https://ntp.niehs.nih.gov/go/15514

TDMS Study 93027-31 Pathology Tables

NTP Experiment-Test: 93027-31         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/26/01
Route: DOSED FEED                                       PEROXISOME PROJECT (WY-14643)                             Time: 07:47:53
                                                          FINAL#2/RATS
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  50892-23-4
       Lock Date:  06/12/96
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 93027-31         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/26/01    
Route: DOSED FEED                                       PEROXISOME PROJECT (WY-14643)                             Time: 07:47:53    
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         SPRAGUE-DAWLEY RATS MALE                     0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM      
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cytoplasmic Alteration                                        9 [1.0]     10 [2.0]     10 [2.8]     10 [2.9]     10 [3.0]     
      Infiltration Cellular, Mononuclear Cell          6 [1.0]      8 [1.0]      6 [1.2]      5 [1.2]      6 [1.0]      6 [1.0]     
      Necrosis, Focal                                                            1 [1.0]      1 [2.0]                               
      Bile Duct, Hyperplasia                                        1 [1.0]                                                         
      Hepatocyte, Periportal, Hyperplasia                                                                               1 [2.0]     
   Pancreas                                           (10)         (10)         (10)         (10)         (9)          (10)         
      Inflammation, Chronic                            1 [1.0]                   1 [1.0]                                            
   Stomach, Forestomach                               (10)                                                             (10)         
      Inflammation, Acute, Focal                                                                                        1 [1.0]     
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 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   5 [1.2]                                                          2 [1.0]     
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 ENDOCRINE SYSTEM                                                                                                                   
   Parathyroid Gland                                  (10)                                                             (4)          
      Syncytial Alteration                                                                                              1 [2.0]     
   Thyroid Gland                                      (10)                                                             (10)         
      Cyst                                             1 [2.0]                                                                      
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
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NTP Experiment-Test: 93027-31         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/26/01    
Route: DOSED FEED                                       PEROXISOME PROJECT (WY-14643)                             Time: 07:47:53    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS MALE                     0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM      
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (8)          (10)         (8)          (8)          (7)          (7)          
      Inflammation, Chronic                            8 [2.3]     10 [2.3]      8 [2.3]      8 [2.3]      7 [2.4]      6 [1.8]     
   Prostate                                           (10)                                                (1)          (10)         
      Inflammation, Chronic                            1 [1.0]                                             1 [3.0]                  
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                                             (10)         
      Hemorrhage                                       2 [1.0]                                                          2 [2.5]     
      Alveolus, Infiltration Cellular, Histiocyte      4 [1.0]                                                          3 [1.3]     
      Interstitium, Inflammation                                                                                        1 [1.0]     
      Interstitium, Inflammation, Chronic                                                                               1 [2.0]     
   Nose                                               (10)                                                             (10)         
      Inflammation, Chronic, Focal                     1 [2.0]                                                                      
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    3                                                              
NTP Experiment-Test: 93027-31         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/26/01    
Route: DOSED FEED                                       PEROXISOME PROJECT (WY-14643)                             Time: 07:47:53    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS MALE                     0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM      
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (9)          (10)         (9)          (10)         (10)         
      Nephropathy                                      8 [1.0]      9 [1.0]      8 [1.0]      8 [1.0]      7 [1.0]      8 [1.0]     
      Corticomedullary Junction, Renal Tubule,                                                                                      
           Regeneration                                             1 [1.0]      4 [1.0]      4 [1.0]      9 [1.0]      5 [1.0]     
   Urinary Bladder                                    (10)                                                             (10)         
      Infiltration Cellular                            1 [1.0]                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
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