TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 NG / 0 UG Include 004 300 NG /100 UG Include 005 300 NG /300 UG Include 006 300 NG /3000 UG Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | |__________________________________________________________________________| Mesentery | + M M M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + + + M + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Pars Distalis, Adenoma | X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X| C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | X | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X | Polyp Stromal, Multiple | X | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Vagina | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Fibrous Histiocytoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | |__________________________________________________________________________| Ureter | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6| DAY ON TEST | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6| | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 0 UG | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | |__________________________________________________________________________| Mesentery | + + M + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + M + M + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X | C-Cell, Carcinoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X | Polyp Stromal, Multiple | X X | Squamous Cell Carcinoma | | |__________________________________________________________________________| Vagina | + | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Fibrous Histiocytoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | X | Fibrous Histiocytoma, Metastatic, | | Skeletal Muscle | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | X | |__________________________________________________________________________| Ureter | + | __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4| DAY ON TEST | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9| | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG / | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0 UG | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Papilloma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | Leiomyosarcoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Hemangioma | | 1 | |__________________________________________________________________________|____________| Mesentery | + M + | 47 | |__________________________________________________________________________|____________| Oral Mucosa | | 12 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | |__________________________________________________________________________|____________| Tooth | | 23 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Pheochromocytoma Benign | | 2 | Bilateral, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M | 45 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Carcinoma | | 1 | Pars Distalis, Adenoma | | 22 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | Bilateral, C-Cell, Adenoma | | 2 | C-Cell, Adenoma | | 8 | C-Cell, Carcinoma | | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Adenoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | Granulosa Cell Tumor Malignant | | 1 | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Polyp Stromal | X | 5 | Polyp Stromal, Multiple | | 3 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | |__________________________________________________________________________|____________| Thymus | + + + | 53 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Adenoma | | 2 | Carcinoma | X | 6 | Carcinoma, Multiple | | 2 | Fibroadenoma | X | 27 | Fibroadenoma, Multiple | X | 13 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibroma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Fibrous Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Carcinoma, Metastatic, Mammary Gland | | 1 | Fibrous Histiocytoma, Metastatic, | | | Skeletal Muscle | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 4| | | DAY ON TEST | 2| 3| 5| | | | 9| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG / | 9| 9| 9| | L | 0 UG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Renal Tubule, Adenoma | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 6| 7| 6| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 8| 4| 4| 0| 3| 6| 9| 3| 6| 3| 3| 3| 3| 1| 2| 2| 3| 6| 8| 2| 3| 3| | 0| 0| 9| 4| 0| 3| 1| 6| 4| 1| 1| 2| 3| 0| 0| 1| 2| 9| 9| 0| 7| 9| 9| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X | Cholangiocarcinoma, Multiple | | Hepatocellular Adenoma, Multiple | X X | Lymphoma Malignant | X | Mesothelioma Malignant | X | |__________________________________________________________________________| Mesentery | M + + + + + + M + + + M M M + + M M M + + M + + M| Fat, Mesothelioma Malignant | X | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 6| 7| 6| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 8| 4| 4| 0| 3| 6| 9| 3| 6| 3| 3| 3| 3| 1| 2| 2| 3| 6| 8| 2| 