TDMS Study 96018-04 Pathology Tables
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/25/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 11:09:28
FINAL #1/MICE
Facility: Southern Research Institute
Chemical CAS #: 75-27-4
Lock Date: 02/18/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/25/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 11:09:28
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 7 12 7
Moribund Sacrifice 7 6 5 4
Accidently Killed 1
Survivors
Terminal Sacrifice 36 36 33 39
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (48) (48) (49)
Edema 10 [2.0] 8 [2.1] 8 [2.0] 4 [2.0]
Hemorrhage 1 [4.0]
Intestine Small, Duodenum (48) (48) (46) (46)
Cyst 1 [3.0]
Inflammation, Chronic 1 [3.0] 1 [2.0]
Epithelium, Hyperplasia 1 [3.0] 1 [3.0] 2 [3.0]
Intestine Small, Jejunum (46) (49) (48) (48)
Hyperplasia, Lymphoid 1 [3.0]
Epithelium, Hyperplasia 1 [3.0]
Intestine Small, Ileum (45) (46) (49) (49)
Diverticulum 1
Epithelium, Hyperplasia 1 [3.0] 2 [3.0]
Liver (50) (50) (50) (50)
Basophilic Focus 3 5 2
Clear Cell Focus 2 1 2 3
Cyst 2 [3.0]
Eosinophilic Focus 7 4 8 4
Hematopoietic Cell Proliferation 4 [2.8] 2 [3.0] 1 [2.0] 1 [2.0]
Hyperplasia, Lymphoid 2 [2.0] 5 [2.0] 6 [2.0] 1 [1.0]
Infarct 2 [3.5]
Infiltration Cellular, Mixed Cell 6 [2.3] 6 [2.2] 7 [1.9] 5 [2.0]
Mixed Cell Focus 3 3 3 2
Necrosis, Focal 3 [1.0] 5 [2.0] 2 [2.0] 4 [1.3]
Tension Lipidosis 2 2
Centrilobular, Necrosis 6 [2.3] 1 [3.0] 2 [2.5] 3 [2.7]
Hepatocyte, Depletion Glycogen 3 [3.0] 2 [3.0] 1 [3.0]
Hepatocyte, Karyomegaly 2 [2.0] 4 [2.0]
Hepatocyte, Vacuolization Cytoplasmic 6 [3.0] 3 [3.3] 6 [3.0] 3 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/25/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 11:09:28
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Kupffer Cell, Hyperplasia 2 [2.5] 1 [2.0]
Kupffer Cell, Pigmentation 7 [2.0] 2 [2.0] 1 [2.0]
Mesentery (21) (17) (16) (17)
Angiectasis 1 [3.0]
Hemorrhage 2 [2.5]
Necrosis 1 [2.0]
Fat, Necrosis 12 [3.4] 8 [3.1] 11 [3.5] 13 [3.0]
Pancreas (50) (48) (49) (49)
Atrophy 1 [2.0] 2 [3.5] 2 [2.0]
Cyst 1 [3.0] 1 [3.0]
Acinus, Cytoplasmic Alteration 3 [3.0] 2 [3.5]
Salivary Glands (50) (50) (50) (50)
Atrophy 1 [3.0]
Hyperplasia, Lymphoid 25 [2.2] 22 [2.4] 26 [2.2] 20 [2.4]
Stomach, Forestomach (50) (49) (50) (50)
Edema 2 [2.0] 1 [2.0] 2 [3.0]
Erosion 1 [2.0] 1 [2.0]
Hemorrhage 1 [2.0]
Inflammation, Chronic Active 4 [1.8] 1 [2.0]
Ulcer 2 [2.0]
Epithelium, Hyperplasia 2 [2.0] 3 [1.7] 4 [1.8] 2 [2.0]
Stomach, Glandular (50) (49) (49) (50)
Cyst 2 [2.5] 2 [3.0]
Edema 2 [2.0] 1 [2.0] 1 [2.0]
Erosion 1 [2.0] 1 [2.0] 1 [3.0]
Tooth (1)
Malformation 1
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Inflammation, Chronic 1 [4.0] 1 [2.0] 1 [1.0]
Mineralization 3 [1.7]
Thrombosis 1 [2.0] 1 [3.0]
Artery, Inflammation, Chronic 1 [2.0]
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (49)
Accessory Adrenal Cortical Nodule 8 [3.0] 5 [3.0] 5 [3.0] 10 [3.0]
