TDMS Study 88139-06 Pathology Tables
NTP Experiment-Test: 88139-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:53:58
13 WEEK SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 56-93-9
Lock Date: 05/18/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88139-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:53:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 9
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Inflammation, Chronic, Focal 1 (10%)
Necrosis, Focal 2 (20%) 1 (10%)
Hepatocyte, Centrilobular, Hypertrophy 3 (30%) 3 (30%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Bilateral, Capsule, Hyperplasia, Focal 5 (50%) 5 (50%)
Capsule, Hyperplasia, Focal 1 (10%)
Thyroid Gland (10) (10)
Ultimobranchial Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10)
Hemorrhage 1 (10%)
Uterus (10) (10)
Endometrium, Hyperplasia, Cystic 3 (30%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88139-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:53:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10)
Hemorrhage 1 (10%)
Hyperplasia, Lymphoid 1 (10%)
Lymph Node, Mesenteric (10) (10)
Hyperplasia, Lymphoid 1 (10%)
Spleen (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Interstitium, Inflammation, Chronic 1 (10%) 2 (20%)
Nose (10) (10)
Olfactory Epithelium, Cytoplasmic Alteration 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Urinary Bladder (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88139-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:53:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 9 9
Accidently Killed 1
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Inflammation, Chronic, Focal 1 (10%)
Hepatocyte, Centrilobular, Hypertrophy 3 (30%) 3 (30%)
Salivary Glands (10) (10)
Infiltration Cellular, Focal, Lymphocyte 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Capsule, Hyperplasia, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Prostate (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88139-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZYLTRIMETHYLAMMONIUM CHLORIDE(BTMAC) Date: 05/12/97
Route: GAVAGE Time: 14:53:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 12.5 25.0 50.0 100.0
MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Lymphoid Follicle, Hyperplasia 2 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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