TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:08:23
31 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFPCBMIX
Lock Date: 11/04/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 05/16/00 - 05/17/00
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 80 NG /10 UG
Include 003 240 NG /30 UG
Include 004 800 NG /100 UG
Include 005 2400 NG/300 UG
Include 006 4000 NG/500 UG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:08:23
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SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 86 98 86
Scheduled Sacrifice 16 10 16 10 16 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Basophilic Focus 1 (10%)
Cholangiofibrosis 1 (10%) 2 (20%) 2 (20%) 1 (10%)
Eosinophilic Focus 3 (30%) 2 (20%)
Eosinophilic Focus, Multiple 4 (40%) 3 (30%)
Fatty Change, Diffuse 3 (30%) 8 (80%) 9 (90%)
Hepatodiaphragmatic Nodule 1 (10%) 1 (10%)
Hyperplasia, Nodular 1 (10%) 4 (40%)
Infarct 1 (10%)
Inflammation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Mixed Cell Focus 3 (30%) 5 (50%) 1 (10%)
Mixed Cell Focus, Multiple 2 (20%) 3 (30%) 1 (10%) 6 (60%)
Necrosis 1 (10%) 1 (10%) 1 (10%) 2 (20%)
Pigmentation 2 (20%) 4 (40%) 9 (90%) 10 (100%) 10 (100%) 10 (100%)
Toxic Hepatopathy 3 (30%) 10 (100%) 10 (100%)
Bile Duct, Fibrosis 1 (10%) 1 (10%)
Bile Duct, Hyperplasia 1 (10%) 10 (100%) 10 (100%)
Centrilobular, Fibrosis 3 (30%) 10 (100%) 10 (100%)
Hepatocyte, Hypertrophy 2 (20%) 4 (40%) 8 (80%) 10 (100%) 10 (100%)
Hepatocyte, Multinucleated 3 (30%) 10 (100%) 10 (100%)
Oval Cell, Hyperplasia 8 (80%) 10 (100%)
Portal, Fibrosis 1 (10%) 4 (40%)
Pancreas (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%)
Acinus, Atrophy 1 (10%) 2 (20%)
Acinus, Vacuolization Cytoplasmic 1 (10%) 10 (100%) 10 (100%)
Stomach, Forestomach (10) (1) (10)
Serosa, Inflammation, Chronic Active 1 (100%)
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CARDIOVASCULAR SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:08:23
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10) (10)
Angiectasis 6 (60%) 2 (20%) 1 (10%) 1 (10%)
Atrophy 2 (20%) 8 (80%)
Degeneration, Cystic 1 (10%)
Hypertrophy 5 (50%) 4 (40%) 3 (30%) 3 (30%) 3 (30%) 1 (10%)
Pituitary Gland (10) (1) (10)
Angiectasis 1 (100%)
Cyst 1 (10%) 1 (10%)
Cytoplasmic Alteration 1 (10%)
Thyroid Gland (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Follicular Cell, Hypertrophy 3 (30%) 3 (30%) 7 (70%) 7 (70%) 9 (90%) 7 (70%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10) (10)
Atrophy 6 (60%) 7 (70%) 7 (70%) 4 (40%) 1 (10%)
Uterus (10) (10) (10) (10) (10) (10)
Decidual Reaction 1 (10%)
Inflammation, Suppurative 1 (10%)
Metaplasia, Squamous 5 (50%) 6 (60%) 6 (60%) 4 (40%) 1 (10%)
Endometrium, Hyperplasia, Cystic 5 (50%) 5 (50%) 6 (60%) 3 (30%) 1 (10%) 1 (10%)
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 (100%) 10 (100%)
Thymus (10) (10) (10) (9) (10) (6)
Atrophy 3 (30%) 2 (20%) 5 (50%) 9 (100%) 9 (90%) 6 (100%)
Cyst 1 (11%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:08:23
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10)
Hyperplasia 2 (20%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Hemorrhage 2 (20%) 1 (10%) 1 (10%)
Infiltration Cellular, Histiocyte 3 (30%) 2 (20%) 4 (40%) 2 (20%) 5 (50%) 2 (20%)
Inflammation 1 (10%)
Inflammation, Granulomatous 1 (10%) 2 (20%) 2 (20%)
Metaplasia, Squamous 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Alveolar Epithelium, Metaplasia, Bronchiolar 3 (30%) 3 (30%)
Interstitium, Fibrosis, Focal 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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