TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 NG / 0 UG
Include 004 300 NG /100 UG
Include 005 300 NG /300 UG
Include 006 300 NG /3000 UG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 80 98 80
Early Deaths
Moribund Sacrifice 22 10 19 13
Natural Death 8 12 10 10
Dosing Accident 1 1
Survivors
Terminal Sacrifice 22 28 24 27
Animals Examined Microscopically 53 50 53 51
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (53) (50) (53) (50)
Perforation 1 (2%)
Muscularis, Inflammation 3 (6%) 3 (6%)
Periesophageal Tissue, Hemorrhage 1 (2%)
Periesophageal Tissue, Inflammation 1 (2%) 1 (2%)
Intestine Large, Rectum (53) (50) (53) (51)
Parasite Metazoan 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%) 2 (4%)
Intestine Large, Cecum (53) (50) (52) (50)
Edema 1 (2%)
Inflammation 1 (2%)
Artery, Inflammation 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Thrombosis 1 (2%)
Lymphoid Tissue, Hyperplasia 1 (2%)
Intestine Small, Jejunum (53) (50) (52) (51)
Hyperplasia, Lymphoid 2 (4%)
Ulcer 1 (2%)
Intestine Small, Ileum (53) (50) (52) (50)
Hyperplasia, Lymphoid 1 (2%)
Liver (53) (50) (52) (51)
Angiectasis 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Basophilic Focus 9 (17%) 4 (8%) 2 (4%) 8 (16%)
Basophilic Focus, Multiple 13 (25%) 1 (2%) 1 (2%) 10 (20%)
Cholangiofibrosis 5 (10%) 7 (13%) 13 (25%)
Clear Cell Focus 3 (6%) 1 (2%) 3 (6%) 5 (10%)
Clear Cell Focus, Multiple 6 (11%) 4 (8%) 6 (12%)
Eosinophilic Focus 7 (13%) 6 (12%) 7 (13%)
Eosinophilic Focus, Multiple 7 (13%) 21 (42%) 33 (63%) 45 (88%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fatty Change, Diffuse 3 (6%) 28 (56%) 31 (60%) 47 (92%)
Fatty Change, Focal 3 (6%) 4 (8%) 1 (2%) 11 (22%)
Hematopoietic Cell Proliferation 27 (51%) 18 (36%) 19 (37%) 29 (57%)
Hemorrhage 1 (2%)
Hyperplasia, Nodular 20 (40%) 24 (46%) 21 (41%)
Inflammation 44 (83%) 47 (94%) 48 (92%) 46 (90%)
Mixed Cell Focus 7 (13%) 2 (4%) 1 (2%)
Mixed Cell Focus, Multiple 19 (36%) 27 (54%) 24 (46%) 26 (51%)
Necrosis 4 (8%) 6 (12%) 4 (8%) 7 (14%)
Pigmentation 2 (4%) 50 (100%) 50 (96%) 44 (86%)
Toxic Hepatopathy 44 (88%) 48 (92%) 48 (94%)
Bile Duct, Cyst 4 (8%) 4 (8%) 5 (10%) 6 (12%)
Bile Duct, Fibrosis 1 (2%) 4 (8%) 5 (10%)
Bile Duct, Hyperplasia 8 (15%) 20 (40%) 29 (56%) 40 (78%)
Centrilobular, Degeneration 5 (9%) 6 (12%) 4 (8%) 2 (4%)
Centrilobular, Fibrosis 1 (2%) 1 (2%)
Hepatocyte, Hypertrophy 1 (2%) 22 (44%) 33 (63%) 47 (92%)
Hepatocyte, Multinucleated 42 (84%) 46 (88%) 44 (86%)
Oval Cell, Hyperplasia 2 (4%) 33 (66%) 39 (75%) 43 (84%)
Portal, Fibrosis 3 (6%) 7 (13%) 10 (20%)
Serosa, Inflammation, Chronic Active 1 (2%)
Mesentery (47) (31) (47) (47)
Artery, Inflammation, Chronic Active 1 (2%) 1 (3%) 2 (4%) 1 (2%)
Fat, Necrosis 1 (2%)
Oral Mucosa (12) (28) (30) (41)
Gingival, Hyperplasia, Squamous 8 (67%) 21 (75%) 22 (73%) 29 (71%)
Pancreas (53) (49) (52) (49)
Inflammation, Chronic Active 5 (10%) 1 (2%) 5 (10%)
Necrosis 1 (2%)
Acinus, Atrophy 4 (8%) 1 (2%) 5 (10%)
Acinus, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Acinus, Vacuolization Cytoplasmic 3 (6%) 7 (13%) 44 (90%)
Artery, Inflammation, Chronic Active 4 (8%) 2 (4%) 3 (6%)
Stomach, Forestomach (53) (50) (52) (51)
Cyst 1 (2%)
Hyperkeratosis 2 (4%) 2 (4%)
Hyperplasia, Squamous 1 (2%) 6 (12%) 7 (13%) 9 (18%)
Inflammation 1 (2%) 6 (12%)
Mineralization 1 (2%)
Ulcer 1 (2%) 2 (4%) 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%)
Stomach, Glandular (53) (50) (52) (51)
