TDMS Study 96020-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:01:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1
REASONS FOR REMOVAL: 25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 NG / 0 UG
INCLUDE 004 300 NG /100 UG
INCLUDE 005 300 NG /300 UG
INCLUDE 006 300 NG /3000 UG
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:01:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF TEF EVALUATION (BINARY MIXTURE; PCB 126
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Angiectasis
Atrophy
Hyperplasia
Hypertrophy
Adrenal Medulla Hyperplasia
Bone Marrow Hyperplasia
Clitoral Gland Inflammation
Clitoral Gland: Duct Cyst
Eye: Retina Atrophy
Kidney Casts Protein
Hydronephrosis
Infarct
Mineralization
Pigmentation
Kidney: Pelvis Inflammation
Kidney: Transitional Epithelium Hyperplasia
Liver Basophilic Focus
Cholangiofibrosis
Clear Cell Focus
Eosinophilic Focus
Fatty Change Diffuse
Fatty Change Focal
Hematopoietic Cell Proliferation
Hyperplasia
Pigmentation
Toxic Hepatopathy
Liver: Bile Duct Fibrosis
Hyperplasia
Liver: Hepatocyte Hypertrophy
Multinucleated
Liver: Oval Cell Hyperplasia
Liver: Portal Fibrosis
Lung Infiltration Cellular Histiocyte
Inflammation
Metaplasia
Lung: Alveolar Epithelium Hyperplasia
Metaplasia Bronchiolar
Lymph Node: Lumbar Ectasia
Hyperplasia
Mammary Gland Hyperplasia
Inflammation Granulomatous
Nose Inflammation
Ovary Atrophy
Inflammation Chronic
Oviduct Cyst
Inflammation Chronic
Pancreas Inflammation Chronic
Pancreas: Acinus Atrophy
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:01:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
Vacuolization Cytoplasmic
Pituitary Gland Angiectasis
Skin Inflammation
Spleen Hematopoietic Cell Proliferation
Pigmentation
Spleen: Lymphoid Follicle Atrophy
Stomach, Forestomach Hyperplasia
Inflammation
Stomach, Forestomach: Artery Inflammation Chronic
Stomach, Glandular Mineralization
Thymus Atrophy
Hyperplasia Lymphoid
Thyroid Gland: Follicle Cyst
Thyroid Gland: Follicular Cell Hypertrophy
Uterus Inflammation
Metaplasia
Uterus: Endometrium Hyperplasia Cystic
===============================================================
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 17/53 (32%) 28/49 (57%) 23/52 (44%) 7/51 (14%) |
|POLY-3 RATE (b) | 17/41.18 28/41.28 23/42.61 7/41.65 |
|POLY-3 PERCENT (g) | 41.3% 67.8% 54.0% 16.8% |
|TERMINAL (d) | 11/22 (50%) 22/28 (79%) 11/24 (46%) 4/27 (15%) |
|FIRST INCIDENCE | 418 491 499 463 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.123 P=0.229 P=0.007N** |
|POLY 3 | P<0.001N** P=0.008 ** P=0.164 P=0.011N* |
|POLY 1.5 | P<0.001N** P=0.009 ** P=0.141 P=0.014N* |
|POLY 6 | P<0.001N** P=0.008 ** P=0.220 P=0.008N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.020 * P=0.132 P=0.018N* |
|COCH-ARM / FISHERS | P<0.001N** P=0.009 ** P=0.140 P=0.023N* |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/49 (4%) 3/52 (6%) 5/51 (10%) |
|POLY-3 RATE (b) | 0/38.18 2/38.87 3/37.99 5/40.32 |
|POLY-3 PERCENT (g) | 0.0% 5.2% 7.9% 12.4% |
|TERMINAL (d) | 0/22 (0%) 2/28 (7%) 2/24 (8%) 3/27 (11%) |
|FIRST INCIDENCE | --- 729 (T) 539 647 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.070 P=0.292 P=0.133 P=0.051 |
|POLY 3 | P=0.059 P=0.240 P=0.117 P=0.034 * |
|POLY 1.5 | P=0.055 P=0.234 P=0.115 P=0.032 * |
|POLY 6 | P=0.063 P=0.247 P=0.119 P=0.037 * |
|LOGISTIC REGRESSION| P=0.062 P=0.292 P=0.117 P=0.039 * |
|COCH-ARM / FISHERS | P=0.051 P=0.228 P=0.118 P=0.026 * |
|ORDER RESTRICTED | P=0.015 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 14/49 (29%) 14/52 (27%) 18/51 (35%) |
|POLY-3 RATE (b) | 13/40.95 14/42.18 14/39.87 18/43.61 |
|POLY-3 PERCENT (g) | 31.7% 33.2% 35.1% 41.3% |
|TERMINAL (d) | 6/22 (27%) 8/28 (29%) 7/24 (29%) 11/27 (41%) |
|FIRST INCIDENCE | 556 484 505 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.256 P=0.519N P=0.521 P=0.349 |
|POLY 3 | P=0.206 P=0.538 P=0.465 P=0.243 |
|POLY 1.5 | P=0.189 P=0.501 P=0.466 P=0.217 |
|POLY 6 | P=0.216 P=0.562 P=0.469 P=0.261 |
|LOGISTIC REGRESSION| P=0.172 P=0.442 P=0.473 P=0.191 |
|COCH-ARM / FISHERS | P=0.151 P=0.406 P=0.477 P=0.162 |
|ORDER RESTRICTED | P=0.277 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 17/49 (35%) 25/52 (48%) 21/51 (41%) |
|POLY-3 RATE (b) | 11/39.56 17/40.68 25/42.59 21/42.72 |
|POLY-3 PERCENT (g) | 27.8% 41.8% 58.7% 49.2% |
|TERMINAL (d) | 7/22 (32%) 13/28 (46%) 14/24 (58%) 14/27 (52%) |
|FIRST INCIDENCE | 499 491 254 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.298 P=0.296 P=0.010 * P=0.094 |
|POLY 3 | P=0.232 P=0.134 P=0.003 ** P=0.033 * |
|POLY 1.5 | P=0.205 P=0.118 P=0.002 ** P=0.027 * |
|POLY 6 | P=0.267 P=0.154 P=0.004 ** P=0.043 * |
|LOGISTIC REGRESSION| P=0.214 P=0.139 P=0.002 ** P=0.033 * |
|COCH-ARM / FISHERS | P=0.168 P=0.088 P=0.003 ** P=0.020 * |
|ORDER RESTRICTED | P=0.008 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 47/53 (89%) 42/49 (86%) 41/52 (79%) 40/51 (78%) |
|POLY-3 RATE (b) | 47/49.32 42/46.24 41/44.30 40/47.73 |
|POLY-3 PERCENT (g) | 95.3% 90.8% 92.6% 83.8% |
|TERMINAL (d) | 21/22 (96%) 26/28 (93%) 24/24 (100%) 24/27 (89%) |
|FIRST INCIDENCE | 418 441 479 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.121N P=0.063N P=0.163N P=0.042N* |
|POLY 3 | P=0.032N* P=0.302N P=0.441N P=0.049N* |
|POLY 1.5 | P=0.059N P=0.287N P=0.258N P=0.054N |
|POLY 6 | P=0.021N* P=0.393N P=0.667N P=0.056N |
|LOGISTIC REGRESSION| P=0.075N P=0.194N P=0.103N P=0.055N |
|COCH-ARM / FISHERS | P=0.184N P=0.439N P=0.135N P=0.125N |
|ORDER RESTRICTED | P=0.017N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 3/49 (6%) 0/52 (0%) 2/51 (4%) |
|POLY-3 RATE (b) | 1/38.43 3/39.68 0/37.39 2/41.77 |
|POLY-3 PERCENT (g) | 2.6% 7.6% 0.0% 4.8% |
|TERMINAL (d) | 0/22 (0%) 1/28 (4%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 664 612 --- 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.531 P=0.334 P=0.520N P=0.498 |
|POLY 3 | P=0.570 P=0.316 P=0.505N P=0.529 |
|POLY 1.5 | P=0.555 P=0.304 P=0.505N P=0.516 |
|POLY 6 | P=0.584 P=0.330 P=0.505N P=0.541 |
|LOGISTIC REGRESSION| P=0.465 P=0.284 P=0.504N P=0.336 |
|COCH-ARM / FISHERS | P=0.517 P=0.280 P=0.505N P=0.485 |
|ORDER RESTRICTED | P=0.427N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 15/49 (31%) 10/52 (19%) 13/51 (25%) |
|POLY-3 RATE (b) | 11/40.49 15/42.24 10/40.66 13/40.68 |
|POLY-3 PERCENT (g) | 27.2% 35.5% 24.6% 32.0% |
|TERMINAL (d) | 6/22 (27%) 7/28 (25%) 3/24 (13%) 10/27 (37%) |
|FIRST INCIDENCE | 451 478 330 636 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.561 P=0.409 P=0.469N P=0.577 |
|POLY 3 | P=0.467 P=0.278 P=0.495N P=0.408 |
|POLY 1.5 | P=0.474 P=0.243 P=0.509N P=0.398 |
|POLY 6 | P=0.453 P=0.324 P=0.472N P=0.420 |
|LOGISTIC REGRESSION| P=0.497 P=0.204 P=0.521N P=0.455 |
|COCH-ARM / FISHERS | P=0.464 P=0.180 P=0.520N P=0.367 |
|ORDER RESTRICTED | P=0.499 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/52 (29%) 8/49 (16%) 13/52 (25%) 6/49 (12%) |
|POLY-3 RATE (b) | 15/38.71 8/39.28 13/39.45 6/39.40 |
|POLY-3 PERCENT (g) | 38.8% 20.4% 33.0% 15.2% |
|TERMINAL (d) | 9/21 (43%) 7/28 (25%) 9/24 (38%) 5/26 (19%) |
|FIRST INCIDENCE | 556 612 479 596 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.036N* P=0.023N* P=0.321N P=0.009N** |
|POLY 3 | P=0.040N* P=0.057N P=0.380N P=0.015N* |
|POLY 1.5 | P=0.046N* P=0.068N P=0.397N P=0.019N* |
|POLY 6 | P=0.037N* P=0.050N P=0.360N P=0.012N* |
|LOGISTIC REGRESSION| P=0.038N* P=0.044N* P=0.399N P=0.013N* |
|COCH-ARM / FISHERS | P=0.065N P=0.103N P=0.413N P=0.034N* |
|ORDER RESTRICTED | P=0.010N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 39/53 (74%) 38/50 (76%) 48/53 (91%) 39/51 (76%) |
|POLY-3 RATE (b) | 39/51.35 38/48.54 48/53.00 39/48.89 |
|POLY-3 PERCENT (g) | 76.0% 78.3% 90.6% 79.8% |
|TERMINAL (d) | 12/22 (55%) 19/28 (68%) 19/24 (79%) 19/27 (70%) |
|FIRST INCIDENCE | 85 441 96 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.270N P=0.288N P=0.186 P=0.334N |
|POLY 3 | P=0.524N P=0.484 P=0.037 * P=0.412 |
|POLY 1.5 | P=0.487N P=0.484 P=0.029 * P=0.430 |
|POLY 6 | P=0.562N P=0.480 P=0.048 * P=0.393 |
|LOGISTIC REGRESSION| P=0.503N P=0.369 P=0.019 * P=0.375 |
|COCH-ARM / FISHERS | P=0.433N P=0.479 P=0.020 * P=0.455 |
|ORDER RESTRICTED | P=0.167 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 38/49 (78%) 40/53 (75%) 40/50 (80%) |
|POLY-3 RATE (b) | 45/50.91 38/45.36 40/48.52 40/45.91 |
|POLY-3 PERCENT (g) | 88.4% 83.8% 82.4% 87.1% |
|TERMINAL (d) | 18/22 (82%) 25/28 (89%) 17/24 (71%) 24/27 (89%) |
|FIRST INCIDENCE | 345 441 254 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.270N P=0.040N* P=0.253N P=0.090N |
|POLY 3 | P=0.475 P=0.350N P=0.282N P=0.551N |
|POLY 1.5 | P=0.535 P=0.261N P=0.244N P=0.438N |
|POLY 6 | P=0.405 P=0.513N P=0.313N P=0.590 |
|LOGISTIC REGRESSION| P=0.509N P=0.185N P=0.180N P=0.269N |
|COCH-ARM / FISHERS | P=0.575N P=0.242N P=0.165N P=0.346N |
|ORDER RESTRICTED | P=0.436N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Clitoral Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 38/53 (72%) 41/49 (84%) 43/53 (81%) 41/50 (82%) |
|POLY-3 RATE (b) | 38/50.38 41/46.10 43/48.31 41/47.73 |
|POLY-3 PERCENT (g) | 75.4% 88.9% 89.0% 85.9% |
|TERMINAL (d) | 13/22 (59%) 25/28 (89%) 21/24 (88%) 22/27 (82%) |
|FIRST INCIDENCE | 345 462 254 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.403N P=0.434N P=0.346 P=0.464N |
|POLY 3 | P=0.411 P=0.063 P=0.057 P=0.138 |
|POLY 1.5 | P=0.411 P=0.087 P=0.084 P=0.158 |
|POLY 6 | P=0.414 P=0.045 * P=0.038 * P=0.122 |
|LOGISTIC REGRESSION| P=0.382 P=0.123 P=0.168 P=0.148 |
|COCH-ARM / FISHERS | P=0.345 P=0.113 P=0.180 P=0.158 |
