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https://ntp.niehs.nih.gov/go/17240

TDMS Study 96022-02 Pathology Tables

NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04
Route: GAVAGE                                                                                                     Time: 14:29:22

                                                         FINAL #1 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFPCBMIX

       Lock Date:  11/04/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1


NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|             
                                           | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    0 UG                                   | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                            1                                             |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                            X         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X              X     X                 X     X     X     X         |             
      Basophilic Focus, Multiple           |    X        X  X  X           X                                      X   |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |       X                                                                  |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                         X     X                                          |             
      Eosinophilic Focus, Multiple         |          X     X                                                     X   |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |    2                    1                 1  1                 2        2|             
      Hematopoietic Cell Proliferation     | 1  1        1     1  1              1  1  1     1              1  1  1  1|             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Inflammation                         | 1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  2  1|             
      Mixed Cell Focus                     |                                        X                          X      |             
      Mixed Cell Focus, Multiple           | X     X  X  X  X  X  X  X     X           X  X     X  X  X     X     X   |             
      Necrosis                             |                                                             1           1|             
      Pigmentation                         |       1                          1                          1            |             
      Bile Duct, Cyst                      |       3                          3        1                              |             
      Bile Duct, Fibrosis                  |                                        1  1              2              2|             
      Bile Duct, Hyperplasia               |                                                    1     1               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|             
                                           | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    0 UG                                   | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Centrilobular, Degeneration          |                                                             2            |             
      Oval Cell, Hyperplasia               |          1                                            1                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |                               1  1     1  1              1              2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               1                                          |             
      Acinus, Atrophy                      |       1                                                                  |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Acinus, Hyperplasia                  | 2                                                                 1      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |          1           2                 1                                 |             
      Inflammation                         |                                        3                                 |             
      Ulcer                                |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                1  2                             1        1     1  1      |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                   +  +  +  +  +  +     +  +        +     +              +|             
      Peridontal Tissue, Inflammation      |                   1  1  1  1  2  1     2  1        1     2              2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1           1              1        1     1           2  1  1   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                              1                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|             
                                           | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    0 UG                                   | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Epicardium, Inflammation             |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2  1  2  1  2  2  2  1  1     2  2  1  2  3  2  2  2  1  2  1  2  1|             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |    2        2           2        2              3        2     2         |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hyperplasia                          | 2           2                          2     2        2        2  2  2  2|             
      Hypertrophy                          | 2     2  2  2  2  2  3  3  1  2  2  1  2  1     3  2  2  2  1  3  1  2  1|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                            1     3     1     1     1        1  2        2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  3     1        3  1     1     2     3     1                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2     2     2        2  2  3  3     2  2  2     2  2     2     1      |             
      Cyst                                 |                                                                   2      |             
      Vacuolization Cytoplasmic            |                                                                      2   |             
      Pars Distalis, Hyperplasia           | 3     3                                            3        3  1         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               1                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hypertrophy         | 1  1        2        1     1        1  2     1           1     1        2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|             
                                           | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    0 UG                                   | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation                         | 2  1  1  2  3  2  3  1  1  3  3  1  2  3  2  2     2  2     2  3  1  1  3|             
      Duct, Cyst                           |    1  3  2  3     3        2  3  3     3  3  2     2     2  2        2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3     3  3  4|             
      Cyst                                 |       2     2        2  3                    2  2  2  2        3  2      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                   1      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |          1                                                               |             
      Metaplasia, Squamous                 | 2     1  2           1  2                 1           2     1     2  2   |             
      Endometrium, Hyperplasia, Cystic     | 2     2  3  3  3     3  2  2  1  1  3  2  2           2  4  1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3     2  2  2  3  2           3  3  4        4           3  2  4     4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  M  M  M  M  +  M  +  M  M  M  M  M  M  +  M  +  +  +  +|             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                                                          |             
      Lumbar, Hemorrhage                   |             2                                                            |             
      Mediastinal, Ectasia                 |    1     1  2                 1                                          |             
      Mediastinal, Hemorrhage              |    1                                                                    2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                          3     3         |             
      Hyperplasia, Plasma Cell             | 2  2  2  2  3  2  2     2  2  2     2  2  3  2  2  2  3  2        2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                           2                              |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  3  2  2  2  1  1  2     3  2  2  2  3  1  2  2     2  3  2  4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|             
                                           | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    0 UG                                   | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pigmentation                         | 1  1  2  1  1  1  1  1  2  2  3  3  1  1  1  2  1  2  1  1  2  2  1  2  1|             
      Capsule, Fibrosis                    |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                  2                          3            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  4  2  2  3     4  2        4  2  4           3  4     4  2  3  3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    2  2           1  2     1     2     1     1     2  1  1  1  2  2  1   |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  2  1  2     2  2     2        1  2     2        1  2  1  2  2  2  2|             
      Inflammation                         |                                                    1        4            |             
      Alveolar Epithelium, Hyperplasia     |                      1  3              1     1           1     1  1  1   |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                      1                                                   |             
      Serosa, Fibrosis                     |                                        1  1                              |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     1        1  1                    1           1        1            |             
      Respiratory Epithelium, Hyperplasia  | 2     2           2                                2        2            |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|             
                             DAY ON TEST   | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|             
                                           | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    0 UG                                   | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                   3      |             
      Iris, Inflammation                   |                                                                   2      |             
      Retina, Atrophy                      |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1        1  1     1           1     1           1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |    X  X                 X                                            X   |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                  3                                       |             
      Mineralization                       | 2  1     1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1|             
      Nephropathy                          |          1     1     3  1  1  1  2     1     2     1  1  1  1  1  2  1   |             
      Pelvis, Inflammation                 | 2                                3                                       |             
      Renal Tubule, Hyperplasia            |       2                          1                                       |             
      Transitional Epithelium, Hyperplasia | 2                                3                                       |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                  +                                       |             
      Transitional Epithelium, Hyperplasia |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                  X                                       |             
      Edema                                |                                                                          |             
      Inflammation                         | 2           2                    2                                       |             
      Transitional Epithelium, Hyperplasia | 2                                3                                       |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|             
                                           | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|             
    0 UG                                   | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             | 3                                                                       2|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X     X        X              X        X               |             
      Basophilic Focus, Multiple           |             X                 X     X        X        X     X  X         |             
      Cholangiofibrosis                    |                                                             3            |             
      Clear Cell Focus                     | X        X                                      X                        |             
      Clear Cell Focus, Multiple           |                                  X                                       |             
      Eosinophilic Focus                   |                   X              X                                       |             
      Eosinophilic Focus, Multiple         |                         X           X                                    |             
      Fatty Change, Diffuse                |    1                                      2  1                           |             
      Fatty Change, Focal                  |       1           1                 1           1                        |             
      Hematopoietic Cell Proliferation     | 1           1  2  2     1        2  1     1        1        1     2  1   |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Inflammation                         | 1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1|             
      Mixed Cell Focus                     |       X                                            X                     |             
      Mixed Cell Focus, Multiple           | X  X     X  X  X  X     X     X  X  X        X  X     X  X  X  X        X|             
      Necrosis                             |                      2                                                   |             
      Pigmentation                         |                         1                       1                        |             
      Bile Duct, Cyst                      |                                                                2         |             
      Bile Duct, Fibrosis                  |    2                                            2                        |             
      Bile Duct, Hyperplasia               |                               1              1                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|             
                                           | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|             
    0 UG                                   | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Centrilobular, Degeneration          |                      3                                                   |             
      Oval Cell, Hyperplasia               |                               1                                1         |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fat, Necrosis                        |                3                                                         |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |                1     1              1           1        1               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia, Focal           |       2                                                                  |             
      Acinus, Hyperplasia                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                              2                           |             
      Inflammation                         |                                              3                           |             
      Ulcer                                |                                              2                           |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   2  2  2        1              1                    1   |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +  +  +  +     +  +  +     +  +  +     +  +              +|             
      Peridontal Tissue, Inflammation      | 1  1  1  2     2  1  2  1     2  1  2     1  2  3     2  1              2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2     1  1  1     1     1     1  2                                 |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|             
                                           | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|             
    0 UG                                   | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Epicardium, Inflammation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3  1  2  2  1  1  1           2  2  1  1  1  1  1  2  2  2  1  1        1|             
      Atrophy                              |                      3                                   3               |             
      Degeneration, Cystic                 |    2              1                                3     2               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2                 2        2           2                                 |             
      Hypertrophy                          | 3  3  3  3  2  1  2           1  2  2  2  2  2  2  3  2  2  2  1  1      |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 2  2  2     1     2              2                                       |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           1     2              1         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3     3  1  3  2  2        2                       2                  |             
      Cyst                                 |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                2         |             
      Pars Distalis, Hyperplasia           | 3                                2  2                    2  3            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2                       2  1  2  1                    1         |             
      Follicle, Cyst                       | 3                                                                        |             
      Follicular Cell, Hypertrophy         |             1           1     1  1  1        2           1        1  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|             
                                           | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|             
    0 UG                                   | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation                         | 3     2  2  2  2  2  1  1  2  1  1  1  1  2  1  3     1  2  2  1  1  2  2|             
      Duct, Cyst                           |    3  2  3  2  2  2  2  2  1  1  2  3  1  2  3  3        2  2  2     3  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  3  3  3  3  3  3     3  3     3  3  3     3  3  3  3  3  3  3     3|             
      Cyst                                 | 3  2     2  2                 2     2  2                    2        2   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             1                                                            |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic Active         |                            1                                1            |             
      Inflammation, Suppurative            |                                     2        1                           |             
      Metaplasia, Squamous                 |          2  1  2  1           2     4  1  1     2     1     4  1         |             
      Endometrium, Hyperplasia, Cystic     | 3  1     2  1  1           4  2        2  1     3  3  2  1     2  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     3  2  2  2  3  3  3  3  3  3  2     3        3  2        3  4  4  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | M  M  +  +  +  M  M  +  M  +  M  +  M  +  M  M  +  +  +  M  +  M  +  +  M|             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Mediastinal, Ectasia                 |       2                                               1           1      |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                           2                              |             
      Hyperplasia, Plasma Cell             | 2  2  2  2  2  2  2     3  2  2  2     2  3  3  2  2  3  2  2  2  2  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Histiocytic             |                2     2                                                   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  2  2  2     3  2  3  2  2  3  2     3  1  2  2  2  2  2  1  3  4  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|             
                                           | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|             
    0 UG                                   | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pigmentation                         | 1  2  2  2  2  2  1  1  1  2  2  1  2  3  1  2  2     2  2  2  2  1  1  2|             
      Capsule, Fibrosis                    |             3                                                            |             
      Lymphoid Follicle, Atrophy           |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2     2  1  1  2  4  3     2  2  3  2  3  3  2  2  3  2  4     2  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           3                              |             
      Hyperplasia                          |    1  2     1           2        2  1        4     1           1     1  1|             
      Inflammation, Granulomatous          |                2  3                    2                                 |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    2  1  1  1     1  2  1  2  2  2  2     2  1  1  2  2  2  2  1        2|             
      Inflammation                         |                1                                            1           1|             
      Alveolar Epithelium, Hyperplasia     |                               1  2  1     1     1  1        1  1        1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                                                                          |             
      Serosa, Fibrosis                     |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1           1                    1  1  1  1        1  1           1      |             
      Respiratory Epithelium, Hyperplasia  | 1           1                                         1                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|             
                                           | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|             
    0 UG                                   | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Iris, Inflammation                   |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1     1  1              1  1              1  1  1  1  1        2  1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |    X                 X                                                   |             
      Infarct                              | 3           4                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    1  1  1  1  1  1  2  1  1  1  1     1  1  1  1  1  1  1  1  1     1  1|             
      Nephropathy                          | 1  1  1  1  1  1  1     1  1  1     1  1  1  1  1  1     1  1  1  1  1  1|             
      Pelvis, Inflammation                 | 3           3                                                            |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia | 2                                            2                           |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Edema                                |    3                                                                     |             
      Inflammation                         | 2  2                       2                                             |             
      Transitional Epithelium, Hyperplasia |    2                                                                     |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7|                                                                 |            |
                             DAY ON TEST   | 2| 8| 2|                                                                 |            |
                                           | 8| 7| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Basophilic Focus                     | X                                                                        |     14     |
      Basophilic Focus, Multiple           |                                                                          |     13     |
      Cholangiofibrosis                    |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      4     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   |       X                                                                  |      5     |
      Eosinophilic Focus, Multiple         |                                                                          |      5     |
      Fatty Change, Diffuse                |                                                                          |      3  1.3|
      Fatty Change, Focal                  |                                                                          |     10  1.3|