Ectopic Tissue 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Erosion 3 (6%) 1 (2%)
Mineralization 4 (8%) 1 (2%) 1 (2%)
Tooth (23) (25) (35) (42)
Peridontal Tissue, Inflammation 23 (100%) 25 (100%) 35 (100%) 42 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (53) (50) (53) (51)
Aorta, Mineralization 1 (2%)
Heart (53) (50) (53) (50)
Cardiomyopathy 22 (42%) 18 (36%) 26 (49%) 25 (50%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Coronary Artery, Inflammation, Chronic Active 1 (2%)
Endocardium, Hyperplasia 1 (2%)
Pericardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (53) (49) (52) (51)
Angiectasis 17 (32%) 28 (57%) 23 (44%) 7 (14%)
Atrophy 2 (4%) 3 (6%) 5 (10%)
Degeneration, Cystic 13 (25%) 14 (29%) 14 (27%) 18 (35%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 11 (21%) 17 (35%) 25 (48%) 21 (41%)
Hypertrophy 47 (89%) 42 (86%) 41 (79%) 40 (78%)
Necrosis 1 (2%) 3 (6%) 2 (4%)
Vacuolization Cytoplasmic 11 (21%) 15 (31%) 10 (19%) 13 (25%)
Adrenal Medulla (52) (49) (52) (49)
Hyperplasia 15 (29%) 8 (16%) 13 (25%) 6 (12%)
Islets, Pancreatic (53) (49) (52) (49)
Hyperplasia 1 (2%)
Pituitary Gland (53) (50) (52) (51)
Angiectasis 17 (32%) 14 (28%) 17 (33%) 7 (14%)
Cyst 1 (2%)
Cytoplasmic Alteration 1 (2%) 2 (4%)
Inflammation 1 (2%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 13 (25%) 17 (34%) 20 (38%) 21 (41%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (53) (49) (52) (50)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%)
C-Cell, Hyperplasia 15 (28%) 16 (33%) 12 (23%) 17 (34%)
Follicle, Cyst 2 (4%)
Follicular Cell, Hyperplasia 1 (2%)
Follicular Cell, Hypertrophy 14 (26%) 28 (57%) 35 (67%) 44 (88%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (53) (49) (53) (50)
Hyperplasia, Squamous 1 (2%)
Inflammation 45 (85%) 38 (78%) 40 (75%) 40 (80%)
Duct, Cyst 38 (72%) 41 (84%) 43 (81%) 41 (82%)
Ovary (53) (48) (52) (50)
Atrophy 45 (85%) 46 (96%) 43 (83%) 36 (72%)
Cyst 14 (26%) 16 (33%) 14 (27%) 19 (38%)
Inflammation, Chronic Active 1 (2%) 4 (8%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Oviduct (1) (1) (2) (3)
Cyst 1 (100%) 2 (100%)
Inflammation, Chronic Active 3 (100%)
Metaplasia, Squamous 1 (100%)
Uterus (53) (50) (52) (50)
Adenomyosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 3 (6%) 4 (8%) 7 (13%) 8 (16%)
Inflammation, Suppurative 3 (6%) 2 (4%) 10 (19%) 8 (16%)
Metaplasia, Squamous 27 (51%) 27 (54%) 36 (69%) 34 (68%)
Cervix, Cyst 1 (2%)
Endometrium, Hyperplasia, Cystic 28 (53%) 25 (50%) 18 (35%) 15 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (53) (50) (53) (51)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia 39 (74%) 38 (76%) 48 (91%) 39 (76%)
Lymph Node (4) (2) (7) (5)
Angiectasis 1 (14%)
Inguinal, Hyperplasia, Plasma Cell 1 (14%)
Lumbar, Ectasia 4 (100%) 1 (14%) 1 (20%)
Lumbar, Hemorrhage 1 (20%)
Lumbar, Hyperplasia, Plasma Cell 4 (100%)
Mediastinal, Ectasia 2 (40%)
Mediastinal, Hemorrhage 1 (14%) 2 (40%)
Mediastinal, Hyperplasia, Histiocytic 1 (14%) 1 (20%)
Mediastinal, Hyperplasia, Lymphoid 1 (50%)
Mediastinal, Hyperplasia, Plasma Cell 1 (50%) 1 (20%)
Pancreatic, Hyperplasia, Histiocytic 1 (14%)
Pancreatic, Pigmentation 1 (14%)
Renal, Ectasia 1 (14%)
Renal, Hyperplasia, Histiocytic 1 (14%)
Renal, Hyperplasia, Plasma Cell 1 (14%)
Lymph Node, Mandibular (53) (49) (50) (49)
Congestion 1 (2%)
Ectasia 3 (6%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Plasma Cell 37 (70%) 33 (67%) 36 (72%) 32 (65%)
Lymph Node, Mesenteric (53) (49) (52) (49)