|ORDER RESTRICTED | P=0.046 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Esophagus: Muscularis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 0/50 (0%) 3/53 (6%) 0/50 (0%) |
|POLY-3 RATE (b) | 3/39.27 0/39.59 3/39.07 0/39.67 |
|POLY-3 PERCENT (g) | 7.6% 0.0% 7.7% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 85 --- 499 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.166N P=0.107N P=0.649N P=0.104N |
|POLY 3 | P=0.172N P=0.116N P=0.661 P=0.116N |
|POLY 1.5 | P=0.175N P=0.121N P=0.653 P=0.121N |
|POLY 6 | P=0.169N P=0.112N P=0.653N P=0.110N |
|LOGISTIC REGRESSION| P=0.211N P=0.204N P=0.630N P=0.177N |
|COCH-ARM / FISHERS | P=0.180N P=0.132N P=0.661N P=0.132N |
|ORDER RESTRICTED | P=0.052N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Eye: Anterior Chamber, Ciliary Body, Cornea |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/50 (4%) 1/52 (2%) 0/51 (0%) |
|POLY-3 RATE (b) | 0/38.18 2/40.02 1/37.28 0/39.98 |
|POLY-3 PERCENT (g) | 0.0% 5.0% 2.7% 0.0% |
|TERMINAL (d) | 0/22 (0%) 1/28 (4%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 603 580 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.358N P=0.275 P=0.500 (e) |
|POLY 3 | P=0.344N P=0.247 P=0.495 (e) |
|POLY 1.5 | P=0.353N P=0.240 P=0.493 (e) |
|POLY 6 | P=0.336N P=0.255 P=0.500 (e) |
|LOGISTIC REGRESSION| P=0.376N P=0.234 P=0.502 (e) |
|COCH-ARM / FISHERS | P=0.375N P=0.233 P=0.495 (e) |
|ORDER RESTRICTED | P=0.319N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Eye: Retina |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/50 (0%) 2/52 (4%) 5/51 (10%) |
|POLY-3 RATE (b) | 1/38.18 0/39.59 2/36.79 5/40.52 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 5.4% 12.3% |
|TERMINAL (d) | 1/22 (5%) 0/28 (0%) 2/24 (8%) 3/27 (11%) |
|FIRST INCIDENCE | 729 (T) --- 729 (T) 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.024 * P=0.452N P=0.531 P=0.157 |
|POLY 3 | P=0.016 * P=0.493N P=0.487 P=0.114 |
|POLY 1.5 | P=0.015 * P=0.498N P=0.485 P=0.106 |
|POLY 6 | P=0.017 * P=0.488N P=0.492 P=0.123 |
|LOGISTIC REGRESSION| P=0.020 * (e) P=0.531 P=0.117 |
|COCH-ARM / FISHERS | P=0.015 * P=0.515N P=0.493 P=0.094 |
|ORDER RESTRICTED | P=0.016 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 20/53 (38%) 15/49 (31%) 14/52 (27%) 17/51 (33%) |
|POLY-3 RATE (b) | 20/41.85 15/39.74 14/39.15 17/40.73 |
|POLY-3 PERCENT (g) | 47.8% 37.8% 35.8% 41.7% |
|TERMINAL (d) | 10/22 (46%) 13/28 (46%) 10/24 (42%) 14/27 (52%) |
|FIRST INCIDENCE | 418 491 330 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.448N P=0.078N P=0.131N P=0.162N |
|POLY 3 | P=0.554 P=0.237N P=0.185N P=0.366N |
|POLY 1.5 | P=0.552 P=0.241N P=0.181N P=0.364N |
|POLY 6 | P=0.548 P=0.254N P=0.194N P=0.387N |
|LOGISTIC REGRESSION| P=0.511N P=0.177N P=0.176N P=0.266N |
|COCH-ARM / FISHERS | P=0.524 P=0.292N P=0.165N P=0.396N |
|ORDER RESTRICTED | P=0.293N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 18/50 (36%) 26/53 (49%) 25/50 (50%) |
|POLY-3 RATE (b) | 22/41.41 18/40.91 26/41.49 25/41.97 |
|POLY-3 PERCENT (g) | 53.1% 44.0% 62.7% 59.6% |
|TERMINAL (d) | 14/22 (64%) 13/28 (46%) 17/24 (71%) 17/27 (63%) |
|FIRST INCIDENCE | 449 625 96 463 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.420 P=0.101N P=0.374 P=0.510N |
|POLY 3 | P=0.246 P=0.264N P=0.243 P=0.348 |
|POLY 1.5 | P=0.223 P=0.284N P=0.249 P=0.315 |
|POLY 6 | P=0.273 P=0.246N P=0.248 P=0.386 |
|LOGISTIC REGRESSION| P=0.292 P=0.205N P=0.233 P=0.409 |
|COCH-ARM / FISHERS | P=0.189 P=0.356N P=0.279 P=0.253 |
|ORDER RESTRICTED | P=0.173 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/50 (2%) 1/53 (2%) 2/51 (4%) |
|POLY-3 RATE (b) | 2/38.76 1/39.59 1/37.45 2/40.67 |
|POLY-3 PERCENT (g) | 5.2% 2.5% 2.7% 4.9% |
|TERMINAL (d) | 0/22 (0%) 1/28 (4%) 0/24 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 636 729 (T) 715 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.529 P=0.482N P=0.514N P=0.674N |
|POLY 3 | P=0.523 P=0.493N P=0.512N P=0.677N |
|POLY 1.5 | P=0.515 P=0.499N P=0.510N P=0.687N |
|POLY 6 | P=0.531 P=0.488N P=0.513N P=0.669N |
|LOGISTIC REGRESSION| P=0.509 P=0.497N P=0.506N P=0.674 |
|COCH-ARM / FISHERS | P=0.499 P=0.522N P=0.500N P=0.676 |
|ORDER RESTRICTED | P=0.535N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Intestine Large, Rectum: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 1/50 (2%) 0/53 (0%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 1/39.59 0/37.40 2/40.01 |
|POLY-3 PERCENT (g) | 0.0% 2.5% 0.0% 5.0% |
|TERMINAL (d) | 0/22 (0%) 1/28 (4%) 0/24 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- 729 (T) --- 720 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.179 P=0.548 (e) P=0.290 |
|POLY 3 | P=0.162 P=0.507 (e) P=0.247 |
|POLY 1.5 | P=0.158 P=0.502 (e) P=0.241 |
|POLY 6 | P=0.167 P=0.512 (e) P=0.254 |
|LOGISTIC REGRESSION| P=0.173 P=0.548 (e) P=0.268 |
|COCH-ARM / FISHERS | P=0.148 P=0.485 (e) P=0.238 |
|ORDER RESTRICTED | P=0.080 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Intestine Small, Jejunum |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/50 (0%) 2/52 (4%) 0/51 (0%) |
|POLY-3 RATE (b) | 0/38.18 0/39.59 2/38.30 0/39.98 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 5.2% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 1/24 (4%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- 330 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.546N (e) P=0.243 (e) |
|POLY 3 | P=0.551N (e) P=0.237 (e) |
|POLY 1.5 | P=0.555N (e) P=0.235 (e) |
|POLY 6 | P=0.546N (e) P=0.240 (e) |
|LOGISTIC REGRESSION| P=0.598N (e) P=0.237 (e) |
|COCH-ARM / FISHERS | P=0.560N (e) P=0.243 (e) |
|ORDER RESTRICTED | P=0.247 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Accumulation, Hyaline Droplet |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/48 (0%) 1/52 (2%) 2/51 (4%) |
|POLY-3 RATE (b) | 2/39.63 0/38.21 1/38.39 2/40.75 |
|POLY-3 PERCENT (g) | 5.1% 0.0% 2.6% 4.9% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 449 --- 142 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.413 P=0.237N P=0.497N P=0.680N |
|POLY 3 | P=0.410 P=0.245N P=0.511N P=0.685N |
|POLY 1.5 | P=0.405 P=0.248N P=0.509N P=0.692N |
|POLY 6 | P=0.416 P=0.240N P=0.512N P=0.675N |
|LOGISTIC REGRESSION| P=0.303 P=0.382N P=0.480N P=0.616 |
|COCH-ARM / FISHERS | P=0.400 P=0.273N P=0.507N P=0.676 |
|ORDER RESTRICTED | P=0.412N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Calculus Micro Observation Only |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/53 (13%) 6/48 (13%) 4/52 (8%) 6/51 (12%) |
|POLY-3 RATE (b) | 7/38.73 6/39.79 4/39.34 6/41.82 |
|POLY-3 PERCENT (g) | 18.1% 15.1% 10.2% 14.4% |
|TERMINAL (d) | 5/22 (23%) 2/28 (7%) 0/24 (0%) 3/27 (11%) |
|FIRST INCIDENCE | 647 491 499 462 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.557N P=0.397N P=0.253N P=0.402N |
|POLY 3 | P=0.562N P=0.479N P=0.248N P=0.440N |
|POLY 1.5 | P=0.576N P=0.511N P=0.261N P=0.471N |
|POLY 6 | P=0.554N P=0.441N P=0.229N P=0.410N |
|LOGISTIC REGRESSION| P=0.582 P=0.516N P=0.274N P=0.493N |
|COCH-ARM / FISHERS | P=0.577 P=0.577N P=0.274N P=0.530N |
|ORDER RESTRICTED | P=0.365N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Casts Protein |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/48 (0%) 0/52 (0%) 0/51 (0%) |
|POLY-3 RATE (b) | 2/39.30 0/38.21 0/37.39 0/39.98 |
|POLY-3 PERCENT (g) | 5.1% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 345 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.413N P=0.236N P=0.249N P=0.233N |
|POLY 3 | P=0.417N P=0.243N P=0.248N P=0.233N |
|POLY 1.5 | P=0.418N P=0.247N P=0.246N P=0.237N |
|POLY 6 | P=0.417N P=0.237N P=0.248N P=0.228N |
|LOGISTIC REGRESSION| P=0.459N P=0.351N P=0.234N P=0.301N |
|COCH-ARM / FISHERS | P=0.421N P=0.273N P=0.252N P=0.257N |
|ORDER RESTRICTED | P=0.028N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Hydronephrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/48 (0%) 0/52 (0%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/38.21 0/37.39 2/40.51 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.9% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- 647 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.053 (e) (e) P=0.248 |
|POLY 3 | P=0.049 * (e) (e) P=0.250 |
|POLY 1.5 | P=0.047 * (e) (e) P=0.242 |
|POLY 6 | P=0.050 (e) (e) P=0.260 |
|LOGISTIC REGRESSION| P=0.048 * (e) (e) P=0.234 |
|COCH-ARM / FISHERS | P=0.046 * (e) (e) P=0.238 |
|ORDER RESTRICTED | P=0.034 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/48 (0%) 0/52 (0%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/38.21 0/37.39 2/40.21 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 5.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- --- 668 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.058 (e) (e) P=0.278 |
|POLY 3 | P=0.048 * (e) (e) P=0.248 |
|POLY 1.5 | P=0.047 * (e) (e) P=0.242 |
|POLY 6 | P=0.049 * (e) (e) P=0.256 |
|LOGISTIC REGRESSION| P=0.052 (e) (e) P=0.250 |
|COCH-ARM / FISHERS | P=0.046 * (e) (e) P=0.238 |
|ORDER RESTRICTED | P=0.033 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 6/48 (13%) 5/52 (10%) 3/51 (6%) |
|POLY-3 RATE (b) | 5/38.24 6/38.87 5/37.96 3/39.98 |
|POLY-3 PERCENT (g) | 13.1% 15.4% 13.2% 7.5% |
|TERMINAL (d) | 4/22 (18%) 4/28 (14%) 4/24 (17%) 3/27 (11%) |
|FIRST INCIDENCE | 714 633 552 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.191N P=0.625 P=0.584N P=0.248N |
|POLY 3 | P=0.205N P=0.512 P=0.628 P=0.330N |
|POLY 1.5 | P=0.215N P=0.484 P=0.621 P=0.346N |
|POLY 6 | P=0.199N P=0.545 P=0.628N P=0.314N |
|LOGISTIC REGRESSION| P=0.197N P=0.532 P=0.630 P=0.257N |
