TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:24:40
53 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFPCBMIX
Lock Date: 11/04/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 10/12/00 - 10/13/00
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 80 NG /10 UG
Include 003 240 NG /30 UG
Include 004 800 NG /100 UG
Include 005 2400 NG/300 UG
Include 006 4000 NG/500 UG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:24:40
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SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 86 98 86
Scheduled Sacrifice 13 12 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 7 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (7) (8) (8) (8)
Angiectasis 1 (13%)
Basophilic Focus 2 (25%) 3 (43%) 1 (13%) 1 (13%) 1 (13%)
Cholangiofibrosis 2 (25%) 5 (63%)
Clear Cell Focus, Multiple 1 (13%)
Eosinophilic Focus 1 (13%) 1 (13%)
Fatty Change, Diffuse 4 (50%) 8 (100%)
Fatty Change, Focal 1 (13%)
Hepatodiaphragmatic Nodule 1 (13%)
Hyperplasia, Nodular 1 (13%) 8 (100%)
Inflammation 7 (88%) 7 (100%) 8 (100%) 8 (100%) 8 (100%)
Mixed Cell Focus 2 (25%) 2 (29%) 2 (25%)
Mixed Cell Focus, Multiple 5 (63%) 3 (43%) 5 (63%) 7 (88%)
Necrosis 1 (13%) 1 (14%) 3 (38%) 2 (25%) 2 (25%)
Pigmentation 5 (71%) 8 (100%) 8 (100%) 8 (100%)
Toxic Hepatopathy 2 (25%) 8 (100%) 8 (100%)
Bile Duct, Cyst 1 (13%)
Bile Duct, Fibrosis 1 (13%)
Bile Duct, Hyperplasia 1 (13%) 1 (13%) 8 (100%)
Centrilobular, Fibrosis 5 (63%) 8 (100%)
Hepatocyte, Hypertrophy 1 (14%) 2 (25%) 8 (100%) 8 (100%)
Hepatocyte, Multinucleated 3 (38%) 8 (100%) 8 (100%)
Oval Cell, Hyperplasia 8 (100%)
Portal, Fibrosis 8 (100%)
Pancreas (8) (7) (8) (8) (8)
Inflammation, Chronic Active 1 (13%) 2 (25%) 1 (13%)
Acinus, Atrophy 1 (14%) 1 (13%) 1 (13%) 1 (13%)
Acinus, Vacuolization Cytoplasmic 6 (75%) 8 (100%)
Stomach, Forestomach (8) (8)
Edema 1 (13%)
Stomach, Glandular (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:24:40
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Erosion 2 (25%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (7) (8) (8) (8)
Angiectasis 2 (29%) 3 (38%) 4 (50%) 1 (13%)
Atrophy 5 (63%)
Degeneration, Cystic 1 (13%) 2 (25%)
Hyperplasia 1 (13%) 1 (13%) 1 (13%)
Hypertrophy 5 (63%) 3 (43%) 6 (75%) 7 (88%) 5 (63%)
Vacuolization Cytoplasmic 1 (13%) 1 (14%) 1 (13%) 1 (13%)
Pituitary Gland (8) (8)
Cyst 1 (13%)
Thyroid Gland (8) (7) (8) (8) (8)
C-Cell, Hyperplasia 1 (13%) 1 (13%)
Follicular Cell, Hypertrophy 3 (38%) 4 (57%) 6 (75%) 7 (88%) 7 (88%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (7) (8) (8) (8)
Atrophy 7 (88%) 6 (86%) 6 (75%) 5 (63%)
Cyst 1 (14%)
Uterus (8) (7) (8) (8) (8)
Inflammation, Suppurative 2 (25%)
Metaplasia, Squamous 6 (75%) 5 (71%) 5 (63%) 5 (63%)
Endometrium, Hyperplasia, Cystic 6 (75%) 6 (86%) 5 (63%) 5 (63%)
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/27/04
Route: GAVAGE Time: 13:24:40
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (13%)
Pigmentation 8 (100%) 8 (100%)
Thymus (8) (7) (8) (8) (6)
Atrophy 5 (63%) 7 (100%) 7 (88%) 8 (100%) 6 (100%)
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (1) (1) (8)
Cyst 1 (13%)
Hyperplasia 1 (13%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (7) (8) (8) (8)
Infiltration Cellular, Histiocyte 7 (88%) 5 (71%) 7 (88%) 6 (75%) 8 (100%)
Inflammation 1 (13%)
Pigmentation 1 (13%)
Alveolar Epithelium, Hyperplasia 1 (13%)
Alveolar Epithelium, Metaplasia, Bronchiolar 3 (38%) 3 (38%) 6 (75%)
Interstitium, Fibrosis 1 (13%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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