TDMS Study 05196-03 Pathology Tables
NTP Experiment-Test: 05196-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 08:31:23
Facility: TSI Mason Research
Chemical CAS #: 10102-18-8
Lock Date: 02/16/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 001 0 PPM
Include 004 2 PPM
Include 003 2 PPM
Include 006 4 PPM
Include 005 4 PPM
Include 008 8 PPM
Include 007 8 PPM
Include 010 16 PPM
Include 009 16 PPM
Include 012 32 PPM
Include 011 32 PPM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05196-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 08:31:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 10 10 10 10 10 8
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (1) (3) (10) (10) (10)
Atrophy 10 (100%)
Hematopoietic Cell Proliferation, Focal 6 (60%) 1 (33%) 3 (30%) 3 (30%) 5 (50%)
Hepatodiaphragmatic Nodule 2 (20%) 1 (100%) 3 (100%) 2 (20%)
Necrosis, Focal 1 (10%)
Kupffer Cell, Pigmentation, Hemosiderin 6 (60%)
Pancreas (10) (10) (10)
Atrophy 10 (100%)
Salivary Glands (10) (10) (10) (10)
Atrophy 1 (10%) 10 (100%)
Stomach, Glandular (10) (10)
Submucosa, Edema 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 2 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Hemorrhage 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05196-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 08:31:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10) (9)
Atrophy 9 (100%)
Inflammation, Focal, Subacute 1 (10%)
Ovary (9) (1) (2) (1) (10)
Cyst 1 (11%) 1 (100%) 2 (100%) 1 (100%)
Uterus (10) (2) (10) (10) (10)
Endometrium, Atrophy 2 (20%) 9 (90%)
Lumen, Dilatation 1 (10%) 2 (100%) 4 (40%) 2 (20%)
Vagina (10) (10) (10) (10) (10)
Lumen, Concretion, Focal 1 (10%)
Lumen, Dilatation, Focal 1 (10%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10)
Pigmentation, Hemosiderin 2 (20%)
Femoral, Depletion Cellular 10 (100%)
Lymph Node, Mandibular (10) (1) (1) (10) (10)
Depletion Lymphoid 2 (20%)
Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mesenteric (10) (1) (1) (10) (10)
Congestion 2 (20%)
Depletion Lymphoid 1 (10%)
Hyperplasia, Lymphoid 1 (100%)
Pigmentation, Hemosiderin 10 (100%) 10 (100%) 10 (100%)
Spleen (10) (10) (10)
Depletion Lymphoid 5 (50%)
Fibrosis, Focal 1 (10%)
Pigmentation, Hemosiderin 10 (100%) 10 (100%) 10 (100%)
Thymus (10) (10) (7)
Depletion Lymphoid 6 (86%)
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INTEGUMENTARY SYSTEM
Mammary Gland (10) (8) (10) (9)
Atrophy 4 (40%) 8 (89%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05196-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 08:31:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (10) (10) (10)
Distal, Femur, Metaphysis, Atrophy 10 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (1) (10)
Hemorrhage, Focal 1 (10%) 1 (10%)
Inflammation, Focal, Subacute 3 (30%)
Mineralization, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Inflammation, Focal, Subacute 1 (10%)
Mineralization, Focal 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 8 (80%)
Papilla, Degeneration 1 (10%) 3 (30%) 6 (60%) 8 (80%) 9 (90%)
Renal Tubule, Dilatation, Focal 1 (10%) 1 (10%) 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05196-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 08:31:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 20 20 20 20 20
Early Deaths
Survivors
Terminal Sacrifice 20 20 20 20 20 20
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (10) (10)
Parasite Metazoan 1 (10%)
Liver (10) (3) (3) (2) (10)
Fatty Change 5 (50%) 3 (100%)
Hematopoietic Cell Proliferation, Focal 2 (20%) 1 (50%) 2 (20%)
Hepatodiaphragmatic Nodule 1 (10%) 3 (100%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 7 (70%) 6 (60%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Zona Fasciculata, Vacuolization Cytoplasmic 10 (100%) 4 (40%)
Pituitary Gland (10) (10)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05196-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 08:31:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (8) (10)
Congestion 2 (20%) 2 (20%)
Depletion Lymphoid 1 (10%)
Lymph Node, Mesenteric (10) (10) (10) (10) (10)
Congestion 5 (50%)
Pigmentation, Hemosiderin 10 (100%) 10 (100%) 10 (100%)
Spleen (10) (10) (10) (10) (10)
Pigmentation, Hemosiderin 10 (100%) 10 (100%) 10 (100%)
Thymus (10) (10) (10) (10) (10)
Congestion 1 (10%)
Depletion Lymphoid 4 (40%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (1) (10)
Pinna, Hyperplasia, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage, Focal 2 (20%) 1 (10%)
Inflammation, Focal, Subacute 1 (10%)
Interstitium, Inflammation, Chronic, Focal 1 (10%)
Pleura, Fibrosis, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05196-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 08:31:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Hemorrhage, Focal 1 (10%)
Inflammation, Focal, Subacute 1 (10%)
Papilla, Degeneration 1 (10%) 1 (10%) 2 (20%) 5 (50%) 7 (70%)
Renal Tubule, Dilatation 3 (30%)
Renal Tubule, Dilatation, Focal 3 (30%) 3 (30%) 3 (30%) 6 (60%) 2 (20%) 2 (20%)
Renal Tubule, Regeneration 10 (100%) 9 (90%) 9 (90%) 9 (90%) 10 (100%) 8 (80%)
Urinary Bladder (10) (1) (10)
Calculus Micro Observation Only 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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