|COCH-ARM / FISHERS | P=0.237N P=0.430 P=0.617 P=0.380N |
|ORDER RESTRICTED | P=0.285N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 42/53 (79%) 39/48 (81%) 42/52 (81%) 33/51 (65%) |
|POLY-3 RATE (b) | 42/50.36 39/47.30 42/48.93 33/46.82 |
|POLY-3 PERCENT (g) | 83.4% 82.5% 85.8% 70.5% |
|TERMINAL (d) | 15/22 (68%) 22/28 (79%) 19/24 (79%) 19/27 (70%) |
|FIRST INCIDENCE | 85 441 254 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.046N* P=0.165N P=0.498N P=0.041N* |
|POLY 3 | P=0.032N* P=0.559N P=0.476 P=0.089N |
|POLY 1.5 | P=0.022N* P=0.604 P=0.466 P=0.078N |
|POLY 6 | P=0.057N P=0.531N P=0.481 P=0.123N |
|LOGISTIC REGRESSION| P=0.020N* P=0.432 P=0.519 P=0.083N |
|COCH-ARM / FISHERS | P=0.018N* P=0.500 P=0.520 P=0.076N |
|ORDER RESTRICTED | P=0.057N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/53 (55%) 30/48 (63%) 34/52 (65%) 34/51 (67%) |
|POLY-3 RATE (b) | 29/44.67 30/41.51 34/43.59 34/43.74 |
|POLY-3 PERCENT (g) | 64.9% 72.3% 78.0% 77.7% |
|TERMINAL (d) | 17/22 (77%) 23/28 (82%) 23/24 (96%) 24/27 (89%) |
|FIRST INCIDENCE | 345 478 142 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.476 P=0.276N P=0.320 P=0.550 |
|POLY 3 | P=0.215 P=0.294 P=0.108 P=0.115 |
|POLY 1.5 | P=0.229 P=0.303 P=0.137 P=0.132 |
|POLY 6 | P=0.204 P=0.284 P=0.084 P=0.101 |
|LOGISTIC REGRESSION| P=0.333 P=0.413 P=0.165 P=0.232 |
|COCH-ARM / FISHERS | P=0.247 P=0.278 P=0.180 P=0.148 |
|ORDER RESTRICTED | P=0.095 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/48 (4%) 7/52 (13%) 17/51 (33%) |
|POLY-3 RATE (b) | 0/38.18 2/38.62 7/38.16 17/42.67 |
|POLY-3 PERCENT (g) | 0.0% 5.2% 18.3% 39.8% |
|TERMINAL (d) | 0/22 (0%) 1/28 (4%) 6/24 (25%) 10/27 (37%) |
|FIRST INCIDENCE | --- 612 451 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.272 P=0.011 * P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.239 P=0.007 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.231 P=0.007 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.248 P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.227 P=0.008 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.223 P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Dilatation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 4/48 (8%) 2/52 (4%) 0/51 (0%) |
|POLY-3 RATE (b) | 1/38.18 4/39.17 2/37.83 0/39.98 |
|POLY-3 PERCENT (g) | 2.6% 10.2% 5.3% 0.0% |
|TERMINAL (d) | 1/22 (5%) 2/28 (7%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 729 (T) 478 618 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.124N P=0.232 P=0.506 P=0.459N |
|POLY 3 | P=0.110N P=0.185 P=0.497 P=0.491N |
|POLY 1.5 | P=0.117N P=0.173 P=0.493 P=0.496N |
|POLY 6 | P=0.105N P=0.199 P=0.504 P=0.485N |
|LOGISTIC REGRESSION| P=0.128N P=0.163 P=0.494 (e) |
|COCH-ARM / FISHERS | P=0.133N P=0.152 P=0.493 P=0.510N |
|ORDER RESTRICTED | P=0.127N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/48 (2%) 3/52 (6%) 8/51 (16%) |
|POLY-3 RATE (b) | 3/39.42 1/38.73 3/38.07 8/40.77 |
|POLY-3 PERCENT (g) | 7.6% 2.6% 7.9% 19.6% |
|TERMINAL (d) | 1/22 (5%) 0/28 (0%) 2/24 (8%) 6/27 (22%) |
|FIRST INCIDENCE | 499 569 499 556 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.016 * P=0.279N P=0.637N P=0.161 |
|POLY 3 | P=0.010 * P=0.310N P=0.648 P=0.105 |
|POLY 1.5 | P=0.009 ** P=0.319N P=0.648 P=0.100 |
|POLY 6 | P=0.010 * P=0.301N P=0.649 P=0.112 |
|LOGISTIC REGRESSION| P=0.011 * P=0.398N P=0.654 P=0.103 |
|COCH-ARM / FISHERS | P=0.009 ** P=0.347N P=0.652 P=0.089 |
|ORDER RESTRICTED | P=0.015 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/48 (0%) 2/52 (4%) 0/51 (0%) |
|POLY-3 RATE (b) | 0/38.18 0/38.21 2/37.67 0/39.98 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 5.3% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 1/24 (4%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- 654 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.545N (e) P=0.239 (e) |
|POLY 3 | P=0.549N (e) P=0.233 (e) |
|POLY 1.5 | P=0.552N (e) P=0.232 (e) |
|POLY 6 | P=0.546N (e) P=0.237 (e) |
|LOGISTIC REGRESSION| P=0.544N (e) P=0.233 (e) |
|COCH-ARM / FISHERS | P=0.557N (e) P=0.243 (e) |
|ORDER RESTRICTED | P=0.244 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Kidney: Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 6/48 (13%) 11/52 (21%) 9/51 (18%) |
|POLY-3 RATE (b) | 2/38.18 6/39.39 11/39.29 9/40.65 |
|POLY-3 PERCENT (g) | 5.2% 15.2% 28.0% 22.1% |
|TERMINAL (d) | 2/22 (9%) 3/28 (11%) 7/24 (29%) 7/27 (26%) |
|FIRST INCIDENCE | 729 (T) 569 539 601 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.240 P=0.190 P=0.012 * P=0.052 |
|POLY 3 | P=0.202 P=0.140 P=0.007 ** P=0.030 * |
|POLY 1.5 | P=0.191 P=0.127 P=0.006 ** P=0.027 * |
|POLY 6 | P=0.214 P=0.159 P=0.008 ** P=0.035 * |
|LOGISTIC REGRESSION| P=0.207 P=0.130 P=0.007 ** P=0.035 * |
|COCH-ARM / FISHERS | P=0.174 P=0.105 P=0.007 ** P=0.022 * |
|ORDER RESTRICTED | P=0.012 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/50 (2%) 2/52 (4%) 3/51 (6%) |
|POLY-3 RATE (b) | 3/38.74 1/39.59 2/37.66 3/40.43 |
|POLY-3 PERCENT (g) | 7.7% 2.5% 5.3% 7.4% |
|TERMINAL (d) | 2/22 (9%) 1/28 (4%) 1/24 (4%) 2/27 (7%) |
|FIRST INCIDENCE | 556 729 (T) 659 596 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.467 P=0.242N P=0.487N P=0.586N |
|POLY 3 | P=0.437 P=0.296N P=0.513N P=0.644N |
|POLY 1.5 | P=0.430 P=0.304N P=0.513N P=0.655N |
|POLY 6 | P=0.447 P=0.290N P=0.510N P=0.631N |
|LOGISTIC REGRESSION| P=0.443 P=0.294N P=0.509N P=0.652N |
|COCH-ARM / FISHERS | P=0.417 P=0.331N P=0.509N P=0.642 |
|ORDER RESTRICTED | P=0.483N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 5/50 (10%) 3/52 (6%) 18/51 (35%) |
|POLY-3 RATE (b) | 22/43.23 5/39.94 3/37.45 18/42.98 |
|POLY-3 PERCENT (g) | 50.9% 12.5% 8.0% 41.9% |
|TERMINAL (d) | 9/22 (41%) 3/28 (11%) 2/24 (8%) 9/27 (33%) |
|FIRST INCIDENCE | 377 664 715 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.089 P<0.001N** P<0.001N** P=0.163N |
|POLY 3 | P=0.046 * P<0.001N** P<0.001N** P=0.262N |
|POLY 1.5 | P=0.036 * P<0.001N** P<0.001N** P=0.282N |
|POLY 6 | P=0.067 P<0.001N** P<0.001N** P=0.237N |
|LOGISTIC REGRESSION| P=0.045 * P<0.001N** P<0.001N** P=0.265N |
|COCH-ARM / FISHERS | P=0.036 * P<0.001N** P<0.001N** P=0.327N |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Cholangiofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 5/50 (10%) 7/52 (13%) 13/51 (25%) |
|POLY-3 RATE (b) | 0/38.18 5/39.94 7/37.86 13/41.27 |
|POLY-3 PERCENT (g) | 0.0% 12.5% 18.5% 31.5% |
|TERMINAL (d) | 0/22 (0%) 3/28 (11%) 5/24 (21%) 10/27 (37%) |
|FIRST INCIDENCE | --- 664 612 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.052 P=0.012 * P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.033 * P=0.007 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.031 * P=0.007 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.036 * P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.038 * P=0.008 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.024 * P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/53 (17%) 5/50 (10%) 3/52 (6%) 11/51 (22%) |
|POLY-3 RATE (b) | 9/38.43 5/39.59 3/37.39 11/41.02 |
|POLY-3 PERCENT (g) | 23.4% 12.6% 8.0% 26.8% |
|TERMINAL (d) | 8/22 (36%) 5/28 (18%) 3/24 (13%) 9/27 (33%) |
|FIRST INCIDENCE | 664 729 (T) 729 (T) 463 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.091 P=0.082N P=0.039N* P=0.578 |
|POLY 3 | P=0.075 P=0.169N P=0.060N P=0.464 |
|POLY 1.5 | P=0.069 P=0.186N P=0.063N P=0.429 |
|POLY 6 | P=0.082 P=0.155N P=0.056N P=0.503 |
|LOGISTIC REGRESSION| P=0.084 P=0.117N P=0.045N* P=0.476 |
|COCH-ARM / FISHERS | P=0.061 P=0.229N P=0.066N P=0.365 |
|ORDER RESTRICTED | P=0.114 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 27/50 (54%) 40/52 (77%) 45/51 (88%) |
|POLY-3 RATE (b) | 14/42.00 27/46.61 40/47.53 45/47.97 |
|POLY-3 PERCENT (g) | 33.3% 57.9% 84.2% 93.8% |
|TERMINAL (d) | 4/22 (18%) 11/28 (39%) 18/24 (75%) 26/27 (96%) |
|FIRST INCIDENCE | 451 441 330 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.052 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.014 * P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.009 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.025 * P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 28/50 (56%) 31/52 (60%) 47/51 (92%) |
|POLY-3 RATE (b) | 3/39.19 28/45.86 31/45.69 47/49.08 |
|POLY-3 PERCENT (g) | 7.7% 61.1% 67.8% 95.8% |
|TERMINAL (d) | 1/22 (5%) 15/28 (54%) 15/24 (63%) 27/27 (100%) |
|FIRST INCIDENCE | 449 441 254 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 4/50 (8%) 1/52 (2%) 11/51 (22%) |
|POLY-3 RATE (b) | 3/38.27 4/40.12 1/37.83 11/41.62 |
|POLY-3 PERCENT (g) | 7.8% 10.0% 2.6% 26.4% |
|TERMINAL (d) | 2/22 (9%) 3/28 (11%) 0/24 (0%) 7/27 (26%) |
|FIRST INCIDENCE | 708 567 603 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** P=0.609 P=0.288N P=0.049 * |
|POLY 3 | P<0.001 ** P=0.526 P=0.308N P=0.027 * |
|POLY 1.5 | P<0.001 ** P=0.508 P=0.312N P=0.022 * |
|POLY 6 | P<0.001 ** P=0.544 P=0.301N P=0.033 * |
|LOGISTIC REGRESSION| P<0.001 ** P=0.531 P=0.310N P=0.026 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.467 P=0.316N P=0.017 * |
|ORDER RESTRICTED | P=0.003 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 18/50 (36%) 19/52 (37%) 29/51 (57%) |
|POLY-3 RATE (b) | 27/49.38 18/44.86 19/44.94 29/46.24 |
|POLY-3 PERCENT (g) | 54.7% 40.1% 42.3% 62.7% |
|TERMINAL (d) | 5/22 (23%) 9/28 (32%) 6/24 (25%) 16/27 (59%) |
|FIRST INCIDENCE | 85 441 142 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.161 P=0.060N P=0.143N P=0.507N |
|POLY 3 | P=0.040 * P=0.110N P=0.156N P=0.274 |
