TDMS Study 93027-41 Pathology Tables
NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:43:30
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 94-75-7
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:43:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 PPM 17 PPM 83 PPM 250 PPM 750 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Clear Cell Focus 1 (10%)
Infiltration Cellular, Mononuclear Cell 1 (10%) 1 (10%) 1 (10%)
Pancreas (10) (10) (10) (10) (10) (10)
Inflammation, Chronic 1 (10%)
Acinar Cell, Atrophy 1 (10%)
Stomach, Glandular (10) (10) (10) (10) (10) (10)
Mineralization 1 (10%) 8 (80%) 6 (60%) 6 (60%) 9 (90%) 9 (90%)
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CARDIOVASCULAR SYSTEM
Heart (10)
Cardiomyopathy 6 (60%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10) (10)
Hypertrophy, Focal 1 (10%) 1 (10%)
Zona Glomerulosa, Vacuolization Cytoplasmic 1 (10%) 1 (10%) 1 (10%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (9) (8) (9) (10)
Inflammation, Chronic 8 (80%) 10 (100%) 7 (78%) 7 (88%) 6 (67%) 8 (80%)
Prostate (10)
Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:43:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 PPM 17 PPM 83 PPM 250 PPM 750 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (10)
Maxilla, Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1)
Hemorrhage 1 (10%) 1 (100%)
Infiltration Cellular, Histiocyte 1 (10%)
Alveolus, Infiltration Cellular, Histiocyte 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Nephropathy 6 (60%) 9 (90%) 9 (90%) 10 (100%) 7 (70%) 4 (40%)
Corticomedullary Junction, Renal Tubule,
Regeneration 1 (10%) 5 (50%) 5 (50%) 9 (90%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:43:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 2500 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10
Early Deaths
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Stomach, Glandular (10)
Mineralization 9 (90%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10)
Cardiomyopathy 3 (30%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10)
Zona Glomerulosa, Vacuolization Cytoplasmic 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10)
Inflammation, Chronic 10 (100%)
Testes (10)
Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:43:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 2500 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10)
Hemorrhage 1 (10%)
Inflammation 2 (20%)
Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10)
Nephropathy 2 (20%)
Corticomedullary Junction, Renal Tubule,
Regeneration 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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