TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:52:31
FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 NG / 0 UG
Include 004 300 NG /100 UG
Include 005 300 NG /300 UG
Include 006 300 NG /3000 UG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:52:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 98 80 98 80
Early Deaths
Moribund Sacrifice 22 10 19 13
Natural Death 8 12 10 10
Dosing Accident 1 1
Survivors
Terminal Sacrifice 22 28 24 27
Animals Examined Microscopically 53 50 53 51
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ALIMENTARY SYSTEM
Intestine Large, Colon (53) (50) (52) (50)
Intestine Large, Rectum (53) (50) (53) (51)
Schwannoma Malignant, Metastatic, Vagina 1 (2%)
Intestine Small, Duodenum (53) (50) (52) (50)
Leiomyoma 2 (4%)
Intestine Small, Jejunum (53) (50) (52) (51)
Fibrosarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (53) (50) (52) (50)
Liver (53) (50) (52) (51)
Carcinoma, Metastatic, Uterus 1 (2%)
Cholangiocarcinoma 6 (12%) 4 (8%) 12 (24%)
Cholangiocarcinoma, Multiple 1 (2%) 5 (10%) 13 (25%)
Hemangioma 1 (2%)
Hepatocellular Adenoma 5 (10%) 14 (27%)
Hepatocellular Adenoma, Multiple 2 (4%) 7 (14%)
Hepatocholangioma 2 (4%) 1 (2%)
Hepatocholangioma, Multiple 1 (2%)
Mesentery (47) (31) (47) (47)
Oral Mucosa (12) (28) (30) (41)
Gingival, Squamous Cell Carcinoma 3 (11%) 5 (17%) 6 (15%)
Pancreas (53) (49) (52) (49)
Carcinoma, Metastatic, Uterus 1 (2%)
Acinus, Adenoma 3 (6%) 1 (2%)
Acinus, Carcinoma 1 (2%) 1 (2%)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:52:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (53) (50) (53) (50)
Fibrosarcoma, Metastatic, Lung 1 (2%)
Fibrous Histiocytoma, Metastatic, Skeletal
Muscle 1 (2%)
Schwannoma Malignant 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (53) (49) (52) (51)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (52) (49) (52) (49)
Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (53) (49) (52) (49)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (53) (50) (52) (51)
Carcinoma 1 (2%)
Pars Distalis, Adenoma 22 (42%) 19 (38%) 17 (33%) 9 (18%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (53) (49) (52) (50)
Bilateral, C-Cell, Adenoma 2 (4%) 3 (6%) 1 (2%)
C-Cell, Adenoma 8 (15%) 6 (12%) 12 (23%) 7 (14%)
C-Cell, Carcinoma 4 (8%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (53) (49) (53) (50)
Adenoma 1 (2%)
Ovary (53) (48) (52) (50)
Granulosa Cell Tumor Malignant 1 (2%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Luteoma 1 (2%)
Uterus (53) (50) (52) (50)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:52:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Carcinoma 1 (2%)
Carcinoma, Multiple 1 (2%)
Fibrosarcoma 1 (2%)
Polyp Stromal 5 (9%) 3 (6%) 6 (12%)
Polyp Stromal, Multiple 3 (6%) 1 (2%) 1 (2%)
Schwannoma Malignant 1 (2%) 2 (4%) 2 (4%)
Schwannoma Malignant, Metastatic, Vagina 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%) 2 (4%)
Cervix, Granular Cell Tumor Benign 1 (2%)
Cervix, Squamous Cell Carcinoma 1 (2%) 2 (4%)
Vagina (1) (1) (1)
Sarcoma 1 (100%)
Schwannoma Malignant 1 (100%)
Squamous Cell Carcinoma 1 (100%)
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HEMATOPOIETIC SYSTEM
Lymph Node (4) (2) (7) (5)
Mediastinal, Carcinoma, Metastatic, Uterus 1 (20%)
Lymph Node, Mesenteric (53) (49) (52) (49)
Spleen (53) (49) (52) (49)
Thymus (53) (48) (50) (47)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (53) (50) (53) (51)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Carcinoma 6 (11%) 1 (2%) 1 (2%) 4 (8%)
Carcinoma, Multiple 2 (4%) 1 (2%)
Fibroadenoma 27 (51%) 21 (42%) 25 (47%) 17 (33%)
Fibroadenoma, Multiple 13 (25%) 8 (16%) 9 (17%) 12 (24%)
Skin (53) (50) (53) (51)
Fibroma 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Fibrosarcoma 1 (2%)
Lipoma 1 (2%)
Neural Crest Tumor 1 (2%)
Squamous Cell Papilloma 1 (2%)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:52:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (1) (3)
Carcinoma, Metastatic, Uterus 1 (33%)
Fibrosarcoma, Metastatic, Lung 1 (100%)
Fibrous Histiocytoma 1 (100%)
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NERVOUS SYSTEM
Brain (53) (50) (52) (51)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
Granular Cell Tumor Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
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RESPIRATORY SYSTEM
Lung (53) (50) (53) (50)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Uterus 1 (2%)
Cystic Keratinizing Epithelioma 1 (2%) 1 (2%) 1 (2%)
Cystic Keratinizing Epithelioma, Multiple 1 (2%)
Fibrous Histiocytoma, Metastatic, Skeletal
Muscle 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Fibrosarcoma 1 (2%)
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SPECIAL SENSES SYSTEM
Harderian Gland (53) (49) (52) (51)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Zymbal's Gland (1)
Adenoma 1 (100%)
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URINARY SYSTEM
Kidney (53) (48) (52) (51)
Carcinoma, Metastatic, Uterus 1 (2%)
Nephroblastoma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:52:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Urinary Bladder (53) (49) (52) (50)
Carcinoma, Metastatic, Uterus 1 (2%)
Papilloma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(53) *(50) *(53) *(51)
Lymphoma Malignant 1 (2%) 2 (4%) 1 (2%)
Mesothelioma Malignant 1 (2%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 09:52:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 51 44 50 47
Total Primary Neoplasms 110 90 126 122
Total Animals with Benign Neoplasms 49 39 46 40
Total Benign Neoplasms 92 67 93 80
Total Animals with Malignant Neoplasms 14 16 23 35
Total Malignant Neoplasms 18 22 33 42
Total Animals with Metastatic Neoplasms 3 1 3 1
Total Metastatic Neoplasm 4 1 6 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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