TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 NG / 0 UG Include 002 10 NG / 10 UG Include 003 100 NG /100 UG Include 005 300 NG /300 UG Include 007 1000 NG/1000 UG Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | |__________________________________________________________________________| Mesentery | + M M M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + + + M + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Pars Distalis, Adenoma | X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X| C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | X | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X | Polyp Stromal, Multiple | X | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Vagina | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Fibrous Histiocytoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | |__________________________________________________________________________| Ureter | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | |__________________________________________________________________________| Mesentery | + + M + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + M + M + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X | C-Cell, Carcinoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X | Polyp Stromal, Multiple | X X | Squamous Cell Carcinoma | | |__________________________________________________________________________| Vagina | + | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Fibrous Histiocytoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | X | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | X | |__________________________________________________________________________| Ureter | + | __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Papilloma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | Leiomyosarcoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Hemangioma | | 1 | |__________________________________________________________________________|____________| Mesentery | + M + | 47 | |__________________________________________________________________________|____________| Oral Mucosa | | 12 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | |__________________________________________________________________________|____________| Tooth | | 23 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Pheochromocytoma Benign | | 2 | Bilateral, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M | 45 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Carcinoma | | 1 | Pars Distalis, Adenoma | | 22 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | Bilateral, C-Cell, Adenoma | | 2 | C-Cell, Adenoma | | 8 | C-Cell, Carcinoma | | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Adenoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | Granulosa Cell Tumor Malignant | | 1 | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Polyp Stromal | X | 5 | Polyp Stromal, Multiple | | 3 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | |__________________________________________________________________________|____________| Thymus | + + + | 53 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Adenoma | | 2 | Carcinoma | X | 6 | Carcinoma, Multiple | | 2 | Fibroadenoma | X | 27 | Fibroadenoma, Multiple | X | 13 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibroma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Fibrous Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Carcinoma, Metastatic, Mammary Gland | | 1 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Renal Tubule, Adenoma | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Schwannoma Malignant, Metastatic, | | Vagina | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + M + M + + + + + +| Nephroblastoma, Metastatic, Kidney | X | |__________________________________________________________________________| Oral Mucosa | + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Tooth | + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Lymphoma Malignant, | | Metastatic, Lymph Node, | | Mesenteric | X| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + M + + M + +| Lymphoma Malignant | X| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Pars Distalis, Adenoma | X X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Carcinoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Bilateral, C-Cell, Adenoma | X X X | C-Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant | X| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Lymphoma Malignant | X| Polyp Stromal | X X X | Squamous Cell Carcinoma | | |__________________________________________________________________________| Vagina | + | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Lymph Node | + + + + +| Lymphoma Malignant | X| Nephroblastoma, Metastatic, Kidney | X | __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lumbar, Lymphoma Malignant | X| Mediastinal, Lymphoma Malignant | X| Pancreatic, Nephroblastoma, | | Metastatic, Kidney | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X X X X X | Lymphoma Malignant | X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Fibroma | | Fibrosarcoma | | Liposarcoma | | Lymphoma Malignant | X| Sarcoma | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Skeletal Muscle | + | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Carcinoma, Metastatic, Pituitary | | Gland | | Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Schwannoma Malignant, Metastatic, | | Skin | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Zymbal's Gland | | __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Nephroblastoma | X | |__________________________________________________________________________| Ureter | +| Lymphoma Malignant | X| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Nephroblastoma, Metastatic, Kidney | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Schwannoma Malignant, Metastatic, | | Vagina | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + + + + M + + + + + + + + + + + + + M + + M +| Nephroblastoma, Metastatic, Kidney | | |__________________________________________________________________________| Oral Mucosa | + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Acinus, Adenoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + M + + M + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Tooth | + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Lymphoma Malignant, | | Metastatic, Lymph Node, | | Mesenteric | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + M + M + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Pars Distalis, Adenoma | X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Carcinoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant | | Polyp Stromal | X X X | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Vagina | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + | Lymphoma Malignant | | Nephroblastoma, Metastatic, Kidney | | __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lumbar, Lymphoma Malignant | | Mediastinal, Lymphoma Malignant | | Pancreatic, Nephroblastoma, | | Metastatic, Kidney | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + M + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + M + + + M + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | Fibroadenoma | X X X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X | Lymphoma Malignant | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Fibroma | X | Fibrosarcoma | | Liposarcoma | X | Lymphoma Malignant | | Sarcoma | X | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Skeletal Muscle | | Hemangiosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | Carcinoma, Metastatic, Pituitary | | Gland | X | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Schwannoma Malignant, Metastatic, | | Skin | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Zymbal's Gland | + | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Nephroblastoma | | |__________________________________________________________________________| Ureter | | Lymphoma Malignant | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Nephroblastoma, Metastatic, Kidney | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Lymphoma Malignant | | 1 | Schwannoma Malignant, Metastatic, | | | Vagina | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + M + | 47 | Nephroblastoma, Metastatic, Kidney | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + | 11 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Acinus, Adenoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Tooth | + | 14 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Aorta, Lymphoma Malignant, | | | Metastatic, Lymph Node, | | | Mesenteric | | 1 | |__________________________________________________________________________|____________| Heart | + + + | 52 | Lymphoma Malignant | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Lymphoma Malignant | | 1 | Pars Distalis, Adenoma | X | 21 | Pars Distalis, Carcinoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | Lymphoma Malignant | | 1 | Bilateral, C-Cell, Adenoma | | 4 | C-Cell, Adenoma | X | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Carcinoma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Carcinoma | | 1 | Lymphoma Malignant | | 1 | Polyp Stromal | X | 7 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Vagina | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node | | 7 | Lymphoma Malignant | | 1 | Nephroblastoma, Metastatic, Kidney | | 1 | Lumbar, Lymphoma Malignant | | 1 | Mediastinal, Lymphoma Malignant | | 1 | Pancreatic, Nephroblastoma, | | | Metastatic, Kidney | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + + + | 50 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Adenoma | | 1 | Carcinoma | X | 4 | Fibroadenoma | | 22 | Fibroadenoma, Multiple | X X | 17 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Basal Cell Carcinoma | | 2 | Fibroma | | 1 | Fibrosarcoma | X | 1 | Liposarcoma | | 1 | Lymphoma Malignant | | 1 | Sarcoma | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Astrocytoma Malignant | | 1 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Lymphoma Malignant | | 1 | Schwannoma Malignant, Metastatic, | | | Skin | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Lymphoma Malignant | | 1 | Nephroblastoma | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | Nephroblastoma, Metastatic, Kidney | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Multiple | | Hepatocellular Adenoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + M M + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + M + + + + + M + + + + + + + + + + + M + + + +| Adenoma | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X X X | C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X | Polyp Stromal, Multiple | X | Sarcoma | X | Sarcoma Stromal | | Squamous Cell Carcinoma | | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + M + + M| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibroadenoma, Multiple | X X X X X X X X | Lymphoma Malignant | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X X | Fibrous Histiocytoma | | Keratoacanthoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________|__________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + M + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Multiple | | Hepatocellular Adenoma | X X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + + M M + + + + + + + + + + + + M M + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +| Acinus, Adenoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Blood Vessel | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + M + + M + + M + + + + + + + + + + + + + + + + M| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X | Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + M + + + + + M + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X | Polyp Stromal, Multiple | X | Sarcoma | | Sarcoma Stromal | X | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + M + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Carcinoma | X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibroadenoma, Multiple | X X X X X X X | Lymphoma Malignant | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Fibrous Histiocytoma | X | Keratoacanthoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________|__________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 52 | Cholangiocarcinoma, Multiple | X | 1 | Hepatocellular Adenoma | | 3 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 46 | |__________________________________________________________________________|____________| Oral Mucosa | + + + | 25 | Gingival, Squamous Cell Carcinoma | | 2 | |__________________________________________________________________________|____________| Pancreas | + + + | 52 | Acinus, Adenoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Tooth | + + + | 33 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 52 | |__________________________________________________________________________|____________| Heart | + + + | 52 | Lymphoma Malignant | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Pheochromocytoma Benign | | 4 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 46 | Adenoma | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Adenoma | X X X | 17 | Pars Intermedia, Adenoma | | 2 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 51 | Bilateral, C-Cell, Adenoma | | 4 | C-Cell, Adenoma | X X | 12 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | |__________________________________________________________________________|____________| Ovary | + + + | 52 | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Polyp Stromal | | 5 | Polyp Stromal, Multiple | | 2 | Sarcoma | | 1 | Sarcoma Stromal | | 1 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Spleen | + + + | 52 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Thymus | + + + | 48 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | Carcinoma | | 2 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X | 25 | Fibroadenoma, Multiple | | 15 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibroma | | 3 | Fibrous Histiocytoma | | 1 | Keratoacanthoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 52 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 52 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Lymphoma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Vagina | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X X | Cholangiocarcinoma, Multiple | X X | Hepatocellular Adenoma | X X | Hepatocholangioma | | |__________________________________________________________________________| Mesentery | + + + M M + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Acinus, Adenoma | X X | Acinus, Carcinoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Lung | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + M M M M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Granulosa Cell Tumor Benign | X | Lymphoma Malignant | X | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Lymphoma Malignant | X | Polyp Stromal | X X | Schwannoma Malignant | X | Schwannoma Malignant, Metastatic, | | Vagina | | Squamous Cell Carcinoma | | Cervix, Granular Cell Tumor Benign | | Cervix, Squamous Cell Carcinoma | X| |__________________________________________________________________________| Vagina | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 53 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Lung | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Fibrosarcoma, Metastatic, Lung | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | | Lymphoma Malignant | X | Squamous Cell Carcinoma | X | Mediastinum, Fibrosarcoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | |__________________________________________________________________________| Zymbal's Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephroblastoma | | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Vagina | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + M + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Cholangiocarcinoma, Multiple | X X X | Hepatocellular Adenoma | X X X | Hepatocholangioma | X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + M M + + M + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | Acinus, Adenoma | X | Acinus, Carcinoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Salivary Glands | + + + M M + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Lung | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + M + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X X| C-Cell, Adenoma | X X X X X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | X | Granulosa Cell Tumor Benign | | Lymphoma Malignant | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| Fibrosarcoma | X | Lymphoma Malignant | | Polyp Stromal | X X X X | Schwannoma Malignant | | Schwannoma Malignant, Metastatic, | | Vagina | X | Squamous Cell Carcinoma | X X| Cervix, Granular Cell Tumor Benign | X | Cervix, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Vagina | + | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M M + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymus | + + + + + + + + + + + + M + + + + + + + + + M + +| Squamous Cell Carcinoma, Metastatic, | | Lung | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Fibrosarcoma, Metastatic, Lung | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + M + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X | Lymphoma Malignant | | Squamous Cell Carcinoma | | Mediastinum, Fibrosarcoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | |__________________________________________________________________________| Zymbal's Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + M + + + + + + + + + + + + + + +| Nephroblastoma | X | |__________________________________________________________________________| Ureter | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Schwannoma Malignant, Metastatic, | | | Vagina | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | Leiomyoma | | 2 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Liver | + + + | 52 | Cholangiocarcinoma | | 4 | Cholangiocarcinoma, Multiple | | 5 | Hepatocellular Adenoma | | 5 | Hepatocholangioma | | 2 | |__________________________________________________________________________|____________| Mesentery | + + + | 47 | |__________________________________________________________________________|____________| Oral Mucosa | + + | 30 | Gingival, Squamous Cell Carcinoma | X | 5 | |__________________________________________________________________________|____________| Pancreas | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | Acinus, Adenoma | | 3 | Acinus, Carcinoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 52 | |__________________________________________________________________________|____________| Tooth | + + + | 35 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Fibrosarcoma, Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X | 17 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | Bilateral, C-Cell, Adenoma | | 3 | C-Cell, Adenoma | | 12 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | |__________________________________________________________________________|____________| Ovary | + + + | 52 | Granulosa Cell Tumor Malignant | | 1 | Granulosa Cell Tumor Benign | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Oviduct | | 2 | |__________________________________________________________________________|____________| Uterus | + + + | 52 | Fibrosarcoma | | 1 | Lymphoma Malignant | | 1 | Polyp Stromal | | 6 | Schwannoma Malignant | X | 2 | Schwannoma Malignant, Metastatic, | | | Vagina | | 1 | Squamous Cell Carcinoma | | 2 | Cervix, Granular Cell Tumor Benign | | 1 | Cervix, Squamous Cell Carcinoma | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Vagina | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | + + | 7 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 50 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Spleen | + + + | 52 | |__________________________________________________________________________|____________| Thymus | + + + | 50 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Carcinoma | | 1 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X | 25 | Fibroadenoma, Multiple | | 9 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibroma | | 1 | Lipoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Fibrosarcoma, Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 52 | Granular Cell Tumor Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Cystic Keratinizing Epithelioma | | 1 | Lymphoma Malignant | | 1 | Squamous Cell Carcinoma | | 1 | Mediastinum, Fibrosarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 2 | |__________________________________________________________________________|____________| Eye | + + + | 52 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Zymbal's Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 52 | Nephroblastoma | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + M + + + + + + + + + + +| Cholangiocarcinoma | X X X X X | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X | Hepatocholangioma | X X | Hepatocholangioma, Multiple | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + M M + + + + + + + + M M| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + | Gingival, Squamous Cell Carcinoma | X X X X | Gingival, Squamous Cell Carcinoma, | | Multiple | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +| Acinus, Adenoma | X | Acinus, Carcinoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +| Bilateral, Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + M + + + + + + + + + + +| Adenoma | X | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + +| Mediastinal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + I + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M M + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Lipoma | X | Sarcoma | | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X X | Cystic Keratinizing Epithelioma, | | Multiple | X X X X | Squamous Cell Carcinoma | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Kidney | + + + + + + + + + + + + + M + + + + + + + + + + +| Nephroblastoma | X | |__________________________________________________________________________| Ureter | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + M + + + + + + + +| Cholangiocarcinoma | X X X | Cholangiocarcinoma, Multiple | X X X X X X X X | Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X | Hepatocholangioma | X X | Hepatocholangioma, Multiple | X | |__________________________________________________________________________| Mesentery | + + + M M M + + + + + + + + + + M M + M + + + + M| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X X X | Gingival, Squamous Cell Carcinoma, | | Multiple | | |__________________________________________________________________________| Pancreas | + + + + + M + + + + + + + + + + M + + + + + + + +| Acinus, Adenoma | | Acinus, Carcinoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + M + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Pars Distalis, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| C-Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + + + + + + M + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Ovary | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Oviduct | + + + | |__________________________________________________________________________| Uterus | + + + + + M + + + + + + + + + + M + + + + + + + +| Adenoma | | Polyp Stromal | X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + | Mediastinal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + M + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Fibroadenoma | X X X| Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Lipoma | | Sarcoma | X | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + M + + + + + + + +| Cystic Keratinizing Epithelioma | X | Cystic Keratinizing Epithelioma, | | Multiple | X X X X | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Kidney | + + + + + + + + + + + + + + + + M + + + + + + + +| Nephroblastoma | | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + M + + + + + + + + + + M + + + + + + + +| Papilloma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 49 | |__________________________________________________________________________|____________| Liver | + + + | 51 | Cholangiocarcinoma | X | 9 | Cholangiocarcinoma, Multiple | X | 21 | Hepatocellular Carcinoma | | 2 | Hepatocellular Adenoma | | 11 | Hepatocellular Adenoma, Multiple | X X | 16 | Hepatocholangioma | X | 5 | Hepatocholangioma, Multiple | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 42 | |__________________________________________________________________________|____________| Oral Mucosa | + + | 36 | Gingival, Squamous Cell Carcinoma | | 8 | Gingival, Squamous Cell Carcinoma, | | | Multiple | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + | 50 | Acinus, Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Acinus, Carcinoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 51 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 51 | |__________________________________________________________________________|____________| Tooth | + + | 31 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 52 | |__________________________________________________________________________|____________| Heart | + + + | 52 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 51 | Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 51 | Bilateral, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 52 | Pars Distalis, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | X | 7 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 50 | |__________________________________________________________________________|____________| Ovary | + + + | 49 | |__________________________________________________________________________|____________| Oviduct | | 3 | |__________________________________________________________________________|____________| Uterus | + + + | 50 | Adenoma | | 1 | Polyp Stromal | | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | | 14 | Mediastinal, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + | 50 | |__________________________________________________________________________|____________| Thymus | + + + | 51 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | Fibroadenoma | | 11 | Fibroadenoma, Multiple | | 1 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Basal Cell Carcinoma | | 1 | Lipoma | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 52 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 52 | Cystic Keratinizing Epithelioma | | 3 | Cystic Keratinizing Epithelioma, | | | Multiple | | 8 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:45:06 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + | 52 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + | 52 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 51 | Nephroblastoma | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 50 | Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------