TDMS Study 96018-04 Pathology Tables
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
FINAL #1/MICE
Facility: Southern Research Institute
Chemical CAS #: 75-27-4
Lock Date: 02/18/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 0| 2| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 8| 3|
| 9| 5| 5| 5| 4| 3| 5| 5| 5| 5| 3| 5| 2| 2| 2| 5| 5| 5| 6| 5| 5| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + A A + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + A + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + M +|
Carcinoma | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X X |
Lymphoma Malignant | X X X X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Hemangiosarcoma | X |
Hepatoblastoma, Metastatic, Liver | X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 0| 2| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 8| 3|
| 9| 5| 5| 5| 4| 3| 5| 5| 5| 5| 3| 5| 2| 2| 2| 5| 5| 5| 6| 5| 5| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma, Metastatic, Skeletal Muscle | X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma, Metastatic, Liver | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Adenoma | X X X|
Pars Intermedia, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 0| 2| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 8| 3|
| 9| 5| 5| 5| 4| 3| 5| 5| 5| 5| 3| 5| 2| 2| 2| 5| 5| 5| 6| 5| 5| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + I + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
Granulosa Cell Tumor Benign | X |
Hemangiosarcoma | X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | X |
Hemangiosarcoma | X |
Lymphoma Malignant | X |
Sarcoma Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Lymphoma Malignant | |
Sarcoma | X |
Bronchial, Hepatoblastoma, | |
Metastatic, Liver | X |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | X |
Mediastinal, Sarcoma, Metastatic, | |
Skeletal Muscle | X X |
Pancreatic, Hemangiosarcoma | |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 0| 2| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 8| 3|
| 9| 5| 5| 5| 4| 3| 5| 5| 5| 5| 3| 5| 2| 2| 2| 5| 5| 5| 6| 5| 5| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hepatoblastoma, Metastatic, Liver | X |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | X X |
Lymphoma Malignant | X X X X X X X X X X |
|__________________________________________________________________________|
Thymus | I + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X |
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X X X |
Subcutaneous Tissue, Sarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoma | |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + |
Lymphoma Malignant | X |
Sarcoma | X X |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 0| 2| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 8| 3|
| 9| 5| 5| 5| 4| 3| 5| 5| 5| 5| 3| 5| 2| 2| 2| 5| 5| 5| 6| 5| 5| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | |
Hemangiosarcoma, Metastatic, Skin | X |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Skin | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + I + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 3| 3| 0| 2| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 8| 3|
| 9| 5| 5| 5| 4| 3| 5| 5| 5| 5| 3| 5| 2| 2| 2| 5| 5| 5| 6| 5| 5| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma, Metastatic, Liver | X |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 2| 2| 2| 2| 2| 3| 2| 3| 6| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 0| 5| 9| 9| 9| 9| 9| 5| 4| 5| 3| 9| 1| 1| 1| 1| 2| 5| 5| 5| 9| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M M + + + + + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + A + + + + + + + + + + + + + + + M + + + + +| 45 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 2 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X X X X X X X | 9 |
Hepatocellular Carcinoma, Multiple | X | 4 |
Hepatocellular Adenoma | X X X X X X X | 10 |
Hepatocellular Adenoma, Multiple | X X X X X X X X| 14 |
Lymphoma Malignant | X X X X X X X | 12 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 21 |
Hemangiosarcoma | | 1 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 2| 2| 2| 2| 2| 3| 2| 3| 6| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 0| 5| 9| 9| 9| 9| 9| 5| 4| 5| 3| 9| 1| 1| 1| 1| 2| 5| 5| 5| 9| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X X X | 10 |
Sarcoma, Metastatic, Skeletal Muscle | | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X | 7 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X | 3 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 2| 2| 2| 2| 2| 3| 2| 3| 6| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 0| 5| 9| 9| 9| 9| 9| 5| 4| 5| 3| 9| 1| 1| 1| 1| 2| 5| 5| 5| 9| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | | 3 |
Pars Intermedia, Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | X X | 4 |
Granulosa Cell Tumor Benign | | 1 |
Hemangiosarcoma | | 2 |
Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deciduoma Benign | | 1 |
Hemangiosarcoma | X | 2 |
Lymphoma Malignant | | 1 |
Sarcoma Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 2 |
Lymphoma Malignant | X X X X | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 2| 2| 2| 2| 2| 3| 2| 3| 6| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 0| 5| 9| 9| 9| 9| 9| 5| 4| 5| 3| 9| 1| 1| 1| 1| 2| 5| 5| 5| 9| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 16 |
Lymphoma Malignant | X X | 2 |
Sarcoma | | 1 |
Bronchial, Hepatoblastoma, | | |
Metastatic, Liver | | 1 |
Iliac, Lymphoma Malignant | X X X X X | 5 |
Inguinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant | X X | 3 |
Mediastinal, Sarcoma, Metastatic, | | |
Skeletal Muscle | | 2 |
Pancreatic, Hemangiosarcoma | X | 1 |
Pancreatic, Lymphoma Malignant | X X X X | 4 |
