TDMS Study 93027-21 Pathology Tables
NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:55:36 13 WEEK SUBCHRONIC Facility: Battelle Columbus Laboratory Chemical CAS #: 25812-30-0 Lock Date: 06/12/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:55:36 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 0 10 100 1000 8000 16,000 PPM PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (10) (10) Parasite Metazoan 1 (10%) Liver (10) (10) (10) (10) (10) (10) Cytoplasmic Alteration 7 (70%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Infiltration Cellular, Mononuclear Cell 3 (30%) Inflammation, Chronic Active 2 (20%) 2 (20%) 3 (30%) 2 (20%) 6 (60%) 4 (40%) Inflammation, Granulomatous 1 (10%) Necrosis 2 (20%) 2 (20%) 2 (20%) 4 (40%) 4 (40%) Pancreas (10) (10) (10) (10) (9) (10) Inflammation, Chronic Active 1 (10%) Stomach, Forestomach (10) (2) (10) Mineralization 1 (50%) Stomach, Glandular (10) (1) (10) Mineralization 2 (20%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:55:36 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 0 10 100 1000 8000 16,000 PPM PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (9) (10) (10) (10) (10) (9) Inflammation, Chronic 8 (89%) 9 (90%) 10 (100%) 10 (100%) 9 (90%) 8 (89%) Testes (10) (10) (9) (10) (9) (10) Atrophy 1 (10%) 1 (11%) Mineralization 1 (11%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Hemorrhage 2 (20%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:55:36 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 0 10 100 1000 8000 16,000 PPM PPM PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Nephropathy 8 (80%) 8 (80%) 9 (90%) 8 (80%) 9 (90%) 6 (60%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------