TDMS Study 93027-27 Pathology Tables
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 25812-30-0
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
Infiltration Cellular, Mixed Cell | 3 3 2 4 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Infiltration Cellular, Mixed Cell | 2 2 2 3 2 2 2 1 3 | 9 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic | 2 1 3 1 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | M M M + M M + M M M | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M M + M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 2 2 3 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 | 1 1.0|
Nephropathy | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Mineralization | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | M + + + + + + + + + | 9 |
Depletion Glycogen | 1 1 1 1 1 | 5 1.0|
Infiltration Cellular, Mixed Cell | 2 2 2 1 2 2 3 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | M M + M M M + M M M | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 9 |
Mineralization | 1 | 1 1.0|
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Depletion Glycogen | 1 1 1 1 | 4 1.0|
Infiltration Cellular, Mixed Cell | 2 2 3 2 2 2 2 1 2 | 9 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 2 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | M M M M + + + M M | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Atrophy | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
Atrophy | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 8 |
Nephropathy | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
6000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Depletion Glycogen | 1 1 1 1 1 1 1 1 | 8 1.0|
Infiltration Cellular, Mixed Cell | 2 2 2 2 1 3 2 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic | 3 2 1 1 1 1 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | M M M M M M M M M | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Atrophy | 2 3 3 3 1 | 5 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
Atrophy | 2 3 3 3 1 | 5 2.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 3 1 | 5 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
6000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
12,000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Depletion Glycogen | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Infiltration Cellular, Mixed Cell | 2 2 1 2 2 2 2 2 3 2 | 10 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 9 |
Inflammation, Chronic | 1 1 1 2 1 1 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | M M M M M M M M + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 9 |
Atrophy | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 9 |
Atrophy | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 3 2 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
12,000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 | 1 1.0|
Nephropathy | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
24,000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
Infiltration Cellular, Mixed Cell | 4 3 3 2 3 2 3 2 3 | 9 2.8|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Depletion Glycogen | 2 2 3 3 3 3 3 3 3 3 | 10 2.8|
Infiltration Cellular, Mixed Cell | 3 2 3 2 3 2 3 2 3 2 | 10 2.5|
Inflammation, Chronic | 3 | 1 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic | 2 2 3 2 3 4 4 4 3 2 | 10 2.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + M M M + + + M M M | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 2 2 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:59:00
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
24,000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 2 3 | 5 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 3 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 2 2 1 2 2 1 1 | 8 1.5|
Nephropathy | 2 1 3 2 2 3 2 3 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Mineralization | 2 3 3 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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---------- END OF REPORT ----------
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