3| 3| | 0| 0| 9| 4| 0| 3| 1| 6| 4| 1| 1| 2| 3| 0| 0| 1| 2| 9| 9| 0| 7| 9| 9| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Mesothelioma Malignant | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X| Pars Distalis, Carcinoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| C-Cell, Adenoma | X X X X| C-Cell, Carcinoma | | Follicular Cell, Adenoma | X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 6| 7| 6| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 8| 4| 4| 0| 3| 6| 9| 3| 6| 3| 3| 3| 3| 1| 2| 2| 3| 6| 8| 2| 3| 3| | 0| 0| 9| 4| 0| 3| 1| 6| 4| 1| 1| 2| 3| 0| 0| 1| 2| 9| 9| 0| 7| 9| 9| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Mesothelioma Malignant | X | Polyp Stromal | X X X| Polyp Stromal, Multiple | X | Schwannoma Malignant | X | Squamous Cell Carcinoma | X | Cervix, Squamous Cell Carcinoma | | |__________________________________________________________________________| Vagina | + | Sarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 6| 7| 6| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 8| 4| 4| 0| 3| 6| 9| 3| 6| 3| 3| 3| 3| 1| 2| 2| 3| 6| 8| 2| 3| 3| | 0| 0| 9| 4| 0| 3| 1| 6| 4| 1| 1| 2| 3| 0| 0| 1| 2| 9| 9| 0| 7| 9| 9| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | Fibroadenoma | X X X X X X X X X X X X X X | Fibroadenoma, Multiple | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X X | Fibrosarcoma | | Neural Crest Tumor | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | Granular Cell Tumor Benign | | Cerebellum, Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | | Mesothelioma Malignant | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 6| 6| 7| 6| 6| 4| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| DAY ON TEST | 3| 3| 2| 8| 4| 4| 0| 3| 6| 9| 3| 6| 3| 3| 3| 3| 1| 2| 2| 3| 6| 8| 2| 3| 3| | 0| 0| 9| 4| 0| 3| 1| 6| 4| 1| 1| 2| 3| 0| 0| 1| 2| 9| 9| 0| 7| 9| 9| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 5| 7| 4| 4| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 2| 7| 9| 2| 3| 3| 3| 2| 6| 3| 4| 9| 2| 5| 2| 3| 2| 3| 3| 0| 3| 1| 2| | | 1| 0| 5| 8| 4| 9| 0| 0| 1| 9| 9| 0| 1| 1| 9| 3| 9| 0| 9| 4| 0| 3| 0| 5| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 300 NG / | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| L | 100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | X X X X | 6 | Cholangiocarcinoma, Multiple | X | 1 | Hepatocellular Adenoma, Multiple | | 2 | Lymphoma Malignant | | 1 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + M + M + + + + M M M M + + + + + M M M| 31 | Fat, Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + | 28 | Gingival, Squamous Cell Carcinoma | X X | 3 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 5| 7| 4| 4| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 2| 7| 9| 2| 3| 3| 3| 2| 6| 3| 4| 9| 2| 5| 2| 3| 2| 3| 3| 0| 3| 1| 2| | | 1| 0| 5| 8| 4| 9| 0| 0| 1| 9| 9| 0| 1| 1| 9| 3| 9| 0| 9| 4| 0| 3| 0| 5| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 300 NG / | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| L | 100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + +| 25 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M M + M + + M + + + + M + + M + M + + + + + +| 41 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | Pars Distalis, Adenoma | X X X X X| 19 | Pars Distalis, Carcinoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 5| 7| 4| 4| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 2| 7| 9| 2| 3| 3| 3| 2| 6| 3| 4| 9| 2| 5| 2| 3| 2| 3| 3| 0| 3| 1| 2| | | 1| 0| 5| 8| 4| 9| 0| 0| 1| 9| 9| 0| 1| 1| 9| 3| 9| 0| 9| 4| 0| 3| 0| 5| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 300 NG / | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| L | 100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | X X| 6 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Oviduct | + | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | Mesothelioma Malignant | | 1 | Polyp Stromal | | 3 | Polyp Stromal, Multiple | | 1 | Schwannoma Malignant | | 1 | Squamous Cell Carcinoma | | 1 | Cervix, Squamous Cell Carcinoma | X | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 5| 7| 4| 4| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 2| 7| 9| 2| 3| 3| 3| 2| 6| 3| 4| 9| 2| 5| 2| 3| 2| 3| 3| 0| 3| 1| 2| | | 1| 0| 5| 8| 4| 9| 0| 0| 1| 9| 9| 0| 1| 1| 9| 3| 9| 0| 9| 4| 0| 3| 0| 5| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 300 NG / | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| L | 100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymph Node | + | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Carcinoma | X | 1 | Fibroadenoma | X X X X X X X | 21 | Fibroadenoma, Multiple | X X X X X X | 8 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroma | | 2 | Fibrosarcoma | X | 1 | Neural Crest Tumor | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 5| 7| 4| 4| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 2| 7| 9| 2| 3| 3| 3| 2| 6| 3| 4| 9| 2| 5| 2| 3| 2| 3| 3| 0| 3| 1| 2| | | 1| 0| 5| 8| 4| 9| 0| 0| 1| 9| 9| 0| 1| 1| 9| 3| 9| 0| 9| 4| 0| 3| 