TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 NG / 0 UG Include 002 10 NG / 10 UG Include 003 100 NG /100 UG Include 005 300 NG /300 UG Include 007 1000 NG/1000 UG Page 1 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Basophilic Focus | X X X X X X X | Basophilic Focus, Multiple | X X X | Clear Cell Focus | | Clear Cell Focus, Multiple | X X X | Eosinophilic Focus | X X X X X| Eosinophilic Focus, Multiple | X X X | Fatty Change, Diffuse | 1 2 2 | Fatty Change, Focal | | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 1 1 1 2 1 1| Inflammation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X| Mixed Cell Focus, Multiple | X X X X X X X X | Necrosis | 1 2 | Pigmentation | 1 | Bile Duct, Cyst | | Bile Duct, Fibrosis | | Bile Duct, Hyperplasia | 1 1 1 | Centrilobular, Degeneration | 2 3 2 | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Hepatocyte, Hypertrophy | | Oval Cell, Hyperplasia | | Serosa, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Mesentery | + M M M + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + | Gingival, Hyperplasia, Squamous | 1 1 1 1 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Hyperplasia | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Mineralization | 1 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 2 2 | |__________________________________________________________________________| Tooth | + + + + + + + + + + +| Peridontal Tissue, Inflammation | 1 1 1 1 1 2 2 1 1 2 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 1 1 1 | Degeneration, Cystic | 2 3 1 3 2 2 2 | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hematopoietic Cell Proliferation | | Hyperplasia | 2 2 2 3 | Hypertrophy | 2 2 2 2 2 3 2 3 2 3 2 1 3 2 1 1 2 2 2 2 2| Necrosis | 3 | Vacuolization Cytoplasmic | 3 2 1 1 1 2| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 2 1 3 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + + + M + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 3 2 2| Cyst | | Pars Distalis, Hyperplasia | 2 3 2 2 1 3 2 3 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 4 2 3 3 | Follicle, Cyst | 2 2 | Follicular Cell, Hypertrophy | 1 1 1 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 2 2 1 2 2 2 3 2 1 2 1 1 1 2 1 2 2 1 3 2 2| Duct, Cyst | 3 2 2 2 2 2 2 1 2 3 3 3 2 2 1 2 2 2 2 3 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4| Cyst | 2 3 2 2 2 2 2 3 | Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Oviduct | | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Cyst | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 2 | Inflammation, Suppurative | 1 1 2 | Metaplasia, Squamous | 4 3 2 3 2 2 4 3 1 1 2 2 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 1 3 3 1 2 2 2 | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 4 4 4 4 2 3 3 3 3 4 3 4 3 4 3 3 2 3 3| |__________________________________________________________________________| Lymph Node | + + | Lumbar, Ectasia | 2 2 | Lumbar, Hyperplasia, Plasma Cell | 2 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 2 3 2 2 3 4 1 2 2 3 3 2 2 2 3 3 3 4 3 2 2 1 2| Pigmentation | 1 2 1 1 1 2 1 2 1 1 2 1 2 1 1 1 1 2 2 1| Red Pulp, Atrophy | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 2 2 2 3 4 2 2 4 2 3 | Hemorrhage | | Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Cyst | 3 | Hyperplasia | 1 2 1 2 1 1 2 1 2 2 2 2 1 | Inflammation, Granulomatous | 2 2 1 | Duct, Cyst | 4 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Fibrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 2 1 1 2 2 2 2 1 3 2 2 2 1 3 2 2 2 2 3 2| Inflammation | 2 2 1 | Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 2 1 1 1 2 1| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 2 1 2 1 2 2 1 1 3 | Olfactory Epithelium, Degeneration | | Olfactory Epithelium, Metaplasia | 3 | Respiratory Epithelium, Hyperplasia | 2 3 3 3 | Respiratory Epithelium, Metaplasia | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | |__________________________________________________________________________| Ear | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 2 | Calculus Micro Observation Only | X X X | Casts Protein | 2 | Inflammation, Chronic Active | 2 | Inflammation, Suppurative | 1 2 1 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 1 1| Pelvis, Dilatation | | Pelvis, Inflammation | 1 | Transitional Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Ureter | | Inflammation | | Transitional Epithelium, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 | __________________________________________|__________________________________________________________________________ Page 7 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 1 1 2 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Basophilic Focus | X | Basophilic Focus, Multiple | X X X X X X X X X | Clear Cell Focus | X X | Clear Cell Focus, Multiple | X X X | Eosinophilic Focus | X X| Eosinophilic Focus, Multiple | X X X X | Fatty Change, Diffuse | | Fatty Change, Focal | 1 | Hematopoietic Cell Proliferation | 1 1 1 1 1 2 1 1 1 1 3| Inflammation | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | X X X| Mixed Cell Focus, Multiple | X X X X X X X X X | Necrosis | 2 2 | Pigmentation | 1 | Bile Duct, Cyst | 2 3 1 3 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 3 1 1 1 | Centrilobular, Degeneration | 1 1 | __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Hepatocyte, Hypertrophy | 1 | Oval Cell, Hyperplasia | 1 1 | Serosa, Inflammation, Chronic Active | | |__________________________________________________________________________| Mesentery | + + M + + + + + + + + + + + + + + M + + + + + + +| Artery, Inflammation, Chronic Active | 1 | |__________________________________________________________________________| Oral Mucosa | + + + + | Gingival, Hyperplasia, Squamous | 1 1 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Hyperplasia | 2 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Mineralization | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + | Peridontal Tissue, Inflammation | 1 1 1 1 2 1 1 1 1 2 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 2 1 1 1 2 1 2 | Degeneration, Cystic | 1 2 3 1 2 3 | __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hematopoietic Cell Proliferation | 1| Hyperplasia | 2 3 2 2 2 2| Hypertrophy | 2 2 2 2 2 2 2 1 2 2 1 3 3 2 3 2 2 1 2 3 1 2 2| Necrosis | | Vacuolization Cytoplasmic | 1 1 1 1| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| Hyperplasia | 1 1 2 2 2 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + M + M + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 2 2 2 3 3 2 4 2 3 3 | Cyst | 2 | Pars Distalis, Hyperplasia | 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 1 1 3 2 2 2 | Follicle, Cyst | | Follicular Cell, Hypertrophy | 1 1 2 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 2 2 1 2 2 2 2 2 2 2 1 2 1 2 1 1 4 2| Duct, Cyst | 2 3 2 1 2 2 3 3 2 3 1 3 2 1 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3| Cyst | 2 2 3 3 2| Inflammation, Chronic Active | | |__________________________________________________________________________| Oviduct | + | __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Cyst | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Inflammation, Suppurative | | Metaplasia, Squamous | 1 2 1 2 1 2 2 2 2 2 4 1 1 1| Endometrium, Hyperplasia, Cystic | 2 2 2 3 1 2 2 1 2 2 2 2 1 | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 3 2 4 3 4 3 2 2 2 4 4 3 2 4| |__________________________________________________________________________| Lymph Node | + + | Lumbar, Ectasia | 2 3 | Lumbar, Hyperplasia, Plasma Cell | 2 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 3 2 3 3 3 2 2 2 3 3 2 2 3 2 2 2 3 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 2 1 4 2 1 1 3 1 2 2 2 1 1 2 4 1 2 2 2 2 4| Pigmentation | 2 1 2 2 1 1 2 2 1 2 1 2 2 3 1 2 1 1 2 1 2 2 1 1| Red Pulp, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 3 2 2 3 2 2 2 2 1 2 2 3 2 2 2 1| Hemorrhage | 2 | Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Cyst | 3 3 | Hyperplasia | 1 2 1 2 1 1 2 1 2 1 1 2 2 2 1| Inflammation, Granulomatous | 2 3 | Duct, Cyst | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Fibrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 1 1 1 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2| Inflammation | 3 1 2 2 1 | Alveolar Epithelium, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 2 2 2 1 2 1 1 | Olfactory Epithelium, Degeneration | 2 | Olfactory Epithelium, Metaplasia | 2 3 | Respiratory Epithelium, Hyperplasia | 2 2 2 2 3 | Respiratory Epithelium, Metaplasia | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 12 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 2| Calculus Micro Observation Only | X X X X | Casts Protein | 2 | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 2 3 2 2 1| Pelvis, Dilatation | 2 | Pelvis, Inflammation | 3 2| Transitional Epithelium, Hyperplasia | 3 | |__________________________________________________________________________| Ureter | + | Inflammation | 2 | Transitional Epithelium, Hyperplasia | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 1 1| __________________________________________|__________________________________________________________________________ Page 13 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 3 1.3| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Parasite Metazoan | | 2 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 3 1.7| Basophilic Focus | X | 9 | Basophilic Focus, Multiple | X | 13 | Clear Cell Focus | X | 3 | Clear Cell Focus, Multiple | | 6 | Eosinophilic Focus | | 7 | Eosinophilic Focus, Multiple | | 7 | Fatty Change, Diffuse | | 3 1.7| Fatty Change, Focal | 1 1 | 3 1.0| Hematopoietic Cell Proliferation | 1 1 | 27 1.2| Inflammation | 2 | 44 1.1| Mixed Cell Focus | | 7 | Mixed Cell Focus, Multiple | X X | 19 | Necrosis | | 4 1.8| Pigmentation | | 2 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Bile Duct, Cyst | | 4 2.3| Bile Duct, Fibrosis | | 1 1.0| Bile Duct, Hyperplasia | 1 | 8 1.3| Centrilobular, Degeneration | | 5 1.8| Hepatocyte, Hypertrophy | | 1 1.0| Oval Cell, Hyperplasia | | 2 1.0| Serosa, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Mesentery | + M + | 47 | Artery, Inflammation, Chronic Active | | 1 1.0| |__________________________________________________________________________|____________| Oral Mucosa | | 12 | Gingival, Hyperplasia, Squamous | | 8 1.3| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Acinus, Hyperplasia | | 2 1.5| |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Hyperplasia, Squamous | | 1 2.0| Mineralization | | 1 1.