TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
31 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFPCBMIX
Lock Date: 11/04/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 05/16/00 - 05/17/00
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 80 NG /10 UG
Include 003 240 NG /30 UG
Include 004 800 NG /100 UG
Include 005 2400 NG/300 UG
Include 006 4000 NG/500 UG
Page 1
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG / | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7| | L |
0 UG | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | X | 1 |
Cholangiofibrosis | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 1 1 1 1 2 2 1 1 1 1 | 10 1.2|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X X | 2 |
Necrosis | 1 | 1 1.0|
Pigmentation | 1 1 | 2 1.0|
Bile Duct, Fibrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 1 2 1 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG / | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7| | L |
0 UG | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Follicular Cell, Hypertrophy | 2 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 3 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Squamous | 1 2 1 2 2 | 5 1.6|
Endometrium, Hyperplasia, Cystic | 1 2 1 2 2 | 5 1.6|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 1 1 1 2 1 1 2 1 1 1 | 10 1.2|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG / | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7| | L |
0 UG | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 2 2 | 2 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
80 NG / | 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| | L |
10 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation | 1 1 1 1 1 1 1 1 1 2 | 10 1.1|
Mixed Cell Focus | X X X X X | 5 |
Mixed Cell Focus, Multiple | X X X | 3 |
Necrosis | 1 | 1 1.0|
Pigmentation | 1 1 1 1 | 4 1.0|
Hepatocyte, Hypertrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Angiectasis | 1 1 1 1 1 1 | 6 1.0|
Degeneration, Cystic | 2 | 1 2.0|
Hypertrophy | 2 2 1 2 | 4 1.8|
|__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
Angiectasis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 3 3 3 3 | 7 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
80 NG / | 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| | L |
10 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Metaplasia, Squamous | 2 1 1 2 2 2 | 6 1.7|
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
240 NG / | 2| 3| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| | L |
30 UG | 8| 7| 8| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation | 2 1 2 1 1 1 1 1 1 1 | 10 1.2|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X | 1 |
Necrosis | 2 | 1 2.0|
Pigmentation | 2 1 1 1 1 1 1 1 1 | 9 1.1|
Hepatocyte, Hypertrophy | 1 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
Serosa, Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Angiectasis | 1 1 | 2 1.0|
Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 1 1 1 2 2 1 1 | 7 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 3 3 2 3 | 7 2.9|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
240 NG / | 2| 3| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| | L |
30 UG | 8| 7| 8| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Uterus | + + + + + + + + + + | 10 |
Decidual Reaction | X | 1 |
Metaplasia, Squamous | 2 2 1 1 2 2 | 6 1.7|
Endometrium, Hyperplasia, Cystic | 2 2 1 1 3 1 | 6 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 2 2 1 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
800 NG / | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Cholangiofibrosis | 2 1 | 2 1.5|
Fatty Change, Diffuse | 2 1 2 | 3 1.7|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 2 2 1 2 2 2 1 3 2 1 | 10 1.8|
Mixed Cell Focus, Multiple | X X X X X X | 6 |
Pigmentation | 1 1 1 2 1 1 1 2 1 1 | 10 1.2|
Toxic Hepatopathy | 1 1 1 | 3 1.0|
Bile Duct, Fibrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
Centrilobular, Fibrosis | 1 1 1 | 3 1.0|
Hepatocyte, Hypertrophy | 2 1 1 1 1 1 1 1 | 8 1.1|
