TDMS Study 05196-04 Pathology Tables
NTP Experiment-Test: 05196-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 07:19:03
Facility: TSI Mason Research
Chemical CAS #: 10102-18-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 001 0 PPM
Include 004 2 PPM
Include 003 2 PPM
Include 006 4 PPM
Include 005 4 PPM
Include 008 8 PPM
Include 007 8 PPM
Include 010 16 PPM
Include 009 16 PPM
Include 012 32 PPM
Include 011 32 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05196-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 07:19:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 2 1 10
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ALIMENTARY SYSTEM
Liver (10) (1) (10)
Hematopoietic Cell Proliferation 5 (50%) 1 (100%) 4 (40%)
Hepatodiaphragmatic Nodule 1 (100%)
Salivary Glands (10) (10)
Inflammation, Subacute 2 (20%) 2 (20%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (1) (10)
Cyst 1 (100%)
Uterus (10) (1) (10)
Endometrium, Hyperplasia 1 (100%)
Lumen, Dilatation 1 (10%)
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HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05196-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 07:19:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage, Focal 1 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05196-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 07:19:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Parathyroid Gland (8) (5)
Unilateral, Cyst 1 (13%)
Thyroid Gland (10) (10)
Inflammation, Focal, Subacute 1 (10%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10)
Pigmentation, Hemosiderin 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05196-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENITE Date: 10/19/04
Route: DOSED WATER Time: 07:19:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 2 4 8 16 32
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage, Focal 1 (10%) 5 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Pelvis, Inflammation, Focal 1 (10%)
Urinary Bladder (10) (10)
Lumen, Concretion 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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