Hyperplasia, Focal 1 [2.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/25/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 11:09:28
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy, Focal 1 [3.0] 1 [2.0] 2 [1.5]
Zona Reticularis, Vacuolization Cytoplasmic 2 [3.0] 1 [4.0]
Adrenal Medulla (50) (48) (49) (49)
Hyperplasia 2 [1.5] 2 [1.5]
Islets, Pancreatic (49) (48) (48) (49)
Hyperplasia 1 [2.0] 4 [2.3] 3 [2.0] 1 [2.0]
Parathyroid Gland (47) (48) (46) (47)
Cyst 2 [3.0] 1 [3.0]
Pituitary Gland (49) (50) (49) (49)
Pars Distalis, Angiectasis 1 [2.0] 1 [2.0] 1 [2.0]
Pars Distalis, Cyst 1 [3.0] 4 [3.0] 3 [3.0]
Pars Distalis, Hyperplasia, Focal 6 [1.8] 6 [1.5] 1 [2.0] 4 [1.5]
Thyroid Gland (50) (49) (49) (50)
Degeneration, Cystic 26 [1.9] 17 [1.7] 12 [1.8] 11 [2.1]
Follicular Cell, Hyperplasia 6 [1.3] 1 [2.0] 5 [1.4] 1 [1.0]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (48) (49) (48) (49)
Inflammation, Chronic 1 [3.0] 1 [2.0] 4 [2.3] 1 [2.0]
Ovary (50) (49) (50) (49)
Angiectasis 5 [2.6] 6 [2.5] 5 [2.6] 9 [2.2]
Cyst 8 [3.0] 13 [3.0] 11 [3.0] 14 [3.0]
Thrombosis 1 [4.0] 1 [3.0]
Corpus Luteum, Hyperplasia 3 [2.0] 1 [2.0] 3 [2.7]
Granulosa Cell, Hyperplasia 2 [2.0]
Interstitial Cell, Hyperplasia 1 [2.0] 1 [3.0] 1 [2.0] 1 [2.0]
Uterus (50) (50) (50) (50)
Angiectasis 3 [3.3] 1 [4.0]
Hyperplasia, Cystic 45 [3.2] 45 [3.1] 43 [3.4] 46 [3.2]
Inflammation, Chronic 2 [2.0] 2 [2.5] 1 [3.0]
Metaplasia, Squamous 1 [3.0] 2 [3.0] 2 [2.5]
Endometrium, Hyperplasia, Atypical 1 [2.0]
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HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/25/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 11:09:28
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bone Marrow (50) (50) (50) (50)
Hyperplasia 22 [2.6] 24 [2.9] 18 [2.9] 11 [2.6]
Myelofibrosis 3 [2.0] 1 [2.0] 1 [3.0]
Lymph Node (16) (9) (7) (4)
Iliac, Hemorrhage 1 [4.0] 1 [4.0]
Iliac, Hyperplasia, Lymphoid 3 [3.0]
Mediastinal, Hemorrhage 1 [3.0] 1 [2.0]
Renal, Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mandibular (50) (50) (50) (47)
Atrophy 2 [3.0] 1 [3.0] 1 [3.0]
Hematopoietic Cell Proliferation 1 [2.0] 2 [2.0] 1 [1.0]
Hemorrhage 3 [1.7] 2 [3.0] 3 [1.7]
Hyperplasia, Lymphoid 8 [2.4] 9 [2.4] 6 [2.8] 9 [2.4]
Pigmentation 22 [2.4] 27 [2.2] 25 [2.3] 20 [2.2]
Lymph Node, Mesenteric (49) (48) (46) (50)
Atrophy 1 [3.0] 2 [3.0]
Hematopoietic Cell Proliferation 2 [1.5] 2 [2.5]
Hemorrhage 3 [2.7] 2 [3.5] 3 [3.7]
Hyperplasia, Lymphoid 6 [2.5] 9 [2.4] 4 [2.5] 7 [2.3]
Pigmentation 1 [3.0] 1 [2.0]
Spleen (50) (49) (48) (50)
Hematopoietic Cell Proliferation 42 [2.7] 30 [2.8] 32 [2.5] 29 [2.3]
Hemorrhage 1 [3.0] 1 [4.0]
Hyperplasia, Lymphoid 3 [2.3] 1 [3.0] 2 [3.0] 3 [3.0]
Metaplasia, Osseous 1 [2.0]
Pigmentation 29 [2.3] 22 [2.0] 30 [2.4] 27 [2.2]
Lymphoid Follicle, Atrophy 1 [3.0] 1 [3.0]
Lymphoid Follicle, Hyperplasia 5 [2.6] 8 [2.6] 13 [2.7] 14 [2.5]
