TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 12:43:04 14 WEEK SSAC FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 12/16/98 - 12/17/98 Treatment Groups: Include 001 0 NG / 0 UG Include 002 10 NG / 10 UG Include 003 100 NG /100 UG Include 005 300 NG /300 UG Include 007 1000 NG/1000 UG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 12:43:04 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ 0 UG 10 UG 100 UG 300 UG 1000 UG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 86 98 98 98 Scheduled Sacrifice 16 10 16 16 16 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) Fatty Change, Diffuse 1 (10%) 6 (60%) Inflammation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) Mixed Cell Focus 1 (10%) 1 (10%) 1 (10%) Necrosis 1 (10%) Pigmentation 4 (40%) 5 (50%) 8 (80%) Hepatocyte, Hypertrophy 4 (40%) 3 (30%) 6 (60%) 10 (100%) Hepatocyte, Multinucleated 7 (70%) Pancreas (10) (10) (10) (10) (10) Basophilic Focus 2 (20%) Acinus, Atrophy 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) (10) Hypertrophy 1 (10%) 1 (10%) 1 (10%) Thyroid Gland (10) (10) (10) (10) (10) Follicular Cell, Hypertrophy 3 (30%) 3 (30%) 4 (40%) 8 (80%) 9 (90%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 12:43:04 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ 0 UG 10 UG 100 UG 300 UG 1000 UG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) (10) (10) (10) Atrophy 4 (40%) 2 (20%) 4 (40%) 3 (30%) 3 (30%) Uterus (10) (10) (10) (10) (10) Metaplasia, Squamous 2 (20%) 1 (10%) 3 (30%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (10) Pigmentation 10 (100%) Thymus (10) (10) (10) (10) (10) Atrophy 4 (40%) 1 (10%) 1 (10%) 5 (50%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) (10) Hemorrhage 1 (10%) Inflammation 1 (10%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 12:43:04 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ 0 UG 10 UG 100 UG 300 UG 1000 UG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------