TDMS Study 96018-04 Pathology Tables
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 10:55:48
FINAL #1/MICE
Facility: Southern Research Institute
Chemical CAS #: 75-27-4
Lock Date: 02/18/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 10:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
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DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 7 12 7
Moribund Sacrifice 7 6 5 4
Accidently Killed 1
Survivors
Terminal Sacrifice 36 36 33 39
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (48) (48) (49)
Edema 10 (20%) 8 (17%) 8 (17%) 4 (8%)
Hemorrhage 1 (2%)
Intestine Small, Duodenum (48) (48) (46) (46)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Intestine Small, Jejunum (46) (49) (48) (48)
Hyperplasia, Lymphoid 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Ileum (45) (46) (49) (49)
Diverticulum 1 (2%)
Epithelium, Hyperplasia 1 (2%) 2 (4%)
Liver (50) (50) (50) (50)
Basophilic Focus 3 (6%) 5 (10%) 2 (4%)
Clear Cell Focus 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Cyst 2 (4%)
Eosinophilic Focus 7 (14%) 4 (8%) 8 (16%) 4 (8%)
Hematopoietic Cell Proliferation 4 (8%) 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 5 (10%) 6 (12%) 1 (2%)
Infarct 2 (4%)
Infiltration Cellular, Mixed Cell 6 (12%) 6 (12%) 7 (14%) 5 (10%)
Mixed Cell Focus 3 (6%) 3 (6%) 3 (6%) 2 (4%)
Necrosis, Focal 3 (6%) 5 (10%) 2 (4%) 4 (8%)
Tension Lipidosis 2 (4%) 2 (4%)
Centrilobular, Necrosis 6 (12%) 1 (2%) 2 (4%) 3 (6%)
Hepatocyte, Depletion Glycogen 3 (6%) 2 (4%) 1 (2%)
Hepatocyte, Karyomegaly 2 (4%) 4 (8%)
Hepatocyte, Vacuolization Cytoplasmic 6 (12%) 3 (6%) 6 (12%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 10:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Kupffer Cell, Hyperplasia 2 (4%) 1 (2%)
Kupffer Cell, Pigmentation 7 (14%) 2 (4%) 1 (2%)
Mesentery (21) (17) (16) (17)
Angiectasis 1 (5%)
Hemorrhage 2 (12%)
Necrosis 1 (5%)
Fat, Necrosis 12 (57%) 8 (47%) 11 (69%) 13 (76%)
Pancreas (50) (48) (49) (49)
Atrophy 1 (2%) 2 (4%) 2 (4%)
Cyst 1 (2%) 1 (2%)
Acinus, Cytoplasmic Alteration 3 (6%) 2 (4%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 25 (50%) 22 (44%) 26 (52%) 20 (40%)
Stomach, Forestomach (50) (49) (50) (50)
Edema 2 (4%) 1 (2%) 2 (4%)
Erosion 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 4 (8%) 1 (2%)
Ulcer 2 (4%)
Epithelium, Hyperplasia 2 (4%) 3 (6%) 4 (8%) 2 (4%)
Stomach, Glandular (50) (49) (49) (50)
Cyst 2 (4%) 2 (4%)
Edema 2 (4%) 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Tooth (1)
Malformation 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Mineralization 3 (6%)
Thrombosis 1 (2%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (49)
Accessory Adrenal Cortical Nodule 8 (16%) 5 (10%) 5 (10%) 10 (20%)
Hyperplasia, Focal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 10:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy, Focal 1 (2%) 1 (2%) 2 (4%)
Zona Reticularis, Vacuolization Cytoplasmic 2 (4%) 1 (2%)
Adrenal Medulla (50) (48) (49) (49)
Hyperplasia 2 (4%) 2 (4%)
Islets, Pancreatic (49) (48) (48) (49)
Hyperplasia 1 (2%) 4 (8%) 3 (6%) 1 (2%)
Parathyroid Gland (47) (48) (46) (47)
Cyst 2 (4%) 1 (2%)
Pituitary Gland (49) (50) (49) (49)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 1 (2%) 4 (8%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 6 (12%) 6 (12%) 1 (2%) 4 (8%)
Thyroid Gland (50) (49) (49) (50)
Degeneration, Cystic 26 (52%) 17 (35%) 12 (24%) 11 (22%)
Follicular Cell, Hyperplasia 6 (12%) 1 (2%) 5 (10%) 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (48) (49) (48) (49)
Inflammation, Chronic 1 (2%) 1 (2%) 4 (8%) 1 (2%)
Ovary (50) (49) (50) (49)
Angiectasis 5 (10%) 6 (12%) 5 (10%) 9 (18%)
Cyst 8 (16%) 13 (27%) 11 (22%) 14 (29%)
Thrombosis 1 (2%) 1 (2%)
Corpus Luteum, Hyperplasia 3 (6%) 1 (2%) 3 (6%)
Granulosa Cell, Hyperplasia 2 (4%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 3 (6%) 1 (2%)
Hyperplasia, Cystic 45 (90%) 45 (90%) 43 (86%) 46 (92%)