|POLY 1.5 | P=0.041 * P=0.096N P=0.130N P=0.301 |
|POLY 6 | P=0.039 * P=0.140N P=0.189N P=0.238 |
|LOGISTIC REGRESSION| P=0.029 * P=0.174N P=0.083N P=0.264 |
|COCH-ARM / FISHERS | P=0.048 * P=0.092N P=0.098N P=0.342 |
|ORDER RESTRICTED | P=0.064 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 20/50 (40%) 24/52 (46%) 21/51 (41%) |
|POLY-3 RATE (b) | 0/38.18 20/40.25 24/39.96 21/41.77 |
|POLY-3 PERCENT (g) | 0.0% 49.7% 60.1% 50.3% |
|TERMINAL (d) | 0/22 (0%) 18/28 (64%) 16/24 (67%) 15/27 (56%) |
|FIRST INCIDENCE | --- 633 552 602 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.060 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P=0.035 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P=0.026 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P=0.055 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.039 * P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P=0.026 * P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 44/53 (83%) 47/50 (94%) 48/52 (92%) 46/51 (90%) |
|POLY-3 RATE (b) | 44/50.14 47/48.90 48/50.71 46/49.21 |
|POLY-3 PERCENT (g) | 87.8% 96.1% 94.7% 93.5% |
|TERMINAL (d) | 19/22 (86%) 27/28 (96%) 23/24 (96%) 26/27 (96%) |
|FIRST INCIDENCE | 85 441 254 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.325N P=0.377N P=0.407 P=0.344N |
|POLY 3 | P=0.527 P=0.102 P=0.175 P=0.247 |
|POLY 1.5 | P=0.506 P=0.088 P=0.129 P=0.216 |
|POLY 6 | P=0.548 P=0.122 P=0.238 P=0.284 |
|LOGISTIC REGRESSION| P=0.554 P=0.092 P=0.123 P=0.253 |
|COCH-ARM / FISHERS | P=0.511 P=0.075 P=0.125 P=0.217 |
|ORDER RESTRICTED | P=0.106 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 26/53 (49%) 27/50 (54%) 26/52 (50%) 27/51 (53%) |
|POLY-3 RATE (b) | 26/43.18 27/41.19 26/38.98 27/43.00 |
|POLY-3 PERCENT (g) | 60.2% 65.6% 66.7% 62.8% |
|TERMINAL (d) | 16/22 (73%) 24/28 (86%) 23/24 (96%) 21/27 (78%) |
|FIRST INCIDENCE | 377 462 499 463 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.401N P=0.275N P=0.456N P=0.353N |
|POLY 3 | P=0.533N P=0.381 P=0.341 P=0.490 |
|POLY 1.5 | P=0.555 P=0.410 P=0.424 P=0.474 |
|POLY 6 | P=0.469N P=0.312 P=0.238 P=0.499 |
|LOGISTIC REGRESSION| P=0.516N P=0.570 P=0.536 P=0.559 |
|COCH-ARM / FISHERS | P=0.463 P=0.380 P=0.539 P=0.421 |
|ORDER RESTRICTED | P=0.486 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 6/50 (12%) 4/52 (8%) 7/51 (14%) |
|POLY-3 RATE (b) | 4/39.53 6/41.80 4/38.13 7/42.46 |
|POLY-3 PERCENT (g) | 10.1% 14.4% 10.5% 16.5% |
|TERMINAL (d) | 0/22 (0%) 1/28 (4%) 2/24 (8%) 2/27 (7%) |
|FIRST INCIDENCE | 533 484 552 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.298 P=0.397 P=0.636 P=0.311 |
|POLY 3 | P=0.298 P=0.404 P=0.625 P=0.301 |
|POLY 1.5 | P=0.280 P=0.382 P=0.626 P=0.280 |
|POLY 6 | P=0.316 P=0.426 P=0.624 P=0.322 |
|LOGISTIC REGRESSION| P=0.231 P=0.294 P=0.632 P=0.214 |
|COCH-ARM / FISHERS | P=0.243 P=0.334 P=0.631 P=0.241 |
|ORDER RESTRICTED | P=0.307 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 50/50 (100%) 50/52 (96%) 44/51 (86%) |
|POLY-3 RATE (b) | 2/38.18 50/50.00 50/50.05 44/48.31 |
|POLY-3 PERCENT (g) | 5.2% 100.0% 99.9% 91.1% |
|TERMINAL (d) | 2/22 (9%) 28/28 (100%) 24/24 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 729 (T) 441 310 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.032 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver |
| Toxic Hepatopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 44/50 (88%) 48/52 (92%) 48/51 (94%) |
|POLY-3 RATE (b) | 0/38.18 44/46.21 48/48.25 48/49.68 |
|POLY-3 PERCENT (g) | 0.0% 95.2% 99.5% 96.6% |
|TERMINAL (d) | 0/22 (0%) 28/28 (100%) 24/24 (100%) 27/27 (100%) |
|FIRST INCIDENCE | --- 462 330 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 4/50 (8%) 5/52 (10%) 6/51 (12%) |
|POLY-3 RATE (b) | 4/38.46 4/39.59 5/37.44 6/40.36 |
|POLY-3 PERCENT (g) | 10.4% 10.1% 13.4% 14.9% |
|TERMINAL (d) | 3/22 (14%) 4/28 (14%) 4/24 (17%) 5/27 (19%) |
|FIRST INCIDENCE | 654 729 (T) 719 622 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.385 P=0.531N P=0.542 P=0.471 |
|POLY 3 | P=0.349 P=0.629N P=0.483 P=0.399 |
|POLY 1.5 | P=0.336 P=0.641N P=0.483 P=0.381 |
|POLY 6 | P=0.365 P=0.619N P=0.485 P=0.418 |
|LOGISTIC REGRESSION| P=0.373 P=0.592N P=0.510 P=0.422 |
|COCH-ARM / FISHERS | P=0.311 P=0.609 P=0.488 P=0.346 |
|ORDER RESTRICTED | P=0.418 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/50 (0%) 4/52 (8%) 5/51 (10%) |
|POLY-3 RATE (b) | 1/38.41 0/39.59 4/38.64 5/41.42 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 10.4% 12.1% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 1/24 (4%) 1/27 (4%) |
|FIRST INCIDENCE | 670 --- 506 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.070 P=0.486N P=0.188 P=0.149 |
|POLY 3 | P=0.054 P=0.494N P=0.178 P=0.118 |
|POLY 1.5 | P=0.050 P=0.499N P=0.175 P=0.109 |
|POLY 6 | P=0.060 P=0.490N P=0.186 P=0.130 |
|LOGISTIC REGRESSION| P=0.046 * P=0.501N P=0.173 P=0.096 |
|COCH-ARM / FISHERS | P=0.047 * P=0.515N P=0.176 P=0.094 |
|ORDER RESTRICTED | P=0.031 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 20/50 (40%) 29/52 (56%) 40/51 (78%) |
|POLY-3 RATE (b) | 8/39.10 20/41.49 29/42.15 40/45.51 |
|POLY-3 PERCENT (g) | 20.5% 48.2% 68.8% 87.9% |
|TERMINAL (d) | 5/22 (23%) 14/28 (50%) 17/24 (71%) 26/27 (96%) |
|FIRST INCIDENCE | 533 484 505 462 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.031 * P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.006 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.005 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.007 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.008 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 6/50 (12%) 4/52 (8%) 2/51 (4%) |
|POLY-3 RATE (b) | 5/39.53 6/41.72 4/38.67 2/41.55 |
|POLY-3 PERCENT (g) | 12.7% 14.4% 10.3% 4.8% |
|TERMINAL (d) | 1/22 (5%) 2/28 (7%) 1/24 (4%) 0/27 (0%) |
|FIRST INCIDENCE | 449 478 552 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.136N P=0.563 P=0.501N P=0.194N |
|POLY 3 | P=0.119N P=0.538 P=0.514N P=0.194N |
|POLY 1.5 | P=0.126N P=0.514 P=0.516N P=0.206N |
|POLY 6 | P=0.115N P=0.561 P=0.507N P=0.185N |
|LOGISTIC REGRESSION| P=0.160N P=0.426 P=0.513N P=0.276N |
|COCH-ARM / FISHERS | P=0.146N P=0.459 P=0.512N P=0.235N |
|ORDER RESTRICTED | P=0.153N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 22/50 (44%) 33/52 (63%) 47/51 (92%) |
|POLY-3 RATE (b) | 1/38.74 22/45.91 33/47.28 47/48.94 |
|POLY-3 PERCENT (g) | 2.6% 47.9% 69.8% 96.0% |
|TERMINAL (d) | 0/22 (0%) 8/28 (29%) 14/24 (58%) 27/27 (100%) |
|FIRST INCIDENCE | 556 441 254 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Multinucleated |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 42/50 (84%) 46/52 (88%) 44/51 (86%) |
|POLY-3 RATE (b) | 0/38.18 42/46.55 46/47.78 44/47.16 |
|POLY-3 PERCENT (g) | 0.0% 90.2% 96.3% 93.3% |
|TERMINAL (d) | 0/22 (0%) 27/28 (96%) 23/24 (96%) 27/27 (100%) |
|FIRST INCIDENCE | --- 441 310 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Oval Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 33/50 (66%) 39/52 (75%) 43/51 (84%) |
|POLY-3 RATE (b) | 2/38.18 33/43.22 39/43.48 43/46.51 |
|POLY-3 PERCENT (g) | 5.2% 76.4% 89.7% 92.5% |
|TERMINAL (d) | 2/22 (9%) 23/28 (82%) 22/24 (92%) 27/27 (100%) |
|FIRST INCIDENCE | 729 (T) 484 499 462 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Liver: Portal |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/50 (6%) 7/52 (13%) 10/51 (20%) |
|POLY-3 RATE (b) | 0/38.18 3/39.90 7/37.83 10/41.29 |
|POLY-3 PERCENT (g) | 0.0% 7.5% 18.5% 24.2% |
|TERMINAL (d) | 0/22 (0%) 2/28 (7%) 6/24 (25%) 7/27 (26%) |
|FIRST INCIDENCE | --- 643 603 490 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** P=0.148 P=0.011 * P=0.003 ** |
|POLY 3 | P=0.004 ** P=0.126 P=0.007 ** P<0.001 ** |
|POLY 1.5 | P=0.004 ** P=0.121 P=0.007 ** P<0.001 ** |
|POLY 6 | P=0.005 ** P=0.132 P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.005 ** P=0.129 P=0.008 ** P=0.002 ** |
|COCH-ARM / FISHERS | P=0.004 ** P=0.111 P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 47/53 (89%) 49/50 (98%) 46/53 (87%) 40/50 (80%) |
|POLY-3 RATE (b) | 47/48.79 49/49.59 46/46.97 40/45.90 |
|POLY-3 PERCENT (g) | 96.3% 98.8% 97.9% 87.1% |
|TERMINAL (d) | 22/22 (100%) 28/28 (100%) 24/24 (100%) 25/27 (93%) |
|FIRST INCIDENCE | 345 441 254 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.031N* P=0.298N P=0.413N P=0.033N* |
|POLY 3 | P<0.001N** P=0.422 P=0.583 P=0.068N |
|POLY 1.5 | P=0.002N** P=0.229 P=0.593 P=0.085N |
|POLY 6 | P<0.001N** P=0.700 P=0.697 P=0.073N |
|LOGISTIC REGRESSION| P<0.001N** P=0.219 P=0.584 P=0.050N |
|COCH-ARM / FISHERS | P=0.027N* P=0.066 P=0.500N P=0.173N |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 2/50 (4%) 4/53 (8%) 2/50 (4%) |
|POLY-3 RATE (b) | 8/40.26 2/39.59 4/38.58 2/40.50 |
|POLY-3 PERCENT (g) | 19.9% 5.1% 10.4% 4.9% |
|TERMINAL (d) | 4/22 (18%) 2/28 (7%) 2/24 (8%) 0/27 (0%) |
|FIRST INCIDENCE | 85 729 (T) 330 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.139N P=0.032N* P=0.181N P=0.040N* |
|POLY 3 | P=0.142N P=0.045N* P=0.193N P=0.042N* |
|POLY 1.5 | P=0.152N P=0.048N* P=0.194N P=0.047N* |
|POLY 6 | P=0.130N P=0.043N* P=0.191N P=0.037N* |
|LOGISTIC REGRESSION| P=0.178N P=0.062N P=0.175N P=0.070N |
|COCH-ARM / FISHERS | P=0.170N P=0.056N P=0.179N P=0.056N |
|ORDER RESTRICTED | P=0.015N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lung |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/50 (6%) 2/53 (4%) 6/50 (12%) |
|POLY-3 RATE (b) | 0/38.18 3/40.28 2/37.40 6/40.41 |
|POLY-3 PERCENT (g) | 0.0% 7.5% 5.4% 14.9% |
|TERMINAL (d) | 0/22 (0%) 2/28 (7%) 2/24 (8%) 3/27 (11%) |