      Hematopoietic Cell Proliferation     |    1  1                                                                  |     27  1.1|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation                         | 1  1  1                                                                  |     49  1.0|
      Mixed Cell Focus                     |    X                                                                     |      5     |
      Mixed Cell Focus, Multiple           |                                                                          |     33     |
      Necrosis                             |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7|                                                                 |            |
                             DAY ON TEST   | 2| 8| 2|                                                                 |            |
                                           | 8| 7| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         |                                                                          |      5  1.0|
      Bile Duct, Cyst                      |                                                                          |      4  2.3|
      Bile Duct, Fibrosis                  |                                                                          |      6  1.7|
      Bile Duct, Hyperplasia               |    1                                                                     |      5  1.0|
      Centrilobular, Degeneration          |                                                                          |      2  2.5|
      Oval Cell, Hyperplasia               |                                                                          |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +                                                                  |  53        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     11  1.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      4  1.5|
      Inflammation                         |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |     12  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |  29        |
      Peridontal Tissue, Inflammation      |    4                                                                     |     29  1.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7|                                                                 |            |
                             DAY ON TEST   | 2| 8| 2|                                                                 |            |
                                           | 8| 7| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1  1  1                                                                  |     20  1.2|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  1.0|
      Epicardium, Inflammation             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     42  1.6|
      Atrophy                              |                                                                          |      2  3.0|
      Degeneration, Cystic                 |       3                                                                  |     12  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |     13  2.0|
      Hypertrophy                          |    1  3                                                                  |     45  2.0|
      Necrosis                             | 4                                                                        |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |     14  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |       2                                                                  |     13  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |       3                                                                  |     23  2.2|
      Cyst                                 |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia           |    1                                                                     |     11  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7|                                                                 |            |
                             DAY ON TEST   | 2| 8| 2|                                                                 |            |
                                           | 8| 7| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |                                                                          |      7  1.4|
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hypertrophy         |    2                                                                     |     22  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 2  2  3                                                                  |     49  1.9|
      Duct, Cyst                           | 2  1  2                                                                  |     40  2.2|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 3  3  3                                                                  |     46  3.0|
      Cyst                                 |                                                                          |     19  2.2|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  1.0|
      Hyperplasia, Cystic                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Inflammation, Suppurative            |       2                                                                  |      4  1.5|
      Metaplasia, Squamous                 | 1                                                                        |     23  1.7|
      Endometrium, Hyperplasia, Cystic     |       1                                                                  |     32  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2  4  4                                                                  |     37  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +                                                                  |  28        |
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7|                                                                 |            |
                             DAY ON TEST   | 2| 8| 2|                                                                 |            |
                                           | 8| 7| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
          Cell                             |    3                                                                     |      1  3.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      7  1.3|
      Mediastinal, Hemorrhage              |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      3  2.7|
      Hyperplasia, Plasma Cell             | 2  4  3                                                                  |     45  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  3  4                                                                  |     49  2.2|
      Pigmentation                         | 2  2  1                                                                  |     52  1.6|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
      Lymphoid Follicle, Atrophy           | 3                                                                        |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
      Atrophy                              | 4     2                                                                  |     40  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |     26  1.5|
      Inflammation, Granulomatous          |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7|                                                                 |            |
                             DAY ON TEST   | 2| 8| 2|                                                                 |            |
                                           | 8| 7| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2  1  3                                                                  |     40  1.7|
      Inflammation                         |                                                                          |      5  1.6|
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |     18  1.2|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |                                                                          |      1  1.0|
      Serosa, Fibrosis                     |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |       4                                                                  |     17  1.2|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      8  1.6|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Cataract                             |                                                                          |      1  3.0|
      Iris, Inflammation                   |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |    3                                                                     |     24  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7|                                                                 |            |
                             DAY ON TEST   | 2| 8| 2|                                                                 |            |
                                           | 8| 7| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      6     |
      Infarct                              |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |    1                                                                     |     46  1.0|
      Nephropathy                          | 1  1  1                                                                  |     41  1.1|
      Pelvis, Inflammation                 |                                                                          |      4  2.8|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Calculus Gross Observation           |                                                                          |      1     |
      Edema                                |                                                                          |      1  3.0|
      Inflammation                         |    2  1                                                                  |      8  1.9|
      Transitional Epithelium, Hyperplasia |    2                                                                     |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|             
                                           | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
    10 UG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                         X                        |             
      Artery, Inflammation, Chronic Active |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Basophilic Focus                     |       X  X                                               X  X     X      |             
      Basophilic Focus, Multiple           |                            X              X                    X         |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |          X                                                               |             
      Eosinophilic Focus                   |                                                    X                     |             
      Eosinophilic Focus, Multiple         |       X  X  X  X  X     X              X  X              X     X         |             
      Fatty Change, Diffuse                |       1  1  1                                      1  1     1     1  1  1|             
      Fatty Change, Focal                  |                1              1        1                       2         |             
      Hematopoietic Cell Proliferation     | 1        1  1  1  1  1     1     1     1  1  1           2     1         |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1  2  1  2  1  1  2  1  1  1  1  1  1     1  1|             
      Mixed Cell Focus                     |                                                                   X  X   |             
      Mixed Cell Focus, Multiple           |       X  X  X  X  X     X        X     X           X        X  X        X|             
      Necrosis                             |                            1  2     2        3           2     2     2   |             
      Pigmentation                         |    1     2                    1     2     1              1  2  1     1  2|             
      Toxic Hepatopathy                    |          2        1                                         1  1         |             
      Artery, Inflammation                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|             
                                           | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
    10 UG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      | 3                 3                       3                              |             
      Bile Duct, Fibrosis                  |          1                                                               |             
      Bile Duct, Hyperplasia               |          2        1                                                      |             
      Centrilobular, Degeneration          |                                        1     2                           |             
      Hepatocyte, Hypertrophy              | 1              1                 1     1  1  1           1  2     1      |             
      Hepatocyte, Multinucleated           |          1                                                  2  2        2|             
      Oval Cell, Hyperplasia               |          1        1                                                      |             
      Serosa, Inflammation                 | 3                                                                    2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  M  +  +  M  +  +  +  +  M  +  +  M  +  M  M  +  M  +  M  M  +  +  M|             
      Inflammation                         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1              1     1                                         3  1      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3                                2                                       |             
      Lipomatosis                          |                      2                                                   |             
      Acinus, Atrophy                      | 2                                3                                       |             
      Acinus, Vacuolization Cytoplasmic    |                                  1                                       |             
      Artery, Inflammation, Chronic Active |                      3                             3                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                     2                                    |             
      Hyperplasia, Squamous                |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |             1                                                     2      |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +        +  +  +        +  +  +  +  +                 +  +  +  +  +|             
      Peridontal Tissue, Inflammation      | 1     1        1  1  1        1  1  4  1  2                 1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|             
                                           | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
    10 UG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1     1     1        1              1     1  1           1         |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                      2                                                   |             
      Epicardium, Inflammation             |    2                                                                     |             
      Pericardium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  1  1  1  1  1  2  2  2     1     1  1     1     1     2  2  2     1|             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |             2        2              3           2  2           2        3|             
      Hyperplasia                          |                2        2        2        2  2                 2         |             
      Hypertrophy                          | 1  2  2  2  4  2  2  3     1  3  1  3  2  1     2  2     2  2  3        3|             
      Vacuolization Cytoplasmic            |                1     2  1  2        3     2        2     1           1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                       3                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2        2     3                 2     1        2      |             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                      1                                                   |             
      Pars Distalis, Hyperplasia           | 2                    4  1  3                             3  3        2  2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2           2     3           3        2        3               |             
      Follicular Cell, Hypertrophy         | 1  2  2  1  1     1  1     1     2  1  2  1  2     1  2  1  1     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|             
                                           | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
    10 UG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2  1  3  1  2  2  2  2  1     2     2  2  1  2  2     1     1  2  1  2|             
      Duct, Cyst                           | 2  1  2  3  2  3     2  2        3  2     2  1  1  3  3     1  3  1     3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     3     3     3  3  3  3     3  3     3     3  3  3  3  3     4  3  3|             
      Cyst                                 |       2           2        3     2  2                    2  2            |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                           3                              |             
      Inflammation, Chronic Active         |                      1                                                   |             
      Inflammation, Suppurative            |                                                                      4   |             
      Metaplasia, Squamous                 | 1     1              2  2                 2     1  4        2           2|             
      Endometrium, Hyperplasia, Cystic     |       1     3     2  4  2        1        2     1           2     2  4  1|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     3  2  2  3  4  2     3  2  2  3  3  3  3  2  2  3  4  3  2     2   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  M  M  M  +  M  M  M  M  +  M  M  +  M  M  M  +  +  +  +  M  +  M  +  M|             
      Lumbar, Ectasia                      |                                                    3                     |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Ectasia                 | 2           1                       1                 2        2         |             
      Mediastinal, Hemorrhage              |                                     2                                    |             
      Mediastinal, Hyperplasia, Plasma Cell| 2                                   2                          2         |             
      Renal, Ectasia                       |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                    2                                    |             
      Hyperplasia, Lymphoid                |          3                                                               |             
      Hyperplasia, Plasma Cell             |       2     2     2  2  2  2  2  2  2     2  2     3     2     2        2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|             
                                           | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
    10 UG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    3                     |             
      Hemorrhage                           |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3     2  2  2  3  2  2  2  3  3  2     2  2  3     2     4  1  3  1  3  1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  2  3  1  1  1  3  1  1  1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |                               2                 2     2              2   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     3  3     3  3  3  3  2  4  2  4  2  4  3  2  2  1  4     2     4  2|             
      Artery, Inflammation, Chronic Active |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 3                    2   |             
      Hyperplasia                          |    1     2     1              1  2  1  2  1  1                 1         |             
      Inflammation, Granulomatous          | 2                                               2                        |             
      Inflammation                         |                                                                3         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|             
                                           | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
    10 UG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |       2  2     2  1  2  2  2  2  2     1  2     2  1     2  3  1  2  1   |             
      Inflammation                         |       1  1  1        1                                         2         |             
      Metaplasia, Squamous                 |                                                    1                     |             
      Alveolar Epithelium, Hyperplasia     |       1  1           2  2                          1        1            |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |          2     1  1        2  1  1                 1     1        2      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2  2  2  2        2        2  1                 1  1        1   |             
      Olfactory Epithelium, Metaplasia     |                   2                 2                                    |             
      Respiratory Epithelium, Hyperplasia  |          2  2  2  2        2        3  2                 1  2            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    2                 3                                                   |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1  1  2           1        3           1           1            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |          X  X           X                                                |             
      Cyst                                 |                                                    2                     |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1  1     1  1  1        1  1  1     2        1  1  2  1|             
      Nephropathy                          |    1     2  1  1  1  2  1  1  1  1  2  1  1  1  1  4     1  1  1  1     1|             
      Pelvis, Inflammation                 |                            2              2                 1            |             
      Transitional Epithelium, Hyperplasia |                            2              1                 2            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            2              1                 1            |             
      Transitional Epithelium, Hyperplasia |                            2              1                              |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|             
                             DAY ON TEST   | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|             
                                           | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    10 UG                                  | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                         3                                                |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                  X                 X                     |             
      Basophilic Focus, Multiple           |       X  X                                      X              X        X|             
      Cholangiofibrosis                    |       1                                                     1            |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |             X              X     X                             X         |             
      Eosinophilic Focus, Multiple         |    X  X  X                          X     X                       X      |             
      Fatty Change, Diffuse                |             1                       1  1        1     1                  |             
      Fatty Change, Focal                  |       2              1        2        1                    2           1|             
      Hematopoietic Cell Proliferation     |    1  1  1  1                 1  1        1  1  1  1        1        1  1|             
      Hepatodiaphragmatic Nodule           |                                                    X                     |             
      Inflammation                         | 1  1  1  1  1  1  1  1  1     1  1  1  1  2  2     1  1  1     1  2  3  1|             
      Mixed Cell Focus                     |    X                          X                                      X   |             
      Mixed Cell Focus, Multiple           |                X     X  X           X  X     X  X  X  X     X           X|             
      Necrosis                             |             2                    2        3                       3  2   |             
      Pigmentation                         |             1        1  1              1     1  2           2        3   |             
      Toxic Hepatopathy                    |             1                                   1           1        1   |             
      Artery, Inflammation                 |                         1                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|             
                             DAY ON TEST   | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|             
                                           | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    10 UG                                  | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Fibrosis                  |                         1                                                |             
      Bile Duct, Hyperplasia               |                                     1              1        1            |             
      Centrilobular, Degeneration          |             3                                                            |             