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Mineralization | | 4 1.5| |__________________________________________________________________________|____________| Tooth | | 23 | Peridontal Tissue, Inflammation | | 23 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Cardiomyopathy | 1 | 22 1.0| Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | 1 2 | 17 1.4| Degeneration, Cystic | | 13 2.1| Hematopoietic Cell Proliferation | | 1 1.0| Hyperplasia | 2 | 11 2.2| Hypertrophy | 2 3 1 | 47 2.0| Necrosis | | 1 3.0| Vacuolization Cytoplasmic | 2 | 11 1.5| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Hyperplasia | 2 | 15 1.8| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M | 45 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | | 17 2.4| Cyst | | 1 2.0| Pars Distalis, Hyperplasia | 3 1 4 | 13 2.4| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | C-Cell, Hyperplasia | | 15 2.1| Follicle, Cyst | | 2 2.0| Follicular Cell, Hypertrophy | 1 2 | 14 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Inflammation | 3 2 2 | 45 1.8| Duct, Cyst | 1 3 | 38 2.1| |__________________________________________________________________________|____________| Ovary | + + + | 53 | Atrophy | 4 4 4 | 45 4.0| Cyst | 3 | 14 2.4| Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Oviduct | | 1 | Cyst | | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Inflammation, Chronic Active | | 3 2.3| Inflammation, Suppurative | | 3 1.3| Metaplasia, Squamous | 2 | 27 2.0| Endometrium, Hyperplasia, Cystic | 3 3 3 | 28 2.0| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 3 3 | 39 3.2| |__________________________________________________________________________|____________| Lymph Node | | 4 | Lumbar, Ectasia | | 4 2.3| Lumbar, Hyperplasia, Plasma Cell | | 4 2.3| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 53 | Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia, Plasma Cell | 2 3 | 37 2.2| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Lymph Node, Mesenteric | + + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 2 2 2 | 51 2.2| Pigmentation | 2 2 1 | 47 1.5| Red Pulp, Atrophy | | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + | 53 | Atrophy | 2 2 | 33 2.3| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 2 2.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 3 3.0| Hyperplasia | 1 | 29 1.5| Inflammation, Granulomatous | | 5 2.0| Duct, Cyst | | 1 4.0| |__________________________________________________________________________|____________| Skin | + + + | 53 | Angiectasis | 3 | 1 3.0| Fibrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hydrocephalus | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Infiltration Cellular, Histiocyte | 2 2 | 47 1.8| Inflammation | | 8 1.8| Alveolar Epithelium, Hyperplasia | 1 1 | 23 1.2| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | 2 1 | 22 1.5| Olfactory Epithelium, Degeneration | | 1 2.0| Olfactory Epithelium, Metaplasia | 1 | 4 2.3| Respiratory Epithelium, Hyperplasia | 2 | 10 2.4| Respiratory Epithelium, Metaplasia | | 1 2.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | Inflammation | | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + | 53 | Retina, Atrophy | | 1 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | 1 | 20 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Accumulation, Hyaline Droplet | | 2 2.0| Calculus Micro Observation Only | | 7 | Casts Protein | | 2 2.0| Inflammation, Chronic Active | | 1 2.0| Inflammation, Suppurative | | 5 1.2| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Mineralization | 1 | 42 1.0| Nephropathy | 1 1 | 29 1.2| Pelvis, Dilatation | | 1 2.0| Pelvis, Inflammation | | 3 2.0| Transitional Epithelium, Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Ureter | | 1 | Inflammation | | 1 2.0| Transitional Epithelium, Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Inflammation | 1 | 7 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X | Basophilic Focus, Multiple | X X X X X | Cholangiofibrosis | | Clear Cell Focus | | Clear Cell Focus, Multiple | | Eosinophilic Focus | X X | Eosinophilic Focus, Multiple | X X X X X X | Fatty Change, Diffuse | | Fatty Change, Focal | 1 1 | Hematopoietic Cell Proliferation | 1 1 1 1 2 1 1 1 1 1 1 1 1 | Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X | Necrosis | 2 2 3 2 2 | Pigmentation | 2 1 1 | Toxic Hepatopathy | 1 | Bile Duct, Cyst | 3 | Bile Duct, Dilatation | 4 | __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 1 1 | Bile Duct, Hyperplasia | 2 | Centrilobular, Degeneration | 2 2 3 1 | Hepatocyte, Hypertrophy | 1 1 1 1 1 | Oval Cell, Hyperplasia | 1 | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + M + M + + + + + +| Artery, Inflammation, Chronic Active | 1 | Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + | Gingival, Hyperplasia, Squamous | 1 1 1 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Mineralization | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 2 | |__________________________________________________________________________| Tooth | + + + + + + + | Peridontal Tissue, Inflammation | 1 1 3 2 2 2 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 1 2 2 2 1 1 2 2 2 | Degeneration, Cystic | 2 2 3 2 | Hyperplasia | 2 1 1 3 1 2 3 2 3 | Hypertrophy | 2 2 3 2 2 2 1 3 2 2 1 3 2 1 3 1 4 1 | Vacuolization Cytoplasmic | 1 2 2 2 2| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + M + + M + +| Hyperplasia | 2 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 3 3 2 2 1 1 2 2 | Cyst | | Pars Distalis, Hyperplasia | 2 2 3 4 3 2 3 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 3 3 2 2 2 | Follicular Cell, Hypertrophy | 1 1 1 1 2 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 2 2 1 2 2 2 2 1 2 2 2 2 1 3 3 2 2 3 2 1 2 2 | Duct, Cyst | 2 1 3 1 2 2 2 3 1 1 2 1 2 2 2 1 3 3 2 3 1| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 | Cyst | 3 2 2 | Inflammation, Chronic Active | 4 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Suppurative | 2 2 | Metaplasia, Squamous | 1 2 4 4 2 1 2 1 2 1 2 4 2 1 | Endometrium, Hyperplasia, Cystic | 2 3 2 2 2 4 1 3 2 | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Hyperplasia | 3 2 2 3 3 3 3 3 2 3 3 4 3 3 3 3 3 4 3 | |__________________________________________________________________________| Lymph Node | + + + + +| Lumbar, Ectasia | 2 2 2 | Lumbar, Hemorrhage | 2 | Lumbar, Hyperplasia | 3 | Lumbar, Hyperplasia, Plasma Cell | 2 | Mediastinal, Hyperplasia, Histiocytic| | Mediastinal, Hyperplasia, Lymphoid | | Renal, Ectasia | 2 | Renal, Hyperplasia, Plasma Cell | 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hemorrhage | | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 3 2 2 2 3 2 3 2 2 2 2 2 2 2 3 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 3 1 3 2 3 2 2 3 2 2 2 2 2 2 2 3 2 | Pigmentation | 1 2 3 2 1 1 1 3 1 2 1 1 1 2 1 1 2 2 2 1 1 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 3 2 4 2 2 3 3 2 3 2 2 3 2 4 | __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 2 1 1 1 2 1 1 2 1 1 2 1 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 3 2 3 2 1 2 2 2 2 2 1 1 1 1 2 2 2 2 2 2 2 | Inflammation | 3 | Mineralization | 1 | Alveolar Epithelium, Hyperplasia | 2 2 1 1 1 1 1 1 2 2 1 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 1 1 1 | Olfactory Epithelium, Metaplasia | 2 2 2 | Respiratory Epithelium, Hyperplasia | 2 2 2 | Respiratory Epithelium, | | Vacuolization Cytoplasmic | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3| DAY ON TEST | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6| | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10 UG | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | 2 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | | Calculus Micro Observation Only | X X | Casts Protein | | Cyst | 3 | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 | Pigmentation | | Transitional Epithelium, Hyperplasia | | |__________________________________________________________________________| Ureter | +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 | __________________________________________|__________________________________________________________________________ Page 26 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 3 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X| Basophilic Focus, Multiple | X X X X X X X | Cholangiofibrosis | 1 | Clear Cell Focus | X X | Clear Cell Focus, Multiple | X | Eosinophilic Focus | X X X X | Eosinophilic Focus, Multiple | X | Fatty Change, Diffuse | 1 | Fatty Change, Focal | 1 1 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 | Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X | Necrosis | 1 2 2 | Pigmentation | 1 1 | Toxic Hepatopathy | 1 | Bile Duct, Cyst | 2 2 | Bile Duct, Dilatation | | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | | Bile Duct, Hyperplasia | 1 | Centrilobular, Degeneration | 1 3 2 | Hepatocyte, Hypertrophy | 1 | Oval Cell, Hyperplasia | 1 | |__________________________________________________________________________| Mesentery | + + + + + + M + + + + + + + + + + + + + M + + M +| Artery, Inflammation, Chronic Active | | Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + + + + | Gingival, Hyperplasia, Squamous | 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Acinus, Atrophy | 2 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + M + + M + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 1| Mineralization | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | |__________________________________________________________________________| Tooth | + + + + + + | Peridontal Tissue, Inflammation | 1 1 1 2 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + M + + + + + + + + +| Cardiomyopathy | 2 2 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 2 1 2 2 1 2 2 1| Degeneration, Cystic | 3 3 2 1 2 3 2 | Hyperplasia | 2 2 3 2 2 3 2 | Hypertrophy | 2 1 2 2 3 3 2 2 1 1 2 2 1 1 2 2 1| Vacuolization Cytoplasmic | 1 2 2 1 1 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 1 2| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + M + M + + + + + +| Hyperplasia | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 1 3 2 2 1 3 1 3| Cyst | 2 3 3 | Pars Distalis, Hyperplasia | 2 2 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 3 1 1 1 1 2 2 1 2| Follicular Cell, Hypertrophy | 1 1 2 3 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 1 2 3 2 1 1 2 2 1 2 1 2 2 1 1 2 2 2 2 2| Duct, Cyst | 3 3 2 1 2 2 1 3 2 3 2 2 1 2 3 2 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 2 2 2| Inflammation, Chronic Active | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation, Suppurative | 2 2 1 | Metaplasia, Squamous | 2 4 1 1 3 4 3 2 3 1 2 2 2 2 4 | Endometrium, Hyperplasia, Cystic | 3 3 3 2 2 3 2 1 1 2 1 1| |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 3 3 4 3 2 3 3 2 4 3 3 3 3 4 4 3 3 2 | |__________________________________________________________________________| Lymph Node | + + | Lumbar, Ectasia | 3 | Lumbar, Hemorrhage | 2 | Lumbar, Hyperplasia | | Lumbar, Hyperplasia, Plasma Cell | | Mediastinal, Hyperplasia, Histiocytic| 2 | Mediastinal, Hyperplasia, Lymphoid | 2 | Renal, Ectasia | | Renal, Hyperplasia, Plasma Cell | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + M + + + + + +| Ectasia | 2 | Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 3| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 3 2 3 2 3 2 3 3 1 2 2 2 2 2 1 2 1| Pigmentation | 2 1 2 2 1 1 2 1 1 1 2 1 1 1 1 1 3 1 2 1 1 2| |__________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + M + + + M + + + + +| Atrophy | 2 3 3 2 4 1 2 4 2 2 2 2 2 3| __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 1 1 2 2 1 1 2 1 1 1 2 1 1| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 3 2 2 2 2 1 2 2 2 2 1 2 3 2 2| Inflammation | 1 1 3 3 | Mineralization | | Alveolar Epithelium, Hyperplasia | 2 1 2 1 2 1 1| Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 2 | Olfactory Epithelium, Metaplasia | | Respiratory Epithelium, Hyperplasia | 1 2 | Respiratory Epithelium, | | Vacuolization Cytoplasmic | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5| DAY