Renal, Lymphoma Malignant | X X X X | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X X X X X | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | X X X X X X X X X X X X X | 16 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Hemangiosarcoma | X X | 4 |
Lymphoma Malignant | X X X X X X X X X X X X X X X X | 26 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X X X X X | 14 |
Thymoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 2| 2| 2| 2| 2| 3| 2| 3| 6| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 0| 5| 9| 9| 9| 9| 9| 5| 4| 5| 3| 9| 1| 1| 1| 1| 2| 5| 5| 5| 9| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mast Cell Tumor Malignant | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 4 |
Subcutaneous Tissue, Sarcoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteoma | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 5 |
Lymphoma Malignant | | 1 |
Sarcoma | | 2 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 2| 2| 2| 2| 2| 3| 2| 3| 6| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 0| 5| 9| 9| 9| 9| 9| 5| 4| 5| 3| 9| 1| 1| 1| 1| 2| 5| 5| 5| 9| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X | 6 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X X X X X | 8 |
Sarcoma, Metastatic, Skin | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 3 |
Carcinoma | X | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | X X X X X X X | 10 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 2| 2| 2| 2| 2| 3| 2| 3| 6| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 0| 5| 9| 9| 9| 9| 9| 5| 4| 5| 3| 9| 1| 1| 1| 1| 2| 5| 5| 5| 9| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X X X X X X X X X X X X X | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2|
| 6| 1| 1| 1| 1| 0| 0| 4| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 2| 2| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Hemangioma | X |
Sarcoma, Metastatic, Skin | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2|
| 6| 1| 1| 1| 1| 0| 0| 4| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 2| 2| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant | X X |
Sarcoma | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Capsule, Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Pars Distalis, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2|
| 6| 1| 1| 1| 1| 0| 0| 4| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 2| 2| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Lymphoma Malignant | X X |
Bronchial, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | X X X X X |
Inguinal, Lymphoma Malignant | X X |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
Popliteal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X X X X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2|
| 6| 1| 1| 1| 1| 0| 0| 4| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 2| 2| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | X |
Carcinoma | X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Liposarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 2|
| 6| 1| 1| 1| 1| 0| 0| 4| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 2| 2| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
175 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 2| 7| 5| 7| 7| 6| 3| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 2| 3| 1| 3| 4| 3| 3| 4| 1| 7| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 6| 1| 5| 7| 5| 7| 5| 5| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + + + + M + A + + + + + + A| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Carcinoma | X | 1 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + A + M + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X X| 3 |
Hepatocellular Carcinoma, Multiple | X X X | 3 |
Hepatocellular Adenoma | X X X X X X | 12 |
Hepatocellular Adenoma, Multiple | X X| 6 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X | 8 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 17 |
Hemangioma | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 2| 7| 5| 7| 7| 6| 3| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 2| 3| 1| 3| 4| 3| 3| 4| 1| 7| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 6| 1| 5| 7| 5| 7| 5| 5| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Pancreas | + + + + + + + + + + + + + + M A + + + + + + + + +| 48 |
Lymphoma Malignant | X X X | 4 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 4 |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
Capsule, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + M + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M A + + + + + + + + +| 48 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 2| 7| 5| 7| 7| 6| 3| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 2| 3| 1| 3| 4| 3| 3| 4| 1| 7| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 6| 1| 5| 7| 5| 7| 5| 5| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Pars Distalis, Adenoma | X X | 3 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 49 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Cystadenoma | X| 1 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deciduoma Benign | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 2 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X| 1 |
Lymphoma Malignant | X X X X X X X | 9 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 2| 7| 5| 7| 7| 6| 3| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 2| 3| 1| 3| 4| 3| 3| 4| 1| 7| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 6| 1| 5| 7| 5| 7| 5| 5| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
Lymphoma Malignant | X | 3 |
Bronchial, Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant | X X | 7 |
Inguinal, Lymphoma Malignant | X | 3 |
Mediastinal, Lymphoma Malignant | X X | 3 |
Pancreatic, Lymphoma Malignant | X | 2 |
Popliteal, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | X X X | 8 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X X X X | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Lymphoma Malignant | X X X X X X | 13 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X X X X X X X X X | 27 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Lymphoma Malignant | X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoacanthoma | | 1 |