      Hepatocyte, Hypertrophy              |       1  1     1           1  1           1                             1|             
      Hepatocyte, Multinucleated           |             1                          1        1           1        1   |             
      Oval Cell, Hyperplasia               | 1                                                           1            |             
      Serosa, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +|             
      Inflammation                         |                                                                      3   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |             1                    1  1        1           1               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2        1                          1                        |             
      Lipomatosis                          |                                                                          |             
      Acinus, Atrophy                      |             2        1                          1                        |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |    1                    1              2     1                           |             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +     +              +  +  +  +        +           +  +  +     +   |             
      Peridontal Tissue, Inflammation      |       1     1              1  1  1  1        2           1  2  1     1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|             
                             DAY ON TEST   | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|             
                                           | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    10 UG                                  | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                           1     2     1        1     1   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Epicardium, Inflammation             |                                                                          |             
      Pericardium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     2        1  1  1  2     1     2  1        2  3  1  1  1  2     1  1|             
      Atrophy                              |                                              4                           |             
      Degeneration, Cystic                 |          1           3        3        3           2                     |             
      Hyperplasia                          |       3                                                                  |             
      Hypertrophy                          | 1  1  2  2  2        3  1     3  1  1  3  3  2  2  2  2     1  2     3  2|             
      Vacuolization Cytoplasmic            |       3     1                       1  1                 1           2  1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2           2                        |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1  2                       2     2        2  3           4         |             
      Cytoplasmic Alteration               |                                     1                                    |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |                2     3        3  3              3                       2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       3              1           2  2  2                                 |             
      Follicular Cell, Hypertrophy         | 2  2     1     1     1  2        1  2  2  1  2           1  1     1  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|             
                             DAY ON TEST   | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|             
                                           | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    10 UG                                  | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  2     1  2  2  1  2     2  1  1  2  2  2     1  1  1  1  2  2  2  1|             
      Duct, Cyst                           | 3  1  2     1  3  3  2  3     1  2  3  2  3  3  3  2  2     2  1  2  3   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  3              3     4  3  3  3  3        3  3           3  3  3  3|             
      Cyst                                 |          2     2                    4           2              2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         | 2              2           2     2                                       |             
      Inflammation, Suppurative            |       1  2                                                               |             
      Metaplasia, Squamous                 | 4  4  1  4     2     2  2  3     4  4           2  1           2     4   |             
      Endometrium, Hyperplasia, Cystic     |       1        2     2  2     2        1        3  3           2  2     2|             
      Serosa, Inflammation, Chronic Active |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3  2  3  4     3     2  2  3  4     2  4  4     2     1     3  3  2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | M  M  +  +  +  M  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Ectasia                 |       1     1                                                            |             
      Mediastinal, Hemorrhage              |                         2                                                |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Renal, Ectasia                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  3  3  2     2     3  2     2  2     2  2  3  2  2  2  2  2  2     2  2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|             
                             DAY ON TEST   | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|             
                                           | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    10 UG                                  | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                         1                                                |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2  2  3  4  2  1  2  2     2  2  2  2  3  3  2  1     1  2  2  3  2  2|             
      Pigmentation                         | 2  1  1  1  1  1  1  1  2  2  1  1  1  1     1  2  1  3  2  2  2  1  1  1|             
      Lymphoid Follicle, Atrophy           | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  2  4  3  2     2  2     2  2  2  2  2  3  1  2  3     3  3  2  2  2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |       1     2                             1  2     2  1     3            |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|             
                             DAY ON TEST   | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|             
                                           | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    80 NG  /                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|             
    10 UG                                  | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     2  2     3     1  1     2     2  1  1  2  1     1     1        1   |             
      Inflammation                         |          2                    1  1                       3               |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                1                    1  1     1                           |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       1  1     2        1                                   1            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     1              1           1                                       |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 1                    1                                                   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                        4                                 |             
      Cornea, Inflammation                 |                                        2                                 |             
      Retina, Atrophy                      |                                  2     3                                 |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |       X                                            X        X            |             
      Cyst                                 |                                              3                           |             
      Inflammation, Suppurative            |                                                 1                        |             
      Mineralization                       |    1     1  1  1     1  1        1     1  1  1  1  1           1        1|             
      Nephropathy                          |          1  1  1     1  1     1        1  1  1  3     1     1  1  1  1  1|             
      Pelvis, Inflammation                 |                                           2           2                 1|             
      Transitional Epithelium, Hyperplasia |                                           2           2                 2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 4|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    80 NG  /                               | 7|                                                                       |      L     |
    10 UG                                  | 7|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
      Degeneration                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  51        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  51        |
      Parasite Metazoan                    |                                                                          |      2     |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | X                                                                        |      8     |
      Basophilic Focus, Multiple           |                                                                          |      8     |
      Cholangiofibrosis                    |                                                                          |      2  1.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      5     |
      Eosinophilic Focus, Multiple         |                                                                          |     16     |
      Fatty Change, Diffuse                |                                                                          |     14  1.0|
      Fatty Change, Focal                  |                                                                          |     10  1.4|
      Hematopoietic Cell Proliferation     | 1                                                                        |     27  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation                         | 2                                                                        |     47  1.2|
      Mixed Cell Focus                     |                                                                          |      5     |
      Mixed Cell Focus, Multiple           |                                                                          |     23     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 4|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    80 NG  /                               | 7|                                                                       |      L     |
    10 UG                                  | 7|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             | 2                                                                        |     13  2.2|
      Pigmentation                         |                                                                          |     18  1.4|
      Toxic Hepatopathy                    |                                                                          |      8  1.1|
      Artery, Inflammation                 |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                                          |      3  3.0|
      Bile Duct, Fibrosis                  |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      5  1.2|
      Centrilobular, Degeneration          |                                                                          |      3  2.0|
      Hepatocyte, Hypertrophy              |                                                                          |     16  1.1|
      Hepatocyte, Multinucleated           |                                                                          |      9  1.3|
      Oval Cell, Hyperplasia               |                                                                          |      4  1.0|
      Serosa, Inflammation                 |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |  35        |
      Inflammation                         |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +                                                                        |  51        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     10  1.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      5  1.8|
      Lipomatosis                          |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      5  1.8|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 4|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    80 NG  /                               | 7|                                                                       |      L     |
    10 UG                                  | 7|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Erosion                              | 2                                                                        |      1  2.0|
      Mineralization                       |                                                                          |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  26        |
      Peridontal Tissue, Inflammation      |                                                                          |     26  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Cardiomyopathy                       |                                                                          |     13  1.1|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  2.0|
      Epicardium, Inflammation             |                                                                          |      1  2.0|
      Pericardium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Angiectasis                          |                                                                          |     35  1.4|
      Atrophy                              |                                                                          |      1  4.0|
      Degeneration, Cystic                 |                                                                          |     12  2.3|
      Hyperplasia                          |                                                                          |      7  2.1|
      Hypertrophy                          |                                                                          |     40  2.1|
      Vacuolization Cytoplasmic            |                                                                          |     16  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  45        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 4|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    80 NG  /                               | 7|                                                                       |      L     |
    10 UG                                  | 7|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Angiectasis                          |                                                                          |     13  2.2|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     14  2.6|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      C-Cell, Hyperplasia                  |                                                                          |     11  2.3|
      Follicular Cell, Hypertrophy         | 3                                                                        |     35  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  51        |
      Inflammation                         | 1                                                                        |     44  1.6|
      Duct, Cyst                           | 2                                                                        |     41  2.2|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
      Atrophy                              | 3                                                                        |     34  3.1|
      Cyst                                 |                                                                          |     12  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Adenomyosis                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      5  1.8|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
      Metaplasia, Squamous                 | 1                                                                        |     24  2.4|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     23  2.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 4|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    80 NG  /                               | 7|                                                                       |      L     |
    10 UG                                  | 7|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hyperplasia                          | 4                                                                        |     41  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |  16        |
      Lumbar, Ectasia                      |                                                                          |      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     | 3                                                                        |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      7  1.4|
      Mediastinal, Hemorrhage              |                                                                          |      2  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      3  2.0|
      Renal, Ectasia                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  51        |
      Ectasia                              |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |     35  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hematopoietic Cell Proliferation     | 4                                                                        |     44  2.3|
      Pigmentation                         | 1                                                                        |     50  1.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  51        |
      Atrophy                              | 3                                                                        |     44  2.5|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Cyst                                 |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 4|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    80 NG  /                               | 7|                                                                       |      L     |
    10 UG                                  | 7|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          |                                                                          |     17  1.5|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Infiltration Cellular, Histiocyte    |                                                                          |     33  1.6|
      Inflammation                         |                                                                          |      9  1.4|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     10  1.2|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |                                                                          |     14  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Inflammation                         | 1                                                                        |     15  1.4|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |     11  1.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3|                                                                       |            |
                             DAY ON TEST   | 6|                                                                       |            |
                                           | 4|                                                                       |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0|                                                                       |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    80 NG  /                               | 7|                                                                       |      L     |
    10 UG                                  | 7|                                                                       |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +                                                                        |  51        |
      Cataract                             |                                                                          |      3  3.0|
      Cornea, Inflammation                 |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |  51        |
      Inflammation                         |                                                                          |      7  1.4|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Calculus Micro Observation Only      |                                                                          |      6     |
      Cyst                                 |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 1                                                                        |     34  1.1|
      Nephropathy                          |                                                                          |     37  1.2|
      Pelvis, Inflammation                 |                                                                          |      6  1.7|
      Transitional Epithelium, Hyperplasia |                                                                          |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Inflammation                         |                                                                          |      3  1.3|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|             
                             DAY ON TEST   | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|             
                                           | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    30 UG                                  | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |          2                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
      Artery, Inflammation, Chronic Active |          3                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |          2                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                                        1      |             
      Basophilic Focus                     | X                       X                                                |             
      Basophilic Focus, Multiple           |                X                                                         |             
      Cholangiofibrosis                    |                                           1                              |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |    X     X                       X                          X  X         |             
      Eosinophilic Focus, Multiple         |                   X           X     X              X              X  X   |             
      Fatty Change, Diffuse                |             1  2     1        1  1  1        1  2        2  1  1  1  1   |             
      Fatty Change, Focal                  |          1                 1                                             |             
      Hematopoietic Cell Proliferation     | 2  1  1  1     1              1     1  1     1           1  1     1  1   |             
      Hyperplasia, Nodular                 |          X              X           X        X                    X  X   |             
      Inflammation                         | 2  1  2  2  1  1  1  1  1  1  1  2  1  2  1  1  1  1  1  1     1  1  2  1|             
      Mixed Cell Focus                     |                            X  X                                          |             
      Mixed Cell Focus, Multiple           |    X     X  X  X     X  X        X     X     X           X     X  X      |             
      Necrosis                             |       3                                                              2   |             
      Pigmentation                         | 2     1  1  2  3     1  1  2  2  1  1     1  1  1  1     2        1  1   |             
      Toxic Hepatopathy                    | 3        2     1  1  1  1     1  1  1     1  2     1     1     1  1  1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|             
                             DAY ON TEST   | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|             
                                           | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    30 UG                                  | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      |                   3                                            2         |             
      Bile Duct, Fibrosis                  |                                     1                                    |             
      Bile Duct, Hyperplasia               | 3        3     1                                         2        1      |             
      Centrilobular, Degeneration          |                            1     2        2           2              3   |             
      Centrilobular, Fibrosis              | 1                                         1                              |             
      Hepatocyte, Hypertrophy              | 4  1              2  1           1  2  1     1     2        1  1         |             
      Hepatocyte, Multinucleated           | 2        1     1           1  1  1  1              1     1           2   |             
      Oval Cell, Hyperplasia               | 3        2     1        1  1  1  1           1           1     1  1  1   |             