Inflammation, Chronic 2 (4%) 2 (4%) 1 (2%)
Metaplasia, Squamous 1 (2%) 2 (4%) 2 (4%)
Endometrium, Hyperplasia, Atypical 1 (2%)
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HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 10:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bone Marrow (50) (50) (50) (50)
Hyperplasia 22 (44%) 24 (48%) 18 (36%) 11 (22%)
Myelofibrosis 3 (6%) 1 (2%) 1 (2%)
Lymph Node (16) (9) (7) (4)
Iliac, Hemorrhage 1 (6%) 1 (14%)
Iliac, Hyperplasia, Lymphoid 3 (19%)
Mediastinal, Hemorrhage 1 (6%) 1 (11%)
Renal, Hyperplasia, Lymphoid 1 (25%)
Lymph Node, Mandibular (50) (50) (50) (47)
Atrophy 2 (4%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 1 (2%)
Hemorrhage 3 (6%) 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 8 (16%) 9 (18%) 6 (12%) 9 (19%)
Pigmentation 22 (44%) 27 (54%) 25 (50%) 20 (43%)
Lymph Node, Mesenteric (49) (48) (46) (50)
Atrophy 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%)
Hemorrhage 3 (6%) 2 (4%) 3 (7%)
Hyperplasia, Lymphoid 6 (12%) 9 (19%) 4 (9%) 7 (14%)
Pigmentation 1 (2%) 1 (2%)
Spleen (50) (49) (48) (50)
Hematopoietic Cell Proliferation 42 (84%) 30 (61%) 32 (67%) 29 (58%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Metaplasia, Osseous 1 (2%)
Pigmentation 29 (58%) 22 (45%) 30 (63%) 27 (54%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 5 (10%) 8 (16%) 13 (27%) 14 (28%)
Thymus (49) (49) (50) (47)
Atrophy 9 (18%) 3 (6%) 6 (12%) 4 (9%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%) 4 (8%) 2 (4%)
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INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 9 (18%) 4 (8%) 4 (8%) 2 (4%)
Skin (50) (50) (50) (50)
Angiectasis 1 (2%)
Edema 2 (4%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Epidermis, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 10:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 3 (6%) 1 (2%) 1 (2%)
Skeletal Muscle (5) (2) (4) (1)
Atrophy 1 (20%) 1 (50%)
Inflammation, Chronic 1 (20%)
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 2 (4%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Necrosis 1 (2%)
Peripheral Nerve (5) (4) (1) (1)
Atrophy 3 (60%) 2 (50%)
Inflammation, Chronic 1 (25%)
Spinal Cord (4) (4) (2) (1)
Atrophy 1 (50%)
Hemorrhage 1 (25%) 1 (50%)
Necrosis 1 (25%) 1 (50%)
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Edema 1 (2%) 1 (2%) 1 (2%)
Emphysema 1 (2%)
Foreign Body 1 (2%) 2 (4%)
Hemorrhage 6 (12%) 7 (14%) 6 (12%) 7 (14%)
Hyperplasia, Lymphoid 1 (2%) 4 (8%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 5 (10%)
Inflammation, Chronic 1 (2%) 1 (2%)
Thrombosis 1 (2%) 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Alveolar Epithelium, Metaplasia, Bronchiolar 2 (4%)
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SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 10:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Eye (48) (50) (50) (50)
Developmental Malformation 1 (2%) 4 (8%)
Hemorrhage 2 (4%)
Inflammation, Chronic 2 (4%)
Harderian Gland (50) (50) (50) (50)
Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%) 1 (2%)
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URINARY SYSTEM
Kidney (50) (49) (50) (50)
Amyloid Deposition 1 (2%)
Cyst 1 (2%)
Hyperplasia, Lymphoid 8 (16%) 5 (10%) 5 (10%) 3 (6%)
Infarct 2 (4%) 2 (4%) 3 (6%) 5 (10%)
Inflammation, Focal, Mixed Cell 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (2%)
Nephropathy 16 (32%) 14 (29%) 7 (14%) 8 (16%)
Renal Tubule, Accumulation, Hyaline Droplet 2 (4%) 6 (12%) 4 (8%) 1 (2%)
Renal Tubule, Necrosis 2 (4%) 2 (4%) 1 (2%)
Renal Tubule, Pigmentation 2 (4%) 1 (2%)
Renal Tubule, Regeneration 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Urinary Bladder (50) (49) (48) (50)
Edema 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 11 (22%) 7 (14%) 4 (8%) 10 (20%)
Inflammation, Chronic 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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