Thymus (49) (49) (50) (47)
Atrophy 9 [2.9] 3 [3.0] 6 [2.7] 4 [3.0]
Hyperplasia, Lymphoid 1 [2.0] 3 [2.7] 4 [2.8] 2 [3.0]
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INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 9 [1.7] 4 [1.3] 4 [2.0] 2 [2.0]
Skin (50) (50) (50) (50)
Angiectasis 1 [3.0]
Edema 2 [3.0] 1 [4.0]
Ulcer 1 [3.0] 1 [3.0] 1 [4.0]
Epidermis, Hyperplasia 1 [3.0] 1 [2.0] 1 [4.0] 1 [3.0]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/25/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 11:09:28
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 3 [2.3] 1 [2.0] 1 [3.0]
Skeletal Muscle (5) (2) (4) (1)
Atrophy 1 [2.0] 1 [1.0]
Inflammation, Chronic 1 [1.0]
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 2 [3.5]
Cyst Epithelial Inclusion 1 1
Hemorrhage 2 [2.5] 1 [2.0]
Necrosis 1 [3.0]
Peripheral Nerve (5) (4) (1) (1)
Atrophy 3 [2.3] 2 [3.0]
Inflammation, Chronic 1 [3.0]
Spinal Cord (4) (4) (2) (1)
Atrophy 1 [2.0]
Hemorrhage 1 [2.0] 1 [2.0]
Necrosis 1 [4.0] 1 [3.0]
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Edema 1 [2.0] 1 [2.0] 1 [3.0]
Emphysema 1 [3.0]
Foreign Body 1 2
Hemorrhage 6 [2.3] 7 [2.3] 6 [2.5] 7 [1.9]
Hyperplasia, Lymphoid 1 [2.0] 4 [2.0] 1 [2.0]
Infiltration Cellular, Polymorphonuclear 1 [3.0] 1 [3.0]
Infiltration Cellular, Histiocyte 2 [2.5] 1 [3.0] 5 [2.8]
Inflammation, Chronic 1 [2.0] 1 [1.0]
Thrombosis 1 [3.0] 2 [2.0] 1 [1.0]
Alveolar Epithelium, Hyperplasia 2 [2.0] 1 [1.0] 2 [1.0]
Alveolar Epithelium, Metaplasia, Bronchiolar 2 [2.5]
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SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96018-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/25/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) Time: 11:09:28
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Eye (48) (50) (50) (50)
Developmental Malformation 1 4
Hemorrhage 2 [2.5]
Inflammation, Chronic 2 [2.0]
Harderian Gland (50) (50) (50) (50)
Hyperplasia, Focal 1 [2.0] 1 [3.0] 2 [2.0] 1 [2.0]
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URINARY SYSTEM
Kidney (50) (49) (50) (50)
Amyloid Deposition 1 [4.0]
Cyst 1 [3.0]
Hyperplasia, Lymphoid 8 [2.1] 5 [2.2] 5 [2.0] 3 [2.0]
Infarct 2 [1.5] 2 [1.0] 3 [1.0] 5 [2.0]
Inflammation, Focal, Mixed Cell 1 [4.0]
Metaplasia, Osseous 2 [1.5] 1 [1.0]
Nephropathy 16 [1.2] 14 [1.4] 7 [1.1] 8 [1.4]
Renal Tubule, Accumulation, Hyaline Droplet 2 [2.5] 6 [3.2] 4 [2.3] 1 [3.0]
Renal Tubule, Necrosis 2 [1.5] 2 [2.0] 1 [2.0]
Renal Tubule, Pigmentation 2 [2.0] 1 [1.0]
Renal Tubule, Regeneration 1 [2.0]
Renal Tubule, Vacuolization Cytoplasmic 1 [3.0] 1 [3.0]
Urinary Bladder (50) (49) (48) (50)
Edema 2 [3.0] 1 [3.0]
Hyperplasia, Lymphoid 11 [2.1] 7 [2.1] 4 [2.0] 10 [2.0]
Inflammation, Chronic 1 [2.0] 1 [3.0]
Transitional Epithelium, Hyperplasia 1 [3.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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