      Portal, Fibrosis                     |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Necrosis                             |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                          4               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1           2  2           1     1        1     2        2     2  2  1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |       2        1     1                                                   |             
      Lipomatosis                          |                                                                          |             
      Acinus, Atrophy                      |                1     1                                                   |             
      Acinus, Vacuolization Cytoplasmic    |                   1        1                                             |             
      Artery, Inflammation, Chronic Active |          3                                               1               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       3                                                                  |             
      Inflammation                         |       3                                                                  |             
      Ulcer                                |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
      Cyst                                 |             2                                                            |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|             
                             DAY ON TEST   | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|             
                                           | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    30 UG                                  | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tooth                                   | +     +  +  +  +  +  +     +     +           +  +        +     +  +  +   |             
      Peridontal Tissue, Inflammation      | 1     1  1  2  2  1  1     2     1           1  1        2     2  2  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1              1                 1     1        1  1  1         |             
      Valve, Hyperplasia                   | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1  1  1  3  2  2  2  2  2  2  1  1  1     1  2  1     2  1  1   |             
      Degeneration, Cystic                 |    2  1              1  2                    2              1  2         |             
      Hyperplasia                          |          2        3  2              2              2     2  2  3         |             
      Hypertrophy                          | 1  2  2  2  2  1  2  2  3  2  2  1  2        3  3  1  1  1  4  3  2  1   |             
      Necrosis                             |                            2              2                              |             
      Vacuolization Cytoplasmic            | 1           2     2                          2              2  1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2     3  2        3                    3           2        1      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |          3     2        3  3  2  2           2                    1      |             
      Cytoplasmic Alteration               |                                              1                           |             
      Pars Distalis, Hyperplasia           | 3  2        2     1  1              2              2        2     1     2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1  2                       2           2     2     2     1         |             
      Follicular Cell, Hypertrophy         |    3        1  2     2  2  2     2  2  2  2  2     4  1     1  1  2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|             
                             DAY ON TEST   | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|             
                                           | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    30 UG                                  | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation                         | 2  1  1  1  2  2  3  1        2  1     1  2  1  1  2  2  2     2  3  2  1|             
      Duct, Cyst                           | 1  1     2  3  2     2  1  2     1  3  1  3  2  2  3  3  3     3  2     2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3     3  3  3  3  3|             
      Cyst                                 |          2     2     2  2     2                 3        2     2         |             
      Inflammation, Chronic Active         |                                              4  4                        |             
      Inflammation                         | 4  2                                                                     |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         3|             
      Inflammation, Suppurative            |       1                                                           1      |             
      Metaplasia, Squamous                 | 3  4     2     3     4  2     2  2  2  2  1  3  3  2  2     2     2      |             
      Endometrium, Hyperplasia, Cystic     |       1           2     1  2  1  3  3  1     3  2     2     2  3  3     4|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  2  3  3                    3  3  3  3  4  2  2  3        3        3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | M  +  +  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  +  +  +  M  M  +|             
      Mediastinal, Ectasia                 |       2                                1                 1     1         |             
      Mediastinal, Hemorrhage              |       2                                                  1               |             
      Mediastinal, Hyperplasia, Lymphoid   |    4              4                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   2                          2           2               |             
      Hemorrhage                           |                                                                   2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 3  2  2  2  2  2  2  2  3  3  2  2  2  2  2  2  3  2     2     2  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       2                                                        2         |             
      Hyperplasia, Histiocytic             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|             
                             DAY ON TEST   | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|             
                                           | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    30 UG                                  | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  2  3  2  1  2     2  2  2  2  2  2  2  2  2  1  3     2  3  1  2  3   |             
      Pigmentation                         | 1  1  1  2  2  2  2  2  2  3  2  2  1  1  1  2  2  1  1  1  1  1  2  1  1|             
      Lymphoid Follicle, Atrophy           |                                                 3     2                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  3  2  2     2  2  4  2  3  3  3  4     4  2  3        3  3     4|             
      Hemorrhage                           |                                                       3                 3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                               1                          1               |             
      Inflammation, Granulomatous          |                                                             3            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          1               |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  2  2  1  2  2  3  2  2  2  2  2  1  2     2     1     1  1  2  2  2   |             
      Inflammation                         |                                                                1         |             
      Metaplasia, Squamous                 |                                                                          |             
      Necrosis                             |                                                 3                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|             
                             DAY ON TEST   | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|             
                                           | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|             
    30 UG                                  | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1      |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       1  1  2  2  2  2  1  2  1  2  1  1                 2  1  1  1  2   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1                                         1  1            |             
      Olfactory Epithelium, Metaplasia     | 2                                                                        |             
      Respiratory Epithelium, Hyperplasia  |                                                          1               |             
      Squamous Epithelium, Hyperplasia     |                                                             1            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1  1     1           1  1           1  1           1     1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                      X                       X  X                        |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    1  1  1  1  1  1  1  1  2  1  1  1  1  2  1  1  1              1  1  1|             
      Nephropathy                          | 1     1  2  1  2  1  1  1  1  1        1     1  1  1     3     2  1      |             
      Pelvis, Dilatation                   | 2                                                                        |             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |             1                                                            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1                                                |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|             
                                           | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    30 UG                                  | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X           X                    X                                 |             
      Basophilic Focus, Multiple           |                               X           X                 X            |             
      Cholangiofibrosis                    |                         1                                   1            |             
      Degeneration, Cystic                 |                                                    1                     |             
      Eosinophilic Focus                   |       X        X  X     X           X                          X         |             
      Eosinophilic Focus, Multiple         |                               X           X     X     X           X      |             
      Fatty Change, Diffuse                |    1           1  1     1              2  2  1  1  1        1        1  1|             
      Fatty Change, Focal                  |    2        2                                                            |             
      Hematopoietic Cell Proliferation     | 1  1     1  1  1        1  1     1  1        1     1  1     1     1  1   |             
      Hyperplasia, Nodular                 |    X        X           X                          X                     |             
      Inflammation                         | 1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  2  1     1  1  1  1  1  1|             
      Mixed Cell Focus                     |                                                                X  X      |             
      Mixed Cell Focus, Multiple           | X  X  X  X  X           X  X           X     X  X  X     X  X        X  X|             
      Necrosis                             |                3                 2              1                        |             
      Pigmentation                         |    1  1     1  2  2     2  1  2  1     2  2  1  1  2     2  2        2  2|             
      Toxic Hepatopathy                    |    1  1  1  1  1  1     1     1           1  1  1  2        1           1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|             
                                           | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    30 UG                                  | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      |             2                                                            |             
      Bile Duct, Fibrosis                  |                               1                                          |             
      Bile Duct, Hyperplasia               |                               2                                          |             
      Centrilobular, Degeneration          |                1                 2                                       |             
      Centrilobular, Fibrosis              |                               1                 1                    1  1|             
      Hepatocyte, Hypertrophy              |    2  1  2  1              1        1        1     1  2           1      |             
      Hepatocyte, Multinucleated           |    1  1        1        1                    1  2        1  1           1|             
      Oval Cell, Hyperplasia               |    1     1        1     1  1  2           1           1     1            |             
      Portal, Fibrosis                     |                         1                                                |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Necrosis                             |                                                 3                        |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1                                1  2  1        1           1  1  1  2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                           2                              |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Lipomatosis                          |                                                                         2|             
      Acinus, Atrophy                      |                                                                         2|             
      Acinus, Vacuolization Cytoplasmic    |                   1           1        1              1           1     1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                      2   |             
      Inflammation                         |                                                                      2   |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    1     1     2                    2                          1         |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|             
                                           | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    30 UG                                  | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tooth                                   | +                 +     +  +     +  +  +        +  +  +  +  +  +  +  +  +|             
      Peridontal Tissue, Inflammation      | 1                 1     2  1     1  1  1        1  1  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1              1              1        1  1  1     1              1  1|             
      Valve, Hyperplasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  3  2  1  2     2  1  2  1  1        2  2  1     1        2  1  1  2  2|             
      Degeneration, Cystic                 |                2                                1  3  3                 2|             
      Hyperplasia                          |       2  2                 1                       2                    2|             
      Hypertrophy                          | 4  2  1     2  2  1     2  2  1     3  1  1  3  3  3  3  2  2  2  2  3  3|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |          1                 1  2     1        1                       2  1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3                          2            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  3           2     2                 3        2     2  2        3  2|             
      Cytoplasmic Alteration               |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  3                       1  2              4        3     3     2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2        3                                   2        1  1        2      |             
      Follicular Cell, Hypertrophy         | 2  2  2  2  1  1           2  2     2        2     2  1     1  2  1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|             
                                           | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    30 UG                                  | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation                         | 1  1  2  1  1  2  2  1  2  2  1     1  1  1  1  1  1  1  1  1  1     1   |             
      Duct, Cyst                           |    2  2  3  2  2  2     3  3  2  2  2  2  2  3  2     2  1  2  2     2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     3     3  3  3     3  3  3  3  3  4  3     3     3  3  3  3  3     3|             
      Cyst                                 |          2  3  2           2           4           2  3                  |             
      Inflammation, Chronic Active         | 4                                                                        |             
      Inflammation                         |             4                                                            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       3                  |             
      Inflammation, Suppurative            |             1                 1                                3         |             
      Metaplasia, Squamous                 | 2           1     1     2           2     2           3     4  4  2     3|             
      Endometrium, Hyperplasia, Cystic     | 2     2     1  4  4     2  2        1     2     1                        |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3     3  1  3  2  2  3  3  2  4  4                 4  2  2  3  3  4  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  M  M  M  +  M  M  +  M  M  +  M  M  M  M  M  M  M  M  +  M  M  +  +  M|             
      Mediastinal, Ectasia                 |                               2                                      1   |             
      Mediastinal, Hemorrhage              |                               2                          1               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |       2                             3                                    |             
      Hyperplasia, Plasma Cell             | 2  3              2     2  2  2              2  2           2     2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                               2                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|             
                                           | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    30 UG                                  | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  2     2  2  1  3  3  2  1  2  1  2  2  2  2  2  2  2  1|             
      Pigmentation                         | 1  1  1  1  2  1  2  2  2  1  2  1     1  3  1  2  1  1  1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2  2  3  2  4  2     4     3  4  2  3  4  3  2     2  3  2  2  2  4  4|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                                3         |             
      Hyperplasia                          | 1  2     2                    1        1  1  2              1        2   |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1  2     2  2  2  1  1  2  1  1  2  2  3  2  2  2  2  1  1|             
      Inflammation                         |             1           1              1     2              1  1         |             
      Metaplasia, Squamous                 |                            1  2                                          |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|             
                                           | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 NG /                               | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    30 UG                                  | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             1            |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    1  1     1  1  2     1  2  2     1  1     1  1  1  2  2  3  2  2  1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1  1  1  1  1     1  3  1  2  1        1  1      |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                         2  1  2                                   1      |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1  1     1     1  1           1           1  1           1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                     X                             X      |             
      Inflammation, Suppurative            | 1              2           2                             2               |             
      Mineralization                       | 1     1     1        1  1  1  1     1  1  1  1     1  1  1     1        1|             
      Nephropathy                          | 2  1  1  1     1  1  1  1  2  1  1  1     1           1  1  1        2  1|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                   2                                                      |             
      Transitional Epithelium, Hyperplasia |                   3     1        1  1                             2      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   2                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 6| 6| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    240 NG /                               | 9| 9| 9|                                                                 |      L     |
    30 UG                                  | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      2     |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  1.0|
      Basophilic Focus                     |                                                                          |      6     |
      Basophilic Focus, Multiple           |                                                                          |      4     |
      Cholangiofibrosis                    |                                                                          |      3  1.0|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |     11     |
      Eosinophilic Focus, Multiple         |    X                                                                     |     12     |
      Fatty Change, Diffuse                | 1     1                                                                  |     27  1.2|
      Fatty Change, Focal                  | 2  2                                                                     |      6  1.7|
      Hematopoietic Cell Proliferation     | 1  1                                                                     |     30  1.0|
      Hyperplasia, Nodular                 |                                                                          |     10     |
      Inflammation                         | 1  1  1                                                                  |     50  1.1|
      Mixed Cell Focus                     |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 6| 6| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    240 NG /                               | 9| 9| 9|                                                                 |      L     |
    30 UG                                  | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus, Multiple           | X                                                                        |     28     |
      Necrosis                             |       1                                                                  |      6  2.0|
      Pigmentation                         |    3  2                                                                  |     38  1.6|
      Toxic Hepatopathy                    |    1  1                                                                  |     32  1.2|
      Bile Duct, Cyst                      |                                                                          |      3  2.3|
      Bile Duct, Fibrosis                  |    2                                                                     |      3  1.3|
      Bile Duct, Hyperplasia               | 1                                                                        |      7  1.9|
      Centrilobular, Degeneration          |       2                                                                  |      8  1.9|
      Centrilobular, Fibrosis              |    1                                                                     |      7  1.0|
      Hepatocyte, Hypertrophy              |       1                                                                  |     22  1.4|
      Hepatocyte, Multinucleated           |    1  2                                                                  |     21  1.2|
      Oval Cell, Hyperplasia               | 1  1                                                                     |     23  1.2|
      Portal, Fibrosis                     |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +                                                                  |  45        |
      Necrosis                             |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     20  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      4  1.5|
      Lipomatosis                          |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      3  1.3|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      8  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |       2                                                                  |      3  2.3|
      Inflammation                         |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 6| 6| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    240 NG /                               | 9| 9| 9|                                                                 |      L     |