0| 5| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 300 NG / | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| L | 100 UG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Granular Cell Tumor Benign | X | 1 | Cerebellum, Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystic Keratinizing Epithelioma | X | 1 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Vagina | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X X | Cholangiocarcinoma, Multiple | X X | Hepatocellular Adenoma | X X | Hepatocholangioma | | |__________________________________________________________________________| Mesentery | + + + M M + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Acinus, Adenoma | X X | Acinus, Carcinoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Lung | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + M M M M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Granulosa Cell Tumor Benign | X | Lymphoma Malignant | X | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Lymphoma Malignant | X | Polyp Stromal | X X | Schwannoma Malignant | X | Schwannoma Malignant, Metastatic, | | Vagina | | Squamous Cell Carcinoma | | Cervix, Granular Cell Tumor Benign | | Cervix, Squamous Cell Carcinoma | X| |__________________________________________________________________________| Vagina | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Lung | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Fibrosarcoma, Metastatic, Lung | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | | Lymphoma Malignant | X | Squamous Cell Carcinoma | X | Mediastinum, Fibrosarcoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7| DAY ON TEST | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1| | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 300 UG | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | |__________________________________________________________________________| Zymbal's Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephroblastoma | | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Vagina | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + M + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Cholangiocarcinoma, Multiple | X X X | Hepatocellular Adenoma | X X X | Hepatocholangioma | X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + M M + + M + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | | Acinus, Adenoma | X | Acinus, Carcinoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Salivary Glands | + + + M M + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Lung | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + M + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X X| C-Cell, Adenoma | X X X X X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | X | Granulosa Cell Tumor Benign | | Lymphoma Malignant | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| Fibrosarcoma | X | Lymphoma Malignant | | Polyp Stromal | X X X X | Schwannoma Malignant | | Schwannoma Malignant, Metastatic, | | Vagina | X | Squamous Cell Carcinoma | X X| Cervix, Granular Cell Tumor Benign | X | Cervix, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Vagina | + | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M M + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymus | + + + + + + + + + + + + M + + + + + + + + + M + +| Squamous Cell Carcinoma, Metastatic, | | Lung | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Fibrosarcoma, Metastatic, Lung | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + M + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X | Lymphoma Malignant | | Squamous Cell Carcinoma | | Mediastinum, Fibrosarcoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7| DAY ON TEST | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3| | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 300 NG / | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 300 UG | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | |__________________________________________________________________________| Zymbal's Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + M + + + + + + + + + + + + + + +| Nephroblastoma | X | |__________________________________________________________________________| Ureter | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Schwannoma Malignant, Metastatic, | | | Vagina | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | Leiomyoma | | 2 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Liver | + + + | 52 | Cholangiocarcinoma | | 4 | Cholangiocarcinoma, Multiple | | 5 | Hepatocellular Adenoma | | 5 | Hepatocholangioma | | 2 | |__________________________________________________________________________|____________| Mesentery | + + + | 47 | |__________________________________________________________________________|____________| Oral Mucosa | + + | 30 | Gingival, Squamous Cell Carcinoma | X | 5 | |__________________________________________________________________________|____________| Pancreas | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | Acinus, Adenoma | | 3 | Acinus, Carcinoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 52 | |__________________________________________________________________________|____________| Tooth | + + + | 35 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Fibrosarcoma, Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X | 17 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | Bilateral, C-Cell, Adenoma | | 3 | C-Cell, Adenoma | | 12 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | |__________________________________________________________________________|____________| Ovary | + + + | 52 | Granulosa Cell Tumor Malignant | | 1 | Granulosa Cell Tumor Benign | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Oviduct | | 2 | |__________________________________________________________________________|____________| Uterus | + + + | 52 | Fibrosarcoma | | 1 | Lymphoma Malignant | | 1 | Polyp Stromal | | 6 | Schwannoma Malignant | X | 2 | Schwannoma Malignant, Metastatic, | | | Vagina | | 1 | Squamous Cell Carcinoma | | 2 | Cervix, Granular Cell Tumor Benign | | 1 | Cervix, Squamous Cell Carcinoma | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Vagina | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | + + | 7 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 50 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Spleen | + + + | 52 | |__________________________________________________________________________|____________| Thymus | + + + | 50 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Carcinoma | | 1 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X | 25 | Fibroadenoma, Multiple | | 9 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibroma | | 1 | Lipoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Fibrosarcoma, Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 52 | Granular Cell Tumor Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Cystic Keratinizing Epithelioma | | 1 | Lymphoma Malignant | | 1 | Squamous Cell Carcinoma | | 1 | Mediastinum, Fibrosarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 2 | |__________________________________________________________________________|____________| Eye | + + + | 52 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 6| 5| 4| | | DAY ON TEST | 5| 0| 7| | | | 0| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 300 NG / | 9| 9| 9| | L | 300 UG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Zymbal's Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 52 | Nephroblastoma | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 2| 7| 6| 7| 6| 7| 6| 4| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 0| 6| 8| 2| 5| 3| 3| 2| 3| 1| 2| 2| 2| 3| | 3| 1| 0| 0| 1| 3| 0| 6| 0| 2| 9| 2| 2| 8| 9| 8| 1| 0| 9| 1| 4| 9| 9| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3000 UG | 1| 2| 3| 4| 5| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | | Cholangiocarcinoma | X X X X X X| Cholangiocarcinoma, Multiple | X X X X X | Hepatocellular Adenoma | X X X X X X X| Hepatocellular Adenoma, Multiple | X X X X X | Hepatocholangioma | | Hepatocholangioma, Multiple | X | |__________________________________________________________________________| Mesentery | + + + M + + + + + + + + + + + + + M + M + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + | Gingival, Squamous Cell Carcinoma | X X X | |__________________________________________________________________________| Pancreas | M + + + + + M + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | | Acinus, Adenoma | X | Acinus, Carcinoma | X| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 2| 7| 6| 7| 6| 7| 6| 4| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 0| 6| 8| 2| 5| 3| 3| 2| 3| 1| 2| 2| 2| 3| | 3| 1| 0| 0| 1| 3| 0| 6| 0| 2| 9| 2| 2| 8| 9| 8| 1| 0| 9| 1| 4| 9| 9| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3000 UG | 1| 2| 3| 4| 5| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + M + + + + + + + + + + + + M + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | M + + + + + M + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | M + + + + M + + + + + + + M + + + M + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 2| 7| 6| 7| 6| 7| 6| 4| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 0| 6| 8| 2| 5| 3| 3| 2| 3| 1| 2| 2| 2| 3| | 3| 1| 0| 0| 1| 3| 0| 6| 0| 2| 9| 2| 2| 8| 9| 8| 1| 0| 9| 1| 4| 9| 9| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3000 UG | 1| 2| 3| 4| 5| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + M + + + + + + + + + + + + + + + + + +| Luteoma | | |__________________________________________________________________________| Oviduct | + + + | |__________________________________________________________________________| Uterus | + + + + + + M + + + + + + + + + + + + + + + + + +| Carcinoma, Multiple | | Polyp Stromal, Multiple | X | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + | Mediastinal, Carcinoma, Metastatic, | | Uterus | | Mediastinal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | M + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + M + + + + + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 2| 7| 6| 7| 6| 7| 6| 4| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 0| 6| 8| 2| 5| 3| 3| 2| 3| 1| 2| 2| 2| 3| | 3| 1| 0| 0| 1| 3| 0| 6| 0| 2| 9| 2| 2| 8| 9| 8| 1| 0| 9| 1| 4| 9| 9| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3000 UG | 1| 2| 3| 4| 5| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibroadenoma, Multiple | X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Carcinoma, Metastatic, Uterus | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | | Cystic Keratinizing Epithelioma | | Cystic Keratinizing Epithelioma, | | Multiple | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 2| 7| 6| 7| 6| 7| 6| 4| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 0| 6| 8| 2| 5| 3| 3| 2| 3| 1| 2| 2| 2| 3| | 3| 1| 0| 0| 1| 3| 0| 6| 0| 2| 9| 2| 2| 8| 9| 8| 1| 0| 9| 1| 4| 9| 9| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3000 UG | 1| 2| 3| 4| 5| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 4| 6| 4| 7| 7| 4| 5| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 8| 3| 2| 3| 4| 9| 2| 6| 3| 1| 9| 9| 0| 2| 3| 2| 4| 5| 3| 3| 6| 3| 8| 3| 2| | 8| 0| 9| 0| 7| 0| 2| 3| 1| 2| 1| 6| 1| 9| 0| 9| 3| 6| 0| 0| 8| 0| 8| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 3000 UG | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Cholangiocarcinoma | X X X X X X| Cholangiocarcinoma, Multiple | X X X X X X X X | Hepatocellular Adenoma | X X X X X X X| Hepatocellular Adenoma, Multiple | X X | Hepatocholangioma | X | Hepatocholangioma, Multiple | | |__________________________________________________________________________| Mesentery | + M + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Acinus, Adenoma | | Acinus, Carcinoma | | |__________________________________________________________________________| Salivary Glands | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 4| 6| 4| 7| 7| 4| 5| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 8| 3| 2| 3| 4| 9| 2| 6| 3| 1| 9| 9| 0| 2| 3| 2| 4| 5| 3| 3| 6| 3| 8| 3| 2| | 8| 0| 9| 0| 7| 0| 2| 3| 1| 2| 1| 6| 1| 9| 0| 9| 3| 6| 0| 0| 8| 0| 8| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 3000 UG | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + M + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 4| 6| 4| 7| 7| 4| 5| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 8| 3| 2| 3| 4| 9| 2| 6| 3| 1| 9| 9| 0| 2| 3| 2| 4| 5| 3| 3| 6| 3| 8| 3| 2| | 8| 0| 9| 0| 7| 0| 2| 3| 1| 2| 1| 6| 1| 9| 0| 9| 3| 6| 0| 0| 8| 0| 8| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 3000 UG | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Luteoma | X| |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Multiple | X | Polyp Stromal, Multiple | | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | Mediastinal, Carcinoma, Metastatic, | | Uterus | X | Mediastinal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + M + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X X | Fibroadenoma | X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 4| 6| 4| 7| 7| 4| 5| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 8| 3| 2| 3| 4| 9| 2| 6| 3| 1| 9| 9| 0| 2| 3| 2| 4| 5| 3| 3| 6| 3| 8| 3| 2| | 8| 0| 9| 0| 7| 0| 2| 3| 1| 2| 1| 6| 1| 9| 0| 9| 3| 6| 0| 0| 8| 0| 8| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 3000 UG | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibroadenoma, Multiple | X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + | Carcinoma, Metastatic, Uterus | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + M + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Cystic Keratinizing Epithelioma | X | Cystic Keratinizing Epithelioma, | | Multiple | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + M + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 4| 6| 4| 7| 7| 4| 5| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 8| 3| 2| 3| 4| 9| 2| 6| 3| 1| 9| 9| 0| 2| 3| 2| 4| 5| 3| 3| 6| 3| 8| 3| 2| | 8| 0| 9| 0| 7| 0| 2| 3| 1| 2| 1| 6| 1| 9| 0| 9| 3| 6| 0| 0| 8| 0| 8| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 NG / | 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 3000 UG | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | |__________________________________________________________________________| Ureter | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 4| | | DAY ON TEST | 0| | | | 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 5| | A | 300 NG / | 7| | L | 3000 UG | 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + | 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + | 51 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + | 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + | 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + | 51 | Fibrosarcoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + | 50 | |__________________________________________________________________________|____________| Liver | + | 51 | Carcinoma, Metastatic, Uterus | | 1 | Cholangiocarcinoma | | 12 | Cholangiocarcinoma, Multiple | | 13 | Hepatocellular Adenoma | | 14 | Hepatocellular Adenoma, Multiple | | 7 | Hepatocholangioma | | 1 | Hepatocholangioma, Multiple | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 47 | |__________________________________________________________________________|____________| Oral Mucosa | + | 41 | Gingival, Squamous Cell Carcinoma | | 6 | |__________________________________________________________________________|____________| Pancreas | + | 49 | Carcinoma, Metastatic, Uterus | | 1 | Acinus, Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 4| | | DAY ON TEST | 0| | | | 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 5| | A | 300 NG / | 7| | L | 3000 UG | 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Acinus, Carcinoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + | 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + | 51 | |__________________________________________________________________________|____________| Stomach, Glandular | + | 51 | |__________________________________________________________________________|____________| Tooth | + | 42 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 51 | |__________________________________________________________________________|____________| Heart | + | 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + | 51 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + | 49 | Pheochromocytoma Benign | | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + | 49 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + | 43 | |__________________________________________________________________________|____________| Pituitary Gland | + | 51 | Pars Distalis, Adenoma | | 9 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 4| | | DAY ON TEST | 0| | | | 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 5| | A | 300 NG / | 7| | L | 3000 UG | 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Thyroid Gland | + | 50 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | | 7 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + | 50 | |__________________________________________________________________________|____________| Ovary | + | 50 | Luteoma | | 1 | |__________________________________________________________________________|____________| Oviduct | | 3 | |__________________________________________________________________________|____________| Uterus | + | 50 | Carcinoma, Multiple | | 1 | Polyp Stromal, Multiple | | 1 | Schwannoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + | 51 | |__________________________________________________________________________|____________| Lymph Node | | 5 | Mediastinal, Carcinoma, Metastatic, | | | Uterus | | 1 | Mediastinal, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + | 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 4| | | DAY ON TEST | 0| | | | 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 5| | A | 300 NG / | 7| | L | 3000 UG | 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymph Node, Mesenteric | + | 49 | |__________________________________________________________________________|____________| Spleen | + | 49 | |__________________________________________________________________________|____________| Thymus | + | 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 51 | Adenoma | | 1 | Carcinoma | | 4 | Fibroadenoma | | 17 | Fibroadenoma, Multiple | | 12 | |__________________________________________________________________________|____________| Skin | + | 51 | Fibroma | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 51 | |__________________________________________________________________________|____________| Skeletal Muscle | | 3 | Carcinoma, Metastatic, Uterus | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + | 51 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + | 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 96020-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 09:44:38 __________________________________________________________________________________________________________________________________ | 4| | | DAY ON TEST | 0| | | | 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 5| | A | 300 NG / | 7| | L | 3000 UG | 5| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Carcinoma, Metastatic, Uterus | | 1 | Cystic Keratinizing Epithelioma | | 1 | Cystic Keratinizing Epithelioma, | | | Multiple | | 1 | |__________________________________________________________________________|____________| Nose | + | 51 | |__________________________________________________________________________|____________| Trachea | + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 51 | |__________________________________________________________________________|____________| Harderian Gland | + | 51 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + | 51 | Carcinoma, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + | 50 | Carcinoma, Metastatic, Uterus | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + | 51 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------