TDMS Study 96018-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/25/03
EXPERIMENT: 96018 TEST: 04 TIME: 10:56:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: HEATH, JAMES E. CAS: 75-27-4
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/25/03
EXPERIMENT: 96018 TEST: 04 TIME: 10:56:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: HEATH, JAMES E. CAS: 75-27-4
Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
---------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Islets, Pancreatic
Liver
Lung
Ovary
Pituitary Gland
Salivary Glands
Spleen
Thymus
Thyroid Gland
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/25/03
EXPERIMENT: 96018 TEST: 04 TIME: 10:56:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: HEATH, JAMES E. CAS: 75-27-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF WATER DISINFECTION BYPRODUCTS (BROMODICHL
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Bone Marrow Hemangiosarcoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Intermedia Adenoma
Skin Hemangiosarcoma
Spleen Hemangiosarcoma
Uterus Hemangiosarcoma
Sarcoma Stromal
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
===============================================================
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 1
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.47 0/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.113N P=0.238N P=0.258N P=0.221N |
|POLY 3 | P=0.111N P=0.247N P=0.247N P=0.237N |
|POLY 1.5 | P=0.112N P=0.244N P=0.243N P=0.237N |
|POLY 6 | P=0.111N P=0.251N P=0.252N P=0.237N |
|LOGISTIC REGRESSION| P=0.113N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 2/50 (4%) 3/50 (6%) |
|POLY-3 RATE (b) | 3/45.58 5/44.03 2/43.59 3/45.46 |
|POLY-3 PERCENT (g) | 6.6% 11.4% 4.6% 6.6% |
|TERMINAL (d) | 2/36 (6%) 4/36 (11%) 1/33 (3%) 3/39 (8%) |
|FIRST INCIDENCE | 702 581 701 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.414N P=0.346 P=0.549N P=0.633N |
|POLY 3 | P=0.445N P=0.337 P=0.520N P=0.661 |
|POLY 1.5 | P=0.443N P=0.343 P=0.512N P=0.662 |
|POLY 6 | P=0.447N P=0.331 P=0.531N P=0.660 |
|LOGISTIC REGRESSION| P=0.437N P=0.339 P=0.529N P=0.663N |
|COCH-ARM / FISHERS | P=0.442N P=0.357 P=0.500N P=0.661N |
|ORDER RESTRICTED | P=0.427N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 2
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/45.47 2/43.97 1/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 2.2% 4.6% 2.3% 0.0% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 604 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.240N P=0.495 P=0.742 P=0.484N |
|POLY 3 | P=0.249N P=0.488 P=0.751 P=0.500N |
|POLY 1.5 | P=0.249N P=0.492 P=0.755 P=0.500N |
|POLY 6 | P=0.250N P=0.485 P=0.746 P=0.500N |
|LOGISTIC REGRESSION| P=0.247N P=0.503 P=0.742 (e) |
|COCH-ARM / FISHERS | P=0.247N P=0.500 P=0.753N P=0.500N |
|ORDER RESTRICTED | P=0.217N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 4/50 (8%) 7/50 (14%) 3/50 (6%) 3/50 (6%) |
|POLY-3 RATE (b) | 4/45.58 7/44.46 3/43.59 3/45.46 |
|POLY-3 PERCENT (g) | 8.8% 15.7% 6.9% 6.6% |
|TERMINAL (d) | 3/36 (8%) 5/36 (14%) 2/33 (6%) 3/39 (8%) |
|FIRST INCIDENCE | 702 581 701 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.239N P=0.255 P=0.556N P=0.465N |
|POLY 3 | P=0.262N P=0.246 P=0.524N P=0.501N |
|POLY 1.5 | P=0.260N P=0.250 P=0.514N P=0.500N |
|POLY 6 | P=0.265N P=0.242 P=0.537N P=0.503N |
|LOGISTIC REGRESSION| P=0.257N P=0.249 P=0.542N P=0.499N |
