TDMS Study 05195-04 Pathology Tables
NTP Experiment-Test: 05195-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:24:19
Facility: TSI Mason Research
Chemical CAS #: 13410-01-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 001 0 PPM
Include 004 3.75 PPM
Include 003 3.75 PPM
Include 006 7.5 PPM
Include 005 7.5 PPM
Include 008 15 PPM
Include 007 15 PPM
Include 010 30 PPM
Include 009 30 PPM
Include 012 60 PPM
Include 011 60 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05195-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:24:19
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B6C3F1 MICE FEMALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 8 7 3 10 10
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ALIMENTARY SYSTEM
Liver (10) (1) (10) (10)
Developmental Malformation 1 (10%) 1 (100%)
Hematopoietic Cell Proliferation, Focal 5 (50%) 3 (30%) 4 (40%)
Salivary Glands (10) (10) (10)
Inflammation, Focal, Subacute 2 (20%) 3 (30%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (9) (1) (10)
Pigmentation, Melanin 1 (100%)
Uterus (10) (1) (10) (10)
Endometrium, Edema 1 (10%) 1 (10%) 3 (30%)
Lumen, Dilatation 1 (10%) 1 (10%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05195-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:24:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10)
Hyperplasia, Lymphoid 1 (10%)
Lymph Node, Mesenteric (10) (10)
Lymphocyte, Depletion Cellular 1 (10%)
Spleen (10) (10)
Pigmentation, Hemosiderin 1 (10%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (1) (10)
Congestion 1 (100%)
Hemorrhage, Focal 1 (10%) 2 (20%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (10) (10)
Inflammation, Focal, Subacute 3 (30%)
Inflammation, Subacute 3 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05195-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:24:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 7 8 7 7 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Hematopoietic Cell Proliferation, Focal 2 (20%) 3 (30%)
Mesentery (1)
Necrosis 1 (100%)
Fat, Developmental Malformation 1 (100%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (10) (10)
Lymphocyte, Depletion Cellular 1 (10%)
Spleen (10) (1) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05195-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:24:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Hemosiderin 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Hyperplasia 1 (100%)
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URINARY SYSTEM
Urinary Bladder (10) (2) (1) (2) (10)
Calculus Gross Observation 2 (100%) 1 (100%) 1 (50%) 2 (20%)
Calculus Micro Observation Only 2 (20%) 2 (100%) 1 (100%) 1 (50%) 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
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