    30 UG                                  | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Ulcer                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      6  1.5|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +     +                                                                  |  33        |
      Peridontal Tissue, Inflammation      | 1     1                                                                  |     33  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |                                                                          |     17  1.0|
      Valve, Hyperplasia                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |    2                                                                     |     39  1.6|
      Degeneration, Cystic                 | 2                                                                        |     13  1.8|
      Hyperplasia                          |                                                                          |     13  2.1|
      Hypertrophy                          | 3  2  2                                                                  |     47  2.1|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |                                                                          |     13  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      9  2.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 6| 6| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    240 NG /                               | 9| 9| 9|                                                                 |      L     |
    30 UG                                  | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Angiectasis                          | 3                                                                        |     19  2.3|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |       1                                                                  |     19  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |                                                                          |     13  1.8|
      Follicular Cell, Hypertrophy         | 1                                                                        |     34  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  51        |
      Inflammation                         | 1  1  1                                                                  |     46  1.4|
      Duct, Cyst                           | 2  2                                                                     |     43  2.1|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              |    3                                                                     |     43  3.0|
      Cyst                                 |                                                                          |     15  2.3|
      Inflammation, Chronic Active         |                                                                          |      3  4.0|
      Inflammation                         |                                                                          |      3  3.3|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      5  1.4|
      Metaplasia, Squamous                 |                                                                          |     28  2.4|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     25  2.2|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 6| 6| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    240 NG /                               | 9| 9| 9|                                                                 |      L     |
    30 UG                                  | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          |    2  3                                                                  |     36  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  M  M                                                                  |  16        |
      Mediastinal, Ectasia                 | 1                                                                        |      7  1.3|
      Mediastinal, Hemorrhage              |                                                                          |      4  1.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 3                                                                        |      3  2.7|
      Hyperplasia, Plasma Cell             |    1                                                                     |     34  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  1  3                                                                  |     49  2.0|
      Pigmentation                         | 1  2  1                                                                  |     52  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Atrophy                              | 2  4  4                                                                  |     44  3.0|
      Hemorrhage                           |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      2  3.0|
      Hyperplasia                          | 2     1                                                                  |     13  1.4|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 6| 6| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    240 NG /                               | 9| 9| 9|                                                                 |      L     |
    30 UG                                  | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 1  2                                                                     |     46  1.7|
      Inflammation                         |                                                                          |      7  1.1|
      Metaplasia, Squamous                 |                                                                          |      2  1.5|
      Necrosis                             |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1  1                                                                     |     39  1.4|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |    3                                                                     |     16  1.3|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      5  1.4|
      Squamous Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 0|                                                                 |            |
                                           | 6| 6| 3|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    240 NG /                               | 9| 9| 9|                                                                 |      L     |
    30 UG                                  | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     20  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      | X                                                                        |      6     |
      Inflammation, Suppurative            |                                                                          |      4  1.8|
      Mineralization                       | 1  1                                                                     |     38  1.1|
      Nephropathy                          | 1  1                                                                     |     37  1.2|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      6  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|             
                             DAY ON TEST   | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|             
                                           | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|             
    100 UG                                 | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |             2  1                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Basophilic Focus                     |    X                                         X                 X         |             
      Basophilic Focus, Multiple           |                                                                   X      |             
      Cholangiofibrosis                    | 1     2     1     3     1                    1              3     3     4|             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                         X        X        X     X  X     X     X  X      |             
      Fatty Change, Diffuse                | 2  1  2  1  2     1     1  2  2  2  2  2  1  1  2  1  2  1  1     2     1|             
      Fatty Change, Focal                  |                                                             2            |             
      Hematopoietic Cell Proliferation     | 1     1     1     1           1     1  1     1     1  1  1  1  1         |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Hyperplasia, Nodular                 | X  X  X  X  X     X  X     X  X     X  X  X  X  X  X  X  X  X     X     X|             
      Inflammation                         | 2  2  2  1  1  1  2  2  1  1  1  1  2  1  1  1  3  1  1  1  1  1  3  2  1|             
      Mixed Cell Focus, Multiple           | X  X  X  X  X     X                                   X  X              X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|             
                             DAY ON TEST   | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|             
                                           | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|             
    100 UG                                 | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Necrosis                             |    3  1        1  1  3  1        2  3  2  2     2           2     2  3   |             
      Pigmentation                         | 2  2  2  2  2  1  2  2  2  1  2  3  2  2  2  3  2  2  2  2  2  2  2  2  2|             
      Toxic Hepatopathy                    | 3  3  2  3  2     2  3  2  2  2  2  3  3  3  3  3  3  3  3  3  2  3  2  3|             
      Artery, Inflammation                 |                                                                          |             
      Bile Duct, Cyst                      | 1     2           3                          2        2     2            |             
      Bile Duct, Fibrosis                  |          2                 2  1     2                    1               |             
      Bile Duct, Hyperplasia               | 1  2  2  3        4           2  3  2  2  1  2  2  2  1  1  3  1  2     2|             
      Centrilobular, Degeneration          |                                        3     2                 1         |             
      Centrilobular, Fibrosis              | 1  1     1           2     2     2  2  1  2  2  1  1  1  1  2  2  1      |             
      Hepatocyte, Glandular Structures     |                                                                          |             
      Hepatocyte, Hypertrophy              | 3  3  2  3  2     2  2  2     2  2  3  3  3  3  3  3  3  3  3  2  3     3|             
      Hepatocyte, Multinucleated           | 2  2  2  2  1     2  2  2  2  2  2  2  1  2  3  2  2  1  2  1  2  2  2  2|             
      Oval Cell, Hyperplasia               | 2  2  2  2  1     1     1  2  2  2  3  2  2  3  2  2  2  3  3  2  2     3|             
      Portal, Fibrosis                     | 1  1     2           2     2     1  3  1  2  2  1  1  1  1  3     2     2|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Necrosis                             |                                                                          |             
      Artery, Inflammation, Chronic Active |                            3                       3     1              3|             
      Fat, Necrosis                        |                               2  2                                       |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1     2     2        1     2  3  2        1     3     1                  |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2                                            1                     |             
      Acinus, Atrophy                      |       2                                            2     2               |             
      Acinus, Vacuolization Cytoplasmic    | 2  2  2  1  2     1     2     2           1  1  1  2  2  1  2     1     2|             
      Artery, Inflammation, Chronic Active | 3  2     2                    2  3           4  2  3     2  1           3|             
      Duct, Dilatation                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                         2                                                |             
      Hyperplasia, Squamous                |                         1        2     2        1                        |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|             
                             DAY ON TEST   | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|             
                                           | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|             
    100 UG                                 | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                             3            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                             2            |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +     +        +  +  +  +  +        +  +  +     +     +     +     +|             
      Peridontal Tissue, Inflammation      | 1  3  2     1        1  2  2  1  1        1  4  4     1     2     3     1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1        1     1        1        1  1  1  2  2  1  1  1  1     2      |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |    3     3                                               2              1|             
      Endocardium, Hyperplasia             |                                                                   3      |             
      Epicardium, Inflammation             |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     2     2     1     3  1  1  1        2     3        1        1     1|             
      Atrophy                              |                                                    2  2                 2|             
      Degeneration, Cystic                 |          2              1        1  3                                    |             
      Hyperplasia                          | 2           2     2                             3                       2|             
      Hypertrophy                          | 1  2  3  3  2     1  2  2     2  1  3  2  3  2     2  3  2  2     3      |             
      Inflammation                         |                                                 3                        |             
      Necrosis                             |                                        3                          2      |             
      Vacuolization Cytoplasmic            | 1     2     1     1           1        2  2  1        3                 2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                2  1                                 |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|             
                             DAY ON TEST   | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|             
                                           | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|             
    100 UG                                 | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3  2              3                           |             
      Vacuolization Cytoplasmic            |       1     1           1                       1        1               |             
      Pars Distalis, Hyperplasia           | 2  1     2                    3              3  2  3  2     3            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2        2                                2                    2      |             
      Follicular Cell, Hypertrophy         | 2        2  2  1  2     3     1     1     1     1  3     2  1  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation                         |    1  1     1              2        1  1  1     1     2  1  1           2|             
      Artery, Inflammation, Chronic Active |                                                                         3|             
      Duct, Cyst                           | 3  2  2  3  3  1  3  2  3  2        3  2  2     2  2  3  2  3  1        2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  3     3     3  3  3  3  4     3  3  3  4  3  3  3  3  3  3  3     3|             
      Cyst                                 |             3                             2  3           2  2           2|             
      Inflammation, Chronic Active         |                                              4                           |             
      Inflammation                         |                                                                   4      |             
      Artery, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hemorrhage                           |                                     4                                    |             
      Inflammation, Chronic Active         |                                                 3                        |             
      Inflammation, Suppurative            |                   2           3                             3     4      |             
      Metaplasia, Squamous                 |    2  2                 2           3           3  3     4     3         |             
      Endometrium, Hyperplasia, Cystic     |       2     2     3  4  2     3     4  3  4  1  1     3     2           1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|             
                             DAY ON TEST   | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|             
                                           | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|             
    100 UG                                 | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          | 2  3  2  3  3  2     4     2  2  2  3     3  4  3  2  3  4  3  3  3  4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  M  M  +  M  M  M  +  +  M  M  +  +  M  +  +  +  M  M  +  M  M  +  +  +|             
      Hemorrhage                           |                                              2                           |             
      Deep Cervical, Congestion            |                                  2                                       |             
      Deep Cervical, Ectasia               |                                  1                                       |             
      Deep Cervical, Hemorrhage            |                                                 2                        |             
      Deep Cervical, Hyperplasia,          |                                                                          |             
          Histiocytic                      |                                                 2                        |             
      Lumbar, Ectasia                      |                                                                          |             
      Mediastinal, Congestion              |                                  2                                       |             
      Mediastinal, Ectasia                 |          2                       2  1                    1               |             
      Mediastinal, Hemorrhage              |          2                          2           2        2        2  1   |             
      Mediastinal, Hyperplasia, Histiocytic|                                                 2                        |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                              3                           |             
      Renal, Ectasia                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    3                     |             
      Hyperplasia, Histiocytic             |                                                 2                        |             
      Hyperplasia, Plasma Cell             | 3  2  2  2                 2  2     2     2  2  2        2        3  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                            2     2                                       |             
      Hyperplasia, Histiocytic             |    2                                                     2               |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  1  2  1     2  2  1  3  1  1  2  1  2  3  2  3  2  3  3  2|             
      Pigmentation                         | 1  2  2  1  1  1  2  2  2  2  1  2     3     1  1  2  1  1  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |    2                             2     1  3                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  3     3  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4  4  4  3|             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|             
                             DAY ON TEST   | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|             
                                           | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|             
    100 UG                                 | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
      Hyperplasia                          |          1                       2              1                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                2                       1  1  1                           |             
      Inflammation                         |                1                                3                        |             
      Necrosis                             |                3                                3                        |             
      Cerebrum, Degeneration               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  2  2  1     2  2  1  2  1  1  2  1  1  1     2  2  2  2  1  2  1  1|             
      Inflammation                         |                                                 3                 3      |             
      Metaplasia, Squamous                 |    2  2     2     3     2                             2                 2|             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1  2  2  2  2     3     1  1  2  3  2  1  1  1  1  2  1  2  2  1  1     2|             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         2     1           2  3        1                  |             
      Olfactory Epithelium, Degeneration   |                         2                                                |             
      Olfactory Epithelium, Metaplasia     |                                                       2                  |             
      Respiratory Epithelium, Hyperplasia  |                         2     2           2           2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|             
                             DAY ON TEST   | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|             
                                           | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|             
    100 UG                                 | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation                 |                                              3                           |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1           1                 1                    1  1  1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2        2              3                                                |             
      Mineralization                       | 1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1        1  1  1  1  1  1|             
      Nephropathy                          | 3  3  1  1  1     1     1  1  3  2     1  1  3  2  3  2  3  4     2  1  2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Pelvis, Inflammation                 |                                                       2                  |             
      Transitional Epithelium, Hyperplasia | 4        1        3     2                 1     2     4  3               |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                       2                  |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|             
                             DAY ON TEST   | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|             
                                           | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    100 UG                                 | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                         1|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X              X                           |             
      Artery, Inflammation, Chronic Active |                         3        3                                       |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                  3                             3         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           3                              |             
      Erosion                              |                                                    2                     |             
      Hyperplasia                          |                                           3                              |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X                    X                                          |             
      Basophilic Focus, Multiple           |                                        X                                 |             
      Cholangiofibrosis                    |          1           3           2        3  3  3  3     3           3  1|             
      Clear Cell Focus, Multiple           |                      X                                                   |             
      Eosinophilic Focus                   |                   X                                                      |             
      Eosinophilic Focus, Multiple         | X     X        X           X     X                    X                  |             
      Fatty Change, Diffuse                | 1  2  2  1     1  2  2  1  1  2  1     2  1  2  2  1  2  1  1  2        2|             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  1     1  1  1     1  1  1     1  1     1     1  1  1     1  1  1     1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |    X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X|             
      Inflammation                         | 1  1  1  2  2  2  2  1  1  2  1  2  1  1  2  2  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus, Multiple           |       X                 X                       X        X  X           X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|             
