TDMS Study 93027-31 Pathology Tables
NTP Experiment-Test: 93027-31 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 04/26/01
Route: DOSED FEED PEROXISOME PROJECT (WY-14643) Time: 07:47:53
FINAL#2/RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 50892-23-4
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 93027-31 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 04/26/01
Route: DOSED FEED PEROXISOME PROJECT (WY-14643) Time: 07:47:53
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SPRAGUE-DAWLEY RATS MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Cytoplasmic Alteration 9 [1.0] 10 [2.0] 10 [2.8] 10 [2.9] 10 [3.0]
Infiltration Cellular, Mononuclear Cell 6 [1.0] 8 [1.0] 6 [1.2] 5 [1.2] 6 [1.0] 6 [1.0]
Necrosis, Focal 1 [1.0] 1 [2.0]
Bile Duct, Hyperplasia 1 [1.0]
Hepatocyte, Periportal, Hyperplasia 1 [2.0]
Pancreas (10) (10) (10) (10) (9) (10)
Inflammation, Chronic 1 [1.0] 1 [1.0]
Stomach, Forestomach (10) (10)
Inflammation, Acute, Focal 1 [1.0]
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CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 5 [1.2] 2 [1.0]
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ENDOCRINE SYSTEM
Parathyroid Gland (10) (4)
Syncytial Alteration 1 [2.0]
Thyroid Gland (10) (10)
Cyst 1 [2.0]
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GENERAL BODY SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 93027-31 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 04/26/01
Route: DOSED FEED PEROXISOME PROJECT (WY-14643) Time: 07:47:53
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
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GENITAL SYSTEM
Preputial Gland (8) (10) (8) (8) (7) (7)
Inflammation, Chronic 8 [2.3] 10 [2.3] 8 [2.3] 8 [2.3] 7 [2.4] 6 [1.8]
Prostate (10) (1) (10)
Inflammation, Chronic 1 [1.0] 1 [3.0]
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HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage 2 [1.0] 2 [2.5]
Alveolus, Infiltration Cellular, Histiocyte 4 [1.0] 3 [1.3]
Interstitium, Inflammation 1 [1.0]
Interstitium, Inflammation, Chronic 1 [2.0]
Nose (10) (10)
Inflammation, Chronic, Focal 1 [2.0]
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SPECIAL SENSES SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 93027-31 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 04/26/01
Route: DOSED FEED PEROXISOME PROJECT (WY-14643) Time: 07:47:53
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (9) (10) (9) (10) (10)
Nephropathy 8 [1.0] 9 [1.0] 8 [1.0] 8 [1.0] 7 [1.0] 8 [1.0]
Corticomedullary Junction, Renal Tubule,
Regeneration 1 [1.0] 4 [1.0] 4 [1.0] 9 [1.0] 5 [1.0]
Urinary Bladder (10) (10)
Infiltration Cellular 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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