Carcinoma | X | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Liposarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 2| 7| 5| 7| 7| 6| 3| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 2| 3| 1| 3| 4| 3| 3| 4| 1| 7| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 6| 1| 5| 7| 5| 7| 5| 5| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 4 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 4 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant | X X X X X X | 7 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 2| 7| 5| 7| 7| 6| 3| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 2| 3| 1| 3| 4| 3| 3| 4| 1| 7| |
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 6| 1| 5| 7| 5| 7| 5| 5| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
175 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 5 |
Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X X X X X | 12 |
|__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X| 2 |
Lymphoma Malignant | X X X X X X X X X X X X X X | 30 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 6| 3|
| 0| 0| 0| 0| 6| 2| 2| 2| 2| 2| 5| 3| 5| 5| 5| 2| 2| 2| 2| 2| 5| 2| 2| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Polyp Adenomatous | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leiomyosarcoma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
Lymphoma Malignant | X |
Rhabdomyosarcoma, Metastatic, | |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 6| 3|
| 0| 0| 0| 0| 6| 2| 2| 2| 2| 2| 5| 3| 5| 5| 5| 2| 2| 2| 2| 2| 5| 2| 2| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Skeletal Muscle | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Acinus, Rhabdomyosarcoma, Metastatic,| |
Skeletal Muscle | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Tongue | + |
|__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 6| 3|
| 0| 0| 0| 0| 6| 2| 2| 2| 2| 2| 5| 3| 5| 5| 5| 2| 2| 2| 2| 2| 5| 2| 2| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + I + + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Granulosa Cell Tumor Benign | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Tubulostromal Adenoma | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | |
Leiomyosarcoma | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 6| 3|
| 0| 0| 0| 0| 6| 2| 2| 2| 2| 2| 5| 3| 5| 5| 5| 2| 2| 2| 2| 2| 5| 2| 2| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Skin | |
|__________________________________________________________________________|
Lymph Node | + + + + |
Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | X X |
Iliac, Rhabdomyosarcoma, Metastatic, | |
Skeletal Muscle | X |
Inguinal, Histiocytic Sarcoma | |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
Mediastinal, Lymphoma Malignant | X |
Mediastinal, Rhabdomyosarcoma, | |
Metastatic, Skeletal Muscle | X |
Renal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + M + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 6| 3|
| 0| 0| 0| 0| 6| 2| 2| 2| 2| 2| 5| 3| 5| 5| 5| 2| 2| 2| 2| 2| 5| 2| 2| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
|__________________________________________________________________________|
Skeletal Muscle | + |
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
Rhabdomyosarcoma | X |
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X|
Fibrosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Osteosarcoma, Metastatic, Bone | |
Osteosarcoma, Metastatic, Uncertain | |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 6| 3|
| 0| 0| 0| 0| 6| 2| 2| 2| 2| 2| 5| 3| 5| 5| 5| 2| 2| 2| 2| 2| 5| 2| 2| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
350 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Primary Site | X |
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + I + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 1| 2| 8| 3| 0| 2| 2| 3| 2| 2| 3| 3| 3| 0| 9| 3| 5| 0| 3| 3| 6| 5| 6| 3| 3| |
| 4| 3| 3| 5| 7| 9| 9| 9| 9| 9| 0| 0| 0| 1| 6| 1| 8| 4| 1| 1| 4| 9| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + A + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + A + + A + + + + + + +| 46 |
Polyp Adenomatous | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X X X | 10 |
Hepatocellular Carcinoma, Multiple | X X | 2 |
Hepatocellular Adenoma | X X X X X X X X | 11 |
Hepatocellular Adenoma, Multiple | X X X | 8 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X | 5 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 16 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 1| 2| 8| 3| 0| 2| 2| 3| 2| 2| 3| 3| 3| 0| 9| 3| 5| 0| 3| 3| 6| 5| 6| 3| 3| |
| 4| 3| 3| 5| 7| 9| 9| 9| 9| 9| 0| 0| 0| 1| 6| 1| 8| 4| 1| 1| 4| 9| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
Lymphoma Malignant | | 1 |
Rhabdomyosarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Lymphoma Malignant | X X | 3 |
Acinus, Rhabdomyosarcoma, Metastatic,| | |
Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 3 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Leiomyosarcoma | X | 1 |
Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 1| 2| 8| 3| 0| 2| 2| 3| 2| 2| 3| 3| 3| 0| 9| 3| 5| 0| 3| 3| 6| 5| 6| 3| 3| |
| 4| 3| 3| 5| 7| 9| 9| 9| 9| 9| 0| 0| 0| 1| 6| 1| 8| 4| 1| 1| 4| 9| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + A + + + + + + + + + +| 48 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + M + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + I + + + + + + + + + + + M +| 48 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | X | 1 |
Granulosa Cell Tumor Benign | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 1| 2| 8| 3| 0| 2| 2| 3| 2| 2| 3| 3| 3| 0| 9| 3| 5| 0| 3| 3| 6| 5| 6| 3| 3| |