|COCH-ARM / FISHERS | P=0.260N P=0.262 P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.283N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 3
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 1/48 (2%) 1/48 (2%) 2/49 (4%) |
|POLY-3 RATE (b) | 3/44.91 1/42.54 1/41.70 2/45.10 |
|POLY-3 PERCENT (g) | 6.7% 2.4% 2.4% 4.4% |
|TERMINAL (d) | 3/36 (8%) 1/36 (3%) 1/33 (3%) 2/39 (5%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.445N P=0.305N P=0.336N P=0.463N |
|POLY 3 | P=0.469N P=0.325N P=0.332N P=0.498N |
|POLY 1.5 | P=0.469N P=0.321N P=0.324N P=0.498N |
|POLY 6 | P=0.469N P=0.329N P=0.342N P=0.499N |
|LOGISTIC REGRESSION| P=0.445N P=0.305N P=0.336N P=0.463N |
|COCH-ARM / FISHERS | P=0.472N P=0.316N P=0.316N P=0.500N |
|ORDER RESTRICTED | P=0.301N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 1/48 (2%) 1/48 (2%) 3/49 (6%) |
|POLY-3 RATE (b) | 3/44.91 1/42.54 1/41.70 3/45.45 |
|POLY-3 PERCENT (g) | 6.7% 2.4% 2.4% 6.6% |
|TERMINAL (d) | 3/36 (8%) 1/36 (3%) 1/33 (3%) 2/39 (5%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.530 P=0.305N P=0.336N P=0.629N |
|POLY 3 | P=0.510 P=0.325N P=0.332N P=0.657N |
|POLY 1.5 | P=0.508 P=0.321N P=0.324N P=0.658N |
|POLY 6 | P=0.513 P=0.329N P=0.342N P=0.655N |
|LOGISTIC REGRESSION| P=0.506 P=0.305N P=0.336N P=0.662N |
|COCH-ARM / FISHERS | P=0.502 P=0.316N P=0.316N P=0.661N |
|ORDER RESTRICTED | P=0.408N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 4
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.91 1/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 2.3% 0.0% 0.0% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 604 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.100N P=0.505N P=0.254N P=0.233N |
|POLY 3 | P=0.100N P=0.518N P=0.249N P=0.239N |
|POLY 1.5 | P=0.100N P=0.512N P=0.244N P=0.238N |
|POLY 6 | P=0.101N P=0.526N P=0.256N P=0.241N |
|LOGISTIC REGRESSION| P=0.100N P=0.497N P=0.226N P=0.241N |
|COCH-ARM / FISHERS | P=0.101N P=0.500N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.075N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 24/50 (48%) 18/50 (36%) 19/50 (38%) 16/50 (32%) |
|POLY-3 RATE (b) | 24/45.90 18/44.38 19/45.29 16/45.73 |
|POLY-3 PERCENT (g) | 52.3% 40.6% 42.0% 35.0% |
|TERMINAL (d) | 20/36 (56%) 16/36 (44%) 12/33 (36%) 14/39 (36%) |
|FIRST INCIDENCE | 649 521 539 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.063N P=0.165N P=0.346N P=0.047N* |
|POLY 3 | P=0.074N P=0.179N P=0.215N P=0.068N |
|POLY 1.5 | P=0.077N P=0.172N P=0.214N P=0.070N |
|POLY 6 | P=0.070N P=0.191N P=0.213N P=0.067N |
|LOGISTIC REGRESSION| P=0.078N P=0.214N P=0.270N P=0.067N |
|COCH-ARM / FISHERS | P=0.088N P=0.156N P=0.210N P=0.076N |
|ORDER RESTRICTED | P=0.065N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 5
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 13/50 (26%) 6/50 (12%) 12/50 (24%) 7/50 (14%) |
|POLY-3 RATE (b) | 13/46.14 6/44.32 12/45.45 7/45.73 |
|POLY-3 PERCENT (g) | 28.2% 13.5% 26.4% 15.3% |
|TERMINAL (d) | 9/36 (25%) 4/36 (11%) 6/33 (18%) 5/39 (13%) |
|FIRST INCIDENCE | 604 547 539 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.166N P=0.078N P=0.581 P=0.092N |
|POLY 3 | P=0.170N P=0.071N P=0.518N P=0.106N |
|POLY 1.5 | P=0.171N P=0.068N P=0.512N P=0.105N |
|POLY 6 | P=0.168N P=0.076N P=0.522N P=0.107N |
|LOGISTIC REGRESSION| P=0.177N P=0.071N P=0.515N P=0.104N |
|COCH-ARM / FISHERS | P=0.180N P=0.062N P=0.500N P=0.105N |
