TDMS Study 93027-34 Pathology Tables
NTP Experiment-Test: 93027-34 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:02:38
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 50892-23-4
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93027-34 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:02:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Clear Cell Focus 1 (10%)
Cytoplasmic Alteration 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Infiltration Cellular, Mononuclear Cell 3 (30%) 1 (10%) 1 (10%) 2 (20%) 1 (10%)
Infiltration Cellular, Mixed Cell 5 (50%) 2 (20%) 6 (60%) 3 (30%) 7 (70%)
Mitotic Alteration 4 (40%) 7 (70%) 10 (100%)
Necrosis, Focal 1 (10%) 1 (10%) 2 (20%)
Pigmentation 3 (30%) 10 (100%)
Hepatocyte, Hyperplasia 1 (10%)
Oval Cell, Hyperplasia 10 (100%)
Pancreas (10) (5) (10) (10) (10) (10)
Inflammation, Chronic 1 (10%) 1 (10%) 3 (30%)
Stomach, Glandular (10) (10)
Inflammation, Chronic Active 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93027-34 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:02:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (4) (8) (10) (10) (10)
Inflammation, Chronic 3 (75%) 1 (13%) 4 (40%) 2 (20%)
Testes (10) (5) (10) (10) (10) (10)
Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Congestion 1 (10%)
Hemorrhage 5 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (5) (10) (10) (10) (10)
Nephropathy 3 (60%) 4 (40%) 4 (40%) 3 (30%)
Urinary Bladder (10) (10)
Infiltration Cellular 3 (30%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93027-34 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:02:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------