TDMS Study 96018-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/25/03
EXPERIMENT: 96018 TEST: 04 TIME: 11:07:37
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: HEATH, JAMES E. CAS: 75-27-4
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/25/03
EXPERIMENT: 96018 TEST: 04 TIME: 11:07:37
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: HEATH, JAMES E. CAS: 75-27-4
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 350 423 563 581 604 606 649 669 689 702 |
| 715 715 723 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 217 318 521 521 581 604 626 640 641 649 |
| 674 689 696 |
| CENSORED DEATHS |
| 547 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 350 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 323 455 460 486 539 583 604 658 659 663 |
| 663 664 669 696 701 707 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 700 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 424 472 522 535 587 631 647 669 686 693 |
| 703 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 98.0 96.0 96.0 96.0 90.0 86.0 72.0 |
| | |
| | |
|175 MG/L | 100.0 100.0 98.0 96.0 96.0 96.0 92.0 87.9 79.7 73.6 |
| | |
| | |
|350 MG/L | 100.0 100.0 100.0 98.0 98.0 94.0 90.0 86.0 76.0 66.0 |
| | |
| | |
|700 MG/L | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 90.0 86.0 78.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 73.6% 66.0% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.683N P=1.000N P=0.573 P=0.692N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 622.4 567.5 602.6 597.2 |
|NATURAL DEATHS (C) | (30.7) (40.4) (27.2) (29.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.1 683.4 686.0 700.0 |
|(STANDARD ERROR) | (10.8) (14.6) (12.5) ( 9.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
175 MG/L = 2
350 MG/L = 3
700 MG/L = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1 4
|
| 2 23 1 1 3 4
| 2 1 33 4 2 1
95 +
| 3 3 4 4 1 1
P | 3 2 3 14 1
E |
R 90 + 3 23 2 4
C |
E | 3 1 24 1
N | 3 2 213 1
T 85 +
| 3 31 41
S | 41 1
U | 22
R 80 + 2 2 4 1 1
V |
I | 2 2 4 4
V | 33 22 11
A 75 +
L | 3 2 2
| 33 1 1
|
70 +
|
| 33
| 3 3
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.