TDMS Study 96020-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:04:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1
REASONS FOR REMOVAL: 25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 NG / 0 UG
INCLUDE 002 10 NG / 10 UG
INCLUDE 003 100 NG /100 UG
INCLUDE 005 300 NG /300 UG
INCLUDE 007 1000 NG/1000 UG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:04:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 NG / 0 UG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 30 CENSORED DEATHS 1 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 345 377 418 426 449 451 451 451 484 499 |
| 533 556 556 556 581 636 640 647 654 654 |
| 664 664 664 664 670 684 688 708 714 719 |
| CENSORED DEATHS |
| 85 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 NG / 10 UG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 31 CENSORED DEATHS 1 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 167 296 330 337 367 378 407 469 469 499 |
| 534 534 563 580 589 603 636 636 639 643 |
| 661 661 664 680 689 689 689 694 698 720 |
| 727 |
| CENSORED DEATHS |
| 178 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 NG /100 UG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 30 CENSORED DEATHS 1 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 254 407 433 458 461 469 469 491 499 531 |
| 556 581 588 589 603 603 636 638 654 654 |
| 654 659 664 664 705 715 715 715 720 722 |
| CENSORED DEATHS |
| 125 |
| |
==================================================================================
TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 300 NG /300 UG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 96 142 254 310 330 363 451 479 499 505 |
| 505 506 539 552 556 580 583 603 603 612 |
| 618 650 654 659 665 684 710 715 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 NG/1000 UG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 27 CENSORED DEATHS 2 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 169 181 206 314 426 477 479 485 491 499 |
| 540 558 563 563 574 580 581 595 606 619 |
| 640 647 654 665 706 714 714 |
| CENSORED DEATHS |
| 71 76 |
| |
==================================================================================
TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 98.1 94.2 82.7 78.8 71.2 53.8 42.3 |
|NG / 0 UG | |
| | |
|10 | 100.0 98.1 98.1 92.3 86.6 82.7 77.0 69.3 55.8 40.4 |
|NG / 10 UG | |
| | |
|100 | 100.0 100.0 98.1 98.1 96.2 86.5 80.8 69.2 53.8 42.3 |
|NG /100 UG | |
| | |
|300 | 100.0 96.2 94.3 88.7 88.7 84.9 75.5 64.2 52.8 45.3 |
|NG /300 UG | |
| | |
|1000 | 100.0 98.0 94.1 92.2 92.2 84.3 78.4 64.7 52.9 47.1 |
|NG/1000 UG | |
| | |
==================================================================================
TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 10 100 300 1000 |
| NG / 0 UG NG / 10 UG NG /100 UG NG /300 UG NG/1000 UG |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 42.3% 40.4% 42.3% 45.3% 47.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.798N P=0.942 P=1.000N P=1.000N P=0.924N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 573.4 556.4 583.6 522.1 527.6 |
|NATURAL DEATHS (C) | (20.5) (26.6) (21.0) (30.7) (29.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 628.8 617.6 635.3 615.8 601.7 |
|(STANDARD ERROR) | (18.8) (21.1) (18.2) (21.9) (24.9) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)
KAPLAN-MEIER SURVIVAL CURVES
0 NG / 0 UG = 1
10 NG / 10 UG = 2
100 NG /100 UG = 3
300 NG /300 UG = 4
1000 NG/1000 UG = 5
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 5 3 1
| 4 4 2 55 3 2 1 1 3
| 4 5 5 4 2 4 22 1 3113 3
| 4 42 2 1 1
P 90 + 4 422 5 33 5
E | 4 2 2 4 2 453
R | 1 4133
C | 2 1514 3
E 80 + 1 315 1 3
N | 4 25 52 33
T | 4 4 2 23 3
| 41551 2 3
S 70 + 514 2 2 11
U | 54 5 4 311
R | 5 44 2211
V | 544 2 1 1
I 60 + 4 543 3
V | 44 4
A | 5 11 22 3
L | 41 1 3 3
50 + 11 544
| 12 1 5
| 2 113 4
| 12 1
40 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 74 obs hidden.