|FIRST INCIDENCE | --- 491 729 (T) 632 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.030 * P=0.157 P=0.257 P=0.028 * |
|POLY 3 | P=0.022 * P=0.128 P=0.232 P=0.018 * |
|POLY 1.5 | P=0.020 * P=0.122 P=0.232 P=0.016 * |
|POLY 6 | P=0.026 * P=0.134 P=0.233 P=0.021 * |
|LOGISTIC REGRESSION| P=0.023 * P=0.110 P=0.257 P=0.020 * |
|COCH-ARM / FISHERS | P=0.017 * P=0.111 P=0.248 P=0.011 * |
|ORDER RESTRICTED | P=0.006 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/53 (43%) 5/50 (10%) 5/53 (9%) 8/50 (16%) |
|POLY-3 RATE (b) | 23/41.69 5/39.59 5/38.38 8/41.69 |
|POLY-3 PERCENT (g) | 55.2% 12.6% 13.0% 19.2% |
|TERMINAL (d) | 15/22 (68%) 5/28 (18%) 2/24 (8%) 4/27 (15%) |
|FIRST INCIDENCE | 345 729 (T) 505 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.109N P<0.001N** P<0.001N** P<0.001N** |
|POLY 3 | P=0.088N P<0.001N** P<0.001N** P<0.001N** |
|POLY 1.5 | P=0.111N P<0.001N** P<0.001N** P<0.001N** |
|POLY 6 | P=0.067N P<0.001N** P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P=0.138N P<0.001N** P<0.001N** P<0.001N** |
|COCH-ARM / FISHERS | P=0.173N P<0.001N** P<0.001N** P=0.002N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Metaplasia Bronchiolar |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 39/50 (78%) 34/53 (64%) 30/50 (60%) |
|POLY-3 RATE (b) | 0/38.18 39/45.77 34/41.55 30/42.62 |
|POLY-3 PERCENT (g) | 0.0% 85.2% 81.8% 70.4% |
|TERMINAL (d) | 0/22 (0%) 25/28 (89%) 23/24 (96%) 22/27 (82%) |
|FIRST INCIDENCE | --- 478 505 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.121 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P=0.030 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P=0.017 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P=0.061 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.049 * P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P=0.025 * P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/49 (0%) 3/50 (6%) 2/49 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/39.12 3/35.88 2/38.99 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 8.4% 5.1% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 2/24 (8%) 2/27 (7%) |
|FIRST INCIDENCE | --- --- 603 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.346 (e) P=0.131 P=0.284 |
|POLY 3 | P=0.318 (e) P=0.106 P=0.241 |
|POLY 1.5 | P=0.311 (e) P=0.105 P=0.234 |
|POLY 6 | P=0.329 (e) P=0.111 P=0.250 |
|LOGISTIC REGRESSION| P=0.336 (e) P=0.108 P=0.284 |
|COCH-ARM / FISHERS | P=0.304 (e) P=0.111 P=0.228 |
|ORDER RESTRICTED | P=0.071 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 37/53 (70%) 33/49 (67%) 36/50 (72%) 32/49 (65%) |
|POLY-3 RATE (b) | 37/46.61 33/44.17 36/42.27 32/44.54 |
|POLY-3 PERCENT (g) | 79.4% 74.7% 85.2% 71.9% |
|TERMINAL (d) | 18/22 (82%) 22/28 (79%) 23/24 (96%) 20/27 (74%) |
|FIRST INCIDENCE | 418 441 363 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.141N P=0.091N P=0.399N P=0.080N |
|POLY 3 | P=0.189N P=0.382N P=0.317 P=0.263N |
|POLY 1.5 | P=0.223N P=0.386N P=0.346 P=0.287N |
|POLY 6 | P=0.161N P=0.398N P=0.312 P=0.246N |
|LOGISTIC REGRESSION| P=0.235N P=0.321N P=0.403 P=0.295N |
|COCH-ARM / FISHERS | P=0.350N P=0.478N P=0.489 P=0.392N |
|ORDER RESTRICTED | P=0.259N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/49 (0%) 2/50 (4%) 2/49 (4%) |
|POLY-3 RATE (b) | 1/38.18 0/39.12 2/36.99 2/39.96 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 5.4% 5.0% |
|TERMINAL (d) | 1/22 (5%) 0/28 (0%) 0/24 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 729 (T) --- 363 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.377 P=0.452N P=0.508 P=0.545 |
|POLY 3 | P=0.367 P=0.495N P=0.489 P=0.516 |
|POLY 1.5 | P=0.359 P=0.501N P=0.481 P=0.502 |
|POLY 6 | P=0.376 P=0.489N P=0.502 P=0.531 |
|LOGISTIC REGRESSION| P=0.267 (e) P=0.508 P=0.414 |
|COCH-ARM / FISHERS | P=0.344 P=0.520N P=0.478 P=0.470 |
|ORDER RESTRICTED | P=0.260 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 1/49 (2%) 1/52 (2%) 2/49 (4%) |
|POLY-3 RATE (b) | 0/38.18 1/38.87 1/38.06 2/38.45 |
|POLY-3 PERCENT (g) | 0.0% 2.6% 2.6% 5.2% |
|TERMINAL (d) | 0/22 (0%) 1/28 (4%) 0/24 (0%) 2/27 (7%) |
|FIRST INCIDENCE | --- 729 (T) 506 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.279 P=0.548 P=0.500 P=0.284 |
|POLY 3 | P=0.254 P=0.504 P=0.499 P=0.238 |
|POLY 1.5 | P=0.248 P=0.498 P=0.497 P=0.232 |
|POLY 6 | P=0.261 P=0.510 P=0.503 P=0.245 |
|LOGISTIC REGRESSION| P=0.247 P=0.548 P=0.501 P=0.284 |
|COCH-ARM / FISHERS | P=0.237 P=0.480 P=0.495 P=0.228 |
|ORDER RESTRICTED | P=0.118 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Lumbar |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/4 (100%) 0/2 (0%) 1/7 (14%) 1/5 (20%) |
|POLY-3 RATE (b) | 4/4.00 0/1.26 1/4.32 1/4.56 |
|POLY-3 PERCENT (g) | 100.0% 0.0% 23.2% 21.9% |
|TERMINAL (d) | 1/1 (100%) 0/1 (0%) 0/2 (0%) 1/4 (25%) |
|FIRST INCIDENCE | 449 --- 552 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.260N P=0.057N P=0.143N P=0.047N* |
|POLY 3 | P=0.066N P=0.027N* P=0.009N** P=0.009N** |
|POLY 1.5 | P=0.114N P<0.001N** P=0.002N** P=0.007N** |
|POLY 6 | P=0.046N* P=0.137N P=0.043N* P=0.014N* |
|LOGISTIC REGRESSION| P=0.376N P=0.065N P=0.017N* P=0.110N |
|COCH-ARM / FISHERS | P=0.330N P=0.067N P=0.015N* P=0.040N* |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Lumbar |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/4 (100%) 0/2 (0%) 0/7 (0%) 0/5 (0%) |
|POLY-3 RATE (b) | 4/4.00 0/1.26 0/3.75 0/4.56 |
|POLY-3 PERCENT (g) | 100.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/1 (100%) 0/1 (0%) 0/2 (0%) 0/4 (0%) |
|FIRST INCIDENCE | 449 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.136N P=0.057N P=0.044N* P=0.025N* |
|POLY 3 | P<0.001N** P=0.027N* P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001N** P<0.001N** P<0.001N** P<0.001N** |
|POLY 6 | P<0.001N** P=0.137N P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P=0.165N P=0.065N P=0.004N** P=0.038N* |
|COCH-ARM / FISHERS | P=0.133N P=0.067N P=0.003N** P=0.008N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 0/2 (0%) 0/7 (0%) 2/5 (40%) |
|POLY-3 RATE (b) | 0/2.13 0/1.26 0/3.75 2/4.56 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 43.9% |
|TERMINAL (d) | 0/1 (0%) 0/1 (0%) 0/2 (0%) 2/4 (50%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.213 (e) (e) P=0.581 |
|POLY 3 | P=0.097 (e) (e) P=0.412 |
|POLY 1.5 | P=0.068 (e) (e) P=0.349 |
|POLY 6 | P=0.140 (e) (e) P=0.482 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.581 |
|COCH-ARM / FISHERS | P=0.054 (e) (e) P=0.278 |
|ORDER RESTRICTED | P=0.130 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 0/2 (0%) 1/7 (14%) 2/5 (40%) |
|POLY-3 RATE (b) | 0/2.13 0/1.26 1/4.66 2/4.56 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 21.5% 43.9% |
|TERMINAL (d) | 0/1 (0%) 0/1 (0%) 0/2 (0%) 2/4 (50%) |
|FIRST INCIDENCE | --- --- 330 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.341 (e) P=0.500 P=0.581 |
|POLY 3 | P=0.275 (e) P=0.653 P=0.412 |
|POLY 1.5 | P=0.220 (e) P=0.635 P=0.349 |
|POLY 6 | P=0.346 (e) P=0.673 P=0.482 |
|LOGISTIC REGRESSION| P=0.102 (e) (e) P=0.581 |
|COCH-ARM / FISHERS | P=0.152 (e) P=0.636 P=0.278 |
|ORDER RESTRICTED | P=0.210 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Renal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 0/2 (0%) 2/7 (29%) 0/5 (0%) |
|POLY-3 RATE (b) | 0/2.13 0/1.26 2/4.81 0/4.56 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 41.6% 0.0% |
|TERMINAL (d) | 0/1 (0%) 0/1 (0%) 0/2 (0%) 0/4 (0%) |
|FIRST INCIDENCE | --- --- 506 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.549N (e) P=0.227 (e) |
|POLY 3 | P=0.358N (e) P=0.422 (e) |
|POLY 1.5 | P=0.419N (e) P=0.386 (e) |
|POLY 6 | P=0.302N (e) P=0.478 (e) |
|LOGISTIC REGRESSION| P=0.624N (e) P=0.356 (e) |
|COCH-ARM / FISHERS | P=0.507N (e) P=0.382 (e) |
|ORDER RESTRICTED | P=0.357N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 2/50 (4%) 3/53 (6%) 2/51 (4%) |
|POLY-3 RATE (b) | 3/39.88 2/40.31 3/38.06 2/40.45 |
|POLY-3 PERCENT (g) | 7.5% 5.0% 7.9% 4.9% |
|TERMINAL (d) | 1/22 (5%) 1/28 (4%) 2/24 (8%) 1/27 (4%) |
|FIRST INCIDENCE | 345 478 506 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.460N P=0.451N P=0.650N P=0.453N |
|POLY 3 | P=0.486N P=0.495N P=0.642 P=0.493N |
|POLY 1.5 | P=0.492N P=0.504N P=0.644 P=0.502N |
|POLY 6 | P=0.478N P=0.486N P=0.646 P=0.482N |
|LOGISTIC REGRESSION| P=0.534N P=0.676N P=0.649N P=0.587N |
|COCH-ARM / FISHERS | P=0.505N P=0.528N P=0.661N P=0.518N |
|ORDER RESTRICTED | P=0.499N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/53 (55%) 14/50 (28%) 22/53 (42%) 15/51 (29%) |
|POLY-3 RATE (b) | 29/44.60 14/42.77 22/41.66 15/42.12 |
|POLY-3 PERCENT (g) | 65.0% 32.7% 52.8% 35.6% |
|TERMINAL (d) | 16/22 (73%) 7/28 (25%) 11/24 (46%) 10/27 (37%) |
|FIRST INCIDENCE | 418 462 499 463 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.045N* P<0.001N** P=0.117N P=0.002N** |
|POLY 3 | P=0.052N P<0.001N** P=0.164N P=0.003N** |
|POLY 1.5 | P=0.053N P=0.002N** P=0.157N P=0.004N** |
|POLY 6 | P=0.055N P<0.001N** P=0.154N P=0.003N** |
|LOGISTIC REGRESSION| P=0.051N P=0.004N** P=0.134N P=0.004N** |
|COCH-ARM / FISHERS | P=0.069N P=0.005N** P=0.122N P=0.008N** |
|ORDER RESTRICTED | P=0.002N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 2/50 (4%) 3/53 (6%) 0/51 (0%) |
|POLY-3 RATE (b) | 5/39.94 2/40.28 3/37.73 0/39.98 |
|POLY-3 PERCENT (g) | 12.5% 5.0% 8.0% 0.0% |
|TERMINAL (d) | 2/22 (9%) 1/28 (4%) 1/24 (4%) 0/27 (0%) |
|FIRST INCIDENCE | 345 491 650 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.054N P=0.173N P=0.345N P=0.027N* |
|POLY 3 | P=0.054N P=0.210N P=0.387N P=0.030N* |