|ORDER RESTRICTED | P=0.094N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 14/50 (28%) 6/50 (12%) 12/50 (24%) 8/50 (16%) |
|POLY-3 RATE (b) | 14/46.56 6/44.32 12/45.45 8/45.73 |
|POLY-3 PERCENT (g) | 30.1% 13.5% 26.4% 17.5% |
|TERMINAL (d) | 9/36 (25%) 4/36 (11%) 6/33 (18%) 6/39 (15%) |
|FIRST INCIDENCE | 604 547 539 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.185N P=0.054N P=0.506N P=0.101N |
|POLY 3 | P=0.194N P=0.047N* P=0.437N P=0.119N |
|POLY 1.5 | P=0.194N P=0.044N* P=0.427N P=0.115N |
|POLY 6 | P=0.195N P=0.052N P=0.448N P=0.124N |
|LOGISTIC REGRESSION| P=0.199N P=0.044N* P=0.416N P=0.113N |
|COCH-ARM / FISHERS | P=0.201N P=0.039N* P=0.410N P=0.114N |
|ORDER RESTRICTED | P=0.105N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 6
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 30/50 (60%) 23/50 (46%) 24/50 (48%) 19/50 (38%) |
|POLY-3 RATE (b) | 30/46.49 23/44.96 24/45.78 19/45.73 |
|POLY-3 PERCENT (g) | 64.5% 51.2% 52.4% 41.6% |
|TERMINAL (d) | 24/36 (67%) 20/36 (56%) 16/33 (49%) 17/39 (44%) |
|FIRST INCIDENCE | 604 521 539 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.019N* P=0.133N P=0.316N P=0.012N* |
|POLY 3 | P=0.022N* P=0.134N P=0.162N P=0.019N* |
|POLY 1.5 | P=0.022N* P=0.127N P=0.160N P=0.019N* |
|POLY 6 | P=0.022N* P=0.148N P=0.162N P=0.020N* |
|LOGISTIC REGRESSION| P=0.022N* P=0.159N P=0.208N P=0.018N* |
|COCH-ARM / FISHERS | P=0.028N* P=0.115N P=0.158N P=0.022N* |
|ORDER RESTRICTED | P=0.015N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, |
| or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 31/50 (62%) 23/50 (46%) 24/50 (48%) 19/50 (38%) |
|POLY-3 RATE (b) | 31/46.91 23/44.96 24/45.78 19/45.73 |
|POLY-3 PERCENT (g) | 66.1% 51.2% 52.4% 41.6% |
|TERMINAL (d) | 24/36 (67%) 20/36 (56%) 16/33 (49%) 17/39 (44%) |
|FIRST INCIDENCE | 604 521 539 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.013N* P=0.101N P=0.260N P=0.008N** |
|POLY 3 | P=0.015N* P=0.102N P=0.125N P=0.012N* |
|POLY 1.5 | P=0.015N* P=0.093N P=0.120N P=0.012N* |
|POLY 6 | P=0.016N* P=0.121N P=0.133N P=0.015N* |
|LOGISTIC REGRESSION| P=0.015N* P=0.110N P=0.149N P=0.011N* |
|COCH-ARM / FISHERS | P=0.019N* P=0.080N P=0.114N P=0.014N* |
|ORDER RESTRICTED | P=0.010N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 7
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 0/50 (0%) 3/50 (6%) |
|POLY-3 RATE (b) | 6/45.53 2/43.54 0/43.48 3/46.27 |
|POLY-3 PERCENT (g) | 13.2% 4.6% 0.0% 6.5% |
|TERMINAL (d) | 5/36 (14%) 2/36 (6%) 0/33 (0%) 2/39 (5%) |
|FIRST INCIDENCE | 715 729 (T) --- 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.172N P=0.139N P=0.025N* P=0.215N |
|POLY 3 | P=0.178N P=0.147N P=0.018N* P=0.234N |
|POLY 1.5 | P=0.179N P=0.143N P=0.017N* P=0.236N |
|POLY 6 | P=0.176N P=0.153N P=0.019N* P=0.232N |
|LOGISTIC REGRESSION| P=0.186N P=0.157N P=0.024N* P=0.243N |
|COCH-ARM / FISHERS | P=0.186N P=0.134N P=0.013N* P=0.243N |
|ORDER RESTRICTED | P=0.031N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/45.47 2/43.54 2/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 2.2% 4.6% 4.6% 0.0% |
|TERMINAL (d) | 1/36 (3%) 2/36 (6%) 2/33 (6%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.279N P=0.500 P=0.470 P=0.484N |
|POLY 3 | P=0.295N P=0.485 P=0.484 P=0.500N |
|POLY 1.5 | P=0.295N P=0.490 P=0.491 P=0.500N |
|POLY 6 | P=0.295N P=0.479 P=0.476 P=0.500N |
|LOGISTIC REGRESSION| P=0.279N P=0.500 P=0.470 (e) |
|COCH-ARM / FISHERS | P=0.296N P=0.500 P=0.500 P=0.500N |
