TDMS Study 54591-10 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: BIORELIANCE TRANS-1,2-DICHLOROETHYLENE DATE: 10/25/04
EXPERIMENT: 54591 TEST: 10 TIME: 11:11:30
TEST TYPE: SUBCHRON 90-DAY PAGE: 1
CONT: NO1-ES-15319 ROUTE: DOSED FEED NTP C#: 54591D
PATHOLOGIST: MISSING CAS: 156-60-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: BIORELIANCE TRANS-1,2-DICHLOROETHYLENE DATE: 10/25/04
EXPERIMENT: 54591 TEST: 10 TIME: 11:11:30
TEST TYPE: SUBCHRON 90-DAY
CONT: NO1-ES-15319 ROUTE: DOSED FEED NTP C#: 54591D
PATHOLOGIST: MISSING CAS: 156-60-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF TRANS-1,2-DICHLOROETHYLENE
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Liver Inflammation Focal
Lung Infiltration Cellular Focal Lymphocyte
Spleen Hematopoietic Cell Proliferation
===============================================================
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Adrenal Cortex: Capsule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/20 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 2/20.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00 |
|POLY-3 PERCENT (g) | 10.0% 0.0% 0.0% 0.0% 0.0% 10.0% |
|TERMINAL (d) | 2/20 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.625 P=1.000N P=1.000N P=1.000N P=1.000N P=0.737 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.734 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.734 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.734 |
|LOGISTIC REGRESSION| P=0.625 (e) (e) (e) (e) P=0.737 |
|COCH-ARM / FISHERS | P=0.627 P=1.000 P=1.000 P=1.000 P=1.000 P=0.719 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Adrenal Cortex: Capsule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 18/20 (90%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 9/10 (90%) |
|POLY-3 RATE (b) | 18/20.00 0/0.00 0/0.00 0/0.00 0/0.00 9/10.00 |
|POLY-3 PERCENT (g) | 90.0% 0.0% 0.0% 0.0% 0.0% 90.0% |
|TERMINAL (d) | 18/20 (90%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 9/10 (90%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.625 P=1.000N P=1.000N P=1.000N P=1.000N P=0.737 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.734 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.734 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.734 |
|LOGISTIC REGRESSION| P=0.625 (e) (e) (e) (e) P=0.737 |
|COCH-ARM / FISHERS | P=0.627 P=1.000 P=1.000 P=1.000 P=1.000 P=0.719N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/20 (15%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 3/20.00 0/0.00 0/0.00 0/0.00 0/0.00 2/10.00 |
|POLY-3 PERCENT (g) | 15.0% 0.0% 0.0% 0.0% 0.0% 20.0% |
|TERMINAL (d) | 3/20 (15%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.466 P=1.000N P=1.000N P=1.000N P=1.000N P=0.568 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.567 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.567 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.567 |
|LOGISTIC REGRESSION| P=0.466 (e) (e) (e) (e) P=0.568 |
|COCH-ARM / FISHERS | P=0.465 P=1.000 P=1.000 P=1.000 P=1.000 P=0.551 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/20 (5%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 1/20.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00 |
|POLY-3 PERCENT (g) | 5.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/20 (5%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.430N P=1.000N P=1.000N P=1.000N P=1.000N P=0.638N |
|POLY 3 | (e) (e) (e) (e) (e) P=0.637N |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.637N |
|POLY 6 | (e) (e) (e) (e) (e) P=0.637N |
|LOGISTIC REGRESSION| P=0.430N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.429N P=1.000 P=1.000 P=1.000 P=1.000 P=0.667N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/16 (69%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/6 (50%) |
|POLY-3 RATE (b) | 11/16.00 0/0.00 0/0.00 0/0.00 0/0.00 3/6.00 |
|POLY-3 PERCENT (g) | 68.8% 0.0% 0.0% 0.0% 0.0% 50.0% |
|TERMINAL (d) | 11/16 (69%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/6 (50%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.290N P=1.000N P=1.000N P=1.000 P=1.000N P=0.379N |
|POLY 3 | (e) (e) (e) (e) (e) P=0.380N |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.380N |
|POLY 6 | (e) (e) (e) (e) (e) P=0.380N |
|LOGISTIC REGRESSION| P=0.290N (e) (e) (e) (e) P=0.379N |
|COCH-ARM / FISHERS | P=0.286N P=1.000 P=1.000 P=1.000 P=1.000 P=0.369N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/20 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/20.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/20 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/20 (30%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 6/20.00 0/0.00 0/0.00 0/1.00 0/0.00 0/10.00 |
|POLY-3 PERCENT (g) | 30.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 6/20 (30%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.047N* P=1.000N P=1.000N P=0.682N P=1.000N P=0.077N |
|POLY 3 | (e) (e) (e) P=0.680N (e) P=0.067N |