                             DAY ON TEST   | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|             
                                           | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    100 UG                                 | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Necrosis                             | 2  1        3  2           2     2        2  1        2     1  2     3   |             
      Pigmentation                         | 2  2  2  2  3  2  3  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2     2  2|             
      Toxic Hepatopathy                    | 1  3  2  3  3  2  2  3  2  4  2  2  3  2  3  3  3  4  2  3  2  3     4  2|             
      Artery, Inflammation                 |                                                                          |             
      Bile Duct, Cyst                      |    3                 3        2           1  3  2  2           2         |             
      Bile Duct, Fibrosis                  |             2  2                             2              2            |             
      Bile Duct, Hyperplasia               | 1  1  1  3  2  2  1  2  1  2  2  2  2  1  2  3  2  2  2  1  1  2     2  1|             
      Centrilobular, Degeneration          |             2                 2           2           2              2   |             
      Centrilobular, Fibrosis              |          2     2  2  1     2  1  2  2  1  2  1  1  1     1     2     2   |             
      Hepatocyte, Glandular Structures     |                                                                      1   |             
      Hepatocyte, Hypertrophy              | 2  2  2  2  3  3  2  2  2  3  3     2  3  3  3  2  3  3  2  2  3     4   |             
      Hepatocyte, Multinucleated           | 1     2  2  2  2  2  1     2  1  2     2  2  2  2  2  2  2  2  2     1  1|             
      Oval Cell, Hyperplasia               | 1  2  2  3  2  1  2  2  2  3  3  2  3  2  2  3  2  3  1  2  3  3     3  1|             
      Portal, Fibrosis                     |    2  1  2     2  1  2  1  3  2     2     2  2  1  2     2  3  3     3  2|             
                                           |__________________________________________________________________________|             
   Mesentery                               | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Necrosis                             |                                              3                           |             
      Artery, Inflammation, Chronic Active |    2     2              3        4                             3         |             
      Fat, Necrosis                        |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |    1           2     1     1  2  3     2  1  1  1           2  2     3   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1                                                         |             
      Acinus, Atrophy                      |                2                                                     1   |             
      Acinus, Vacuolization Cytoplasmic    |    3  1  1     2     2  1     2  1  1  1  2  2  2  2  1  2  2  2     1  2|             
      Artery, Inflammation, Chronic Active |          4           2     3     3  1     2  2     2           2         |             
      Duct, Dilatation                     |          2                                                               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3                                2                           |             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |             3                       3     2  1     2  1     4            |             
      Inflammation                         |             3                       2        1           1               |             
      Mineralization                       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|             
                             DAY ON TEST   | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|             
                                           | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    100 UG                                 | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Ulcer                                |             2                                                            |             
      Artery, Inflammation, Chronic Active |                         2                                                |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +        +  +  +  +     +  +  +     +  +  +  +  +        +        +   |             
      Peridontal Tissue, Inflammation      |    1        1  1  2  1     1  2  1     4  1  1  1  1        1        4   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1     1  1  1  1  1  1        1  1  1  1        1     1  1  1     2   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                  3                             1         |             
      Endocardium, Hyperplasia             |                                                                          |             
      Epicardium, Inflammation             |             2  1           1                 1                          1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1        1     1              1  1     1  2     1        1  1           1|             
      Atrophy                              |    4  2  2     2  3  2  2  2        2        3     3                 3   |             
      Degeneration, Cystic                 |       2                 2  2                 3     3  1              3   |             
      Hyperplasia                          |             1                 3  2  1                 2        2     3   |             
      Hypertrophy                          | 1  3  3  2  3  2  3  2  3  3  2  2  1  3  3  3  3  3     2  1  1     3  2|             
      Inflammation                         |                                                                          |             
      Necrosis                             |                   3                    1                                 |             
      Vacuolization Cytoplasmic            |    2           2        3  2  1  2  1     2        2  1              2  2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3        2        2  3           2        2  2     2         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|             
                             DAY ON TEST   | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|             
                                           | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    100 UG                                 | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2     2     2                                      3            |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           | 3  4                       2           2     1  3  2     2     2         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                  2     2  2           2                 2|             
      Follicular Cell, Hypertrophy         | 1  2  1  2  3  2  2  1  2        2     1  2     2  2  2     3     2  1  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1     2  1  1  1  1  1  1  2     1  1  1  2     2     1  1     1  1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Duct, Cyst                           | 2  2  1     2  2  1  3  3  2  2  2  1  2  3  3  3  2  3  3  3  3  1  3  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  3  3  3  3  3  3  3  3     3     3     3  3     3  3  3        3  3|             
      Cyst                                 |       3           2  2  2  2     3  2  2        2     2     2        3   |             
      Inflammation, Chronic Active         |                                        4                                 |             
      Inflammation                         |                   4     2                                                |             
      Artery, Inflammation                 |                                  4                                       |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |    2                       3                 3                           |             
      Hemorrhage                           |    3                                                                     |             
      Inflammation, Chronic Active         |    3                                   4              3                  |             
      Inflammation, Suppurative            |                         2  4                                             |             
      Metaplasia, Squamous                 | 3  3  2  2  1  1     2     2           4        4     4  2           3  2|             
      Endometrium, Hyperplasia, Cystic     | 1  3     3  1  1     2  3  3     1        1  2           1  1  2     3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|             
                             DAY ON TEST   | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|             
                                           | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    100 UG                                 | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          | 2  3  3  3  2  3  3  2  4  4  3  4  4  3  3        3  3  2  3  3  3  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M|             
      Hemorrhage                           |                                                                          |             
      Deep Cervical, Congestion            |                                                                          |             
      Deep Cervical, Ectasia               |                                                                          |             
      Deep Cervical, Hemorrhage            |                                                                          |             
      Deep Cervical, Hyperplasia,          |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lumbar, Ectasia                      |                                                 3                        |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |       2     1           1                                                |             
      Mediastinal, Hemorrhage              | 1  2     2  1  2  3     2  2        2                                    |             
      Mediastinal, Hyperplasia, Histiocytic|                                     2                                    |             
      Mediastinal, Hyperplasia, Plasma Cell|                   3                                                      |             
      Pancreatic, Hyperplasia, Histiocytic |                                     2                                    |             
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |             
      Renal, Ectasia                       |                            3                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         2                       2              2         |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             |    2        3           2     3  2     2  2        2     2  2  2     3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  2        2                              |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                            2        1  2  2                              |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  2  2  2  2  1  2  3  3  2  2  2  2  2  2  2  2  2  2  2  2  1  3  2|             
      Pigmentation                         | 1  1  2  2  1  2  1  2  1     1  1  1  1  1  1  2  1  2  2  2  1  1  1  1|             
      Lymphoid Follicle, Atrophy           | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  3  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4     4  4|             
      Necrosis                             |                               3                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|             
                             DAY ON TEST   | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|             
                                           | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    100 UG                                 | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                               |             
      Hyperplasia                          |                               2                                2         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Cerebrum, Degeneration               |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                                 3      |             
      Hemorrhage                           |                                                                   3      |             
      Infiltration Cellular, Histiocyte    | 2  1  2  1  1  1  1  1  2  1  1  1  2     1  2  1  2  1  2  2  2        2|             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |                      2           1           2  3        2     2         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1  1  2  2  1  1  1  2  1  1  1  2  2     1  2  1  2     2  3  3        2|             
      Serosa, Fibrosis                     |                3                                                         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1  2           2              1        2               |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                  3              2                        |             
      Respiratory Epithelium, Hyperplasia  |                   1              3              2        2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|             
                             DAY ON TEST   | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|             
                                           | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 NG /                               | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    100 UG                                 | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |                                                                2         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1     1              4     1  1           1           1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1     1  1  1     1     1     1  1  1  1     1  1  1  1  1  1  1|             
      Nephropathy                          | 1  3     2  1  2  1  3  3  2  3  4  3  1  3  3  2  4  1  1  2  3  1  3  1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Pelvis, Inflammation                 |                         4        2        3              2  2            |             
      Transitional Epithelium, Hyperplasia |    1              1     4     1  2        3              3  2            |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                         3                                                |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  2        3              1  3            |             
      Metaplasia, Squamous                 |                         3                                                |             
      Artery, Inflammation, Chronic Active |                                  3                                       |             
      Transitional Epithelium, Hyperplasia |                                           3              2  2            |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      2     |
      Artery, Inflammation, Chronic Active |       3                                                                  |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Artery, Inflammation, Chronic Active |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
      Dilatation                           |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      5     |
      Basophilic Focus, Multiple           |    X                                                                     |      3     |
      Cholangiofibrosis                    | 1     1                                                                  |     21  2.2|
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Eosinophilic Focus, Multiple         |                                                                          |     14     |
      Fatty Change, Diffuse                | 2  2  1                                                                  |     45  1.5|
      Fatty Change, Focal                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       1                                                                  |     32  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatodiaphragmatic Nodule           | X                                                                        |      2     |
      Hyperplasia, Nodular                 | X  X  X                                                                  |     45     |
      Inflammation                         | 1  1                                                                     |     52  1.4|
      Mixed Cell Focus, Multiple           |       X                                                                  |     16     |
      Necrosis                             |                                                                          |     26  2.0|
      Pigmentation                         | 2  2  2                                                                  |     52  2.1|
      Toxic Hepatopathy                    | 2  2  1                                                                  |     51  2.6|
      Artery, Inflammation                 |       3                                                                  |      1  3.0|
      Bile Duct, Cyst                      |                                                                          |     14  2.1|
      Bile Duct, Fibrosis                  |    1                                                                     |     10  1.7|
      Bile Duct, Hyperplasia               | 2  2  2                                                                  |     46  1.8|
      Centrilobular, Degeneration          |                                                                          |      8  2.0|
      Centrilobular, Fibrosis              | 2  2  2                                                                  |     36  1.6|
      Hepatocyte, Glandular Structures     |                                                                          |      1  1.0|
      Hepatocyte, Hypertrophy              | 3  2  3                                                                  |     47  2.6|
      Hepatocyte, Multinucleated           | 2  1  1                                                                  |     48  1.8|
      Oval Cell, Hyperplasia               | 2  1  2                                                                  |     49  2.1|
      Portal, Fibrosis                     | 2                                                                        |     37  1.8|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +                                                                  |  49        |
      Necrosis                             |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      9  2.7|
      Fat, Necrosis                        |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Hyperplasia, Squamous      |       2                                                                  |     24  1.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Acinus, Atrophy                      |                                                                          |      5  1.8|
      Acinus, Vacuolization Cytoplasmic    | 2     1                                                                  |     39  1.6|
      Artery, Inflammation, Chronic Active |       1                                                                  |     21  2.3|
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      2  2.5|
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |     11  2.0|
      Inflammation                         |                                                                          |      4  1.8|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +  +                                                                  |  34        |
      Peridontal Tissue, Inflammation      | 3  3  2                                                                  |     34  1.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1  1  2                                                                  |     34  1.1|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |       1                                                                  |      7  2.0|
      Endocardium, Hyperplasia             |                                                                          |      1  3.0|
      Epicardium, Inflammation             |                                                                          |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |       1                                                                  |     25  1.3|
      Atrophy                              |                                                                          |     15  2.4|
      Degeneration, Cystic                 |                                                                          |     11  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          |                                                                          |     12  2.1|
      Hypertrophy                          |    2  3                                                                  |     44  2.3|
      Inflammation                         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      4  2.3|
      Vacuolization Cytoplasmic            |    1  2                                                                  |     24  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |       2                                                                  |     12  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      7  2.4|
      Vacuolization Cytoplasmic            |                                                                          |      5  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     18  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Hyperplasia                  |       2                                                                  |     10  2.0|
      Follicular Cell, Hypertrophy         | 2     2                                                                  |     38  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Inflammation                         | 1     2                                                                  |     34  1.2|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Duct, Cyst                           |       2                                                                  |     45  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 3  3                                                                     |     42  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |       2                                                                  |     19  2.3|
      Inflammation, Chronic Active         |    4                                                                     |      3  4.0|
      Inflammation                         |                                                                          |      3  3.3|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |                                                                          |      3  2.7|
      Hemorrhage                           |                                                                          |      2  3.5|
      Inflammation, Chronic Active         | 3                                                                        |      5  3.2|
      Inflammation, Suppurative            |    3                                                                     |      7  3.0|
      Metaplasia, Squamous                 | 1  2                                                                     |     24  2.5|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     30  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 4  3  3                                                                  |     48  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | M  +  M                                                                  |  25        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Deep Cervical, Congestion            |                                                                          |      1  2.0|
      Deep Cervical, Ectasia               |                                                                          |      1  1.0|
      Deep Cervical, Hemorrhage            |                                                                          |      1  2.0|
      Deep Cervical, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |                                                                          |      1  2.0|
      Lumbar, Ectasia                      |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      7  1.4|
      Mediastinal, Hemorrhage              |                                                                          |     15  1.9|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      2  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      2  3.0|
      Renal, Ectasia                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      4  2.3|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 2                                                                        |     27  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Ectasia                              |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     52  2.0|
      Pigmentation                         | 1  2  1                                                                  |     50  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +                                                                  |  51        |
      Atrophy                              | 3     3                                                                  |     49  3.9|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia                          |       3                                                                  |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      4  1.3|