Hepatocyte, Multinucleated | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Vacuolization Cytoplasmic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 2 1 2 | 3 1.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 1 2 1 2 2 1 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
800 NG / | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Ovary | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Metaplasia, Squamous | 2 2 1 2 | 4 1.8|
Endometrium, Hyperplasia, Cystic | 2 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 9 |
Atrophy | 2 2 2 2 3 2 2 4 2 | 9 2.3|
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
Inflammation, Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
800 NG / | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L |
100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2400 NG/ | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8| | L |
300 UG | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Cholangiofibrosis | 1 2 | 2 1.5|
Eosinophilic Focus | X X X | 3 |
Eosinophilic Focus, Multiple | X X X X | 4 |
Fatty Change, Diffuse | 1 2 1 2 1 2 1 1 | 8 1.4|
Hyperplasia, Nodular | X | 1 |
Infarct | 3 | 1 3.0|
Inflammation | 2 2 2 2 1 1 1 2 2 1 | 10 1.6|
Necrosis | 1 1 | 2 1.0|
Pigmentation | 2 2 2 2 3 2 2 2 2 2 | 10 2.1|
Toxic Hepatopathy | 2 2 2 2 2 2 2 2 2 3 | 10 2.1|
Bile Duct, Hyperplasia | 2 2 2 1 2 1 1 1 1 2 | 10 1.5|
Centrilobular, Fibrosis | 2 2 2 2 2 2 2 1 2 1 | 10 1.8|
Hepatocyte, Hypertrophy | 3 3 2 3 3 3 3 2 3 3 | 10 2.8|
Hepatocyte, Multinucleated | 3 2 2 2 2 2 2 2 2 3 | 10 2.2|
Oval Cell, Hyperplasia | 1 2 2 1 1 1 1 1 | 8 1.3|
Portal, Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Atrophy | 1 | 1 1.0|
Acinus, Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 1 1 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Angiectasis | 1 | 1 1.0|
Atrophy | 1 1 | 2 1.0|
Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2400 NG/ | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8| | L |
300 UG | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Follicular Cell, Hypertrophy | 2 2 2 2 1 2 1 2 2 | 9 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Metaplasia, Squamous | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 4 2 4 4 4 4 3 3 3 | 9 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 5 1.0|
Inflammation, Granulomatous | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2400 NG/ | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8| | L |
300 UG | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 2 1 1 | 3 1.3|
Interstitium, Fibrosis, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Cholangiofibrosis | 1 | 1 1.0|
Eosinophilic Focus | X X | 2 |
Eosinophilic Focus, Multiple | X X X | 3 |
Fatty Change, Diffuse | 1 1 2 1 1 1 2 1 3 | 9 1.4|
Hyperplasia, Nodular | X X X X | 4 |
Inflammation | 2 2 1 2 2 1 1 1 1 1 | 10 1.4|
Pigmentation | 2 3 2 3 3 3 3 2 3 2 | 10 2.6|
Toxic Hepatopathy | 3 3 2 2 3 3 3 3 3 3 | 10 2.8|
Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 1 1 | 10 1.2|
Centrilobular, Fibrosis | 3 3 2 2 2 3 2 2 2 2 | 10 2.3|
Hepatocyte, Hypertrophy | 4 4 4 3 3 3 3 3 3 4 | 10 3.4|
Hepatocyte, Multinucleated | 2 3 2 3 3 2 3 3 3 2 | 10 2.6|
Oval Cell, Hyperplasia | 2 2 1 1 1 2 1 1 1 1 | 10 1.3|
Portal, Fibrosis | 3 2 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
Acinus, Atrophy | 1 1 | 2 1.0|
Acinus, Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 1 1 1 | 10 1.1|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Angiectasis | 1 | 1 1.0|
Atrophy | 2 2 2 2 2 2 1 1 | 8 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Cyst | 2 | 1 2.0|
Cytoplasmic Alteration | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Inflammation, Chronic Active | 3 | 1 3.0|
Follicular Cell, Hypertrophy | 1 1 2 2 1 1 4 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Endometrium, Hyperplasia, Cystic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 1 1 2 1 1 1 1 2 2 1 | 10 1.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + M M + M M | 6 |
Atrophy | 4 4 4 3 3 4 | 6 3.7|
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:17:20
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
Inflammation, Granulomatous | 1 2 | 2 1.5|
Metaplasia, Squamous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
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