TDMS Study 93027-37 Pathology Tables
NTP Experiment-Test: 93027-37 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:04:17
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 50892-23-4
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-37 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:04:17
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SYRIAN HAMSTERS MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Gallbladder (10) (10)
Infiltration Cellular, Mixed Cell 8 (80%) 7 (70%)
Liver (10) (10) (10) (10) (10) (10)
Cytoplasmic Alteration 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Infiltration Cellular, Mixed Cell 10 (100%) 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%)
Pigmentation 2 (20%) 1 (10%)
Vacuolization Cytoplasmic 1 (10%) 4 (40%) 2 (20%)
Pancreas (10) (10) (10) (9) (10) (10)
Atrophy 1 (10%) 1 (10%)
Inflammation, Chronic 7 (70%) 7 (70%) 9 (90%) 9 (100%) 7 (70%) 8 (80%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (10) (2) (10)
Degeneration 2 (100%)
Prostate (10) (10) (10) (10) (10) (9)
Atrophy 1 (10%) 1 (10%) 3 (30%) 10 (100%) 9 (100%)
Inflammation, Chronic 1 (10%)
Seminal Vesicle (10) (10) (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%) 3 (30%) 10 (100%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-37 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:04:17
____________________________________________________________________________________________________________________________________
SYRIAN HAMSTERS MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Testes (10) (10) (10) (10) (10) (10)
Atrophy 2 (20%) 2 (20%) 1 (10%) 4 (40%) 7 (70%) 10 (100%)
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HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage 2 (20%) 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (10) (9) (10) (10) (10)
Mineralization 1 (10%) 2 (20%) 3 (33%) 2 (20%) 1 (10%)
Nephropathy 5 (50%) 3 (30%) 6 (67%) 2 (20%) 3 (30%) 1 (10%)
Urinary Bladder (10) (10)
Infiltration Cellular 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-37 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 07/08/99
Route: DOSED FEED Time: 10:04:17
____________________________________________________________________________________________________________________________________
SYRIAN HAMSTERS MALE 0 PPM 5 PPM 10 PPM 50 PPM 100 PPM 500 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mineralization 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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