|ORDER RESTRICTED | P=0.213N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 8
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 4/50 (8%) 2/50 (4%) 3/50 (6%) |
|POLY-3 RATE (b) | 6/45.53 4/43.54 2/43.48 3/46.27 |
|POLY-3 PERCENT (g) | 13.2% 9.2% 4.6% 6.5% |
|TERMINAL (d) | 5/36 (14%) 4/36 (11%) 2/33 (6%) 2/39 (5%) |
|FIRST INCIDENCE | 715 729 (T) 729 (T) 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.151N P=0.376N P=0.169N P=0.215N |
|POLY 3 | P=0.162N P=0.398N P=0.148N P=0.234N |
|POLY 1.5 | P=0.164N P=0.389N P=0.142N P=0.236N |
|POLY 6 | P=0.160N P=0.409N P=0.156N P=0.232N |
|LOGISTIC REGRESSION| P=0.169N P=0.416N P=0.172N P=0.243N |
|COCH-ARM / FISHERS | P=0.170N P=0.370N P=0.134N P=0.243N |
|ORDER RESTRICTED | P=0.142N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/45.47 2/44.75 0/43.48 1/45.46 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 0.0% 2.2% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 1/39 (3%) |
|FIRST INCIDENCE | --- 521 --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.541 P=0.235 (e) P=0.516 |
|POLY 3 | P=0.537 P=0.234 (e) P=0.500 |
|POLY 1.5 | P=0.538 P=0.234 (e) P=0.500 |
|POLY 6 | P=0.535 P=0.233 (e) P=0.500 |
|LOGISTIC REGRESSION| P=0.508 P=0.309 (e) P=0.516 |
|COCH-ARM / FISHERS | P=0.539 P=0.247 (e) P=0.500 |
|ORDER RESTRICTED | P=0.318 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 9
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 1/49 (2%) 1/50 (2%) 1/49 (2%) |
|POLY-3 RATE (b) | 4/45.64 1/42.75 1/43.74 1/44.46 |
|POLY-3 PERCENT (g) | 8.8% 2.3% 2.3% 2.3% |
|TERMINAL (d) | 2/36 (6%) 0/35 (0%) 0/33 (0%) 1/38 (3%) |
|FIRST INCIDENCE | 702 674 659 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.137N P=0.207N P=0.219N P=0.177N |
|POLY 3 | P=0.134N P=0.199N P=0.192N P=0.187N |
|POLY 1.5 | P=0.134N P=0.195N P=0.187N P=0.186N |
|POLY 6 | P=0.133N P=0.204N P=0.198N P=0.188N |
|LOGISTIC REGRESSION| P=0.137N P=0.197N P=0.188N P=0.186N |
|COCH-ARM / FISHERS | P=0.137N P=0.187N P=0.181N P=0.187N |
|ORDER RESTRICTED | P=0.082N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Ovary |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/49 (2%) 0/50 (0%) 4/49 (8%) |
|POLY-3 RATE (b) | 2/45.53 1/42.97 0/43.48 4/44.63 |
|POLY-3 PERCENT (g) | 4.4% 2.3% 0.0% 9.0% |
|TERMINAL (d) | 1/36 (3%) 0/35 (0%) 0/33 (0%) 3/38 (8%) |
|FIRST INCIDENCE | 715 604 --- 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.181 P=0.520N P=0.271N P=0.354 |
|POLY 3 | P=0.161 P=0.520N P=0.248N P=0.328 |
|POLY 1.5 | P=0.161 P=0.516N P=0.243N P=0.329 |
|POLY 6 | P=0.161 P=0.524N P=0.253N P=0.328 |
|LOGISTIC REGRESSION| P=0.163 P=0.501N P=0.255N P=0.325 |
|COCH-ARM / FISHERS | P=0.161 P=0.508N P=0.247N P=0.329 |
|ORDER RESTRICTED | P=0.074 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 10
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 3/50 (6%) 1/49 (2%) 3/49 (6%) |
|POLY-3 RATE (b) | 3/44.47 3/43.54 1/43.66 3/44.63 |
|POLY-3 PERCENT (g) | 6.8% 6.9% 2.3% 6.7% |
|TERMINAL (d) | 3/35 (9%) 3/36 (8%) 0/33 (0%) 3/39 (8%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 604 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.502N P=0.651N P=0.326N P=0.613N |
|POLY 3 | P=0.542N P=0.653 P=0.312N P=0.661N |
|POLY 1.5 | P=0.543N P=0.658 P=0.309N P=0.661N |
|POLY 6 | P=0.541N P=0.646 P=0.316N P=0.660N |
|LOGISTIC REGRESSION| P=0.538N P=0.651N P=0.306N P=0.613N |
|COCH-ARM / FISHERS | P=0.547N P=0.651N P=0.309N P=0.661N |