|POLY 1.5 | P=0.055N P=0.219N P=0.382N P=0.031N* |
|POLY 6 | P=0.053N P=0.201N P=0.384N P=0.028N* |
|LOGISTIC REGRESSION| P=0.061N P=0.298N P=0.359N P=0.044N* |
|COCH-ARM / FISHERS | P=0.060N P=0.243N P=0.358N P=0.031N* |
|ORDER RESTRICTED | P=0.013N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Mesentery: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/47 (2%) 1/31 (3%) 2/47 (4%) 1/47 (2%) |
|POLY-3 RATE (b) | 1/34.51 1/23.96 2/33.24 1/36.01 |
|POLY-3 PERCENT (g) | 2.9% 4.2% 6.0% 2.8% |
|TERMINAL (d) | 0/19 (0%) 1/17 (6%) 2/21 (10%) 0/23 (0%) |
|FIRST INCIDENCE | 688 729 (T) 729 (T) 720 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.547N P=0.760 P=0.528 P=0.717N |
|POLY 3 | P=0.547N P=0.679 P=0.487 P=0.752N |
|POLY 1.5 | P=0.553N P=0.674 P=0.487 P=0.756N |
|POLY 6 | P=0.542N P=0.685 P=0.491 P=0.748N |
|LOGISTIC REGRESSION| P=0.540N P=0.690 P=0.503 P=0.748N |
|COCH-ARM / FISHERS | P=0.564N P=0.640 P=0.500 P=0.753N |
|ORDER RESTRICTED | P=0.563N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 17/50 (34%) 13/53 (25%) 15/51 (29%) |
|POLY-3 RATE (b) | 22/43.64 17/43.73 13/40.22 15/41.65 |
|POLY-3 PERCENT (g) | 50.4% 38.9% 32.3% 36.0% |
|TERMINAL (d) | 10/22 (46%) 9/28 (32%) 5/24 (21%) 10/27 (37%) |
|FIRST INCIDENCE | 418 441 539 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.216N P=0.124N P=0.067N P=0.059N |
|POLY 3 | P=0.295N P=0.186N P=0.067N P=0.124N |
|POLY 1.5 | P=0.285N P=0.205N P=0.062N P=0.121N |
|POLY 6 | P=0.317N P=0.181N P=0.069N P=0.135N |
|LOGISTIC REGRESSION| P=0.265N P=0.268N P=0.053N P=0.102N |
|COCH-ARM / FISHERS | P=0.302N P=0.281N P=0.049N* P=0.139N |
|ORDER RESTRICTED | P=0.087N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 5/50 (10%) 6/53 (11%) 5/51 (10%) |
|POLY-3 RATE (b) | 4/38.51 5/41.00 6/38.67 5/41.38 |
|POLY-3 PERCENT (g) | 10.4% 12.2% 15.5% 12.1% |
|TERMINAL (d) | 2/22 (9%) 3/28 (11%) 1/24 (4%) 2/27 (7%) |
|FIRST INCIDENCE | 664 478 603 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.572N P=0.597 P=0.388 P=0.569 |
|POLY 3 | P=0.584N P=0.540 P=0.370 P=0.545 |
|POLY 1.5 | P=0.601 P=0.516 P=0.361 P=0.521 |
|POLY 6 | P=0.566N P=0.561 P=0.389 P=0.572 |
|LOGISTIC REGRESSION| P=0.582 P=0.492 P=0.357 P=0.506 |
|COCH-ARM / FISHERS | P=0.564 P=0.463 P=0.371 P=0.475 |
|ORDER RESTRICTED | P=0.512 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/53 (19%) 14/50 (28%) 11/53 (21%) 12/51 (24%) |
|POLY-3 RATE (b) | 10/39.82 14/43.24 11/40.12 12/41.65 |
|POLY-3 PERCENT (g) | 25.1% 32.4% 27.4% 28.8% |
|TERMINAL (d) | 6/22 (27%) 7/28 (25%) 3/24 (13%) 7/27 (26%) |
|FIRST INCIDENCE | 418 441 539 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.520N P=0.388 P=0.529 P=0.559 |
|POLY 3 | P=0.563 P=0.312 P=0.508 P=0.449 |
|POLY 1.5 | P=0.550 P=0.269 P=0.489 P=0.420 |
|POLY 6 | P=0.571 P=0.362 P=0.549 P=0.485 |
|LOGISTIC REGRESSION| P=0.544 P=0.214 P=0.481 P=0.434 |
|COCH-ARM / FISHERS | P=0.507 P=0.194 P=0.500 P=0.366 |
|ORDER RESTRICTED | P=0.514 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Oral Mucosa: Gingival |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/12 (67%) 21/28 (75%) 22/30 (73%) 29/41 (71%) |
|POLY-3 RATE (b) | 8/11.04 21/26.86 22/27.81 29/38.96 |
|POLY-3 PERCENT (g) | 72.5% 78.2% 79.1% 74.4% |
|TERMINAL (d) | 2/3 (67%) 10/15 (67%) 12/15 (80%) 17/24 (71%) |
|FIRST INCIDENCE | 451 491 451 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.333 P=0.193 P=0.184 P=0.160 |
|POLY 3 | P=0.449N P=0.518 P=0.491 P=0.604 |
|POLY 1.5 | P=0.466N P=0.478 P=0.480 P=0.571 |
|POLY 6 | P=0.438N P=0.589 P=0.525 P=0.655 |
|LOGISTIC REGRESSION| P=0.493N P=0.431 P=0.491 P=0.526 |
|COCH-ARM / FISHERS | P=0.494N P=0.430 P=0.469 P=0.524 |
|ORDER RESTRICTED | P=0.638 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Ovary |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 46/48 (96%) 43/52 (83%) 36/50 (72%) |
|POLY-3 RATE (b) | 45/49.16 46/47.26 43/48.11 36/46.64 |
|POLY-3 PERCENT (g) | 91.5% 97.4% 89.4% 77.2% |
|TERMINAL (d) | 21/22 (96%) 27/28 (96%) 22/24 (92%) 21/27 (78%) |
|FIRST INCIDENCE | 345 441 254 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.022N* P=0.255N P=0.363N P=0.025N* |
|POLY 3 | P<0.001N** P=0.179 P=0.493N P=0.033N* |
|POLY 1.5 | P<0.001N** P=0.124 P=0.480N P=0.040N* |
|POLY 6 | P<0.001N** P=0.313 P=0.514N P=0.031N* |
|LOGISTIC REGRESSION| P=0.004N** P=0.130 P=0.499N P=0.065N |
|COCH-ARM / FISHERS | P=0.008N** P=0.064 P=0.483N P=0.087N |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 16/48 (33%) 14/52 (27%) 19/50 (38%) |
|POLY-3 RATE (b) | 14/40.50 16/41.13 14/39.03 19/42.91 |
|POLY-3 PERCENT (g) | 34.6% 38.9% 35.9% 44.3% |
|TERMINAL (d) | 8/22 (36%) 10/28 (36%) 11/24 (46%) 12/27 (44%) |
|FIRST INCIDENCE | 451 484 330 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.272 P=0.546N P=0.519N P=0.380 |
|POLY 3 | P=0.226 P=0.429 P=0.546 P=0.243 |
|POLY 1.5 | P=0.194 P=0.383 P=0.554 P=0.204 |
|POLY 6 | P=0.265 P=0.482 P=0.532 P=0.290 |
|LOGISTIC REGRESSION| P=0.175 P=0.369 P=0.563 P=0.183 |
|COCH-ARM / FISHERS | P=0.147 P=0.294 P=0.564 P=0.147 |
|ORDER RESTRICTED | P=0.276 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Ovary |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/48 (0%) 0/52 (0%) 4/50 (8%) |
|POLY-3 RATE (b) | 1/38.95 0/38.21 0/37.39 4/39.49 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 0.0% 10.1% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 3/27 (11%) |
|FIRST INCIDENCE | 451 --- --- 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.015 * P=0.492N P=0.500N P=0.234 |
|POLY 3 | P=0.009 ** P=0.504N P=0.508N P=0.181 |
|POLY 1.5 | P=0.009 ** P=0.508N P=0.507N P=0.175 |
|POLY 6 | P=0.009 ** P=0.499N P=0.508N P=0.189 |
|LOGISTIC REGRESSION| P=0.009 ** P=0.666N P=0.498N P=0.163 |
|COCH-ARM / FISHERS | P=0.009 ** P=0.525N P=0.505N P=0.164 |
|ORDER RESTRICTED | P=0.012 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Oviduct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/1 (100%) 0/1 (0%) 2/2 (100%) 0/3 (0%) |
|POLY-3 RATE (b) | 1/1.00 0/1.00 2/2.00 0/2.94 |
|POLY-3 PERCENT (g) | 100.0% 0.0% 100.0% 0.0% |
|TERMINAL (d) | 1/1 (100%) 0/1 (0%) 0/0 (0%) 0/2 (0%) |
|FIRST INCIDENCE | 729 (T) --- 539 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.281N P=0.500N (e) P=0.362N |
|POLY 3 | P<0.001N** P=1.000 (e) P<0.001N** |
|POLY 1.5 | P<0.001N** P=1.000N (e) P<0.001N** |
|POLY 6 | P<0.001N** P=1.000 (e) P<0.001N** |
|LOGISTIC REGRESSION| P=0.281N P=0.250N (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.500N (e) P=0.250N |
|ORDER RESTRICTED | P=0.025N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Oviduct |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/1 (0%) 0/1 (0%) 0/2 (0%) 3/3 (100%) |
|POLY-3 RATE (b) | 0/1.00 0/1.00 0/1.14 3/3.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/1 (0%) 0/1 (0%) 0/0 (0%) 2/2 (100%) |
|FIRST INCIDENCE | --- --- --- 714 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.042 * (e) (e) P=0.188 |
|POLY 3 | P<0.001 ** (e) (e) P=0.250 |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.250 |
|POLY 6 | P<0.001 ** (e) (e) P=0.250 |
|LOGISTIC REGRESSION| P=0.062 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.028 * (e) (e) P=0.250 |
|ORDER RESTRICTED | P=0.008 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 5/49 (10%) 1/52 (2%) 5/49 (10%) |
|POLY-3 RATE (b) | 0/38.18 5/40.27 1/37.39 5/38.46 |
|POLY-3 PERCENT (g) | 0.0% 12.4% 2.7% 13.0% |
|TERMINAL (d) | 0/22 (0%) 2/28 (7%) 1/24 (4%) 4/27 (15%) |
|FIRST INCIDENCE | --- 491 729 (T) 668 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.129 P=0.047 * P=0.517 P=0.052 |
|POLY 3 | P=0.105 P=0.034 * P=0.496 P=0.030 * |
|POLY 1.5 | P=0.099 P=0.031 * P=0.495 P=0.028 * |
|POLY 6 | P=0.113 P=0.039 * P=0.498 P=0.032 * |
|LOGISTIC REGRESSION| P=0.100 P=0.026 * P=0.517 P=0.036 * |
|COCH-ARM / FISHERS | P=0.088 P=0.023 * P=0.495 P=0.023 * |
|ORDER RESTRICTED | P=0.016 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/49 (8%) 1/52 (2%) 5/49 (10%) |
|POLY-3 RATE (b) | 0/38.18 4/40.03 1/37.39 5/38.23 |
|POLY-3 PERCENT (g) | 0.0% 10.0% 2.7% 13.1% |
|TERMINAL (d) | 0/22 (0%) 2/28 (7%) 1/24 (4%) 5/27 (19%) |
|FIRST INCIDENCE | --- 491 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.081 P=0.087 P=0.517 P=0.051 |
|POLY 3 | P=0.063 P=0.066 P=0.496 P=0.029 * |
|POLY 1.5 | P=0.060 P=0.061 P=0.495 P=0.028 * |
|POLY 6 | P=0.066 P=0.072 P=0.498 P=0.031 * |
|LOGISTIC REGRESSION| P=0.064 P=0.050 P=0.517 P=0.051 |
|COCH-ARM / FISHERS | P=0.054 P=0.050 P=0.495 P=0.023 * |
|ORDER RESTRICTED | P=0.012 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/49 (0%) 1/52 (2%) 1/49 (2%) |
|POLY-3 RATE (b) | 2/38.18 0/38.93 1/37.39 1/38.68 |
|POLY-3 PERCENT (g) | 5.2% 0.0% 2.7% 2.6% |
|TERMINAL (d) | 2/22 (9%) 0/28 (0%) 1/24 (4%) 0/27 (0%) |
|FIRST INCIDENCE | 729 (T) --- 729 (T) 596 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.664N P=0.186N P=0.469N P=0.444N |
|POLY 3 | P=0.703N P=0.232N P=0.507N P=0.495N |
|POLY 1.5 | P=0.706N P=0.239N P=0.509N P=0.507N |
|POLY 6 | P=0.700N P=0.225N P=0.504N P=0.482N |
|LOGISTIC REGRESSION| P=0.692N (e) P=0.469N P=0.503N |
|COCH-ARM / FISHERS | P=0.710N P=0.268N P=0.507N P=0.530N |
|ORDER RESTRICTED | P=0.268N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/49 (6%) 7/52 (13%) 44/49 (90%) |
|POLY-3 RATE (b) | 0/38.18 3/39.04 7/38.39 44/45.45 |
|POLY-3 PERCENT (g) | 0.0% 7.7% 18.2% 96.8% |
|TERMINAL (d) | 0/22 (0%) 2/28 (7%) 5/24 (21%) 27/27 (100%) |