ON TEST | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8| | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8| 10 UG | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 1| |__________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | X | Calculus Micro Observation Only | X X | Casts Protein | 1 | Cyst | | Inflammation, Chronic Active | 2 | Inflammation, Suppurative | 1 2 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 1 1 1 1 1 1 | Pigmentation | 2 | Transitional Epithelium, Hyperplasia | 1 1 | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 1 1 1| __________________________________________|__________________________________________________________________________ Page 32 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Parasite Metazoan | | 2 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 1 1.0| Basophilic Focus | | 7 | Basophilic Focus, Multiple | X X X | 15 | Cholangiofibrosis | | 1 1.0| Clear Cell Focus | | 2 | Clear Cell Focus, Multiple | | 1 | Eosinophilic Focus | X X | 8 | Eosinophilic Focus, Multiple | X | 8 | Fatty Change, Diffuse | | 1 1.0| Fatty Change, Focal | | 4 1.0| Hematopoietic Cell Proliferation | 1 1 1 | 29 1.0| Hepatodiaphragmatic Nodule | | 2 | Inflammation | 1 1 1 | 41 1.0| Mixed Cell Focus | | 3 | Mixed Cell Focus, Multiple | X | 19 | Necrosis | | 8 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Pigmentation | | 5 1.2| Toxic Hepatopathy | | 2 1.0| Bile Duct, Cyst | | 3 2.3| Bile Duct, Dilatation | | 1 4.0| Bile Duct, Fibrosis | 1 | 3 1.0| Bile Duct, Hyperplasia | | 2 1.5| Centrilobular, Degeneration | | 7 2.0| Hepatocyte, Hypertrophy | 1 | 7 1.0| Oval Cell, Hyperplasia | | 2 1.0| |__________________________________________________________________________|____________| Mesentery | + M + | 47 | Artery, Inflammation, Chronic Active | | 1 1.0| Fat, Necrosis | | 2 3.0| |__________________________________________________________________________|____________| Oral Mucosa | + | 11 | Gingival, Hyperplasia, Squamous | 1 | 8 1.0| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Inflammation, Chronic Active | | 3 1.3| Acinus, Atrophy | | 2 1.5| |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Hyperplasia, Squamous | | 1 1.0| Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Mineralization | | 3 1.3| |__________________________________________________________________________|____________| Tooth | + | 14 | Peridontal Tissue, Inflammation | 2 | 14 1.6| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 52 | Cardiomyopathy | 1 1 1 | 19 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | 2 1 2 | 26 1.7| Degeneration, Cystic | 2 | 12 2.3| Hyperplasia | 2 3 | 18 2.2| Hypertrophy | 2 2 1 | 38 1.9| Vacuolization Cytoplasmic | 1 | 12 1.6| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Hyperplasia | 2 3 | 13 1.8| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | 3 | 20 2.2| Cyst | | 3 2.7| Pars Distalis, Hyperplasia | 3 | 13 2.5| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | C-Cell, Hyperplasia | 2 2 | 19 1.9| Follicular Cell, Hypertrophy | 1 | 17 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Inflammation | 2 1 2 | 49 1.8| Duct, Cyst | 1 3 | 40 2.0| |__________________________________________________________________________|____________| Ovary | + + + | 53 | Atrophy | 4 3 3 | 44 4.0| Cyst | | 7 2.1| Inflammation, Chronic Active | | 1 4.0| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Hyperplasia | | 1 3.0| Inflammation, Suppurative | | 5 1.8| Metaplasia, Squamous | 2 | 30 2.2| Endometrium, Hyperplasia, Cystic | 2 2 | 23 2.1| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Atrophy | | 1 3.0| Hyperplasia | 3 | 38 3.0| |__________________________________________________________________________|____________| Lymph Node | | 7 | Lumbar, Ectasia | | 4 2.3| Lumbar, Hemorrhage | | 2 2.0| Lumbar, Hyperplasia | | 1 3.0| Lumbar, Hyperplasia, Plasma Cell | | 1 2.0| Mediastinal, Hyperplasia, Histiocytic| | 1 2.0| Mediastinal, Hyperplasia, Lymphoid | | 1 2.0| Renal, Ectasia | | 1 2.0| Renal, Hyperplasia, Plasma Cell | | 1 3.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Lymph Node, Mandibular | + + + | 51 | Ectasia | 2 | 3 2.0| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 2 2.0| Hyperplasia, Plasma Cell | 2 2 2 | 37 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 2 2 2 | 51 2.1| Pigmentation | 2 1 2 | 46 1.5| |__________________________________________________________________________|____________| Thymus | + + + | 50 | Atrophy | 3 2 2 | 33 2.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 2 2.0| Hyperplasia | 1 1 2 | 29 1.4| |__________________________________________________________________________|____________| Skin | + + + | 53 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Infiltration Cellular, Histiocyte | 2 1 1 | 41 1.9| Inflammation | | 5 2.2| Mineralization | | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 | 20 1.4| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | | 6 1.5| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | 1 | 13 1.2| Olfactory Epithelium, Metaplasia | | 3 2.0| Respiratory Epithelium, Hyperplasia | | 5 1.8| Respiratory Epithelium, | | | Vacuolization Cytoplasmic | | 1 2.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Retina, Atrophy | | 3 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | 1 1 1 | 14 1.1| |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Calculus Gross Observation | | 1 | Calculus Micro Observation Only | | 4 | Casts Protein | | 1 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 6| 7| | | DAY ON TEST | 3| 9| 2| | | | 1| 4| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| | A | 10 NG / | 8| 8| 8| | L | 10 UG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Cyst | | 1 3.0| Inflammation, Chronic Active | | 1 2.0| Inflammation, Suppurative | | 3 1.3| Mineralization | 1 1 | 38 1.1| Nephropathy | 1 1 2 | 22 1.0| Pigmentation | | 1 2.0| Transitional Epithelium, Hyperplasia | | 2 1.0| |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Inflammation | | 8 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Perforation | | Muscularis, Inflammation | 2 | Periesophageal Tissue, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X | Basophilic Focus, Multiple | X X X X | Clear Cell Focus | X | Clear Cell Focus, Multiple | | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X X X X X| Fatty Change, Diffuse | 3 1 1 | Fatty Change, Focal | 1 1 1 1 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 2 1 1 1| Hyperplasia, Nodular | X | Inflammation | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X | Necrosis | 2 1 2 | Pigmentation | 1 1 2 1 1 1 2 1 1 1 2 1 1 2 1 1 1 2 1 1| __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Toxic Hepatopathy | 1 1 2 2 1 1 1 1 1 2 1 1 1 1 1 1 2 1| Bile Duct, Cyst | | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 2 1 3 1 2 1 1 1| Centrilobular, Degeneration | 3 | Hepatocyte, Hypertrophy | 1 1 1 2 2 | Hepatocyte, Multinucleated | 1 1 1 1 2 2 1 2 | Oval Cell, Hyperplasia | 2 2 1 1 1 2 1 1 1| |__________________________________________________________________________| Mesentery | + M M + + + + + + + + + + + + + + M + + + + + + +| Artery, Inflammation, Chronic Active | 2 | Fat, Necrosis | 3 2 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + | Gingival, Hyperplasia, Squamous | 1 1 1 2 1 1 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | | Artery, Inflammation, Chronic Active | 3| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3| Hyperplasia, Squamous | | Inflammation | 4| Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4| Mineralization | | Ulcer | 3| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 2 1 1 1 1 2 1 2 1 1 1 2 1 1| __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 2| Coronary Artery, Inflammation, | | Chronic Active | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 1 1 1 2 1 1 2 2 1 2 2 2 1 2 | Degeneration, Cystic | 2 3 2 2 1 4 | Hyperplasia | 3 2 2 2 2 3 2 3 2 2 | Hypertrophy | 3 2 1 4 2 1 2 2 1 4 1 1 1 2 2 2 3 2 1 2 1| Vacuolization Cytoplasmic | 2 1 1 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 3 3 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + + M + + + + + M + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 2 2 2 2| Cytoplasmic Alteration | | Pars Distalis, Hyperplasia | 2 2 3 2 3 3 2 3 2 3 4 2 3| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 3 2 2 1 3 2 2 2 2 | Follicular Cell, Hypertrophy | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 2 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 1 1 1 1 2 1 3 1 2 2 2 3 2 1 2 2 1 2 1 1 | Duct, Cyst | 2 2 3 2 3 3 3 2 3 2 3 3 2 3 1 3 1 1 1 3 2 2 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 2 2 2 2 2 3 3 2| |__________________________________________________________________________| Oviduct | + | Cyst | 3 | Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | 2 | Inflammation, Chronic Active | 3 | Inflammation, Suppurative | 3 2 1 2 | Metaplasia, Squamous | 1 2 3 1 4 2 3 4 2 2 2 3 2 1 1 1 3 1 2 | Endometrium, Hyperplasia, Cystic | 3 4 3 2 2 1 2 2 2 2 3 1 3 3 1 3| |__________________________________________________________________________| Vagina | | Inflammation | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | | Hyperplasia | 2 4 2 3 2 3 3 3 3 3 3 3 3 2 3 2 4 4 3| |__________________________________________________________________________| Lymph Node | | Renal, Ectasia | | Renal, Hemorrhage | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 2 2| Hyperplasia, Lymphoid | 2 2 | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 3 4 2 2| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Inflammation, Chronic Active | 4| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 3 2 1 2 2 2 3 2 2 2 3 2 2 1 1 3 2 1 2 3 3| Hyperplasia | | Pigmentation | 2 2 1 2 1 1 2 1 2 1 1 2 2 2 1 2 2 1 1| Lymphoid Follicle, Atrophy | 2 | Red Pulp, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + M + + M| Atrophy | 4 3 4 4 3 3 3 2 3 3 2 2 2 4 3 3 2 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 1 1 3 2 1 3 2 1 2 1 1 2 1 | Inflammation, Granulomatous | 3 2 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | Ulcer | 2 2 | Dermis, Fibrosis | 3 | Epidermis, Hyperplasia | 4 | Subcutaneous Tissue, Inflammation | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Infiltration Cellular, Histiocyte | 2 2 1 1 1 2 2 2 2 2 2 2 1 2 1 1 2 1 2 1 2 2| Inflammation | 2 | Metaplasia, Squamous | 1 | Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 2| Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 1 2 2 1 2 2 1 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 | Olfactory Epithelium, Metaplasia | 3 | Respiratory Epithelium, Hyperplasia | 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | 2 2 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Calculus Micro Observation Only | | Cyst | | Infarct | | Inflammation, Suppurative | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Necrosis | | Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| Pigmentation | 1 1 | Pelvis, Inflammation | 1 | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7| DAY ON TEST | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2| | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 100 UG | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Renal Tubule, Degeneration | | Transitional Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 | __________________________________________|__________________________________________________________________________ Page 46 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +| Perforation | X | Muscularis, Inflammation | | Periesophageal Tissue, Inflammation | 4 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + M + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X | Basophilic Focus, Multiple | X | Clear Cell Focus | X | Clear Cell Focus, Multiple | X | Eosinophilic Focus | X X X | Eosinophilic Focus, Multiple | X X X X X X X X X X X X X| Fatty Change, Diffuse | 1 2 2 3 1| Fatty Change, Focal | 2 1 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 2 1 1 2 2 1| Hyperplasia, Nodular | X | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X | Necrosis | 2 3 | Pigmentation | 2 1 1 1 1 1 2 2 1 1 2 1 1 1 1| __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Toxic Hepatopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1| Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 1 1 | Bile Duct, Hyperplasia | | Centrilobular, Degeneration | 2 | Hepatocyte, Hypertrophy | 1 2 1 1 2 1 2 2 1 1| Hepatocyte, Multinucleated | 1 2 1 | Oval Cell, Hyperplasia | 1 1 1 1 1| |__________________________________________________________________________| Mesentery | + + + + M M + + + + + + + + + + + + M M + + + + +| Artery, Inflammation, Chronic Active | | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + | Gingival, Hyperplasia, Squamous | 1 1 2 2 1 1 2 2 1 2 | |__________________________________________________________________________| Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Acinus, Atrophy | 2 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Hyperplasia, Squamous | 2 1 | Inflammation | | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 1 1 1 | Ulcer | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + | Peridontal Tissue, Inflammation | 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + M + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 | Coronary Artery, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 2 1 2 2 2 2 1 1 2 1 2| Degeneration, Cystic | 1 3 2 2 2 2 3| Hyperplasia | 2 2 1 3 2 3 2 2 2 1 2| Hypertrophy | 1 1 4 2 3 2 1 2 1 2 1 3 2 3 4 1 2 2 1 3 | Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 2 1 1 3 1| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Parathyroid Gland | + M + + M + + M + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 2 3 3 3 | Cytoplasmic Alteration | 2 2 2 | Pars Distalis, Hyperplasia | 4 2 2 2 2 2 | |__________________________________________________________________________| Thyroid Gland | + M + + + + + M + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 4 3 2 1 3 2 2 1 1| Follicular Cell, Hypertrophy | 1 1 2 2 1 2 1 1 1 3 2 1 2 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 1 1 2 2 2 1 2 1 2 1 2 2 1 2 2 3 1 2 2 2 2| Duct, Cyst | 3 1 3 2 2 3 3 3 3 2 1 2 3 3 1 3 2 3 2 3 3 3| |__________________________________________________________________________| Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 3 3 2 2 2 2 2 | |__________________________________________________________________________| Oviduct | | Cyst | | Inflammation, Chronic Active | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 2 2| Metaplasia, Squamous | 2 2 1 1 3 2 4 2 2 3 1 3 2 1 2| Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 2 4 3 2 2 1 3 3 2 2| |__________________________________________________________________________| Vagina | + | Inflammation | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 3 | Hyperplasia | 3 3 3 3 3 2 3 3 3 2 4 3 3 3 3 2 2 3 4 3 4| |__________________________________________________________________________| Lymph Node | + + | Renal, Ectasia | 2 | Renal, Hemorrhage | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| Ectasia | 1 2 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 3 2 2 3 2 2 3 3 3 2 2 3 2 3 2 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4| Inflammation, Chronic Active | | |__________________________________________________________________________| Spleen | + + + + + + + M + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 3 3 1 2 2 1 2 2 2 3 2 2 3 2 2 3 3 3 3| Hyperplasia | 2 | Pigmentation | 2 2 2 1 1 2 2 3 1 2 1 1 2 1 1 1 1 2 1 1 1| Lymphoid Follicle, Atrophy | 2 | Red Pulp, Atrophy | | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + M + + + + + + + + + + + +| Atrophy | 2 4 2 2 3 3 4 3 4 3 2 2 3 3 2 3 4 2 4 2 2 3 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 1 1 1 2 2 2 1 1 1 2| Inflammation, Granulomatous | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Ulcer | | Dermis, Fibrosis | | Epidermis, Hyperplasia | | Subcutaneous Tissue, Inflammation | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Lung | + + + + + + + M + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Histiocyte | 1 1 2 2 2 2 2 1 1 2 1 1 1 2 1 2 2 2 2 2 1 2| Inflammation | 2 | Metaplasia, Squamous | | Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 1 1| Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 1 2 2 1 1 1 1 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 2 1 1 1 1 1 | Olfactory Epithelium, Metaplasia | 2 2 2 1 | Respiratory Epithelium, Hyperplasia | 2 2 1 3 1 2 | |__________________________________________________________________________| Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 2 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + M + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 1 | Calculus Micro Observation Only | X | Cyst | 2 | Infarct | 3 | Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | 1| Nephropathy | 1 1 1 1 1 2 1 1 1 1 1| Pigmentation | | Pelvis, Inflammation | 2 3 1 | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7| DAY ON TEST | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2| | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 NG / | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 100 UG | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Renal Tubule, Degeneration | 3 | Transitional Epithelium, Hyperplasia | 1 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 | __________________________________________|__________________________________________________________________________ Page 53 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | Perforation | | 1 | Muscularis, Inflammation | | 1 2.0| Periesophageal Tissue, Inflammation | | 1 4.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | Mineralization | | 1 3.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 52 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 52 | Angiectasis | | 1 1.0| Basophilic Focus | | 8 | Basophilic Focus, Multiple | X | 6 | Clear Cell Focus | | 2 | Clear Cell Focus, Multiple | | 1 | Eosinophilic Focus | | 4 | Eosinophilic Focus, Multiple | X X X | 26 | Fatty Change, Diffuse | 1 | 9 1.7| Fatty Change, Focal | 1 | 7 1.1| Hematopoietic Cell Proliferation | 1 1 | 30 1.1| Hyperplasia, Nodular | | 2 | Inflammation | 1 1 2 | 46 1.1| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mixed Cell Focus | | 4 | Mixed Cell Focus, Multiple | X X | 26 | Necrosis | | 5 2.0| Pigmentation | 2 2 2 | 38 1.3| Toxic Hepatopathy | 3 1 1 | 34 1.2| Bile Duct, Cyst | | 1 2.0| Bile Duct, Fibrosis | | 3 1.0| Bile Duct, Hyperplasia | 2 | 9 1.6| Centrilobular, Degeneration | | 2 2.5| Hepatocyte, Hypertrophy | 1 2 | 17 1.4| Hepatocyte, Multinucleated | 2 1 1 | 14 1.4| Oval Cell, Hyperplasia | 2 | 15 1.3| |__________________________________________________________________________|____________| Mesentery | + + + | 46 | Artery, Inflammation, Chronic Active | | 1 2.0| Fat, Necrosis | | 2 2.5| |__________________________________________________________________________|____________| Oral Mucosa | + + + | 25 | Gingival, Hyperplasia, Squamous | 4 | 18 1.6| |__________________________________________________________________________|____________| Pancreas | + + + | 52 | Inflammation, Chronic Active | 1 | 3 1.3| Acinus, Atrophy | | 1 2.0| Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 52 | Hyperkeratosis | | 1 3.0| Hyperplasia, Squamous | | 2 1.5| Inflammation | | 1 4.0| Ulcer | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Stomach, Glandular | + + + | 52 | Inflammation, Chronic Active | | 1 4.0| Mineralization | | 3 1.0| Ulcer | | 1 3.0| |__________________________________________________________________________|____________| Tooth | + + + | 33 | Peridontal Tissue, Inflammation | 1 1 2 | 33 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 52 | |__________________________________________________________________________|____________| Heart | + + + | 52 | Cardiomyopathy | 1 1 | 22 1.0| Coronary Artery, Inflammation, | | | Chronic Active | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Angiectasis | 2 2 2 | 33 1.6| Degeneration, Cystic | | 13 2.2| Hyperplasia | 3 3 | 23 2.2| Hypertrophy | 3 2 1 | 44 2.0| Vacuolization Cytoplasmic | 2 2 | 14 1.2| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Hyperplasia | | 14 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 46 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pituitary Gland | + + + | 53 | Angiectasis | 3 1 3 | 15 2.5| Cytoplasmic Alteration | | 3 2.0| Pars Distalis, Hyperplasia | | 19 2.5| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 51 | C-Cell, Hyperplasia | 2 3 | 22 2.1| Follicular Cell, Hypertrophy | 1 | 34 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Inflammation | 2 2 1 | 46 1.7| Duct, Cyst | 3 3 2 | 48 2.4| |__________________________________________________________________________|____________| Ovary | + + + | 52 | Atrophy | 4 4 4 | 45 4.0| Cyst | 2 | 17 2.2| |__________________________________________________________________________|____________| Oviduct | | 1 | Cyst | | 1 3.0| Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Adenomyosis | | 1 2.0| Inflammation, Chronic Active | | 1 3.0| Inflammation, Suppurative | 1 | 8 1.8| Metaplasia, Squamous | 3 | 35 2.1| Endometrium, Hyperplasia, Cystic | 3 1 4 | 34 2.3| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Degeneration | | 1 3.0| Hyperplasia | 2 2 | 42 2.9| |__________________________________________________________________________|____________| Lymph Node | | 2 | Renal, Ectasia | | 1 2.0| Renal, Hemorrhage | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | Ectasia | | 6 1.7| Hyperplasia, Lymphoid | | 3 2.0| Hyperplasia, Plasma Cell | 2 3 3 | 40 2.4| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Hyperplasia, Lymphoid | | 1 4.0| Inflammation, Chronic Active | | 1 4.0| |__________________________________________________________________________|____________| Spleen | + + + | 52 | Hematopoietic Cell Proliferation | 2 2 2 | 49 2.2| Hyperplasia | | 1 2.0| Pigmentation | 2 2 2 | 43 1.5| Lymphoid Follicle, Atrophy | | 2 2.0| Red Pulp, Atrophy | | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + | 48 | Atrophy | 2 2 | 43 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Cyst | | 2 2.0| Hyperplasia | 1 2 | 25 1.5| Inflammation, Granulomatous | | 4 2.3| |__________________________________________________________________________|____________| Skin | + + + | 53 | Inflammation | | 1 2.0| Ulcer | | 2 2.0| Dermis, Fibrosis | | 1 3.0| Epidermis, Hyperplasia | | 1 4.0| Subcutaneous Tissue, Inflammation | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 