|ORDER RESTRICTED | P=0.504N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 0/49 (0%) 0/49 (0%) |
|POLY-3 RATE (b) | 2/44.47 0/43.54 0/43.23 0/44.63 |
|POLY-3 PERCENT (g) | 4.5% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/35 (6%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.110N P=0.232N P=0.251N P=0.215N |
|POLY 3 | P=0.111N P=0.242N P=0.243N P=0.236N |
|POLY 1.5 | P=0.112N P=0.239N P=0.241N P=0.237N |
|POLY 6 | P=0.110N P=0.245N P=0.247N P=0.236N |
|LOGISTIC REGRESSION| P=0.110N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.242N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 11
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Skeletal Muscle |
| Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.77 1/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 2.3% 0.0% 0.0% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 649 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.100N P=0.511N P=0.252N P=0.233N |
|POLY 3 | P=0.100N P=0.517N P=0.249N P=0.239N |
|POLY 1.5 | P=0.100N P=0.512N P=0.244N P=0.238N |
|POLY 6 | P=0.101N P=0.525N P=0.255N P=0.240N |
|LOGISTIC REGRESSION| P=0.101N P=0.508N P=0.235N P=0.238N |
|COCH-ARM / FISHERS | P=0.101N P=0.500N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.075N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 4/50 (8%) 4/50 (8%) |
|POLY-3 RATE (b) | 5/46.93 1/43.54 4/44.08 4/46.42 |
|POLY-3 PERCENT (g) | 10.7% 2.3% 9.1% 8.6% |
|TERMINAL (d) | 2/36 (6%) 1/36 (3%) 3/33 (9%) 2/39 (5%) |
|FIRST INCIDENCE | 563 729 (T) 539 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.559 P=0.115N P=0.543N P=0.481N |
|POLY 3 | P=0.553 P=0.120N P=0.539N P=0.507N |
|POLY 1.5 | P=0.549 P=0.113N P=0.523N P=0.503N |
|POLY 6 | P=0.556 P=0.128N P=0.560N P=0.513N |
|LOGISTIC REGRESSION| P=0.522 P=0.085N P=0.464N P=0.515N |
|COCH-ARM / FISHERS | P=0.537 P=0.102N P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.373N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 12
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 4/50 (8%) 4/50 (8%) |
|POLY-3 RATE (b) | 5/46.93 1/43.54 4/44.08 4/46.42 |
|POLY-3 PERCENT (g) | 10.7% 2.3% 9.1% 8.6% |
|TERMINAL (d) | 2/36 (6%) 1/36 (3%) 3/33 (9%) 2/39 (5%) |
|FIRST INCIDENCE | 563 729 (T) 539 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.559 P=0.115N P=0.543N P=0.481N |
|POLY 3 | P=0.553 P=0.120N P=0.539N P=0.507N |
|POLY 1.5 | P=0.549 P=0.113N P=0.523N P=0.503N |
|POLY 6 | P=0.556 P=0.128N P=0.560N P=0.513N |
|LOGISTIC REGRESSION| P=0.522 P=0.085N P=0.464N P=0.515N |
|COCH-ARM / FISHERS | P=0.537 P=0.102N P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.373N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Skin |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 4/45.91 0/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 8.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/36 (8%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 604 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.021N* P=0.066N P=0.075N P=0.058N |
|POLY 3 | P=0.017N* P=0.067N P=0.067N P=0.061N |
|POLY 1.5 | P=0.017N* P=0.065N P=0.065N P=0.061N |
|POLY 6 | P=0.017N* P=0.070N P=0.071N P=0.062N |
|LOGISTIC REGRESSION| P=0.020N* P=0.064N P=0.064N P=0.063N |
|COCH-ARM / FISHERS | P=0.020N* P=0.059N P=0.059N P=0.059N |
|ORDER RESTRICTED | P=0.002N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 13
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 4/50 (8%) 1/50 (2%) 3/50 (6%) 2/50 (4%) |