|FIRST INCIDENCE | --- 701 552 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.162 P=0.012 * P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.122 P=0.007 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.117 P=0.007 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.127 P=0.008 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.135 P=0.008 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.107 P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pancreas: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/49 (8%) 2/52 (4%) 3/49 (6%) |
|POLY-3 RATE (b) | 0/38.18 4/39.04 2/38.06 3/38.67 |
|POLY-3 PERCENT (g) | 0.0% 10.3% 5.3% 7.8% |
|TERMINAL (d) | 0/22 (0%) 3/28 (11%) 1/24 (4%) 2/27 (7%) |
|FIRST INCIDENCE | --- 701 506 601 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.437 P=0.095 P=0.249 P=0.151 |
|POLY 3 | P=0.410 P=0.062 P=0.236 P=0.120 |
|POLY 1.5 | P=0.395 P=0.059 P=0.234 P=0.115 |
|POLY 6 | P=0.428 P=0.066 P=0.240 P=0.127 |
|LOGISTIC REGRESSION| P=0.390 P=0.074 P=0.234 P=0.119 |
|COCH-ARM / FISHERS | P=0.367 P=0.050 P=0.243 P=0.107 |
|ORDER RESTRICTED | P=0.109 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 17/53 (32%) 14/50 (28%) 17/52 (33%) 7/51 (14%) |
|POLY-3 RATE (b) | 17/40.84 14/41.76 17/39.38 7/40.52 |
|POLY-3 PERCENT (g) | 41.6% 33.5% 43.2% 17.3% |
|TERMINAL (d) | 11/22 (50%) 8/28 (29%) 9/24 (38%) 5/27 (19%) |
|FIRST INCIDENCE | 418 491 506 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008N** P=0.184N P=0.518N P=0.006N** |
|POLY 3 | P=0.008N** P=0.293N P=0.535 P=0.012N* |
|POLY 1.5 | P=0.009N** P=0.328N P=0.521 P=0.014N* |
|POLY 6 | P=0.008N** P=0.253N P=0.581 P=0.010N* |
|LOGISTIC REGRESSION| P=0.008N** P=0.311N P=0.531 P=0.012N* |
|COCH-ARM / FISHERS | P=0.013N* P=0.407N P=0.556 P=0.023N* |
|ORDER RESTRICTED | P=0.011N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 1/50 (2%) 0/52 (0%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 1/40.20 0/36.79 2/39.98 |
|POLY-3 PERCENT (g) | 0.0% 2.5% 0.0% 5.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 2/27 (7%) |
|FIRST INCIDENCE | --- 534 --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.172 P=0.510 (e) P=0.284 |
|POLY 3 | P=0.163 P=0.510 (e) P=0.247 |
|POLY 1.5 | P=0.159 P=0.503 (e) P=0.241 |
|POLY 6 | P=0.167 P=0.517 (e) P=0.254 |
|LOGISTIC REGRESSION| P=0.155 P=0.414 (e) P=0.284 |
|COCH-ARM / FISHERS | P=0.149 P=0.485 (e) P=0.238 |
|ORDER RESTRICTED | P=0.080 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/50 (0%) 1/52 (2%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/39.59 1/36.79 2/40.04 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.7% 5.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 1/24 (4%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- 729 (T) 714 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.155 (e) P=0.517 P=0.284 |
|POLY 3 | P=0.134 (e) P=0.493 P=0.247 |
|POLY 1.5 | P=0.132 (e) P=0.492 P=0.241 |
|POLY 6 | P=0.137 (e) P=0.496 P=0.254 |
|LOGISTIC REGRESSION| P=0.149 (e) P=0.517 P=0.264 |
|COCH-ARM / FISHERS | P=0.128 (e) P=0.495 P=0.238 |
|ORDER RESTRICTED | P=0.080 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 17/50 (34%) 20/52 (38%) 21/51 (41%) |
|POLY-3 RATE (b) | 13/41.27 17/42.72 20/40.07 21/42.87 |
|POLY-3 PERCENT (g) | 31.5% 39.8% 49.9% 49.0% |
|TERMINAL (d) | 6/22 (27%) 11/28 (39%) 11/24 (46%) 15/27 (56%) |
|FIRST INCIDENCE | 451 484 505 458 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.243 P=0.431 P=0.148 P=0.177 |
|POLY 3 | P=0.159 P=0.283 P=0.065 P=0.072 |
|POLY 1.5 | P=0.153 P=0.259 P=0.066 P=0.067 |
|POLY 6 | P=0.155 P=0.303 P=0.072 P=0.074 |
|LOGISTIC REGRESSION| P=0.168 P=0.238 P=0.077 P=0.075 |
|COCH-ARM / FISHERS | P=0.131 P=0.200 P=0.092 P=0.055 |
|ORDER RESTRICTED | P=0.062 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Skin |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/50 (0%) 0/53 (0%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/39.59 0/37.40 2/41.69 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.8% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.048 * (e) (e) P=0.245 |
|POLY 3 | P=0.049 * (e) (e) P=0.257 |
|POLY 1.5 | P=0.047 * (e) (e) P=0.248 |
|POLY 6 | P=0.051 (e) (e) P=0.267 |
|LOGISTIC REGRESSION| P=0.008 ** (e) (e) P=0.088 |
|COCH-ARM / FISHERS | P=0.044 * (e) (e) P=0.238 |
|ORDER RESTRICTED | P=0.036 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 51/53 (96%) 41/49 (84%) 47/52 (90%) 45/49 (92%) |
|POLY-3 RATE (b) | 51/51.98 41/45.57 47/50.21 45/46.44 |
|POLY-3 PERCENT (g) | 98.1% 90.0% 93.6% 96.9% |
|TERMINAL (d) | 22/22 (100%) 28/28 (100%) 24/24 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 85 441 142 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.221N P=0.008N** P=0.267N P=0.051N |
|POLY 3 | P=0.354 P=0.050N P=0.228N P=0.633N |
|POLY 1.5 | P=0.383 P=0.036N* P=0.215N P=0.481N |
|POLY 6 | P=0.354 P=0.122N P=0.263N P=0.870N |
|LOGISTIC REGRESSION| P=0.558 P=0.016N* P=0.212N P=0.189N |
|COCH-ARM / FISHERS | P=0.498 P=0.035N* P=0.211N P=0.302N |
|ORDER RESTRICTED | P=0.160N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 47
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 47/53 (89%) 48/49 (98%) 51/52 (98%) 49/49 (100%) |
|POLY-3 RATE (b) | 47/50.25 48/48.68 51/51.01 49/49.00 |
|POLY-3 PERCENT (g) | 93.5% 98.6% 100.0% 100.0% |
|TERMINAL (d) | 21/22 (96%) 28/28 (100%) 24/24 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 85 441 254 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.362N P=0.250N P=0.417 P=0.332N |
|POLY 3 | P=0.174 P=0.170 P=0.055 P=0.060 |
|POLY 1.5 | P=0.115 P=0.111 P=0.033 * P=0.033 * |
|POLY 6 | P=0.319 P=0.302 P=0.156 P=0.165 |
|LOGISTIC REGRESSION| P=0.089 P=0.097 P=0.053 P=0.028 * |
|COCH-ARM / FISHERS | P=0.078 P=0.069 P=0.059 P=0.017 * |
|ORDER RESTRICTED | P=0.002 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 5/49 (10%) 4/52 (8%) 2/49 (4%) |
|POLY-3 RATE (b) | 0/38.18 5/40.77 4/38.83 2/39.64 |
|POLY-3 PERCENT (g) | 0.0% 12.3% 10.3% 5.1% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 567 310 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.454N P=0.036 * P=0.068 P=0.243 |
|POLY 3 | P=0.435N P=0.036 * P=0.061 P=0.245 |
|POLY 1.5 | P=0.454N P=0.031 * P=0.060 P=0.237 |
|POLY 6 | P=0.417N P=0.042 * P=0.064 P=0.255 |
|LOGISTIC REGRESSION| P=0.540N P=0.021 * P=0.061 P=0.118 |
|COCH-ARM / FISHERS | P=0.497N P=0.023 * P=0.057 P=0.228 |
|ORDER RESTRICTED | P=0.082 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 48
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/50 (0%) 2/52 (4%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/39.59 2/37.84 2/40.33 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 5.3% 5.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- 612 632 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.247 (e) P=0.239 P=0.259 |
|POLY 3 | P=0.234 (e) P=0.234 P=0.249 |
|POLY 1.5 | P=0.229 (e) P=0.233 P=0.242 |
|POLY 6 | P=0.242 (e) P=0.239 P=0.258 |
|LOGISTIC REGRESSION| P=0.233 (e) P=0.233 P=0.243 |
|COCH-ARM / FISHERS | P=0.222 (e) P=0.243 P=0.238 |
|ORDER RESTRICTED | P=0.114 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 6/50 (12%) 7/52 (13%) 9/51 (18%) |
|POLY-3 RATE (b) | 1/38.18 6/41.04 7/39.86 9/41.81 |
|POLY-3 PERCENT (g) | 2.6% 14.6% 17.6% 21.5% |
|TERMINAL (d) | 1/22 (5%) 3/28 (11%) 1/24 (4%) 5/27 (19%) |
|FIRST INCIDENCE | 729 (T) 491 479 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.086 P=0.090 P=0.041 * P=0.018 * |
|POLY 3 | P=0.075 P=0.067 P=0.033 * P=0.011 * |
|POLY 1.5 | P=0.066 P=0.060 P=0.030 * P=0.009 ** |
|POLY 6 | P=0.086 P=0.075 P=0.038 * P=0.014 * |
|LOGISTIC REGRESSION| P=0.057 P=0.055 P=0.031 * P=0.010 * |
|COCH-ARM / FISHERS | P=0.055 P=0.048 * P=0.028 * P=0.007 ** |
|ORDER RESTRICTED | P=0.010 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 49
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/50 (0%) 1/52 (2%) 6/51 (12%) |
|POLY-3 RATE (b) | 0/38.18 0/39.59 1/37.47 6/41.36 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.7% 14.5% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 3/27 (11%) |
|FIRST INCIDENCE | --- --- 710 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.523 P=0.026 * |
|POLY 3 | P<0.001 ** (e) P=0.496 P=0.019 * |
|POLY 1.5 | P<0.001 ** (e) P=0.495 P=0.017 * |
|POLY 6 | P<0.001 ** (e) P=0.499 P=0.022 * |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.499 P=0.017 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.495 P=0.012 * |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 1/50 (2%) 2/52 (4%) 1/51 (2%) |
|POLY-3 RATE (b) | 0/38.18 1/40.00 2/37.86 1/40.67 |
|POLY-3 PERCENT (g) | 0.0% 2.5% 5.3% 2.5% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 612 618 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.676 P=0.511 P=0.240 P=0.509 |
|POLY 3 | P=0.684 P=0.509 P=0.234 P=0.513 |
|POLY 1.5 | P=0.675 P=0.503 P=0.233 P=0.506 |
|POLY 6 | P=0.694 P=0.516 P=0.239 P=0.520 |
|LOGISTIC REGRESSION| P=0.650 P=0.470 P=0.233 P=0.429 |
|COCH-ARM / FISHERS | P=0.661 P=0.485 P=0.243 P=0.490 |
|ORDER RESTRICTED | P=0.223 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 50
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/50 (0%) 0/52 (0%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/39.59 0/37.39 2/40.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 5.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- --- 720 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.059 (e) (e) P=0.290 |
|POLY 3 | P=0.047 * (e) (e) P=0.247 |
|POLY 1.5 | P=0.046 * (e) (e) P=0.241 |
|POLY 6 | P=0.048 * (e) (e) P=0.254 |
|LOGISTIC REGRESSION| P=0.054 (e) (e) P=0.268 |
|COCH-ARM / FISHERS | P=0.045 * (e) (e) P=0.238 |