52 | Hemorrhage | | 1 2.0| Infiltration Cellular, Histiocyte | 1 2 2 | 47 1.6| Inflammation | | 2 2.0| Metaplasia, Squamous | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 17 1.1| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 2 1 | 23 1.4| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | 1 | 13 1.2| Olfactory Epithelium, Metaplasia | | 5 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 3| 3| | | | 9| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 100 NG / | 9| 9| 9| | L | 100 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Respiratory Epithelium, Hyperplasia | | 7 2.0| |__________________________________________________________________________|____________| Trachea | + + + | 52 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Retina, Atrophy | | 4 2.3| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | 1 | 16 1.1| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 52 | Accumulation, Hyaline Droplet | | 1 1.0| Calculus Micro Observation Only | | 1 | Cyst | | 1 2.0| Infarct | | 1 3.0| Inflammation, Suppurative | | 1 1.0| Mineralization | 1 1 | 39 1.0| Necrosis | | 1 1.0| Nephropathy | 1 1 2 | 29 1.1| Pigmentation | 1 | 3 1.0| Pelvis, Inflammation | | 4 1.8| Renal Tubule, Degeneration | | 1 3.0| Transitional Epithelium, Hyperplasia | 2 | 4 1.8| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Inflammation | | 5 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 60 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 2 1 1 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 4 | Ulcer | 4 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X | Basophilic Focus, Multiple | | Cholangiofibrosis | 1 2 1 2 | Clear Cell Focus | X | Eosinophilic Focus | X X X X X| Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X | Fatty Change, Diffuse | 3 2 1 1 2 3 3 2 2 1 1 2 1 1 1 1| Fatty Change, Focal | 2 | Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1 1 1 | Hyperplasia, Nodular | X X X X X X X X X X X X | Inflammation | 1 1 2 2 2 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X | Necrosis | 1 | Pigmentation | 2 1 2 3 2 2 2 2 1 1 1 2 2 2 2 2 2 1 2 2 4 2 1 2 2| Toxic Hepatopathy | 2 1 3 2 2 3 2 2 2 2 2 3 1 2 1 2 2 1 2 2 3 3 3 2| Bile Duct, Cyst | 4 2| __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 1 1 2 2 1 1 1 1 1 1 | Centrilobular, Degeneration | 2 1 1 | Centrilobular, Fibrosis | 1 | Hepatocyte, Hypertrophy | 2 2 2 3 2 2 1 2 3 1 3 3 1 1 3 3 3| Hepatocyte, Multinucleated | 1 2 2 1 1 2 2 1 1 2 2 2 1 1 1 2 1 1 2 2 1 1 2| Oval Cell, Hyperplasia | 2 1 3 1 1 1 1 2 1 1 1 1 1 1 3 1 3 1| Portal, Fibrosis | 1 2 | |__________________________________________________________________________| Mesentery | + + + M M + + + + + + + + + + + + + + + M + + + +| Artery, Inflammation, Chronic Active | | Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 2 2 1 2 1 2 3 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Acinus, Atrophy | | Acinus, Hyperplasia | | Acinus, Vacuolization Cytoplasmic | 1 1 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 2 2| Hyperplasia, Squamous | 3 2 2| Inflammation | 2 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Tissue | 4 | Erosion | 2 | Mineralization | 2 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 1 2 1 1 1 1 1 1 3 2 2 1 2 2 1 3| __________________________________________|__________________________________________________________________________| Page 62 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 3| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1| Pericardium, Necrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 2 2 2 2 2 2 2 1 1 2| Atrophy | 2 3 | Degeneration, Cystic | 1 1 2 2 1 3 2 2| Hyperplasia | 2 2 3 3 3 2 4 2 2 2 2 2| Hypertrophy | 3 3 2 3 2 2 3 1 4 2 1 4 2 4 3 2 2 3 3| Vacuolization Cytoplasmic | 1 1 2 1 2 2 1| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 4 2 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + M M M M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 2 2 2 2| Inflammation | | Vacuolization Cytoplasmic | 2 | Pars Distalis, Hyperplasia | 2 2 3 1 2 3 3 4 2 1 3 2 2 3| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 2 2 2 3 2 | Follicular Cell, Hypertrophy | 1 1 3 2 1 1 1 1 1 1 1 2 1 1 2 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 4 1 1 1 1 1 1 1 1 2 2 1 3 1 1 2 2 1 1 2 1| Duct, Cyst | 3 1 3 3 2 3 2 3 2 1 3 3 2 2 2 2 2 2 1 2 3 2 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 3 3 2 1 2 | Inflammation, Suppurative | 2 | |__________________________________________________________________________| Oviduct | + | Cyst | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Inflammation, Suppurative | 2 2 2 2 | Metaplasia, Squamous | 2 2 3 3 2 4 1 4 3 3 1 4 2 3 1 2 3 3| Endometrium, Hyperplasia, Cystic | 1 2 3 2 2 1 4 3 2 2 3 | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 4 2 2 3 2 2 4 2 3 2 4 3 2 3 3 3 1 2 2 3 2| |__________________________________________________________________________| Lymph Node | + + | Angiectasis | | Inguinal, Hyperplasia, Plasma Cell | | Lumbar, Ectasia | | Mediastinal, Hemorrhage | 2 | Mediastinal, Hyperplasia, Histiocytic| | Pancreatic, Hyperplasia, Histiocytic | 2 | Pancreatic, Pigmentation | 2 | Renal, Ectasia | | Renal, Hyperplasia, Histiocytic | | Renal, Hyperplasia, Plasma Cell | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 64 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Ectasia | 2 | Hyperplasia, Lymphoid | 2 2 | Hyperplasia, Plasma Cell | 2 3 2 3 2 2 2 2 2 2 2 3 2 3 3 2 3 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Histiocytic | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | Hematopoietic Cell Proliferation | 2 1 1 1 1 2 2 2 1 3 2 3 1 2 2 3 2 2 2 2 2 | Pigmentation | 2 2 2 2 2 2 1 1 1 1 1 1 1 2 1 1 2 1 2 2 2 2 2 2 3| Lymphoid Follicle, Atrophy | 3 2| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Atrophy | 4 4 4 3 3 4 4 4 4 4 4 2 4 4 4 3 4 4 4 4 4| Cyst | | Hemorrhage | 2 | Epithelial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 | Hyperplasia | 1 1 1 2 2 3 2 2 2 1 1 2| Inflammation, Granulomatous | 2| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 1 1 2 1 1 2 2 2 2 1 3 2 1 2 2 2| Inflammation | 2 3 | Metaplasia, Squamous | 2 | Mineralization | 2| Alveolar Epithelium, Hyperplasia | 1 1 2| Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 2 1 2 2 2 1 2 1 2 2 1 3 2 1 2 1 1| Mediastinum, Necrosis | | Serosa, Inflammation | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 2 1 2 2 1 | Olfactory Epithelium, Metaplasia | 2 2 2 | Respiratory Epithelium, Hyperplasia | 2 2 2 1 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Anterior Chamber, Ciliary Body, | | Cornea, Inflammation | | Cornea, Inflammation | | Retina, Atrophy | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 2 2 | |__________________________________________________________________________| Zymbal's Gland | | __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Calculus Micro Observation Only | X X | Cyst | | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| Nephropathy | 2 2 1 1 1 1 2 1 1 1 1 1 1 3| Pigmentation | 1 2 1 | Pelvis, Dilatation | 2| Pelvis, Inflammation | 3 2 2 | Renal Tubule, Degeneration | 2 2 | Transitional Epithelium, Hyperplasia | 1 2 4 1 3 2 | |__________________________________________________________________________| Ureter | | Inflammation | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 1 1 | Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 67 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Ulcer | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + M + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Basophilic Focus | X | Basophilic Focus, Multiple | X | Cholangiofibrosis | 2 4 2 | Clear Cell Focus | X X| Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X | Fatty Change, Diffuse | 2 1 1 1 1 2 3 1 1 1 1 1| Fatty Change, Focal | | Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1| Hyperplasia, Nodular | X X X X X X X X X X X| Inflammation | 1 1 2 2 1 1 1 2 1 1 1 1 2 1 2 1 1 1 2 1 1| Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X| Necrosis | 1 1 1 | Pigmentation | 2 2 3 1 2 2 1 2 2 2 2 2 2 2 2 3 1 2 2 2 2 2| Toxic Hepatopathy | 2 2 2 1 2 2 3 2 3 3 1 3 3 2 2 2 1 1 2 2 2| Bile Duct, Cyst | 2 2 2 | __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 1 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 2 1 3 2 1 2 1 2 1 2 | Centrilobular, Degeneration | 2 | Centrilobular, Fibrosis | | Hepatocyte, Hypertrophy | 1 3 3 3 2 3 1 2 1 1 1 2 2| Hepatocyte, Multinucleated | 2 2 2 2 1 1 1 2 2 1 1 2 2 2 2 2 2 2 2 2| Oval Cell, Hyperplasia | 1 1 1 1 1 1 2 3 2 1 2 3 2 2 2 1 2 2 2| Portal, Fibrosis | 2 2 1 1 1| |__________________________________________________________________________| Mesentery | + + + + + + + + + M M + + M + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 3 2 | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 2 2 2 1 1 1 1 3 3 1 1 1| |__________________________________________________________________________| Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | 1 | Acinus, Hyperplasia | 3 | Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1| Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Salivary Glands | + + + M M + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperkeratosis | | Hyperplasia, Squamous | 2 2 2 | Inflammation | | Ulcer | 3 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +| Ectopic Tissue | | Erosion | | Mineralization | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 2 2 1 3 2 1 1 1 1 1 3 1 1 1 1 1| __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1| Pericardium, Necrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| Angiectasis | 1 1 3 2 1 3 2 2 1 | Atrophy | 4| Degeneration, Cystic | 2 2 2 3 1 1 | Hyperplasia | 1 2 3 3 2 4 2 3 3 3 3 | Hypertrophy | 1 2 1 3 4 3 2 3 2 3 2 2 1 3 2 2 2 3 2 1| Vacuolization Cytoplasmic | 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 2 1 2 3 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + M + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 2 2 2 3 2 2 1 2 | Inflammation | 2 | Vacuolization Cytoplasmic | | Pars Distalis, Hyperplasia | 3 3 3 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 3 2 2 3| Follicular Cell, Hypertrophy | 1 2 1 2 1 2 1 1 3 3 2 2 2 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 3 1 1 2 2 2 1 1 1 2 1 1| Duct, Cyst | 2 2 3 2 2 2 2 2 2 3 2 2 1 3 3 2 1| |__________________________________________________________________________| Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4| Cyst | 3 3 2 2 4 2 4 3 | Inflammation, Suppurative | | |__________________________________________________________________________| Oviduct | + | Cyst | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 1 4 2 3 | Inflammation, Suppurative | 1 1 1 2 1 | Metaplasia, Squamous | 4 4 2 1 1 4 4 2 4 3 4 4 4 4 3 4 4| Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 4 3 4 2 3 3 2 3 3 3 4 3 4 3 3 3 2 4 3 | |__________________________________________________________________________| Lymph Node | + + + | Angiectasis | 2 | Inguinal, Hyperplasia, Plasma Cell | | Lumbar, Ectasia | 2 | Mediastinal, Hemorrhage | | Mediastinal, Hyperplasia, Histiocytic| | Pancreatic, Hyperplasia, Histiocytic | | Pancreatic, Pigmentation | | Renal, Ectasia | | Renal, Hyperplasia, Histiocytic | | Renal, Hyperplasia, Plasma Cell | 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node, Mandibular | + + + M M + + + + + + + + + + + + + + + + + M + +| Congestion | 3 | Ectasia | 2 1| Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 3 2 2 2 3 3 3 3 2 2 3 2 1 2 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Histiocytic | | |__________________________________________________________________________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 2 2 2 2 3 2 2| Pigmentation | 2 2 2 1 3 3 1 3 2 2 2 2 2 1 1 1 1 1 2 2 1 3 3| Lymphoid Follicle, Atrophy | 2 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + M + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4| Cyst | 3 | Hemorrhage | 3 2 | Epithelial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 1 2 1 1 1 1 1 1 1 | Inflammation, Granulomatous | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + M + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 2 2 1 3 2 2 2 2 1 1 2 2 2 2 2 2 2 1 1 2| Inflammation | 1 1 | Metaplasia, Squamous | 1 | Mineralization | | Alveolar Epithelium, Hyperplasia | 2 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 1 2 2 2 2 2 1 1 3 2 2 2 1 2| Mediastinum, Necrosis | | Serosa, Inflammation | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 1 2 2 1 2 | Olfactory Epithelium, Metaplasia | 2 3 2 | Respiratory Epithelium, Hyperplasia | 2 2 3 2 2 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + M + + + + + + + + + + + + + + + + + + + +| Anterior Chamber, Ciliary Body, | | Cornea, Inflammation | 3 | Cornea, Inflammation | | Retina, Atrophy | 2 2| |__________________________________________________________________________| Harderian Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 1 1 1 1| |__________________________________________________________________________| Zymbal's Gland | + | __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + M + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 2 | Calculus Micro Observation Only | X X | Cyst | 3 | Inflammation, Chronic Active | 3 | Inflammation, Suppurative | 1 1 1 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 2 1 1 1 1 2 1 2 2 1 1 1 1 1 1 1 2 1| Pigmentation | 1 2 1 1| Pelvis, Dilatation | 3 | Pelvis, Inflammation | | Renal Tubule, Degeneration | | Transitional Epithelium, Hyperplasia | 1 2 2 2 1 | |__________________________________________________________________________| Ureter | + | Inflammation | 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation | 2 1 1 1 | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 74 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 3 1.3| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 52 | Hyperplasia, Lymphoid | | 2 3.5| Ulcer | | 1 4.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 52 | Angiectasis | | 2 2.0| Basophilic Focus | | 2 | Basophilic Focus, Multiple | | 1 | Cholangiofibrosis | | 7 2.0| Clear Cell Focus | | 3 | Eosinophilic Focus | X | 7 | Eosinophilic Focus, Multiple | X | 33 | Fatty Change, Diffuse | 1 1 2 | 31 1.5| Fatty Change, Focal | | 1 2.0| Hematopoietic Cell Proliferation | 1 | 19 1.1| Hyperplasia, Nodular | X | 24 | Inflammation | 1 1 1 | 48 1.2| Mixed Cell Focus | | 2 | Mixed Cell Focus, Multiple | | 24 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Necrosis | | 4 1.0| Pigmentation | 2 2 2 | 50 1.9| Toxic Hepatopathy | 2 1 1 | 48 2.0| Bile Duct, Cyst | | 5 2.4| Bile Duct, Fibrosis | 1 | 4 1.0| Bile Duct, Hyperplasia | 1 2 | 29 1.4| Centrilobular, Degeneration | | 4 1.5| Centrilobular, Fibrosis | | 1 1.0| Hepatocyte, Hypertrophy | 2 2 2 | 33 2.1| Hepatocyte, Multinucleated | 2 2 1 | 46 1.6| Oval Cell, Hyperplasia | 2 1 | 39 1.6| Portal, Fibrosis | | 7 1.4| |__________________________________________________________________________|____________| Mesentery | + + + | 47 | Artery, Inflammation, Chronic Active | | 2 2.5| Fat, Necrosis | | 1 3.0| |__________________________________________________________________________|____________| Oral Mucosa | + + | 30 | Gingival, Hyperplasia, Squamous | 2 | 22 1.6| |__________________________________________________________________________|____________| Pancreas | + + + | 52 | Inflammation, Chronic Active | | 1 1.0| Acinus, Atrophy | | 1 1.0| Acinus, Hyperplasia | | 1 3.0| Acinus, Vacuolization Cytoplasmic | | 7 1.0| Artery, Inflammation, Chronic Active | 2 | 2 2.5| |__________________________________________________________________________|____________| Salivary Glands | + + + | 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 52 | Hyperkeratosis | | 2 2.0| Hyperplasia, Squamous | 1 | 7 2.0| Inflammation | | 1 2.0| Ulcer | | 2 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 52 | Ectopic Tissue | | 1 4.0| Erosion | | 1 2.0| Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Tooth | + + + | 35 | Peridontal Tissue, Inflammation | 2 1 1 | 35 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Aorta, Mineralization | | 1 3.0| |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | 2 | 26 1.1| Pericardium, Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Angiectasis | 1 | 23 1.7| Atrophy | | 3 3.0| Degeneration, Cystic | | 14 1.8| Hyperplasia | 3 3 | 25 2.6| Hypertrophy | 2 1 | 41 2.3| Vacuolization Cytoplasmic | 2 1 | 10 1.4| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Hyperplasia | 2 2 | 13 2.1| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 77 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 52 | Angiectasis | 2 | 17 2.0| Inflammation | | 1 2.0| Vacuolization Cytoplasmic | | 1 2.0| Pars Distalis, Hyperplasia | 3 | 20 2.5| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | C-Cell, Hyperplasia | | 12 2.3| Follicular Cell, Hypertrophy | 2 1 | 35 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Inflammation | 1 2 | 40 1.4| Duct, Cyst | 3 3 3 | 43 2.3| |__________________________________________________________________________|____________| Ovary | + + + | 52 | Atrophy | 4 4 4 | 43 4.0| Cyst | | 14 2.6| Inflammation, Suppurative | | 1 2.0| |__________________________________________________________________________|____________| Oviduct | | 2 | Cyst | | 2 2.0| |__________________________________________________________________________|____________| Uterus | + + + | 52 | Inflammation, Chronic Active | 3 | 7 2.6| Inflammation, Suppurative | 2 | 10 1.6| Metaplasia, Squamous | 3 | 36 2.9| Endometrium, Hyperplasia, Cystic | 4 1 | 18 2.2| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 78 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 3 4 3 | 48 2.8| |__________________________________________________________________________|____________| Lymph Node | + + | 7 | Angiectasis | | 1 2.0| Inguinal, Hyperplasia, Plasma Cell | 2 | 1 2.0| Lumbar, Ectasia | | 1 2.0| Mediastinal, Hemorrhage | | 1 2.0| Mediastinal, Hyperplasia, Histiocytic| 2 | 1 2.0| Pancreatic, Hyperplasia, Histiocytic | | 1 2.0| Pancreatic, Pigmentation | | 1 2.0| Renal, Ectasia | 2 | 1 2.0| Renal, Hyperplasia, Histiocytic | 2 | 1 2.0| Renal, Hyperplasia, Plasma Cell | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 50 | Congestion | | 1 3.0| Ectasia | | 3 1.7| Hyperplasia, Lymphoid | | 2 2.0| Hyperplasia, Plasma Cell | 3 3 | 36 2.4| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Hemorrhage | | 1 2.0| Hyperplasia, Histiocytic | 2 | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + | 52 | Fibrosis | | 1 3.0| Hematopoietic Cell Proliferation | 2 2 3 | 47 2.0| Pigmentation | 1 1 1 | 51 1.7| Lymphoid Follicle, Atrophy | | 4 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 79 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Thymus | + + + | 50 | Atrophy | 4 2 3 | 42 3.8| Cyst | | 1 3.0| Hemorrhage | | 3 2.3| Epithelial Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | 3 | 3 2.3| Hyperplasia | 1 | 22 1.4| Inflammation, Granulomatous | 1 | 3 1.7| |__________________________________________________________________________|____________| Skin | + + + | 53 | Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 52 | Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Infiltration Cellular, Histiocyte | 1 2 1 | 46 1.7| Inflammation | | 4 1.8| Metaplasia, Squamous | | 2 1.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Mineralization | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 5 1.4| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 | 34 1.7| Mediastinum, Necrosis | 3 | 1 3.0| Serosa, Inflammation | 2 | 1 2.0| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | | 13 1.6| Olfactory Epithelium, Metaplasia | | 6 2.2| Respiratory Epithelium, Hyperplasia | | 11 2.1| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 2 | |__________________________________________________________________________|____________| Eye | + + + | 52 | Anterior Chamber, Ciliary Body, | | | Cornea, Inflammation | | 1 3.0| Cornea, Inflammation | 3 | 1 3.0| Retina, Atrophy | | 2 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | Inflammation | 1 | 14 1.3| |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 52 | Accumulation, Hyaline Droplet | | 1 2.0| Calculus Micro Observation Only | | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Cyst | | 1 3.0| Inflammation, Chronic Active | | 1 3.0| Inflammation, Suppurative | | 5 1.0| Mineralization | 1 1 | 42 1.0| Nephropathy | 2 1 | 34 1.3| Pigmentation | | 7 1.3| Pelvis, Dilatation | | 2 2.5| Pelvis, Inflammation | | 3 2.3| Renal Tubule, Degeneration | | 2 2.0| Transitional Epithelium, Hyperplasia | | 11 1.9| |__________________________________________________________________________|____________| Ureter | | 1 | Inflammation | | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | Inflammation | | 7 1.4| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Perforation | X | Muscularis, Inflammation | 3 1 2 | Periesophageal Tissue, Hemorrhage | | Periesophageal Tissue, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +| Metaplasia, Squamous | 3 | Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + M M + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + M + + + + + + + + + + +| Angiectasis | 2 3 | Basophilic Focus | | Basophilic Focus, Multiple | | Cholangiofibrosis | 3 4 4 3 4 3 4 4 4 3 4 2 4 4 3 3 3 3 4 4 | Clear Cell Focus | | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X | Fatty Change, Diffuse | 2 2 2 2 1 1 1 2 2 1 2 2 2 2 1 2 2 1 1| Fatty Change, Focal | 2 2 2 2 | Hematopoietic Cell Proliferation | 1 1 1 | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X| Inflammation | 1 1 1 2 2 1 1 2 2 2 3 3 1 1 1 1 1 1 2 2 1 1| Metaplasia | | Mixed Cell Focus | | __________________________________________|__________________________________________________________________________| Page 83 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Mixed Cell Focus, Multiple | X | Necrosis | 2 2 3 2 2 3 2 2 3 2| Pigmentation | 1 3 2 2 3 2 2 2 2 2 2 1 1 1 2 3 2 2 3 2 1 2 2 3| Toxic Hepatopathy | 4 3 4 4 4 4 4 4 3 4 4 2 4 4 4 4 4 4 4 4 4 4 2 2| Bile Duct, Cyst | 2 2 3 3 4 3 2 2 2 2 3 | Bile Duct, Hyperplasia | 1 3 3 2 3 2 2 3 2 2 2 3 2 3 2 2 2 2 2 3 3 1| Centrilobular, Degeneration | 3| Centrilobular, Fibrosis | | Hepatocyte, Hypertrophy | 4 3 3 3 3 3 4 4 3 4 3 3 4 4 4 3 3 4 3 3 4 3 3 2| Hepatocyte, Multinucleated | 1 3 3 2 2 1 3 2 3 1 1 2 1 2 2 1 2 2 3 1 2 3 2| Oval Cell, Hyperplasia | 3 2 3 3 4 3 3 4 3 3 3 4 3 3 3 2 3 3 3 4 3 2| Portal, Fibrosis | 2 2 2 2 2 2 2 2 2 2 3 3 3 2 2 2 3 | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + M M + + + + + + + + M