|POLY 1.5 | (e) (e) (e) P=0.680N (e) P=0.067N |
|POLY 6 | (e) (e) (e) P=0.680N (e) P=0.067N |
|LOGISTIC REGRESSION| P=0.047N* (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.045N* P=1.000 P=1.000 P=0.714N P=1.000 P=0.065N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Focal Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/20 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/20.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/20 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Focal Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/20 (35%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 7/20.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00 |
|POLY-3 PERCENT (g) | 35.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 7/20 (35%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.030N* P=1.000N P=1.000N P=1.000N P=1.000N P=0.049N* |
|POLY 3 | (e) (e) (e) (e) (e) P=0.039N* |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.039N* |
|POLY 6 | (e) (e) (e) (e) (e) P=0.039N* |
|LOGISTIC REGRESSION| P=0.030N* (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.028N* P=1.000 P=1.000 P=1.000 P=1.000 P=0.038N* |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Preputial Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/20 (75%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 7/10 (70%) |
|POLY-3 RATE (b) | 15/20.00 0/0.00 0/0.00 0/0.00 0/0.00 7/10.00 |
|POLY-3 PERCENT (g) | 75.0% 0.0% 0.0% 0.0% 0.0% 70.0% |
|TERMINAL (d) | 15/20 (75%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 7/10 (70%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.471N P=1.000N P=1.000N P=1.000N P=1.000N P=0.557N |
|POLY 3 | (e) (e) (e) (e) (e) P=0.556N |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.556N |
|POLY 6 | (e) (e) (e) (e) (e) P=0.556N |
|LOGISTIC REGRESSION| P=0.471N (e) (e) (e) (e) P=0.557N |
|COCH-ARM / FISHERS | P=0.471N P=1.000 P=1.000 P=1.000 P=1.000 P=0.548N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Preputial Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/20 (5%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 1/20.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00 |
|POLY-3 PERCENT (g) | 5.0% 0.0% 0.0% 0.0% 0.0% 10.0% |
|TERMINAL (d) | 1/20 (5%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.449 P=1.000N P=1.000N P=1.000N P=1.000N P=0.600 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.599 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.599 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.599 |
|LOGISTIC REGRESSION| P=0.449 (e) (e) (e) (e) P=0.600 |
|COCH-ARM / FISHERS | P=0.449 P=1.000 P=1.000 P=1.000 P=1.000 P=0.563 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/20 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 6/10 (60%) |
|POLY-3 RATE (b) | 4/20.00 0/0.00 0/0.00 0/0.00 0/0.00 6/10.00 |
|POLY-3 PERCENT (g) | 20.0% 0.0% 0.0% 0.0% 0.0% 60.0% |
|TERMINAL (d) | 4/20 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 6/10 (60%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.025 * P=1.000N P=1.000N P=1.000N P=1.000N P=0.040 * |
|POLY 3 | (e) (e) (e) (e) (e) P=0.030 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.030 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.030 * |
|LOGISTIC REGRESSION| P=0.025 * (e) (e) (e) (e) P=0.040 * |
|COCH-ARM / FISHERS | P=0.024 * P=1.000 P=1.000 P=1.000 P=1.000 P=0.039 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 54591 TEST: 10 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - TRANS-1,2-DICHLOROETHYLENE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/20 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 2/20.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00 |
|POLY-3 PERCENT (g) | 10.0% 0.0% 0.0% 0.0% 0.0% 10.0% |
|TERMINAL (d) | 2/20 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.625 P=1.000N P=1.000N P=1.000N P=1.000N P=0.737 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.734 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.734 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.734 |
|LOGISTIC REGRESSION| P=0.625 (e) (e) (e) (e) P=0.737 |
|COCH-ARM / FISHERS | P=0.627 P=1.000 P=1.000 P=1.000 P=1.000 P=0.719 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | UNTREAT 3125 PPM 6250 PPM 12500 25000 50000 |
| | CONTROL PPM PPM PPM |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/20 (5%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 1/20.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00 |
|POLY-3 PERCENT (g) | 5.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/20 (5%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.430N P=1.000N P=1.000N P=1.000N P=1.000N P=0.638N |
|POLY 3 | (e) (e) (e) (e) (e) P=0.637N |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.637N |
|POLY 6 | (e) (e) (e) (e) (e) P=0.637N |
|LOGISTIC REGRESSION| P=0.430N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.429N P=1.000 P=1.000 P=1.000 P=1.000 P=0.667N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).