|ORDER RESTRICTED | P=0.033 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/50 (6%) 1/52 (2%) 0/51 (0%) |
|POLY-3 RATE (b) | 0/38.18 3/41.18 1/37.39 0/39.98 |
|POLY-3 PERCENT (g) | 0.0% 7.3% 2.7% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 1/24 (4%) 0/27 (0%) |
|FIRST INCIDENCE | --- 478 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.269N P=0.132 P=0.517 (e) |
|POLY 3 | P=0.244N P=0.132 P=0.496 (e) |
|POLY 1.5 | P=0.256N P=0.124 P=0.495 (e) |
|POLY 6 | P=0.234N P=0.142 P=0.498 (e) |
|LOGISTIC REGRESSION| P=0.293N P=0.062 P=0.517 (e) |
|COCH-ARM / FISHERS | P=0.282N P=0.111 P=0.495 (e) |
|ORDER RESTRICTED | P=0.226N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 51
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 1/50 (2%) 1/52 (2%) 0/51 (0%) |
|POLY-3 RATE (b) | 4/38.98 1/39.59 1/37.99 0/39.98 |
|POLY-3 PERCENT (g) | 10.3% 2.5% 2.6% 0.0% |
|TERMINAL (d) | 2/22 (9%) 1/28 (4%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 556 729 (T) 539 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.122N P=0.142N P=0.183N P=0.051N |
|POLY 3 | P=0.128N P=0.172N P=0.184N P=0.056N |
|POLY 1.5 | P=0.130N P=0.178N P=0.186N P=0.059N |
|POLY 6 | P=0.126N P=0.168N P=0.182N P=0.054N |
|LOGISTIC REGRESSION| P=0.132N P=0.172N P=0.186N P=0.061N |
|COCH-ARM / FISHERS | P=0.135N P=0.200N P=0.187N P=0.064N |
|ORDER RESTRICTED | P=0.011N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 33/53 (62%) 48/48 (100%) 42/50 (84%) 45/47 (96%) |
|POLY-3 RATE (b) | 33/43.47 48/48.00 42/43.09 45/45.28 |
|POLY-3 PERCENT (g) | 75.9% 100.0% 97.5% 99.4% |
|TERMINAL (d) | 18/22 (82%) 28/28 (100%) 24/24 (100%) 26/26 (100%) |
|FIRST INCIDENCE | 449 441 479 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.371 P=0.102 P=0.141 P=0.150 |
|POLY 3 | P=0.016 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P=0.007 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P=0.048 * P<0.001 ** P=0.002 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.015 * P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P=0.009 ** P<0.001 ** P=0.011 * P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 52
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Thymus |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/48 (0%) 3/50 (6%) 0/47 (0%) |
|POLY-3 RATE (b) | 1/39.00 0/38.21 3/38.30 0/37.46 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 7.8% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 418 --- 96 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.324N P=0.500N P=0.296 P=0.504N |
|POLY 3 | P=0.328N P=0.504N P=0.298 P=0.508N |
|POLY 1.5 | P=0.333N P=0.509N P=0.292 P=0.513N |
|POLY 6 | P=0.324N P=0.499N P=0.307 P=0.503N |
|LOGISTIC REGRESSION| P=0.501N P=0.699N P=0.429 P=0.630N |
|COCH-ARM / FISHERS | P=0.340N P=0.525N P=0.287 P=0.530N |
|ORDER RESTRICTED | P=0.270N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Thymus |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/48 (0%) 0/50 (0%) 0/47 (0%) |
|POLY-3 RATE (b) | 2/39.43 0/38.21 0/35.50 0/37.46 |
|POLY-3 PERCENT (g) | 5.1% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/28 (0%) 0/24 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 85 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.419N P=0.250N P=0.251N P=0.244N |
|POLY 3 | P=0.427N P=0.243N P=0.260N P=0.248N |
|POLY 1.5 | P=0.428N P=0.249N P=0.261N P=0.254N |
|POLY 6 | P=0.429N P=0.238N P=0.258N P=0.242N |
|LOGISTIC REGRESSION| P=0.539N P=0.501N P=0.180N P=0.390N |
|COCH-ARM / FISHERS | P=0.437N P=0.273N P=0.262N P=0.278N |
|ORDER RESTRICTED | P=0.033N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 53
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/53 (28%) 16/49 (33%) 12/52 (23%) 17/50 (34%) |
|POLY-3 RATE (b) | 15/41.78 16/42.03 12/38.36 17/42.66 |
|POLY-3 PERCENT (g) | 35.9% 38.1% 31.3% 39.9% |
|TERMINAL (d) | 7/22 (32%) 10/28 (36%) 7/24 (29%) 12/27 (44%) |
|FIRST INCIDENCE | 377 491 552 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.432 P=0.482N P=0.307N P=0.563N |
|POLY 3 | P=0.372 P=0.509 P=0.419N P=0.440 |
|POLY 1.5 | P=0.344 P=0.476 P=0.405N P=0.407 |
|POLY 6 | P=0.392 P=0.537 P=0.422N P=0.467 |
|LOGISTIC REGRESSION| P=0.330 P=0.440 P=0.367N P=0.381 |
|COCH-ARM / FISHERS | P=0.280 P=0.396 P=0.349N P=0.340 |
|ORDER RESTRICTED | P=0.509 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicle |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/49 (0%) 0/52 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/38.43 0/39.12 0/36.79 0/39.67 |
|POLY-3 PERCENT (g) | 5.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/28 (0%) 0/24 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 664 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.407N P=0.217N P=0.241N P=0.217N |
|POLY 3 | P=0.422N P=0.233N P=0.246N P=0.230N |
|POLY 1.5 | P=0.422N P=0.239N P=0.247N P=0.236N |
|POLY 6 | P=0.423N P=0.227N P=0.244N P=0.223N |
|LOGISTIC REGRESSION| P=0.411N P=0.229N P=0.243N P=0.226N |
|COCH-ARM / FISHERS | P=0.427N P=0.268N P=0.252N P=0.262N |
|ORDER RESTRICTED | P=0.027N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 54
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 28/49 (57%) 35/52 (67%) 44/50 (88%) |
|POLY-3 RATE (b) | 14/43.47 28/43.27 35/45.78 44/47.40 |
|POLY-3 PERCENT (g) | 32.2% 64.7% 76.5% 92.8% |
|TERMINAL (d) | 5/22 (23%) 20/28 (71%) 20/24 (83%) 27/27 (100%) |
|FIRST INCIDENCE | 418 441 142 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.036 * P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Tooth: Peridontal Tissue |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/23 (100%) 25/25 (100%) 35/35 (100%) 42/42 (100%) |
|POLY-3 RATE (b) | 23/23.00 25/25.00 35/35.00 42/42.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 10/10 (100%) 17/17 (100%) 17/17 (100%) 25/25 (100%) |
|FIRST INCIDENCE | 451 491 254 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 55
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/53 (13%) 3/49 (6%) 7/52 (13%) 8/50 (16%) |
|POLY-3 RATE (b) | 7/40.77 3/39.40 7/39.03 8/39.25 |
|POLY-3 PERCENT (g) | 17.2% 7.6% 17.9% 20.4% |
|TERMINAL (d) | 3/22 (14%) 2/28 (7%) 4/24 (17%) 7/27 (26%) |
|FIRST INCIDENCE | 345 569 499 668 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.322 P=0.120N P=0.589N P=0.598N |
|POLY 3 | P=0.233 P=0.168N P=0.581 P=0.467 |
|POLY 1.5 | P=0.236 P=0.174N P=0.582 P=0.465 |
|POLY 6 | P=0.229 P=0.161N P=0.589 P=0.471 |
|LOGISTIC REGRESSION| P=0.251 P=0.222N P=0.599 P=0.479 |
|COCH-ARM / FISHERS | P=0.237 P=0.193N P=0.598 P=0.451 |
|ORDER RESTRICTED | P=0.258 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 2/50 (4%) 10/52 (19%) 8/50 (16%) |
|POLY-3 RATE (b) | 3/39.57 2/39.59 10/39.56 8/39.90 |
|POLY-3 PERCENT (g) | 7.6% 5.1% 25.3% 20.1% |
|TERMINAL (d) | 0/22 (0%) 2/28 (7%) 6/24 (25%) 5/27 (19%) |
|FIRST INCIDENCE | 345 729 (T) 506 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.181 P=0.466N P=0.046 * P=0.150 |
|POLY 3 | P=0.123 P=0.500N P=0.031 * P=0.097 |
|POLY 1.5 | P=0.117 P=0.506N P=0.031 * P=0.092 |
|POLY 6 | P=0.132 P=0.496N P=0.033 * P=0.103 |
|LOGISTIC REGRESSION| P=0.126 P=0.550N P=0.035 * P=0.091 |
|COCH-ARM / FISHERS | P=0.115 P=0.528N P=0.033 * P=0.083 |
|ORDER RESTRICTED | P=0.023 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 56
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 4/50 (8%) 7/52 (13%) 8/50 (16%) |
|POLY-3 RATE (b) | 3/38.79 4/40.12 7/39.10 8/39.83 |
|POLY-3 PERCENT (g) | 7.7% 10.0% 17.9% 20.1% |
|TERMINAL (d) | 2/22 (9%) 3/28 (11%) 2/24 (8%) 6/27 (22%) |
|FIRST INCIDENCE | 533 567 310 588 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.166 P=0.602 P=0.181 P=0.159 |
|POLY 3 | P=0.120 P=0.518 P=0.156 P=0.102 |
|POLY 1.5 | P=0.114 P=0.504 P=0.153 P=0.095 |
|POLY 6 | P=0.127 P=0.533 P=0.165 P=0.112 |
|LOGISTIC REGRESSION| P=0.119 P=0.507 P=0.151 P=0.105 |
|COCH-ARM / FISHERS | P=0.106 P=0.467 P=0.152 P=0.083 |
|ORDER RESTRICTED | P=0.084 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Uterus |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 27/50 (54%) 36/52 (69%) 34/50 (68%) |
|POLY-3 RATE (b) | 27/44.63 27/43.83 36/44.30 34/45.44 |
|POLY-3 PERCENT (g) | 60.5% 61.6% 81.3% 74.8% |
|TERMINAL (d) | 12/22 (55%) 18/28 (64%) 21/24 (88%) 20/27 (74%) |
|FIRST INCIDENCE | 345 441 310 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.351 P=0.323N P=0.133 P=0.368 |
|POLY 3 | P=0.163 P=0.546 P=0.018 * P=0.097 |
|POLY 1.5 | P=0.133 P=0.531 P=0.024 * P=0.081 |
|POLY 6 | P=0.203 P=0.546 P=0.012 * P=0.114 |
|LOGISTIC REGRESSION| P=0.130 P=0.556 P=0.036 * P=0.081 |
|COCH-ARM / FISHERS | P=0.103 P=0.455 P=0.043 * P=0.059 |
|ORDER RESTRICTED | P=0.035 * (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 57
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 300 NG / 300 NG / 300 NG / |
| | 0 UG 100 UG 300 UG 3000 UG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 28/53 (53%) 25/50 (50%) 18/52 (35%) 15/50 (30%) |
|POLY-3 RATE (b) | 28/44.64 25/44.81 18/41.18 15/41.92 |
|POLY-3 PERCENT (g) | 62.7% 55.8% 43.7% 35.8% |
|TERMINAL (d) | 13/22 (59%) 16/28 (57%) 13/24 (54%) 8/27 (30%) |
|FIRST INCIDENCE | 345 441 142 409 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.013N* P=0.167N P=0.040N* P=0.006N** |
|POLY 3 | P=0.014N* P=0.319N P=0.051N P=0.007N** |
|POLY 1.5 | P=0.017N* P=0.356N P=0.044N* P=0.009N** |
|POLY 6 | P=0.011N* P=0.299N P=0.066N P=0.007N** |
|LOGISTIC REGRESSION| P=0.021N* P=0.421N P=0.046N* P=0.012N* |
|COCH-ARM / FISHERS | P=0.024N* P=0.464N P=0.046N* P=0.016N* |
|ORDER RESTRICTED | P=0.005N** (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).