TDMS Study 54591-10 Pathology Tables
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
Facility: BIORELIANCE
Chemical CAS #: 156-60-5
Lock Date: 02/15/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 8 10 10 9 10 9
Accidently Killed 2 1 1
Animals Examined Microscopically 10 10 1 2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (1)
Inflammation, Focal 3 (30%) 3 (30%)
Necrosis 1 (100%)
Stomach, Glandular (10) (10)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Capsule, Hyperplasia 9 (90%) 9 (90%)
Adrenal Medulla (10) (10)
Angiectasis 1 (10%)
Thyroid Gland (10) (10)
Ectopic Tissue 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (7) (9)
Atrophy 4 (57%) 7 (78%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ovary (10) (10) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10)
Hemorrhage 1 (10%) 1 (10%)
Spleen (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Infiltration Cellular, Focal, Lymphocyte 2 (20%) 5 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 50000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10
Early Deaths
Survivors
Terminal Sacrifice 9
Accidently Killed 1
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10)
Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10)
Capsule, Hyperplasia 9 (90%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (6)
Atrophy 3 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10)
Hemorrhage 1 (10%)
Spleen (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 50000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 6 (60%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (9) (10)
Cyst 1 (10%)
Stomach, Glandular (10) (10)
Cyst 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Valve, Pigmentation 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Capsule, Hyperplasia 1 (10%) 1 (10%)
Adrenal Medulla (10) (10)
Angiectasis 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10)
Atrophy 9 (90%) 6 (60%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREAT VEHICLE 3125 PPM 6250 PPM 12500 25000
CONTROL CONTROL PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (9)
Hemorrhage 1 (11%)
Spleen (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 50000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10
Early Deaths
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Stomach, Glandular (10)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10)
Capsule, Hyperplasia 1 (10%)
Adrenal Medulla (10)
Angiectasis 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10)
Atrophy 7 (70%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10)
Hematopoietic Cell Proliferation 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 54591-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY TRANS-1,2-DICHLOROETHYLENE Date: 08/05/02
Route: DOSED FEED Time: 09:54:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 50000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10)
Inflammation, Focal 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------