TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15
53 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFPCBMIX
Lock Date: 11/04/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 10/12/00 - 10/13/00
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 80 NG /10 UG
Include 003 240 NG /30 UG
Include 004 800 NG /100 UG
Include 005 2400 NG/300 UG
Include 006 4000 NG/500 UG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15
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SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 86 98 86
Scheduled Sacrifice 13 12 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 7 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (7) (8) (8) (8)
Angiectasis 1 [2.0]
Basophilic Focus 2 3 1 1 1
Cholangiofibrosis 2 [1.5] 5 [2.4]
Clear Cell Focus, Multiple 1
Eosinophilic Focus 1 1
Fatty Change, Diffuse 4 [1.0] 8 [2.1]
Fatty Change, Focal 1 [1.0]
Hepatodiaphragmatic Nodule 1
Hyperplasia, Nodular 1 8
Inflammation 7 [1.0] 7 [1.1] 8 [1.4] 8 [1.9] 8 [1.4]
Mixed Cell Focus 2 2 2
Mixed Cell Focus, Multiple 5 3 5 7
Necrosis 1 [1.0] 1 [1.0] 3 [1.0] 2 [1.0] 2 [1.0]
Pigmentation 5 [1.0] 8 [1.1] 8 [2.0] 8 [2.5]
Toxic Hepatopathy 2 [1.0] 8 [1.3] 8 [3.1]
Bile Duct, Cyst 1 [2.0]
Bile Duct, Fibrosis 1 [1.0]
Bile Duct, Hyperplasia 1 [1.0] 1 [1.0] 8 [2.1]
Centrilobular, Fibrosis 5 [1.2] 8 [2.0]
Hepatocyte, Hypertrophy 1 [1.0] 2 [1.5] 8 [1.6] 8 [3.8]
Hepatocyte, Multinucleated 3 [1.0] 8 [1.4] 8 [2.6]
Oval Cell, Hyperplasia 8 [2.6]
Portal, Fibrosis 8 [2.0]
Pancreas (8) (7) (8) (8) (8)
Inflammation, Chronic Active 1 [2.0] 2 [1.0] 1 [1.0]
Acinus, Atrophy 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
Acinus, Vacuolization Cytoplasmic 6 [1.0] 8 [1.8]
Stomach, Forestomach (8) (8)
Edema 1 [2.0]
Stomach, Glandular (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Erosion 2 [1.5]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (7) (8) (8) (8)
Angiectasis 2 [1.0] 3 [1.0] 4 [1.3] 1 [1.0]
Atrophy 5 [2.2]
Degeneration, Cystic 1 [2.0] 2 [1.5]
Hyperplasia 1 [2.0] 1 [2.0] 1 [2.0]
Hypertrophy 5 [1.0] 3 [2.0] 6 [1.8] 7 [2.1] 5 [1.0]
Vacuolization Cytoplasmic 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
Pituitary Gland (8) (8)
Cyst 1 [1.0]
Thyroid Gland (8) (7) (8) (8) (8)
C-Cell, Hyperplasia 1 [1.0] 1 [1.0]
Follicular Cell, Hypertrophy 3 [1.0] 4 [1.5] 6 [1.0] 7 [1.4] 7 [1.6]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (7) (8) (8) (8)
Atrophy 7 [3.0] 6 [2.8] 6 [3.0] 5 [3.0]
Cyst 1 [2.0]
Uterus (8) (7) (8) (8) (8)
Inflammation, Suppurative 2 [1.5]
Metaplasia, Squamous 6 [1.8] 5 [1.6] 5 [2.0] 5 [1.8]
Endometrium, Hyperplasia, Cystic 6 [2.0] 6 [1.7] 5 [3.0] 5 [1.8]
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 1 [1.0]
Pigmentation 8 [1.5] 8 [1.3]
Thymus (8) (7) (8) (8) (6)
Atrophy 5 [2.0] 7 [2.0] 7 [2.1] 8 [3.0] 6 [3.8]
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (1) (1) (8)
Cyst 1 [3.0]
Hyperplasia 1 [1.0]
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (7) (8) (8) (8)
Infiltration Cellular, Histiocyte 7 [1.1] 5 [1.2] 7 [1.0] 6 [1.3] 8 [1.4]
Inflammation 1 [2.0]
Pigmentation 1 [2.0]
Alveolar Epithelium, Hyperplasia 1 [2.0]
Alveolar Epithelium, Metaplasia, Bronchiolar 3 [1.3] 3 [2.3] 6 [1.7]
Interstitium, Fibrosis 1 [3.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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