Hemorrhage 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 2 (4%)
Spleen (53) (49) (52) (49)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 51 (96%) 41 (84%) 47 (90%) 45 (92%)
Pigmentation 47 (89%) 48 (98%) 51 (98%) 49 (100%)
Lymphoid Follicle, Atrophy 5 (10%) 4 (8%) 2 (4%)
Red Pulp, Atrophy 1 (2%) 1 (2%) 1 (2%)
Thymus (53) (48) (50) (47)
Atrophy 33 (62%) 48 (100%) 42 (84%) 45 (96%)
Cyst 1 (2%)
Hemorrhage 1 (2%) 3 (6%)
Hyperplasia, Lymphoid 2 (4%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Mammary Gland (53) (50) (53) (51)
Cyst 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Hyperplasia 29 (55%) 14 (28%) 22 (42%) 15 (29%)
Inflammation, Granulomatous 5 (9%) 2 (4%) 3 (6%)
Duct, Cyst 1 (2%)
Skin (53) (50) (53) (51)
Angiectasis 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Edema 1 (2%)
Fibrosis 1 (2%)
Inflammation 2 (4%)
Necrosis 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (1) (3)
Inflammation 1 (33%)
Necrosis 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (53) (50) (52) (51)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (2%) 1 (2%) 1 (2%)
Cerebellum, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (53) (50) (53) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 47 (89%) 49 (98%) 46 (87%) 40 (80%)
Inflammation 8 (15%) 2 (4%) 4 (8%) 2 (4%)
Metaplasia, Squamous 3 (6%) 2 (4%) 6 (12%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 23 (43%) 5 (10%) 5 (9%) 8 (16%)
Alveolar Epithelium, Metaplasia, Bronchiolar 39 (78%) 34 (64%) 30 (60%)
Mediastinum, Necrosis 1 (2%) 1 (2%)
Serosa, Inflammation 1 (2%)
Nose (53) (50) (53) (51)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Hyperplasia 1 (2%)
Inflammation 22 (42%) 17 (34%) 13 (25%) 15 (29%)
Nerve, Degeneration 1 (2%)
Olfactory Epithelium, Degeneration 1 (2%) 1 (2%)
Olfactory Epithelium, Dysplasia 1 (2%)
Olfactory Epithelium, Metaplasia 4 (8%) 5 (10%) 6 (11%) 5 (10%)
Respiratory Epithelium, Hyperplasia 10 (19%) 14 (28%) 11 (21%) 12 (24%)
Respiratory Epithelium, Metaplasia 1 (2%)
Trachea (53) (50) (53) (50)
Inflammation 1 (2%)
Peritracheal Tissue, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (53) (50) (52) (51)
Anterior Chamber, Ciliary Body, Cornea,
Inflammation 2 (4%) 1 (2%)
Cornea, Inflammation 1 (2%) 1 (2%)
Retina, Atrophy 1 (2%) 2 (4%) 5 (10%)
Harderian Gland (53) (49) (52) (51)
Inflammation 20 (38%) 15 (31%) 14 (27%) 17 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (48) (52) (51)
Accumulation, Hyaline Droplet 2 (4%) 1 (2%) 2 (4%)
Calculus Micro Observation Only 7 (13%) 6 (13%) 4 (8%) 6 (12%)
Casts Protein 2 (4%)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 2 (4%)
Infarct 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 5 (9%) 6 (13%) 5 (10%) 3 (6%)
Mineralization 42 (79%) 39 (81%) 42 (81%) 33 (65%)
Nephropathy 29 (55%) 30 (63%) 34 (65%) 34 (67%)
Pigmentation 2 (4%) 7 (13%) 17 (33%)
Pelvis, Dilatation 1 (2%) 4 (8%) 2 (4%)
Pelvis, Inflammation 3 (6%) 1 (2%) 3 (6%) 8 (16%)
Renal Tubule, Degeneration 2 (4%)
Renal Tubule, Hyperplasia 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%) 6 (13%) 11 (21%) 9 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:44:17
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Ureter (1) (1) (1)
Inflammation 1 (100%) 1 (100%) 1 (100%)
Transitional Epithelium, Hyperplasia 1 (100%) 1 (100%)
Urinary Bladder (53) (49) (52) (50)
Inflammation 7 (13%) 3 (6%) 7 (13%) 8 (16%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
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