TDMS Study 88139-05 Pathology Tables
NTP Experiment-Test: 88139-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:29:54
13 WEEK SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 56-93-9
Lock Date: 05/18/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88139-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10
Early Deaths
Dosing Accident 1
Natural Death 2
Survivors
Terminal Sacrifice 10 10 9 9 8
Accidently Killed 1
Animals Examined Microscopically 10 3 2 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (1) (10)
Inflammation, Focal 5 (50%) 4 (40%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 (100%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Pancreas (10) (1) (10)
Acinus, Atrophy 1 (10%)
Acinus, Degeneration, Focal 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (10) (1) (10)
Inflammation, Focal 5 (50%) 1 (100%) 4 (40%)
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ENDOCRINE SYSTEM
Pituitary Gland (10) (10)
Pars Distalis, Cyst 1 (10%)
Thyroid Gland (10) (1) (10)
Follicle, Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88139-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Uterus (10) (2) (1) (1) (10)
Bilateral, Cyst 2 (100%) 1 (100%)
Bilateral, Dilatation 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (1) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (10) (10)
Congestion 1 (10%)
Inflammation, Focal 3 (30%) 1 (100%) 3 (30%) 6 (60%)
Nose (10) (10)
Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88139-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10
Animals Examined Microscopically 10 2 1 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (2) (10)
Inflammation, Focal 4 (40%) 5 (50%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Inflammation, Focal 8 (80%) 5 (50%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (10)
Cyst 1 (10%) 1 (10%)
Thyroid Gland (10) (10)
Follicle, Cyst 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (1) (10)
Inflammation, Focal, Granulomatous 1 (100%)
Prostate (10) (10)
Infiltration Cellular, Focal, Lymphocyte 1 (10%)
Inflammation 1 (10%)
Testes (10) (1) (10)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88139-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Hematopoietic Cell Proliferation 3 (30%) 4 (40%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10)
Inflammation, Focal 6 (60%) 1 (10%) 5 (50%)
Nose (10) (10)
Inflammation 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (10)
Renal Tubule, Hemorrhage, Focal 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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