TDMS Study 93020-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 07/19/04
EXPERIMENT: 93020 TEST: 08 TIME: 09:19:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05451 ROUTE: SKIN APPLICATION NTP C#: 93020D
PATHOLOGIST: FARNELL, DANIEL CAS: 693-13-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 07/19/04
EXPERIMENT: 93020 TEST: 08 TIME: 09:19:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05451 ROUTE: SKIN APPLICATION NTP C#: 93020D
PATHOLOGIST: FARNELL, DANIEL CAS: 693-13-0
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 515 517 592 598 640 672 682 702 706 721 |
| 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 54 435 545 603 626 660 670 691 701 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 48 55 493 496 597 625 653 669 681 690 |
| 713 715 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 48 474 484 498 558 573 642 664 667 674 |
| 679 710 712 |
| CENSORED DEATHS |
| 31 |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 90.0 78.0 |
| | |
| | |
|10 MG/KG | 98.0 98.0 98.0 98.0 98.0 96.0 94.0 92.0 88.0 80.0 |
| | |
| | |
|20 MG/KG | 96.0 96.0 96.0 96.0 96.0 96.0 92.0 90.0 86.0 76.0 |
| | |
| | |
|40 MG/KG | 98.0 98.0 98.0 98.0 98.0 93.9 91.8 87.8 83.7 73.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 80.0% 76.0% 73.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.499 P=1.000N P=0.911 P=0.672 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 642.7 569.5 536.3 567.9 |
|NATURAL DEATHS (C) | (23.3) (63.1) (68.8) (49.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 710.0 697.1 682.7 673.2 |
|(STANDARD ERROR) | ( 7.1) (15.2) (19.8) (20.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 44 305 365 488 506 521 603 603 619 653 |
| 654 681 683 697 698 715 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 540 555 568 579 588 617 619 625 653 653 |
| 653 683 684 690 695 707 |
| CENSORED DEATHS |
| 12 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 1 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 67 417 560 579 584 603 614 653 687 690 |
| CENSORED DEATHS |
| 15 |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 1 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 481 528 551 582 604 617 619 669 718 |
| CENSORED DEATHS |
| 105 |
| |
==================================================================================
DIISOPROPYLCARBODIIMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 98.0 98.0 98.0 94.0 94.0 94.0 88.0 84.0 78.0 66.0 |
| | |
| | |
|10 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 89.8 77.6 67.3 |
| | |
| | |
|20 MG/KG | 98.0 98.0 98.0 98.0 95.9 95.9 95.9 87.8 83.7 79.6 |
| | |
| | |
|40 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 95.9 89.8 85.7 81.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 67.3% 79.6% 81.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.065N P=0.985N P=0.211N P=0.125N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 562.1 631.8 545.4 596.6 |
|NATURAL DEATHS (C) | (43.8) (13.4) (58.6) (24.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 672.2 683.6 678.0 692.7 |
|(STANDARD ERROR) | (18.4) (15.7) (20.5) (14.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIISOPROPYLCARBODIIMIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
10 MG/KG = 2
20 MG/KG = 3
40 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 32 1
|
| 32 2 4
| 3 2 4 43 1 2 1
P 95 +
E | 4 4 2 112
R | 3 12 2 1
C | 4 4
E 90 + 4 4 3 2 1 21
N |
T | 4 3 4 3 21 1
| 4 3 42 12 1
S 85 +
U | 43 32 2
R | 33 121
V | 44
I 80 + 3 211 2
V |
A | 4 331 1
L | 3 3
75 +
| 4 4
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
DIISOPROPYLCARBODIIMIDE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
10 MG/KG = 2
20 MG/KG = 3
40 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 4 2
|
| 1 3 1 3 4 4 2 2
| 1 1 3 4 42 2
95 +
| 1 1 43 224
P | 1 1
E | 22 4
R 90 + 1 1 2 3 2
C |
E | 1 13
N | 322 3 4
T 85 +
| 1 12 2 4 3 4
S | 1 1
U | 4 4
R 80 + 3 3
V |
I | 1 1
V |
A 75 +
L | 121
|
| 22
70 + 12 1
|
| 2 2
| 1 1
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.