 97.2 50 241.1 97.4 50 242.0 97.7 50
8 265.6 50 258.4 97.3 50 251.7 94.8 50 256.9 96.7 50
9 277.8 50 270.1 97.2 50 270.8 97.5 50 266.3 95.9 50
10 290.6 50 282.8 97.3 50 282.2 97.1 50 279.7 96.2 50
11 302.1 50 295.2 97.7 50 293.7 97.2 50 290.6 96.2 50
12 311.6 50 304.4 97.7 50 303.0 97.2 50 298.9 95.9 50
13 321.5 50 315.0 98.0 50 313.0 97.4 50 307.7 95.7 50
17 355.6 50 346.8 97.5 50 343.2 96.5 50 331.5 93.2 50
21 377.6 50 367.6 97.4 50 364.7 96.6 50 348.7 92.3 50
25 395.1 50 385.9 97.7 50 380.7 96.4 50 363.2 91.9 50
29 411.9 50 399.7 97.0 50 394.8 95.8 50 366.2 88.9 50
33 425.4 50 412.5 97.0 50 408.2 96.0 50 365.2 85.8 49
37 431.6 50 420.0 97.3 50 415.0 96.2 50 366.6 84.9 47
41 439.0 50 429.0 97.7 50 421.2 95.9 50 365.3 83.2 39
45 449.5 50 436.6 97.1 50 429.7 95.6 50 362.2 80.6 34
49 455.5 50 445.7 97.8 50 436.2 95.8 50 365.5 80.2 32
53 463.1 50 450.5 97.3 50 443.7 95.8 50 377.8 81.6 32
57 468.8 50 454.7 97.0 50 446.8 95.3 50 378.0 80.6 32
61 474.7 50 461.0 97.1 50 451.3 95.1 45* 385.0 81.1 32
65 479.7 50 463.5 96.6 49 459.3 95.7 49 383.9 80.0 32
69 480.0 49 463.7 96.6 49 458.8 95.6 49 388.8 81.0 32
73 474.7 49 463.1 97.6 48 464.5 97.9 48 390.0 82.2 32
77 482.2 45 467.1 96.9 47 467.7 97.0 48 394.2 81.8 31
81 479.7 44 463.1 96.5 45 463.5 96.6 47 396.2 82.6 30
85 477.6 43 463.9 97.1 43 469.6 98.3 46 406.0 85.0 30
89 484.2 37 463.0 95.6 38 471.7 97.4 45 409.4 84.6 28
93 481.5 35 462.7 96.1 36 461.3 95.8 45 397.6 82.6 24
97 469.1 33 460.1 98.1 34 463.1 98.7 39 390.0 83.1 22
101 471.0 24 463.1 98.3 32 467.3 99.2 34 372.3 79.0 19
TERM. SAC. 20 30 32 17
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR DERMAL STUDY OF DIISOPROPYLCARBODIIMIDE
==========================================================================================================
WEEK 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 89.6 50 90.1 100.6 50 91.2 101.8 50 90.0 100.4 50
1 89.6 50 90.1 100.6 50 91.2 101.8 50 90.0 100.4 50
2 104.0 50 104.2 100.2 50 104.7 100.7 50 104.9 100.9 50
3 118.2 50 118.4 100.2 50 118.2 100.0 50 117.3 99.2 50
4 132.1 50 131.6 99.6 49* 131.0 99.2 50 130.7 98.9 50
5 141.8 50 141.3 99.6 50 140.5 99.1 50 139.7 98.5 50
6 148.5 50 147.5 99.3 50 147.0 99.0 50 145.8 98.2 50
7 156.1 50 154.6 99.0 50 154.0 98.7 50 153.3 98.2 50
8 162.5 50 159.8 98.3 50 159.8 98.3 50 158.8 97.7 50
9 169.4 50 165.0 97.4 50 164.8 97.3 50 164.1 96.9 50
10 172.2 50 169.4 98.4 50 168.6 97.9 50 168.1 97.6 50
11 174.8 50 172.3 98.6 50 171.1 97.9 50 169.5 97.0 50
12 180.7 50 177.5 98.2 50 177.3 98.1 50 175.4 97.1 50
13 184.5 50 180.8 98.0 50 179.8 97.5 50 177.8 96.4 50
17 196.1 50 192.0 97.9 50 192.1 98.0 50 186.1 94.9 50
21 204.5 50 199.7 97.7 50 199.7 97.7 50 192.8 94.3 49
25 213.2 50 206.3 96.8 50 206.8 97.0 50 198.8 93.2 49
29 223.7 50 216.0 96.6 50 215.2 96.2 50 206.5 92.3 49
33 231.7 50 223.3 96.4 50 222.8 96.2 50 213.2 92.0 49
37 235.0 49 227.9 97.0 49 227.3 96.7 50 219.0 93.2 49
41 242.4 49 233.8 96.5 49 233.0 96.1 50 221.0 91.2 49
45 252.2 49 243.3 96.5 49 239.5 95.0 50 226.5 89.8 49
49 261.0 49 252.6 96.8 48 248.1 95.1 50 236.8 90.7 49
53 271.1 48 260.7 96.2 47 256.9 94.8 50 247.7 91.4 49
57 274.0 48 266.9 97.4 47 263.6 96.2 49 252.7 92.2 49
61 283.2 47 273.7 96.6 47 271.9 96.0 49 260.1 91.8 49
65 288.7 46 281.6 97.5 47 278.8 96.6 49 267.0 92.5 48
69 292.3 46 284.7 97.4 47 281.4 96.3 48 272.5 93.2 46
73 296.4 46 285.7 96.4 47 284.2 95.9 48 277.8 93.7 46
77 298.0 46 292.8 98.3 44 286.2 96.0 48 282.6 94.8 46
81 306.3 43 298.4 97.4 43 293.9 96.0 45 287.5 93.9 45
85 312.8 43 306.3 97.9 42 305.3 97.6 44 294.4 94.1 44
89 313.3 42 307.9 98.3 40 309.1 98.7 43 304.5 97.2 39
93 313.5 38 310.8 99.1 39 308.8 98.5 41 301.7 96.2 37
97 318.2 35 310.7 97.6 38 311.6 97.9 40 292.5 91.9 32
101 319.5 33 313.3 98.1 36 308.7 96.6 35 280.7 87.9 30
TERM. SAC. 30 32 32 25
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.