TDMS Study 96018-04 Pathology Tables
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
FINAL#1 MICE
Facility: Southern Research Institute
Chemical CAS #: 75-27-4
Lock Date: 02/18/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 7 7 12 7
Moribund Sacrifice 7 6 5 4
Accidently Killed 1
Survivors
Terminal Sacrifice 36 36 33 39
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Gallbladder (46) (45) (48) (45)
Histiocytic Sarcoma 1 (2%)
Intestine Large, Colon (50) (49) (49) (49)
Intestine Large, Cecum (49) (48) (48) (49)
Intestine Small, Duodenum (48) (48) (46) (46)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (46) (49) (48) (48)
Carcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (45) (46) (49) (49)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Liver (50) (50) (50) (50)
Hemangiosarcoma 2 (4%) 1 (2%)
Hepatoblastoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 9 (18%) 3 (6%) 10 (20%) 6 (12%)
Hepatocellular Carcinoma, Multiple 4 (8%) 3 (6%) 2 (4%) 1 (2%)
Hepatocellular Adenoma 10 (20%) 12 (24%) 11 (22%) 9 (18%)
Hepatocellular Adenoma, Multiple 14 (28%) 6 (12%) 8 (16%) 7 (14%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Mesentery (21) (17) (16) (17)
Hemangioma 1 (6%)
Hemangiosarcoma 1 (5%)
Hepatoblastoma, Metastatic, Liver 1 (5%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (6%)
Histiocytic Sarcoma 1 (6%)
Leiomyosarcoma, Metastatic, Stomach,
Glandular 1 (6%)
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (6%)
Sarcoma, Metastatic, Skin 1 (6%)
Sarcoma, Metastatic, Skeletal Muscle 1 (5%)
Pancreas (50) (48) (49) (49)
Sarcoma, Metastatic, Skeletal Muscle 2 (4%)
Acinus, Rhabdomyosarcoma, Metastatic,
Skeletal Muscle 1 (2%)
Salivary Glands (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Stomach, Forestomach (50) (49) (50) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%)
Stomach, Glandular (50) (49) (49) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Leiomyosarcoma 1 (2%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (49)
Histiocytic Sarcoma 1 (2%)
Capsule, Adenoma 1 (2%)
Adrenal Medulla (50) (48) (49) (49)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (48) (48) (49)
Adenoma 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Carcinoma 1 (2%)
Pituitary Gland (49) (50) (49) (49)
Schwannoma Malignant, Metastatic, Brain 1 (2%)
Pars Distalis, Adenoma 3 (6%) 3 (6%) 1 (2%) 3 (6%)
Pars Intermedia, Adenoma 2 (4%)
Thyroid Gland (50) (49) (49) (50)
Follicular Cell, Adenoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (48) (49) (48) (49)
Histiocytic Sarcoma 1 (2%)
Ovary (50) (49) (50) (49)
Cystadenoma 4 (8%) 1 (2%) 1 (2%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%)
Hemangiosarcoma 2 (4%) 1 (2%) 4 (8%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Tubulostromal Adenoma 1 (2%)
Uterus (50) (50) (50) (50)
Deciduoma Benign 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 1 (2%)
Sarcoma Stromal 2 (4%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Lymph Node (16) (9) (7) (4)
Sarcoma 1 (6%)
Bronchial, Hepatoblastoma, Metastatic, Liver 1 (6%)
Iliac, Rhabdomyosarcoma, Metastatic,
Skeletal Muscle 1 (14%)
Inguinal, Histiocytic Sarcoma 1 (14%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (14%)
Mediastinal, Rhabdomyosarcoma, Metastatic,
Skeletal Muscle 1 (14%)
Mediastinal, Sarcoma, Metastatic, Skeletal
Muscle 2 (13%)
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Pancreatic, Hemangiosarcoma 1 (6%)
Lymph Node, Mandibular (50) (50) (50) (47)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (48) (46) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (49) (48) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 4 (8%)
Thymus (49) (49) (50) (47)
Histiocytic Sarcoma 1 (2%)
Thymoma Malignant 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoacanthoma 1 (2%)
Carcinoma 2 (4%) 1 (2%)
Skin (50) (50) (50) (50)
Mast Cell Tumor Malignant 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 4 (8%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 4 (8%) 1 (2%) 3 (6%) 2 (4%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (5) (2) (4) (1)
Leiomyosarcoma, Metastatic, Stomach,
Glandular 1 (25%)
Rhabdomyosarcoma 1 (25%)
Sarcoma 2 (40%) 1 (50%)
Sarcoma, Metastatic, Skin 1 (20%) 1 (25%)
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Cranial Nerve, Schwannoma Malignant 1 (2%)
Spinal Cord (4) (4) (2) (1)
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 6 (12%) 2 (4%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 2 (4%) 3 (6%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%) 2 (4%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Nose (50) (50) (50) (50)
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SPECIAL SENSES SYSTEM
Eye (48) (50) (50) (50)
Harderian Gland (50) (50) (50) (50)
Adenoma 3 (6%) 5 (10%) 2 (4%) 3 (6%)
Carcinoma 1 (2%) 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
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URINARY SYSTEM
Kidney (50) (49) (50) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Urinary Bladder (50) (49) (48) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 1 (2%) 1 (2%)
Lymphoma Malignant 29 (58%) 30 (60%) 16 (32%) 23 (46%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Date: 03/31/03
Route: DOSED WATER Time: 10:54:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 44 37 43
Total Primary Neoplasms 128 89 71 74
Total Animals with Benign Neoplasms 34 25 24 28
Total Benign Neoplasms 52 35 29 31
Total Animals with Malignant Neoplasms 43 38 31 35
Total Malignant Neoplasms 76 54 42 43
Total Animals with Metastatic Neoplasms 5 2 9 2
Total Metastatic Neoplasm 16 3 20 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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