      Inflammation                         |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  3.0|
      Cerebrum, Degeneration               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1  2  1                                                                  |     48  1.5|
      Inflammation                         |    4                                                                     |      3  3.3|
      Metaplasia, Squamous                 |       2                                                                  |     14  2.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1  1  1                                                                  |     46  1.6|
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     10  1.7|
      Olfactory Epithelium, Degeneration   |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  2.3|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Cornea, Inflammation                 |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7|                                                                 |            |
                             DAY ON TEST   | 5| 3| 2|                                                                 |            |
                                           | 5| 9| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    800 NG /                               | 8| 8| 8|                                                                 |      L     |
    100 UG                                 | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     13  1.2|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Inflammation, Suppurative            |                                                                          |      3  2.3|
      Mineralization                       |    1  1                                                                  |     44  1.0|
      Nephropathy                          | 1  1  2                                                                  |     48  2.0|
      Artery, Inflammation, Chronic Active |       3                                                                  |      1  3.0|
      Pelvis, Inflammation                 |                                                                          |      6  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |     16  2.3|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      4  2.3|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|             
                             DAY ON TEST   | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|             
                                           | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 UG                                 | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                            2                                            2|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Basophilic Focus                     |                                                                          |             
      Cholangiofibrosis                    |    3     4  4  3  4  4        3     4  4  4  2  4     4  4  4  2     4  4|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                  X                                       |             
      Eosinophilic Focus, Multiple         |                                                                   X      |             
      Fatty Change, Diffuse                | 2  1  2  3  2  3  2  1  1  2  1  3  2  2  2  2  2     2  2  1  1  3  2  1|             
      Fatty Change, Focal                  |                      3                                                   |             
      Hematopoietic Cell Proliferation     | 1     1  1           2                    1  2  1           1            |             
      Hyperplasia, Nodular                 | X  X  X  X  X  X  X  X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X|             
      Inflammation                         | 1  1  2  1  1  1  2  2  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1|             
      Metaplasia                           |                                           1  1                           |             
      Mixed Cell Focus                     | X                                                                        |             
      Mixed Cell Focus, Multiple           |             X                                                            |             
      Necrosis                             | 2                 3  2  2        2                                       |             
      Pigmentation                         | 2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  1  2|             
      Toxic Hepatopathy                    | 3  4  4  4  4  3  4  4  3  3  4  3  3  4  4  4  4  4  4  3  4  2  3  4  3|             
      Bile Duct, Cyst                      | 2  2  3     2  2     3                       2     2  2     2        2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|             
                             DAY ON TEST   | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|             
                                           | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 UG                                 | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  | 2                                      2                                 |             
      Bile Duct, Hyperplasia               | 1  1  1  2  2  1  1  2  1  1  2  1  2  2  2  3  2  2  2  2  2  2  1  3  1|             
      Centrilobular, Degeneration          |                         2        2                                       |             
      Centrilobular, Fibrosis              | 2  2  1  1  1  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2|             
      Hepatocyte, Glandular Structures     |                                                                      2   |             
      Hepatocyte, Hypertrophy              | 3  3  3  3  3  4  3  4  3  3  3  3  3  3  3  3  3  4  3  3  3  3  3  4  3|             
      Hepatocyte, Multinucleated           | 3  2  1  2  1  2  2  1  3  2  2  3  2  2  1  1  2  2  2  3  2  2  3     3|             
      Oval Cell, Hyperplasia               | 3  3  3  3  3  3  3  4  2  3  3  2  3  3  3  4  3  3  3  2  3  3  3  4  3|             
      Portal, Fibrosis                     | 2  3  3  3  3  1  3  3  3  2  2  2  3  3  3  3  3  3  3  2  3  2  2  3  3|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active | 3                    2                                      1            |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |    1     2           1  2           1  1  3        2  1  3               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              2                           |             
      Inflammation, Chronic Active         |                                        1                       2         |             
      Acinus, Atrophy                      |                            1           1     1                 1         |             
      Acinus, Vacuolization Cytoplasmic    | 2  2  1  1  3  2  1  2  2  2  2     1  2  2     2  2  2  2  2  1  1  2  1|             
      Artery, Inflammation, Chronic Active |                      3     3                 3     2                     |             
      Duct, Dilatation                     |          3                                   3                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                               |             
      Erosion                              |                                              2                           |             
      Hemorrhage                           |                                              2                           |             
      Mineralization                       |                      1                    1  1                           |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +     +     +  +  +     +     +           +  +  +     +        +|             
      Peridontal Tissue, Inflammation      |    2     1     4     1  1  1     1     1           1  2  3     1        1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|             
                             DAY ON TEST   | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|             
                                           | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 UG                                 | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Adventitia, Hemorrhage        |                                                                          |             
      Aorta, Adventitia, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1     1     1                       1        1  1  1            |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                      3     4           3                 3               |             
      Coronary Artery, Thrombosis          |                                                                          |             
      Epicardium, Inflammation             | 3  2        2                    1  1  2  1     1  1                     |             
      Valve, Fibrosis                      |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1              1                              |             
      Atrophy                              | 2  3  2  2  2        2  2  2  3     3  2  3  2  2  2  2  2  2  2     3   |             
      Degeneration, Cystic                 | 2                             2     3                 2  2               |             
      Hyperplasia                          |       3                                      2  2                        |             
      Hypertrophy                          | 3  1  1  2  2  3  2  2  2  1  3     4  3  2  1     2  3  1  3  2  1  1  1|             
      Necrosis                             |                                  2                                       |             
      Vacuolization Cytoplasmic            | 1     2        2  1  2        1  1  2  1  1     2  1  2        2         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      C-Cell, Hyperplasia                  |    1                       3           2  3  2                       1  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|             
                             DAY ON TEST   | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|             
                                           | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 UG                                 | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         | 3  2  1  1  1  2     2     2  3  1  2  2  2  2  1  2  2  2     2  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1     1     1     1        1  1        1           1  1        1     2|             
      Duct, Cyst                           |    2  2  2  3  2     2  2     2  2  3  2  3  2  4  3  3  3  3  3  4  3  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3           3                    3                       3      |             
      Cyst                                 |       1        2     2        2     2           2                        |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |                      3              2     3                          3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
      Hyperplasia                          | 3  2  3  3  3  3  3  3     3  3        2  4  3  3  3  2  3  3  2  2     2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  M  M  M  +  M  M  +  M  +  M  +  M  +  M  M  M  M  +  +  M  M  +  +  +|             
      Mediastinal, Ectasia                 |                                  2                       2           1   |             
      Mediastinal, Hemorrhage              |             2                    2                    1  2        2      |             
      Mediastinal, Hyperplasia, Histiocytic|                                        2                                 |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                                        2                                 |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|             
                             DAY ON TEST   | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|             
                                           | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 UG                                 | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                      3                                                   |             
      Renal, Hyperplasia                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   4                                                      |             
      Ectasia                              |                      2                                                   |             
      Hemorrhage                           |                                  2                                       |             
      Hyperplasia, Lymphoid                |       4                                                                  |             
      Hyperplasia, Plasma Cell             | 2        2     3     2  3  2  2              2              2  2  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                  2                                1      |             
      Hyperplasia, Histiocytic             |                2                                                  2      |             
      Hyperplasia, Lymphoid                |                                                                      4   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  2  2  2  2     2  2  2  2  1  1  2  2  1  1  2  1  2  2  1  1  2   |             
      Pigmentation                         | 1  1  1  1  2  2  2  1  2  2  1  2  1  2  1  1  2  1  1  1  1  2  1  1  1|             
      Lymphoid Follicle, Atrophy           |                   2              3                                       |             
      Red Pulp, Atrophy                    |                                                                         2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  4  2  4  4  4  4  4  4  4  4  4  4     4  4  3  4  4  4  4  4  3  4|             
      Artery, Inflammation, Chronic Active |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |          X                                                               |             
      Inflammation                         |                         3                                                |             
      Ulcer                                |                         3                                                |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                            3                                             |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|             
                             DAY ON TEST   | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|             
                                           | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 UG                                 | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2        2                       2        2      |             
      Inflammation                         |                3                                                         |             
      Necrosis                             |                3                                                         |             
      Artery, Inflammation, Chronic Active |                                                          2               |             
      Meninges, Inflammation               |                                                          3               |             
      Meninges, Vein, Thrombosis           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         1                                                |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1     1  1  1  1  1  1  1  1  1  1     1  1  1     1  1  1  1|             
      Inflammation                         |                                                                2         |             
      Metaplasia, Squamous                 |                                  2     2  2  2     1  4              2   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    1     1  1        1     1  1  1  1  2  1           1        1  1  2  1|             
      Mediastinum, Inflammation            | 3                                                                        |             
      Serosa, Fibrosis                     | 1           2     1           2           2  1  1  1        2            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1        1  4        2           3           1  1  1           1  2   |             
      Necrosis                             |                4                                                         |             
      Ulcer                                |                                                                          |             
      Glands, Hyperplasia                  |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                         3                       2                    2   |             
      Respiratory Epithelium, Hyperplasia  |    2        2  2        2           2           3  2  2              3   |             
      Squamous Epithelium, Hyperplasia     |                2                                                         |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|             
                             DAY ON TEST   | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|             
                                           | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 UG                                 | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1        1     1                          1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2  1     1     2  1  1  1  1  1     1     1     1     1  1     1     1|             
      Nephropathy                          | 2  1  3  3  3  3  1  1  1  2  2     1  1  3  3  2  3  2  3  3  1  1  3  1|             
      Pigmentation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       2                  |             
      Transitional Epithelium, Hyperplasia |                                                       3                  |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|             
                                           | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|             
    300 UG                                 | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                1         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation, Chronic Active |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Basophilic Focus                     |          X                                X              X  X            |             
      Cholangiofibrosis                    | 4     3  2  4        2  4  4  3  3  4  3  4  3  3  4  3     3  3  3  2  3|             
      Degeneration, Cystic                 |                                                    2                     |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                      X                 X                                X|             
      Fatty Change, Diffuse                | 1  1  2  2  1  1     2  2  2  1     1  1  2  1  2  2     2  2  2  2  1  2|             
      Fatty Change, Focal                  |                            2     3  4     3  2        2           2  2   |             
      Hematopoietic Cell Proliferation     |       1  1           1        1     1  1     1  1  1  1  1  1            |             
      Hyperplasia, Nodular                 | X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Inflammation                         | 2  1  2  1  2  1  1  1  1  1  1  1  1  1  1  1  2  1  1  2  1  1  2  1  1|             
      Metaplasia                           |                      1                                      1            |             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Necrosis                             | 2  3  2  3  3                       2        3  2  2     3              2|             
      Pigmentation                         | 2  2  2  2  2  2  2  3  2  2  2  2  1  2  2  2  2  2  1  2  2  2  2  2  2|             
      Toxic Hepatopathy                    | 4  4  4  3  4  3     3  4  3  3  3  3  3  4  4  4  4  3  3  3  3  4  3  4|             
      Bile Duct, Cyst                      | 2        2                 2  2     2     2  3  3  3  2  2        2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|             
                                           | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|             
    300 UG                                 | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                                              2                           |             
      Bile Duct, Hyperplasia               | 3  1  2  3  2  1     1  2  2  2  2  2  2  2  2  2  3  2  2  3  2  3  2  2|             
      Centrilobular, Degeneration          |                                              3                           |             
      Centrilobular, Fibrosis              | 2  2  2  2  2  2     1  1  1  1  1  2  2  2  3  2  2  2  2  3  2  4  2  2|             
      Hepatocyte, Glandular Structures     |                         1                       1                    1   |             
      Hepatocyte, Hypertrophy              | 4  3  3  3  3  3     3  3  3  3  3  3  3  3  4  3  3  3  4  3  3  4  3  3|             
      Hepatocyte, Multinucleated           | 2  2  2  2  1  3  2  3  2  2  2  2  1  3  2  1  1  1  1  1  1  3  1  2  2|             
      Oval Cell, Hyperplasia               | 3  3  4  3  3  3     3  3  3  3  3  3  2  3  4  3  3  3  3  3  3  4  3  3|             
      Portal, Fibrosis                     | 3  3  3  2  3  2     3  3  3  3  3  3  2  3  3  2  2  3  3  3  2  4  2  2|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |       2  3              1                 2        2        3            |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 2  2  3  2  1        1     1  3  2        1     1     2  2  2     1  1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                     1                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                1                                   2           1         |             
      Acinus, Vacuolization Cytoplasmic    | 1  1  1  2  2  2     2  1  2  2  2  2  1  2  2  3  2  2  2  3  3  2  3   |             
      Artery, Inflammation, Chronic Active | 4     3  4              2           3     2        1     2  3            |             
      Duct, Dilatation                     | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                                        |             
      Hyperplasia, Squamous                | 2              2                                      2                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                     1              2                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +  +  +        +     +     +        +     +  +  +  +  +        +   |             
      Peridontal Tissue, Inflammation      |    1  1  2  1        1     1     1        1     1  1  2  1  1        2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|             
                                           | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|             
    300 UG                                 | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Adventitia, Hemorrhage        |             2                                                            |             
      Aorta, Adventitia, Inflammation      |             3                                                            |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1                             1        1        1        1   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                      2                             2        3  3     2   |             
      Coronary Artery, Thrombosis          |                                                                          |             
      Epicardium, Inflammation             |                            1     2  2                                1   |             
      Valve, Fibrosis                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                              1         |             
      Atrophy                              | 3  3     2  2  2     2  3  3  3  3  4     2  2  3  2  3  4  3  2  2  3   |             
      Degeneration, Cystic                 |                                     2                                    |             
      Hyperplasia                          |                         2     2     3  2                       2     2   |             
      Hypertrophy                          | 2  3  2  3              2  1  1  1  3     3  2  2  2  1  3  1  2  3     2|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 2        1                    1     2     2  2  2  3     3     1  3     1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                      2        2                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 3                        |             
      Artery, Inflammation, Chronic Active |                                                             3            |             
      C-Cell, Hyperplasia                  |       1                          1  1     1        2  2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|             
                                           | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|             
    300 UG                                 | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicular Cell, Hyperplasia         |                                              2                    3      |             
      Follicular Cell, Hypertrophy         | 1     3  2  2  2     2     2  2  2  2  2  2     3  2  2  2  2  3     2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     1        1     1        1  1     1  2                 1     1      |             
      Duct, Cyst                           | 3  1  3  2  2  2  1  2  1     3  3  3     2  2  2  3  2  1  2  3  3  2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         4                       2                        |             
