TDMS Study 93027-41 Pathology Tables

NTP Experiment-Test: 93027-41         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID)                    Date: 07/08/99
Route: DOSED FEED                                                                                                 Time: 09:43:30
                                                       13 WEEK SUBCHRONIC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  94-75-7
       Lock Date:  06/12/96
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-41         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID)                    Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 09:43:30  
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         SPRAGUE-DAWLEY RATS MALE                  0 PPM        17 PPM       83 PPM       250 PPM      750 PPM      1250 PPM        
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Clear Cell Focus                                                                                                  1 (10%)     
      Infiltration Cellular, Mononuclear Cell          1 (10%)      1 (10%)                                1 (10%)                  
   Pancreas                                           (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic                                                                   1 (10%)                               
      Acinar Cell, Atrophy                                                                                 1 (10%)                  
   Stomach, Glandular                                 (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                   1 (10%)      8 (80%)      6 (60%)      6 (60%)      9 (90%)      9 (90%)     
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 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                                          
      Cardiomyopathy                                   6 (60%)                                                                      
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 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Hypertrophy, Focal                               1 (10%)                                1 (10%)                               
      Zona Glomerulosa, Vacuolization Cytoplasmic                   1 (10%)      1 (10%)      1 (10%)      1 (10%)      1 (10%)     
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (10)         (10)         (9)          (8)          (9)          (10)         
      Inflammation, Chronic                            8 (80%)     10 (100%)     7 (78%)      7 (88%)      6 (67%)      8 (80%)     
   Prostate                                           (10)                                                                          
      Inflammation, Chronic                            1 (10%)                                                                      
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93027-41         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID)                    Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 09:43:30  
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS MALE                  0 PPM        17 PPM       83 PPM       250 PPM      750 PPM      1250 PPM        
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (10)                                                                          
      Maxilla, Inflammation, Chronic                   1 (10%)                                                                      
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                   (1)                                    
      Hemorrhage                                       1 (10%)                                1 (100%)                              
      Infiltration Cellular, Histiocyte                1 (10%)                                                                      
      Alveolus, Infiltration Cellular, Histiocyte      1 (10%)                                                                      
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Nephropathy                                      6 (60%)      9 (90%)      9 (90%)     10 (100%)     7 (70%)      4 (40%)     
      Corticomedullary Junction, Renal Tubule,                                                                                      
           Regeneration                                             1 (10%)      5 (50%)      5 (50%)      9 (90%)     10 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93027-41         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID)                    Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 09:43:30  
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS MALE                  2500 PPM                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10                                                                            
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                                                                            
  Animals Examined Microscopically                    10                                                                            
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Stomach, Glandular                                 (10)                                                                          
      Mineralization                                   9 (90%)                                                                      
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                                          
      Cardiomyopathy                                   3 (30%)                                                                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)                                                                          
      Zona Glomerulosa, Vacuolization Cytoplasmic      2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (10)                                                                          
      Inflammation, Chronic                           10 (100%)                                                                     
   Testes                                             (10)                                                                          
      Atrophy                                          1 (10%)                                                                      
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93027-41         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID)                    Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 09:43:30  
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS MALE                  2500 PPM                                                                         
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                                                          
      Hemorrhage                                       1 (10%)                                                                      
      Inflammation                                     2 (20%)                                                                      
      Inflammation, Chronic                            1 (10%)                                                                      
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)                                                                          
      Nephropathy                                      2 (20%)                                                                      
      Corticomedullary Junction, Renal Tubule,                                                                                      
           Regeneration                               10 (100%)                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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