| 4| 3| 3| 5| 7| 9| 9| 9| 9| 9| 0| 0| 0| 1| 6| 1| 8| 4| 1| 1| 4| 9| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Tubulostromal Adenoma | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Histiocytic Sarcoma | X | 1 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 4 |
Sarcoma, Metastatic, Skin | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Lymphoma Malignant | | 1 |
Iliac, Lymphoma Malignant | X | 3 |
Iliac, Rhabdomyosarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
Inguinal, Histiocytic Sarcoma | X | 1 |
Inguinal, Lymphoma Malignant | X | 2 |
Mediastinal, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
Mediastinal, Rhabdomyosarcoma, | | |
Metastatic, Skeletal Muscle | | 1 |
Renal, Lymphoma Malignant | X X | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 1| 2| 8| 3| 0| 2| 2| 3| 2| 2| 3| 3| 3| 0| 9| 3| 5| 0| 3| 3| 6| 5| 6| 3| 3| |
| 4| 3| 3| 5| 7| 9| 9| 9| 9| 9| 0| 0| 0| 1| 6| 1| 8| 4| 1| 1| 4| 9| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + A + + M + + + +| 46 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X | 11 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Lymphoma Malignant | X X X X X | 13 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 4 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
Rhabdomyosarcoma | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 1| 2| 8| 3| 0| 2| 2| 3| 2| 2| 3| 3| 3| 0| 9| 3| 5| 0| 3| 3| 6| 5| 6| 3| 3| |
| 4| 3| 3| 5| 7| 9| 9| 9| 9| 9| 0| 0| 0| 1| 6| 1| 8| 4| 1| 1| 4| 9| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 3 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Sarcoma, Metastatic, Skin | X | 2 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 1| 2| 8| 3| 0| 2| 2| 3| 2| 2| 3| 3| 3| 0| 9| 3| 5| 0| 3| 3| 6| 5| 6| 3| 3| |
| 4| 3| 3| 5| 7| 9| 9| 9| 9| 9| 0| 0| 0| 1| 6| 1| 8| 4| 1| 1| 4| 9| 9| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
350 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 4 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X X X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3|
| 6| 0| 0| 5| 0| 2| 2| 9| 2| 2| 1| 1| 7| 1| 1| 5| 2| 5| 7| 5| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + A + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + I + + + + + + + + A + + + I + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3|
| 6| 0| 0| 5| 0| 2| 2| 9| 2| 2| 1| 1| 7| 1| 1| 5| 2| 5| 7| 5| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
Adenoma | X X |
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + I + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Brain | X |
Pars Distalis, Adenoma | X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3|
| 6| 0| 0| 5| 0| 2| 2| 9| 2| 2| 1| 1| 7| 1| 1| 5| 2| 5| 7| 5| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + I + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Hemangiosarcoma | X X X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + |
Lymphoma Malignant | |
Iliac, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + M + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
Lymphoma Malignant | X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3|
| 6| 0| 0| 5| 0| 2| 2| 9| 2| 2| 1| 1| 7| 1| 1| 5| 2| 5| 7| 5| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranial Nerve, Schwannoma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Histiocytic Sarcoma | X |
Mediastinum, Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3|
| 6| 0| 0| 5| 0| 2| 2| 9| 2| 2| 1| 1| 7| 1| 1| 5| 2| 5| 7| 5| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 9| 2| 3| 9| 9| 9| 9| 9| 4| 9| 3| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + I + + + + + + + M + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X | 3 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | X | 1 |
Hepatocellular Carcinoma | X X X X| 6 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X X | 9 |
Hepatocellular Adenoma, Multiple | X X X X X | 7 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 4 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 17 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 9| 2| 3| 9| 9| 9| 9| 9| 4| 9| 3| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X X | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X | 6 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 2 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 9| 2| 3| 9| 9| 9| 9| 9| 4| 9| 3| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Schwannoma Malignant, Metastatic, | | |
Brain | | 1 |
Pars Distalis, Adenoma | X | 3 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | X| 1 |
Hemangiosarcoma | X | 4 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant | X X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 9| 2| 3| 9| 9| 9| 9| 9| 4| 9| 3| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Lymphoma Malignant | X X | 2 |
Renal, Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | X | 1 |
Lymphoma Malignant | X X X X X X | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | X | 1 |
Lymphoma Malignant | X X X X X X X X X X X | 20 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Lymphoma Malignant | X X X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 9| 2| 3| 9| 9| 9| 9| 9| 4| 9| 3| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranial Nerve, Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Histiocytic Sarcoma | | 1 |
Mediastinum, Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 96018-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/25/03
Route: DOSED WATER Time: 11:01:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 9| 2| 3| 9| 9| 9| 9| 9| 4| 9| 3| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
700 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X | 8 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X X X X X X X X | 23 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
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---------- END OF REPORT ----------
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