https://ntp.niehs.nih.gov/go/19911

TDMS Study 93027-37 Pathology Tables

NTP Experiment-Test: 93027-37         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99
Route: DOSED FEED                                                                                                 Time: 10:04:17
                                                       13 WEEK SUBCHRONIC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  50892-23-4
       Lock Date:  06/12/96
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-37         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 10:04:17  
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         SYRIAN HAMSTERS MALE                      0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM         
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   Gallbladder                                        (10)                                                             (10)         
      Infiltration Cellular, Mixed Cell                8 (80%)                                                          7 (70%)     
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cytoplasmic Alteration                                       10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Infiltration Cellular, Mixed Cell               10 (100%)    10 (100%)    10 (100%)    10 (100%)     9 (90%)     10 (100%)    
      Pigmentation                                     2 (20%)      1 (10%)                                                         
      Vacuolization Cytoplasmic                                                               1 (10%)      4 (40%)      2 (20%)     
   Pancreas                                           (10)         (10)         (10)         (9)          (10)         (10)         
      Atrophy                                          1 (10%)                                                          1 (10%)     
      Inflammation, Chronic                            7 (70%)      7 (70%)      9 (90%)      9 (100%)     7 (70%)      8 (80%)     
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (10)         (2)                                                 (10)         
      Degeneration                                                  2 (100%)                                                        
   Prostate                                           (10)         (10)         (10)         (10)         (10)         (9)          
      Atrophy                                          1 (10%)      1 (10%)                   3 (30%)     10 (100%)     9 (100%)    
      Inflammation, Chronic                                         1 (10%)                                                         
   Seminal Vesicle                                    (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                          1 (10%)      1 (10%)                   3 (30%)     10 (100%)    10 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 93027-37         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 10:04:17  
____________________________________________________________________________________________________________________________________
         SYRIAN HAMSTERS MALE                      0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM         
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT                                                                                                               
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                          2 (20%)      2 (20%)      1 (10%)      4 (40%)      7 (70%)     10 (100%)    
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                                             (10)         
      Hemorrhage                                       2 (20%)                                                          1 (10%)     
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (9)          (10)         (10)         (10)         
      Mineralization                                   1 (10%)      2 (20%)      3 (33%)      2 (20%)                   1 (10%)     
      Nephropathy                                      5 (50%)      3 (30%)      6 (67%)      2 (20%)      3 (30%)      1 (10%)     
   Urinary Bladder                                    (10)                                                             (10)         
      Infiltration Cellular                            1 (10%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 93027-37         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 10:04:17  
____________________________________________________________________________________________________________________________________
         SYRIAN HAMSTERS MALE                      0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM         
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT                                                                                                               
      Mineralization                                   1 (10%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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