|POLY-3 RATE (b) | 4/46.93 1/43.54 3/44.08 2/45.69 |
|POLY-3 PERCENT (g) | 8.5% 2.3% 6.8% 4.4% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 2/33 (6%) 1/39 (3%) |
|FIRST INCIDENCE | 563 729 (T) 539 669 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.361N P=0.194N P=0.535N P=0.334N |
|POLY 3 | P=0.367N P=0.202N P=0.534N P=0.350N |
|POLY 1.5 | P=0.367N P=0.194N P=0.520N P=0.344N |
|POLY 6 | P=0.367N P=0.214N P=0.553N P=0.356N |
|LOGISTIC REGRESSION| P=0.382N P=0.146N P=0.451N P=0.348N |
|COCH-ARM / FISHERS | P=0.371N P=0.181N P=0.500N P=0.339N |
|ORDER RESTRICTED | P=0.300N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 0/49 (0%) 0/48 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 4/45.47 0/43.17 0/41.61 0/45.46 |
|POLY-3 PERCENT (g) | 8.8% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/36 (11%) 0/36 (0%) 0/32 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.020N* P=0.063N P=0.078N P=0.053N |
|POLY 3 | P=0.018N* P=0.067N P=0.072N P=0.060N |
|POLY 1.5 | P=0.018N* P=0.066N P=0.070N P=0.060N |
|POLY 6 | P=0.018N* P=0.068N P=0.075N P=0.060N |
|LOGISTIC REGRESSION| P=0.020N* (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.021N* P=0.061N P=0.064N P=0.059N |
|ORDER RESTRICTED | P=0.002N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 14
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/45.47 2/44.03 0/43.48 2/45.81 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 0.0% 4.4% |
|TERMINAL (d) | 0/36 (0%) 1/36 (3%) 0/33 (0%) 1/39 (3%) |
|FIRST INCIDENCE | --- 581 --- 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.263 P=0.235 (e) P=0.251 |
|POLY 3 | P=0.247 P=0.230 (e) P=0.239 |
|POLY 1.5 | P=0.247 P=0.232 (e) P=0.238 |
|POLY 6 | P=0.247 P=0.228 (e) P=0.240 |
|LOGISTIC REGRESSION| P=0.239 P=0.251 (e) P=0.236 |
|COCH-ARM / FISHERS | P=0.247 P=0.247 (e) P=0.247 |
|ORDER RESTRICTED | P=0.117 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/45.47 1/44.03 0/43.48 2/45.81 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 0.0% 4.4% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 1/39 (3%) |
|FIRST INCIDENCE | --- 581 --- 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.150 P=0.491 (e) P=0.251 |
|POLY 3 | P=0.140 P=0.494 (e) P=0.239 |
|POLY 1.5 | P=0.140 P=0.495 (e) P=0.238 |
|POLY 6 | P=0.141 P=0.492 (e) P=0.240 |
|LOGISTIC REGRESSION| P=0.127 P=0.551 (e) P=0.236 |
|COCH-ARM / FISHERS | P=0.140 P=0.500 (e) P=0.247 |
|ORDER RESTRICTED | P=0.075 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 15
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) 1/49 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/45.91 0/42.54 1/42.61 1/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 2.4% 2.2% |
|TERMINAL (d) | 1/36 (3%) 0/35 (0%) 1/33 (3%) 1/39 (3%) |
|FIRST INCIDENCE | 604 --- 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.482N P=0.248N P=0.525N P=0.484N |
|POLY 3 | P=0.492N P=0.254N P=0.526N P=0.503N |
|POLY 1.5 | P=0.494N P=0.250N P=0.518N P=0.501N |
|POLY 6 | P=0.490N P=0.260N P=0.536N P=0.506N |
|LOGISTIC REGRESSION| P=0.498N P=0.229N P=0.504N P=0.501N |
|COCH-ARM / FISHERS | P=0.499N P=0.253N P=0.508N P=0.500N |
|ORDER RESTRICTED | P=0.284N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/49 (2%) 2/49 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/45.91 1/42.54 2/42.61 1/45.46 |
|POLY-3 PERCENT (g) | 4.4% 2.4% 4.7% 2.2% |
