https://ntp.niehs.nih.gov/go/15490

TDMS Study 93027-21 Pathology Tables

NTP Experiment-Test: 93027-21         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                          PEROXISOME PROJECT (GEMFIBROZIL)                             Date: 07/08/99
Route: DOSED FEED                                                                                                 Time: 09:55:36
                                                       13 WEEK SUBCHRONIC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  25812-30-0
       Lock Date:  06/12/96
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-21         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                          PEROXISOME PROJECT (GEMFIBROZIL)                             Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 09:55:36  
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         SPRAGUE-DAWLEY RATS MALE                  0            10           100          1000         8000         16,000          
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Rectum                            (10)                                                             (10)         
      Parasite Metazoan                                1 (10%)                                                                      
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cytoplasmic Alteration                                        7 (70%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Infiltration Cellular, Mononuclear Cell          3 (30%)                                                                      
      Inflammation, Chronic Active                     2 (20%)      2 (20%)      3 (30%)      2 (20%)      6 (60%)      4 (40%)     
      Inflammation, Granulomatous                                                             1 (10%)                               
      Necrosis                                         2 (20%)      2 (20%)      2 (20%)                   4 (40%)      4 (40%)     
   Pancreas                                           (10)         (10)         (10)         (10)         (9)          (10)         
      Inflammation, Chronic Active                                               1 (10%)                                            
   Stomach, Forestomach                               (10)                                   (2)                       (10)         
      Mineralization                                                                          1 (50%)                               
   Stomach, Glandular                                 (10)                                   (1)                       (10)         
      Mineralization                                   2 (20%)                                1 (100%)                              
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 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   1 (10%)                                                                      
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93027-21         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                          PEROXISOME PROJECT (GEMFIBROZIL)                             Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 09:55:36  
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS MALE                  0            10           100          1000         8000         16,000          
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (9)          (10)         (10)         (10)         (10)         (9)          
      Inflammation, Chronic                            8 (89%)      9 (90%)     10 (100%)    10 (100%)     9 (90%)      8 (89%)     
   Testes                                             (10)         (10)         (9)          (10)         (9)          (10)         
      Atrophy                                                                                 1 (10%)      1 (11%)                  
      Mineralization                                                             1 (11%)                                            
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                                             (10)         
      Hemorrhage                                       2 (20%)                                                                      
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93027-21         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                          PEROXISOME PROJECT (GEMFIBROZIL)                             Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 09:55:36  
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS MALE                  0            10           100          1000         8000         16,000          
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy                                      8 (80%)      8 (80%)      9 (90%)      8 (80%)      9 (90%)      6 (60%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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