M| Artery, Inflammation, Chronic Active | 1 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + | Gingival, Hyperplasia, Squamous | 1 1 2 1 2 2 1 3 1 2 2 2 | Pharyngeal, Inflammation | 3 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +| Inflammation, Chronic Active | | Acinus, Atrophy | 1 2 2 1 | Acinus, Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 2 2 1 3 2 1 2 2 1 2 2 | Artery, Inflammation, Chronic Active | | Duct, Dilatation | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +| Hyperplasia, Squamous | 1 2 2 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + + + + + +| Cyst | 1 | Erosion | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 84 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Peridontal Tissue, Inflammation | 1 2 1 2 1 1 1 2 2 2 1 1 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 | Fibrosis | | Hemorrhage | 3 | Inflammation, Chronic Active | 3 | Thrombosis | | Coronary Artery, Inflammation, | | Chronic Active | 1 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + + + + + +| Angiectasis | 2 | Atrophy | 3 2 2 4 2 3 3 4 4 2 2 4 2 2 2 2 | Degeneration, Cystic | 3 2 2 2 1 1 1 1| Hyperplasia | 3 2 3 2 2 2| Hypertrophy | 1 1 3 4 1 3 2 1 3 2 3 3 2 1 1 3 1 | Necrosis | 2| Vacuolization Cytoplasmic | 2 2 2 2 2 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +| Hyperplasia | 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Pars Distalis, Hyperplasia | 1 3 3 3 2 2 2 1 2 | Pars Intermedia, Hyperplasia | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 2 2 2 2 1 | Follicular Cell, Hypertrophy | 2 2 3 2 2 1 2 2 2 3 1 1 2 2 2 2 2 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 | Duct, Cyst | 2 3 3 3 2 2 3 1 2 2 1 2 2 2 2 2 3 3 3 3 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + M M + + + + + + + + + +| Atrophy | 3 4 4 3 4 4 4 4 | Cyst | 3 3 2 2 3| Inflammation, Chronic Active | | |__________________________________________________________________________| Oviduct | | Inflammation, Chronic Active | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + M + + + + + + + + + + +| Adenomyosis | 3 | Hemorrhage | | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 4 1 | Metaplasia, Squamous | 4 1 3 2 2 4 3 1| Ulcer | 3 | Endometrium, Hyperplasia, Cystic | 2 2 1 1 4 2 3 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 4 3 3 3 3 3 3 4 3 2 3 3 3 2 2 3 2 2 2 3 2 | |__________________________________________________________________________| Lymph Node | + + + + + +| Angiectasis | | Mediastinal, Ectasia | 2 2| __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Mediastinal, Hemorrhage | 2| Mediastinal, Hyperplasia, Histiocytic| 2 | Mediastinal, Hyperplasia, Plasma Cell| 2 2 | Pancreatic, Hyperplasia, Histiocytic | 3 3 2 | Pancreatic, Hyperplasia, Plasma Cell | 3 | Pancreatic, Pigmentation | 2 | Renal, Ectasia | | Renal, Hyperplasia, Histiocytic | | Renal, Hyperplasia, Lymphoid | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + I + + + + + + + +| Ectasia | 2 3 3 2 | Hemorrhage | 2| Hyperplasia, Lymphoid | 2 2 2 | Hyperplasia, Plasma Cell | 2 2 2 3 2 3 3 3 3 3 3 2 2 3 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M M + + + + + + + + + +| Hyperplasia, Histiocytic | | Hyperplasia, Lymphoid | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + M + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 1 1 2 2 1 2 2 3 1 3 2 2 2 1 2 1 2 1 2 2 1| Pigmentation | 2 2 2 1 2 2 2 1 1 1 2 1 1 2 1 2 2 2 2 1 2 2 3| Lymphoid Follicle, Atrophy | 3 2 3 | Red Pulp, Atrophy | 2 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 3 4 3 4 4 4 4 4 4 3 4 2 4 4 4 4 4 4 4 3 3| Hemorrhage | 3 | Inflammation | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 1 1 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 87 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Inflammation | 3 | Ulcer | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Hemorrhage | | Inflammation | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 2 2 1 1 1 2 2 2 2 1 2 1 1 2 1 2 1 1 1 1| Inflammation | 3 | Metaplasia, Squamous | 2 2 3 2 2 2 2 3| Alveolar Epithelium, Hyperplasia | 1 2 2 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 3 2 2 1 1 1 2 2 3 2 1 2 2 1| Bronchiole, Hyperplasia | | Mediastinum, Hemorrhage | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation | 2 1 1 1 1 1 1 3 2 1 2 2 1 1 1| Glands, Hyperplasia | 2 2 2 2 2 | Olfactory Epithelium, Degeneration | 2 | Olfactory Epithelium, Metaplasia | 2 2 2 3 2 2 2 2 | Respiratory Epithelium, Hyperplasia | 3 3 2 3 2 3 2 3 3 2| __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| DAY ON TEST | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7| | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 1000 UG | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Peritracheal Tissue, Hemorrhage | | Peritracheal Tissue, Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Anterior Chamber, Ciliary Body, | | Cornea, Inflammation | 3 3 3 | Retina, Atrophy | 2 2 2 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 1 1 1 1 1 3 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + M + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Calculus Micro Observation Only | | Infarct | | Inflammation, Chronic Active | 3 | Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 2 1 2 1 4 3 2 2 3 3 2 2 3 2 2 2 2 3 3 2| Pigmentation | 3 2 3 3 2 4 2 2 2 2 3 3 1 2 1 2 2 1 | Pelvis, Dilatation | 3 | Pelvis, Inflammation | 2 1 2 | Renal Tubule, Degeneration | 3 | Transitional Epithelium, Hyperplasia | 2 3 | |__________________________________________________________________________| Ureter | + | Mineralization | 3 | Transitional Epithelium, Hyperplasia | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 89 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| Cyst | | Perforation | X | Muscularis, Inflammation | | Periesophageal Tissue, Hemorrhage | 3 | Periesophageal Tissue, Inflammation | 3 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + M + + + + + + + + + + M + + + + + + + +| Metaplasia, Squamous | | Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + M + + + + + + + + + + M + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + M + + + + + + + +| Angiectasis | 2 2 | Basophilic Focus | X X | Basophilic Focus, Multiple | X X X | Cholangiofibrosis | 3 2 3 4 3 3 2 4 3 3 3 4 3 2 4 3| Clear Cell Focus | X | Eosinophilic Focus | | Eosinophilic Focus, Multiple | X X X X X X X X X X| Fatty Change, Diffuse | 3 2 2 2 1 1 2 1 2 2 1 1 1 1 1 1 | Fatty Change, Focal | 1 3 3 2 1 1 2| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1| Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X| Inflammation | 2 2 1 2 1 3 1 1 1 2 1 2 1 1 1 2 3 1 1 1 1| Metaplasia | 1 | Mixed Cell Focus | X | __________________________________________|__________________________________________________________________________| Page 90 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Mixed Cell Focus, Multiple | X | Necrosis | 2 2 3 2 3 3 2 1 2 | Pigmentation | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| Toxic Hepatopathy | 3 1 3 4 4 3 4 2 4 4 4 3 2 4 4 4 3 4 4 3 4 3| Bile Duct, Cyst | 3 3 2 2 2 2 2 3 2 2 | Bile Duct, Hyperplasia | 1 1 2 2 2 2 2 3 2 2 1 1 2 2 2 3 2 2 1 2 2| Centrilobular, Degeneration | 2 2 | Centrilobular, Fibrosis | 2 | Hepatocyte, Hypertrophy | 3 2 4 3 4 3 4 3 4 4 3 3 3 3 4 4 2 1 4 3 3 3 4| Hepatocyte, Multinucleated | 2 2 3 2 2 1 2 2 2 2 2 3 1 1 1 3 1 2 1 2 2 2| Oval Cell, Hyperplasia | 2 2 3 4 2 3 2 4 4 3 1 1 3 4 3 4 3 3 1 3 2| Portal, Fibrosis | 2 2 3 3 2 2 3 2 2 3 3 2 2 2 2| |__________________________________________________________________________| Mesentery | + + + M M M + + + + + + + + + + M M + M + + + + M| Artery, Inflammation, Chronic Active | 3 3 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 2 2 1 4 2 1 2 2 3 2 2| Pharyngeal, Inflammation | | |__________________________________________________________________________| Pancreas | + + + + + M + + + + + + + + + + M + + + + + + + +| Inflammation, Chronic Active | 2 1 3 | Acinus, Atrophy | 1 2 3 | Acinus, Vacuolization Cytoplasmic | 2 2 2 2 2 1 2 2 2 2 1 2 3 2 1 1 2 3| Artery, Inflammation, Chronic Active | 3 | Duct, Dilatation | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia, Squamous | 3 1 2 2 | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +| Cyst | | Erosion | 2 2 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 91 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Peridontal Tissue, Inflammation | 1 2 1 1 1 1 1 2 1 2 3 1 2 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + M + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1| Fibrosis | 2 | Hemorrhage | | Inflammation, Chronic Active | | Thrombosis | 3 | Coronary Artery, Inflammation, | | Chronic Active | 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| Angiectasis | 1 2 2 2 | Atrophy | 2 2 2 3 2 3 3 3 2 2 3 3 4 3 2 2 | Degeneration, Cystic | 3 2 2 3 2 1 3 2 | Hyperplasia | 3 2 1 2 2 2 3 3 4 4 3 | Hypertrophy | 3 3 2 3 2 2 4 1 2 4 1 4 1 1| Necrosis | | Vacuolization Cytoplasmic | 2 1 3 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia | 3 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + M + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Angiectasis | 2 | Pars Distalis, Hyperplasia | 2 2 1 | Pars Intermedia, Hyperplasia | 3 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 92 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| C-Cell, Hyperplasia | 2 1 2 2 2 2 2 | Follicular Cell, Hypertrophy | 2 2 1 3 2 1 1 2 2 2 1 2 3 2 2 2 2 1 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + + + + + + M + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 2 1 1| Duct, Cyst | 3 2 2 2 2 3 3 2 3 2 2 3 2 3 3 2 2 2 2| |__________________________________________________________________________| Ovary | + + + + + M + + + + + + + + + + M + + + + + + + +| Atrophy | 4 4 4 4 4 4 | Cyst | 3 2 2 2 2 3 2| Inflammation, Chronic Active | 4 | |__________________________________________________________________________| Oviduct | + + + | Inflammation, Chronic Active | 3 3 3 | |__________________________________________________________________________| Uterus | + + + + + M + + + + + + + + + + M + + + + + + + +| Adenomyosis | | Hemorrhage | 3 | Inflammation, Chronic Active | 4 3 | Inflammation, Suppurative | 2 | Metaplasia, Squamous | 2 3 2 2 3 1 | Ulcer | | Endometrium, Hyperplasia, Cystic | 4 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 4 3 2 2 3 2 2 3 2 2 2 2 3 3 2 3 3 3 3 3 4 3 3| |__________________________________________________________________________| Lymph Node | + + + + + + + + | Angiectasis | 2 | Mediastinal, Ectasia | 2 | __________________________________________|__________________________________________________________________________| Page 93 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Mediastinal, Hemorrhage | 3 | Mediastinal, Hyperplasia, Histiocytic| 2 3 | Mediastinal, Hyperplasia, Plasma Cell| | Pancreatic, Hyperplasia, Histiocytic | | Pancreatic, Hyperplasia, Plasma Cell | | Pancreatic, Pigmentation | | Renal, Ectasia | 2 | Renal, Hyperplasia, Histiocytic | 2 3 | Renal, Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| Ectasia | 2 2 | Hemorrhage | | Hyperplasia, Lymphoid | 4 2 | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 3 3 2 3 3 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + M + + + + + + + +| Hyperplasia, Histiocytic | 3 | Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Spleen | + + + + + M + + + + + + + + + + M + + + + + + + +| Hematopoietic Cell Proliferation | 4 1 2 2 2 1 2 1 2 1 2 1 1 3 1 2 3 2 2| Pigmentation | 3 3 1 1 1 1 2 2 2 2 2 2 1 2 1 1 1 1 2 2| Lymphoid Follicle, Atrophy | 2 2 | Red Pulp, Atrophy | 2 2 2 | |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +| Atrophy | 4 2 4 4 4 4 4 4 3 3 4 4 2 2 3 2 4 4 4 4 3 2| Hemorrhage | | Inflammation | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Cyst | 3 | Hyperplasia | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 94 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Inflammation | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Hemorrhage | 3 | Inflammation | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + M + + + + + + + +| Infiltration Cellular, Histiocyte | 1 2 2 2 1 2 1 1 2 2 1 2 1 2 1 1 2 1 2 2| Inflammation | | Metaplasia, Squamous | 2 1 | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 3 2 2 2 1 2 2 1 2 2 2 2 2 2 3| Bronchiole, Hyperplasia | 3 | Mediastinum, Hemorrhage | 3 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation | 1 1 1 1 2 2 1 1 1 1 1 1 2 1| Glands, Hyperplasia | 2 2 2 | Olfactory Epithelium, Degeneration | 2 | Olfactory Epithelium, Metaplasia | 3 2 2 2 2 2 | Respiratory Epithelium, Hyperplasia | 3 3 3 3 2 2 2 3 2 | __________________________________________|__________________________________________________________________________| Page 95 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 _____________________________________________________________________________________________________________________ | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6| DAY ON TEST | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6| | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1000 NG/ | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 1000 UG | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| Peritracheal Tissue, Hemorrhage | 3 | Peritracheal Tissue, Inflammation | 3 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + M + + + + + + + +| Anterior Chamber, Ciliary Body, | | Cornea, Inflammation | | Retina, Atrophy | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Inflammation | 1 1 3 1 1 1 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + M + + + + + + + +| Accumulation, Hyaline Droplet | 1 | Calculus Micro Observation Only | X | Infarct | 2 | Inflammation, Chronic Active | | Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 2 3 2 3 1 2 2 2 3 1 1 2 3 2 2 4 2 1 2 1| Pigmentation | 2 1 2 2 2 1 1 2 2 2 2 2 2 1 | Pelvis, Dilatation | | Pelvis, Inflammation | 2 | Renal Tubule, Degeneration | | Transitional Epithelium, Hyperplasia | 3 1 2 | |__________________________________________________________________________| Ureter | | Mineralization | | Transitional Epithelium, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + M + + + + + + + + + + M + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 96 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | Cyst | | 1 3.0| Perforation | | 2 | Muscularis, Inflammation | | 3 2.0| Periesophageal Tissue, Hemorrhage | | 1 3.0| Periesophageal Tissue, Inflammation | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 50 | Metaplasia, Squamous | | 1 3.0| Parasite Metazoan | X | 3 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 49 | Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 49 | |__________________________________________________________________________|____________| Liver | + + + | 51 | Angiectasis | 2 | 5 2.2| Basophilic Focus | X | 3 | Basophilic Focus, Multiple | | 3 | Cholangiofibrosis | 3 2 2 | 39 3.2| Clear Cell Focus | | 1 | Eosinophilic Focus | | 1 | Eosinophilic Focus, Multiple | X X | 17 | Fatty Change, Diffuse | 2 2 1 | 38 1.6| Fatty Change, Focal | 2 | 12 1.9| Hematopoietic Cell Proliferation | | 11 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Hyperplasia, Nodular | X X X | 42 | Inflammation | 1 1 1 | 46 1.5| Metaplasia | | 1 1.0| Mixed Cell Focus | | 1 | Mixed Cell Focus, Multiple | | 2 | Necrosis | 2 | 20 2.3| Pigmentation | 2 2 2 | 50 2.0| Toxic Hepatopathy | 4 3 4 | 49 3.5| Bile Duct, Cyst | 2 2 | 23 2.4| Bile Duct, Hyperplasia | 2 1 2 | 46 2.0| Centrilobular, Degeneration | | 3 2.3| Centrilobular, Fibrosis | | 1 2.0| Hepatocyte, Hypertrophy | 4 3 3 | 50 3.3| Hepatocyte, Multinucleated | 1 1 1 | 48 1.9| Oval Cell, Hyperplasia | 3 2 3 | 46 2.9| Portal, Fibrosis | 2 2 | 34 2.3| |__________________________________________________________________________|____________| Mesentery | + + + | 42 | Artery, Inflammation, Chronic Active | | 4 2.5| |__________________________________________________________________________|____________| Oral Mucosa | + + | 36 | Gingival, Hyperplasia, Squamous | 1 | 24 1.8| Pharyngeal, Inflammation | | 1 3.0| |__________________________________________________________________________|____________| Pancreas | + + + | 50 | Inflammation, Chronic Active | 1 | 4 1.8| Acinus, Atrophy | 1 | 8 1.6| Acinus, Vacuolization Cytoplasmic | 1 2 1 | 40 1.9| Artery, Inflammation, Chronic Active | 3 | 2 3.0| Duct, Dilatation | | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 51 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 98 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Hyperplasia, Squamous | 1 | 8 1.8| Ulcer | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 51 | Cyst | | 1 1.0| Erosion | | 2 2.0| |__________________________________________________________________________|____________| Tooth | + + | 31 | Peridontal Tissue, Inflammation | 2 2 | 31 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 52 | |__________________________________________________________________________|____________| Heart | + + + | 52 | Cardiomyopathy | 1 1 | 15 1.0| Fibrosis | | 1 2.0| Hemorrhage | | 1 3.0| Inflammation, Chronic Active | | 1 3.0| Thrombosis | | 1 3.0| Coronary Artery, Inflammation, | | | Chronic Active | | 6 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 51 | Angiectasis | | 5 1.8| Atrophy | 2 2 3 | 35 2.6| Degeneration, Cystic | | 16 1.9| Hyperplasia | 2 | 19 2.6| Hypertrophy | 2 | 32 2.2| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 1 1 | 13 1.6| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 99 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Adrenal Medulla | + + + | 51 | Hyperplasia | | 3 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 52 | Angiectasis | | 1 2.0| Pars Distalis, Hyperplasia | 2 | 13 2.0| Pars Intermedia, Hyperplasia | | 2 2.5| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | C-Cell, Hyperplasia | | 15 1.7| Follicular Cell, Hypertrophy | 1 2 2 | 42 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 50 | Inflammation | 2 1 1 | 23 1.1| Duct, Cyst | 2 3 3 | 43 2.4| |__________________________________________________________________________|____________| Ovary | + + + | 49 | Atrophy | 4 3 | 16 3.8| Cyst | 3 | 13 2.5| Inflammation, Chronic Active | | 1 4.0| |__________________________________________________________________________|____________| Oviduct | | 3 | Inflammation, Chronic Active | | 3 3.0| |__________________________________________________________________________|____________| Uterus | + + + | 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 100 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Adenomyosis | | 1 3.0| Hemorrhage | | 1 3.0| Inflammation, Chronic Active | | 2 3.5| Inflammation, Suppurative | 2 | 5 2.0| Metaplasia, Squamous | | 14 2.4| Ulcer | | 1 3.0| Endometrium, Hyperplasia, Cystic | 3 2 | 12 2.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 2 3 3 | 49 2.7| |__________________________________________________________________________|____________| Lymph Node | | 14 | Angiectasis | | 1 2.0| Mediastinal, Ectasia | | 3 2.0| Mediastinal, Hemorrhage | | 2 2.5| Mediastinal, Hyperplasia, Histiocytic| | 3 2.3| Mediastinal, Hyperplasia, Plasma Cell| | 2 2.0| Pancreatic, Hyperplasia, Histiocytic | | 3 2.7| Pancreatic, Hyperplasia, Plasma Cell | | 1 3.0| Pancreatic, Pigmentation | | 1 2.0| Renal, Ectasia | | 1 2.0| Renal, Hyperplasia, Histiocytic | | 2 2.5| Renal, Hyperplasia, Lymphoid | | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | Ectasia | | 6 2.3| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 5 2.4| Hyperplasia, Plasma Cell | 3 3 | 31 2.5| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 49 | Hyperplasia, Histiocytic | 2 | 2 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 101 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hyperplasia, Lymphoid | | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + | 50 | Hematopoietic Cell Proliferation | 2 2 2 | 44 1.8| Pigmentation | 1 2 1 | 46 1.7| Lymphoid Follicle, Atrophy | | 5 2.4| Red Pulp, Atrophy | | 5 2.2| |__________________________________________________________________________|____________| Thymus | + + + | 51 | Atrophy | 4 4 4 | 49 3.6| Hemorrhage | | 1 3.0| Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | Cyst | | 1 3.0| Hyperplasia | | 3 1.0| |__________________________________________________________________________|____________| Skin | + + + | 53 | Inflammation | | 1 3.0| Ulcer | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Hemorrhage | | 1 3.0| Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 102 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 52 | Infiltration Cellular, Histiocyte | 2 2 1 | 45 1.5| Inflammation | | 1 3.0| Metaplasia, Squamous | 2 | 11 2.1| Alveolar Epithelium, Hyperplasia | 1 | 5 1.4| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 2 2 | 32 1.9| Bronchiole, Hyperplasia | | 1 3.0| Mediastinum, Hemorrhage | | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + | 53 | Hyperplasia | | 1 3.0| Inflammation | 2 1 | 31 1.3| Glands, Hyperplasia | | 8 2.0| Olfactory Epithelium, Degeneration | | 2 2.0| Olfactory Epithelium, Metaplasia | 3 | 15 2.2| Respiratory Epithelium, Hyperplasia | 3 | 20 2.6| |__________________________________________________________________________|____________| Trachea | + + + | 52 | Peritracheal Tissue, Hemorrhage | | 1 3.0| Peritracheal Tissue, Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 103 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 10:01:01 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 3| | | | 9| 9| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 1000 NG/ | 9| 9| 9| | L | 1000 UG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Anterior Chamber, Ciliary Body, | | | Cornea, Inflammation | | 3 3.0| Retina, Atrophy | 2 | 5 2.2| |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | Inflammation | 1 | 16 1.4| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 51 | Accumulation, Hyaline Droplet | | 1 1.0| Calculus Micro Observation Only | | 1 | Infarct | | 1 2.0| Inflammation, Chronic Active | | 1 3.0| Inflammation, Suppurative | 2 | 1 2.0| Mineralization | 1 | 35 1.0| Nephropathy | 2 2 3 | 43 2.2| Pigmentation | 2 1 2 | 35 2.0| Pelvis, Dilatation | | 1 3.0| Pelvis, Inflammation | 2 | 5 1.8| Renal Tubule, Degeneration | | 1 3.0| Transitional Epithelium, Hyperplasia | 2 | 6 2.2| |__________________________________________________________________________|____________| Ureter | | 1 | Mineralization | | 1 3.0| Transitional Epithelium, Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 104 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------