TDMS Study 93027-44 Pathology Tables
NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:45:35
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 94-75-7
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:45:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 12 PPM 28 PPM 83 PPM 250 PPM 700 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Gallbladder (9)
Inflammation 1 (11%)
Mineralization 1 (11%)
Liver (10) (10) (10) (10) (10) (10)
Mineralization 1 (10%)
Necrosis, Focal 1 (10%) 1 (10%) 1 (10%) 1 (10%) 1 (10%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Preputial Gland (10) (10) (10) (10) (10) (10)
Inflammation, Chronic 1 (10%)
Testes (10) (10) (10) (10) (10) (10)
Interstitial Cell, Hyperplasia 1 (10%)
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HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:45:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 12 PPM 28 PPM 83 PPM 250 PPM 700 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Nephropathy 1 (10%) 2 (20%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:45:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 1680 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10
Early Deaths
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (10)
Inflammation 1 (10%)
Liver (10)
Necrosis, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Parathyroid Gland (9)
Cyst 2 (22%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99
Route: DOSED FEED Time: 09:45:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 1680 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10)
Corticomedullary Junction, Renal Tubule,
Regeneration 9 (90%)
a Number of animals examined microscopically at site and number of animals with lesion
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