|TERMINAL (d) | 1/36 (3%) 1/35 (3%) 2/33 (6%) 1/39 (3%) |
|FIRST INCIDENCE | 604 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.421N P=0.512N P=0.666 P=0.484N |
|POLY 3 | P=0.440N P=0.527N P=0.667 P=0.503N |
|POLY 1.5 | P=0.440N P=0.520N P=0.675 P=0.501N |
|POLY 6 | P=0.439N P=0.535N P=0.657 P=0.506N |
|LOGISTIC REGRESSION| P=0.440N P=0.505N P=0.685 P=0.501N |
|COCH-ARM / FISHERS | P=0.443N P=0.508N P=0.684 P=0.500N |
|ORDER RESTRICTED | P=0.447N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 16
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.63 0/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 689 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.117N P=0.251N P=0.264N P=0.234N |
|POLY 3 | P=0.111N P=0.248N P=0.248N P=0.238N |
|POLY 1.5 | P=0.112N P=0.244N P=0.244N P=0.237N |
|POLY 6 | P=0.110N P=0.252N P=0.254N P=0.239N |
|LOGISTIC REGRESSION| P=0.116N P=0.245N P=0.245N P=0.237N |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.030N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.47 0/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.113N P=0.238N P=0.258N P=0.221N |
|POLY 3 | P=0.111N P=0.247N P=0.247N P=0.237N |
|POLY 1.5 | P=0.112N P=0.244N P=0.243N P=0.237N |
|POLY 6 | P=0.111N P=0.251N P=0.252N P=0.237N |
|LOGISTIC REGRESSION| P=0.113N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 17
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.47 1/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 2.3% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 1/36 (3%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.097N P=0.500N P=0.258N P=0.221N |
|POLY 3 | P=0.100N P=0.515N P=0.247N P=0.237N |
|POLY 1.5 | P=0.100N P=0.510N P=0.243N P=0.237N |
|POLY 6 | P=0.100N P=0.521N P=0.252N P=0.237N |
|LOGISTIC REGRESSION| P=0.097N P=0.500N (e) (e) |
|COCH-ARM / FISHERS | P=0.101N P=0.500N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.074N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 8/50 (16%) 2/50 (4%) 0/50 (0%) 4/50 (8%) |
|POLY-3 RATE (b) | 8/46.12 2/43.97 0/43.48 4/45.63 |
|POLY-3 PERCENT (g) | 17.4% 4.6% 0.0% 8.8% |
|TERMINAL (d) | 5/36 (14%) 1/36 (3%) 0/33 (0%) 3/39 (8%) |
|FIRST INCIDENCE | 604 604 --- 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.145N P=0.058N P=0.009N** P=0.164N |
|POLY 3 | P=0.143N P=0.053N P=0.005N** P=0.182N |
|POLY 1.5 | P=0.144N P=0.051N P=0.004N** P=0.179N |
|POLY 6 | P=0.143N P=0.057N P=0.005N** P=0.185N |
|LOGISTIC REGRESSION| P=0.150N P=0.050N P=0.005N** P=0.177N |
|COCH-ARM / FISHERS | P=0.151N P=0.046N* P=0.003N** P=0.178N |
|ORDER RESTRICTED | P=0.012N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 18
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 8/50 (16%) 3/50 (6%) 1/50 (2%) 4/50 (8%) |
|POLY-3 RATE (b) | 8/46.12 3/43.97 1/43.48 4/45.63 |
|POLY-3 PERCENT (g) | 17.4% 6.8% 2.3% 8.8% |
|TERMINAL (d) | 5/36 (14%) 2/36 (6%) 1/33 (3%) 3/39 (8%) |
|FIRST INCIDENCE | 604 604 729 (T) 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.137N P=0.116N P=0.029N* P=0.164N |
|POLY 3 | P=0.140N P=0.113N P=0.020N* P=0.182N |
|POLY 1.5 | P=0.140N P=0.109N P=0.018N* P=0.179N |
|POLY 6 | P=0.140N P=0.120N P=0.022N* P=0.185N |
|LOGISTIC REGRESSION| P=0.144N P=0.106N P=0.020N* P=0.177N |
|COCH-ARM / FISHERS | P=0.145N P=0.100N P=0.015N* P=0.178N |
|ORDER RESTRICTED | P=0.030N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/45.47 2/43.75 1/43.71 1/46.10 |
|POLY-3 PERCENT (g) | 0.0% 4.6% 2.3% 2.2% |
|TERMINAL (d) | 0/36 (0%) 1/36 (3%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | --- 674 669 522 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.508 P=0.232 P=0.475 P=0.500 |
|POLY 3 | P=0.506 P=0.229 P=0.492 P=0.503 |
|POLY 1.5 | P=0.504 P=0.231 P=0.495 P=0.502 |
|POLY 6 | P=0.508 P=0.226 P=0.488 P=0.504 |
|LOGISTIC REGRESSION| P=0.486 P=0.233 P=0.508 P=0.438 |
|COCH-ARM / FISHERS | P=0.500 P=0.247 P=0.500 P=0.500 |
|ORDER RESTRICTED | P=0.260 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 19
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 29/50 (58%) 30/50 (60%) 16/50 (32%) 23/50 (46%) |
|POLY-3 RATE (b) | 29/46.58 30/46.20 16/44.51 23/46.21 |
|POLY-3 PERCENT (g) | 62.3% 64.9% 35.9% 49.8% |
|TERMINAL (d) | 23/36 (64%) 22/36 (61%) 12/33 (36%) 21/39 (54%) |
|FIRST INCIDENCE | 563 547 539 535 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.040N* P=0.463 P=0.029N* P=0.096N |
|POLY 3 | P=0.050N P=0.479 P=0.008N** P=0.154N |
|POLY 1.5 | P=0.049N* P=0.474 P=0.007N** P=0.152N |
|POLY 6 | P=0.055N P=0.496 P=0.010N* P=0.161N |
|LOGISTIC REGRESSION| P=0.048N* P=0.410 P=0.012N* P=0.151N |
|COCH-ARM / FISHERS | P=0.057N P=0.500 P=0.008N** P=0.158N |
|ORDER RESTRICTED | P=0.026N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 34/50 (68%) 25/50 (50%) 24/50 (48%) 28/50 (56%) |
|POLY-3 RATE (b) | 34/46.44 25/44.88 24/45.72 28/46.89 |
|POLY-3 PERCENT (g) | 73.2% 55.7% 52.5% 59.7% |
|TERMINAL (d) | 28/36 (78%) 22/36 (61%) 16/33 (49%) 24/39 (62%) |
|FIRST INCIDENCE | 604 521 539 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.140N P=0.060N P=0.119N P=0.083N |
|POLY 3 | P=0.160N P=0.056N P=0.028N* P=0.116N |
|POLY 1.5 | P=0.174N P=0.054N P=0.029N* P=0.124N |
|POLY 6 | P=0.149N P=0.061N P=0.026N* P=0.111N |
|LOGISTIC REGRESSION| P=0.191N P=0.078N P=0.050N P=0.142N |
|COCH-ARM / FISHERS | P=0.214N P=0.052N P=0.034N* P=0.151N |
|ORDER RESTRICTED | P=0.057N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 20
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 43/50 (86%) 38/50 (76%) 32/50 (64%) 35/50 (70%) |
|POLY-3 RATE (b) | 43/48.28 38/47.47 32/47.98 35/48.42 |
|POLY-3 PERCENT (g) | 89.1% 80.0% 66.7% 72.3% |
|TERMINAL (d) | 32/36 (89%) 27/36 (75%) 19/33 (58%) 27/39 (69%) |
|FIRST INCIDENCE | 563 521 323 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.053N P=0.285N P=0.133N P=0.049N* |
|POLY 3 | P=0.024N* P=0.170N P=0.006N** P=0.029N* |
|POLY 1.5 | P=0.025N* P=0.168N P=0.006N** P=0.030N* |
|POLY 6 | P=0.027N* P=0.172N P=0.007N** P=0.033N* |
|LOGISTIC REGRESSION| P=0.035N* P=0.209N P=0.013N* P=0.041N* |
|COCH-ARM / FISHERS | P=0.041N* P=0.154N P=0.010N* P=0.045N* |
|ORDER RESTRICTED | P=0.012N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 46/50 (92%) 44/50 (88%) 38/50 (76%) 43/50 (86%) |
|POLY-3 RATE (b) | 46/48.28 44/47.47 38/48.49 43/49.22 |
|POLY-3 PERCENT (g) | 95.3% 92.7% 78.4% 87.4% |
|TERMINAL (d) | 35/36 (97%) 33/36 (92%) 23/33 (70%) 34/39 (87%) |
|FIRST INCIDENCE | 563 521 323 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.164N P=0.480N P=0.282N P=0.175N |
|POLY 3 | P=0.087N P=0.457N P=0.012N* P=0.142N |
|POLY 1.5 | P=0.103N P=0.442N P=0.014N* P=0.165N |
|POLY 6 | P=0.092N P=0.466N P=0.012N* P=0.148N |
|LOGISTIC REGRESSION| P=0.164N P=0.522N P=0.036N* P=0.243N |
|COCH-ARM / FISHERS | P=0.198N P=0.370N P=0.027N* P=0.262N |
|ORDER RESTRICTED | P=0.031N* (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).