      Cyst                                 |       2                    2                                             |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                       +                  |             
      Cyst                                 |                                                       3                  |             
      Inflammation                         |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 1  2                                                  3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 3  3  4  3  3  4  3  2  3  2  3  3  3  3  3  3  3  3  3  3  3  2  2     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  M  +  M  M  M  M  M  +  M  M  M  M  M  +  +  M  +  M  +  M  M  +  M  M|             
      Mediastinal, Ectasia                 |                         2                    1           2        2      |             
      Mediastinal, Hemorrhage              |                         2                                2               |             
      Mediastinal, Hyperplasia, Histiocytic|       2                                                                  |             
      Pancreatic, Ectasia                  |                                           2                              |             
      Pancreatic, Hemorrhage               |                         2                                                |             
      Pancreatic, Hyperplasia, Histiocytic | 3                       2                 3                              |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|             
                                           | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|             
    300 UG                                 | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                            2              2                              |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Plasma Cell             | 2  2  2              2  2  3                 2  2        2        2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                                            |             
      Hemorrhage                           |                         1                 2                              |             
      Hyperplasia, Histiocytic             |       2     2                                               3            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  1  3  2  1  1     2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  3  2  2|             
      Pigmentation                         |    1     1  1  1  1  2  1  2  1  2  1  1  1     1  1  1  1  2  2  1  2  1|             
      Lymphoid Follicle, Atrophy           |          2                                                               |             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4  3  4  4  4  4  3     4  4     2  4  4  4  4|             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1  1        1  1     1                     |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|             
                                           | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|             
    300 UG                                 | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Meninges, Inflammation               |                                                                          |             
      Meninges, Vein, Thrombosis           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1     1  1  1  1  1  1  2  2  1  2  1  1  2  1     1  1  1|             
      Inflammation                         |                                                                      4   |             
      Metaplasia, Squamous                 | 3                       2  2     2        2  2                    2      |             
      Alveolar Epithelium, Hyperplasia     |                                                          1               |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1     1     1        1  1  2  1  1  1  1  1  1  1  1  1     1     1  1   |             
      Mediastinum, Inflammation            |                                                                          |             
      Serosa, Fibrosis                     |          2     1     2                                3     2  1         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2     2              2  1     2     1  1  3                 2     1|             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
      Glands, Hyperplasia                  |                                     3                             3      |             
      Olfactory Epithelium, Metaplasia     |       1                             3           3                 2      |             
      Respiratory Epithelium, Hyperplasia  |       2     2                       3           3                 3      |             
      Squamous Epithelium, Hyperplasia     |                            2                                             |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|             
                             DAY ON TEST   | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|             
                                           | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 NG/                               | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|             
    300 UG                                 | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation                 |                                                             3            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1                                   1           1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    1     1  1  1  1  1  1  1     1  1                 1  1  1  1     1  1|             
      Nephropathy                          | 3  1  2  3  2  1     1  2  2  2  2  3  1  3  1  2  3  2  2  3  1  1  1   |             
      Pigmentation                         |                                                 2                        |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      1     |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |       2                                                                  |      3  2.0|
      Basophilic Focus                     |                                                                          |      4     |
      Cholangiofibrosis                    | 4  4  4                                                                  |     42  3.4|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |    X                                                                     |      2     |
      Eosinophilic Focus, Multiple         |                                                                          |      4     |
      Fatty Change, Diffuse                | 2  1  2                                                                  |     49  1.7|
      Fatty Change, Focal                  | 3                                                                        |     10  2.6|
      Hematopoietic Cell Proliferation     |    1  1                                                                  |     22  1.1|
      Hyperplasia, Nodular                 | X  X  X                                                                  |     50     |
      Inflammation                         | 1  1                                                                     |     51  1.2|
      Metaplasia                           |                                                                          |      4  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Mixed Cell Focus, Multiple           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             |       2                                                                  |     17  2.4|
      Pigmentation                         | 3  2  2                                                                  |     53  2.0|
      Toxic Hepatopathy                    | 4  4  4                                                                  |     52  3.5|
      Bile Duct, Cyst                      |    2  3                                                                  |     25  2.2|
      Bile Duct, Fibrosis                  |                                                                          |      3  2.0|
      Bile Duct, Hyperplasia               | 2  3  2                                                                  |     52  1.9|
      Centrilobular, Degeneration          |                                                                          |      3  2.3|
      Centrilobular, Fibrosis              | 3  2  3                                                                  |     52  1.9|
      Hepatocyte, Glandular Structures     |    1                                                                     |      5  1.2|
      Hepatocyte, Hypertrophy              | 3  4  3                                                                  |     52  3.2|
      Hepatocyte, Multinucleated           | 2  1  2                                                                  |     52  1.9|
      Oval Cell, Hyperplasia               | 3  3  3                                                                  |     52  3.0|
      Portal, Fibrosis                     | 3  3  3                                                                  |     52  2.7|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +                                                                  |  52        |
      Artery, Inflammation, Chronic Active |                                                                          |      9  2.1|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  53        |
      Gingival, Hyperplasia, Squamous      |    1                                                                     |     27  1.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Edema                                | 2                                                                        |      4  1.8|
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Acinus, Atrophy                      | 2  1                                                                     |      9  1.2|
      Acinus, Vacuolization Cytoplasmic    | 1  2  3                                                                  |     49  1.9|
      Artery, Inflammation, Chronic Active |       2                                                                  |     14  2.6|
      Duct, Dilatation                     |                                                                          |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Squamous                | 1                                                                        |      4  1.8|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |    1                                                                     |      6  1.2|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |  29        |
      Peridontal Tissue, Inflammation      | 1  1                                                                     |     29  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Adventitia, Hemorrhage        |                                                                          |      1  2.0|
      Aorta, Adventitia, Inflammation      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |    1                                                                     |     14  1.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |    2                                                                     |     10  2.7|
      Coronary Artery, Thrombosis          |       2                                                                  |      1  2.0|
      Epicardium, Inflammation             |                                                                          |     13  1.5|
      Valve, Fibrosis                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      4  1.0|
      Atrophy                              | 2  2  2                                                                  |     44  2.4|
      Degeneration, Cystic                 |                                                                          |      6  2.2|
      Hyperplasia                          |    2                                                                     |     10  2.2|
      Hypertrophy                          | 2  1  1                                                                  |     45  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1                                                                        |     27  1.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Pars Distalis, Hyperplasia           |    3                                                                     |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |    2  2                                                                  |     15  1.8|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.5|
      Follicular Cell, Hypertrophy         | 1  3  1                                                                  |     44  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |     21  1.1|
      Duct, Cyst                           | 2  3  2                                                                  |     48  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 3                                                                        |      7  3.0|
      Cyst                                 |                                                                          |      8  1.9|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Uterus                                  | +  +  +                                                                  |  53        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Atrophy                              | 3                                                                        |      2  2.5|
      Hyperplasia                          |    4  2                                                                  |     47  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | M  +  M                                                                  |  20        |
      Mediastinal, Ectasia                 |                                                                          |      7  1.7|
      Mediastinal, Hemorrhage              |                                                                          |      7  1.9|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      2  2.0|
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      4  2.5|
      Renal, Ectasia                       |    2                                                                     |      1  2.0|
      Renal, Hemorrhage                    |    2                                                                     |      1  2.0|
      Renal, Hyperplasia, Histiocytic      |                                                                          |      1  3.0|
      Renal, Hyperplasia                   |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  52        |
      Atrophy                              |                                                                          |      1  4.0|
      Ectasia                              | 2                                                                        |      4  2.0|
      Hemorrhage                           | 1                                                                        |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
      Hyperplasia, Plasma Cell             | 3                                                                        |     22  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      4  1.5|
      Hyperplasia, Histiocytic             |                                                                          |      5  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 3  2  2                                                                  |     50  1.9|
      Pigmentation                         | 1  1  2                                                                  |     50  1.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      3  2.3|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Atrophy                              | 4  4  4                                                                  |     50  3.8|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      6  1.2|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation                         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           | 2                                                                        |      5  2.0|
      Inflammation                         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Meninges, Inflammation               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Meninges, Vein, Thrombosis           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      2  1.0|
      Infiltration Cellular, Histiocyte    | 1  1                                                                     |     46  1.1|
      Inflammation                         |                                                                          |      2  3.0|
      Metaplasia, Squamous                 | 2  4                                                                     |     16  2.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1  1                                                                     |     35  1.1|
      Mediastinum, Inflammation            |                                                                          |      1  3.0|
      Serosa, Fibrosis                     |       2                                                                  |     16  1.6|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |    1  3                                                                  |     22  1.7|
      Necrosis                             |                                                                          |      1  4.0|
      Ulcer                                |       2                                                                  |      1  2.0|
      Glands, Hyperplasia                  |                                                                          |      2  3.0|
      Olfactory Epithelium, Metaplasia     |       2                                                                  |      8  2.3|
      Respiratory Epithelium, Hyperplasia  |    2  3                                                                  |     16  2.4|
      Squamous Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Cornea, Inflammation                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 5|                                                                 |            |
                             DAY ON TEST   | 8| 3| 6|                                                                 |            |
                                           | 3| 2| 5|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    2400 NG/                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 5| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Mineralization                       |    1  1                                                                  |     34  1.1|
      Nephropathy                          | 1  3  3                                                                  |     50  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|             
                             DAY ON TEST   | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|             
                                           | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cholangiofibrosis                    |    4           4  3  2  4     3           4     3                 4  3   |             
      Eosinophilic Focus, Multiple         |       X                                                  X  X     X      |             
      Fatty Change, Diffuse                | 2     1  2     2  1  2  1  2     1  1  2  1  3  2  2  2  1  2  1  1  2   |             
      Fatty Change, Focal                  |    2                                                           3  2      |             
      Hematopoietic Cell Proliferation     |       1                                      1                           |             
      Hyperplasia, Nodular                 | X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Inflammation                         | 1  2  2  2  1  1  2  1  1  2  2  2  1  1  2     2  1  1  1  1  1  2  1  1|             
      Metaplasia                           |                                                                2  2      |             
      Mineralization                       | 2                                                                        |             
      Mixed Cell Focus                     |                X                                                  X      |             
      Necrosis                             | 3  3              3     2  2                    3     3        3         |             
      Pigmentation                         |    1  2  1  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2     2  2  1|             
      Thrombosis                           |                                                                          |             
      Toxic Hepatopathy                    | 4  4  2  4  4  4  4  4  4  3  4  3  4  3  4  4  4  4  4  3  3  4  4  4  4|             
      Bile Duct, Cyst                      |    2           2  2     1                 2  2     2              2      |             
      Bile Duct, Dilatation                |                   2                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|             
                             DAY ON TEST   | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|             
                                           | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                         2                                                |             
      Bile Duct, Hyperplasia               | 3  3  1  3  3  3  3  3  3  1  3  1  3  1  3  3  2  2  2  1     3  2  2  3|             
      Centrilobular, Degeneration          |                                                             2            |             
      Centrilobular, Fibrosis              | 2     2  2  2  2  2  2  2  2  3  2  3  2     3  2  2  2  2  2     2  2  2|             
      Hepatocyte, Glandular Structures     | 2           3     1     1     3     4           1     2  1     2        3|             
      Hepatocyte, Hypertrophy              | 4  4  2  4  4  3  4  3  4  3  4  2  4  3  4  4  3  3  3  4  4  4  4  4  4|             
      Hepatocyte, Multinucleated           | 1  1  2  1  1     2  1  1  3  2  3     3  1  1  2  2  2  2  2        1   |             
      Oval Cell, Hyperplasia               | 3  4  1  4  3  4  4  4  4  2  3  2  3  2  4  4  3  4  2  2  2  4  3  3  3|             
      Portal, Fibrosis                     | 3  3     4  3  3  3  3  3     3  2  4  2  3  3  3  3  2  3  3  4  3  3  4|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                    3              3      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Gingival, Hyperplasia, Squamous      |    2              2  1     1     1              1  1        4  1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             2  1              2     2                                   2|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                3        1|             
      Acinus, Atrophy                      |                                                             1  3        2|             
      Acinus, Vacuolization Cytoplasmic    |    2     1     2  2  2  1  2  1  1     3  3  1  1  3  1  1        3  1   |             
      Artery, Inflammation, Chronic Active |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Squamous                |                2                    1  2                                 |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                               1                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|             
                             DAY ON TEST   | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|             
                                           | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                               2                                         2|             
      Glands, Cyst                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +        +     +  +     +     +              +  +  +        +         |             
      Peridontal Tissue, Inflammation      |    2        1     2  1     1     1              1  1  1        1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Adventitia, Hemorrhage        |                                                                          |             
      Aorta, Adventitia, Inflammation      | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                         2              2  1     1  1                     |             
      Atrium, Thrombosis                   |                                                          3               |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                   3     3                 2              3               |             
      Epicardium, Hemorrhage               |                                     2                                    |             
      Epicardium, Inflammation             |                            2           2     1                           |             
      Myocardium, Hemorrhage               |                                     2                                    |             
      Myocardium, Inflammation             |                                                                          |             
      Myocardium, Necrosis                 |                                                          3               |             
      Ventricle, Thrombosis                |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        1           1              1      |             
      Atrophy                              | 2  3     2  2  3  2  2  2  2  2  2     2  4  3     2     2        2  3   |             
      Degeneration, Cystic                 |                                  1        2                              |             
      Hyperplasia                          |                                                                2         |             
      Hypertrophy                          | 2     3  1     1  2        1  1  1     2  3  2  1  2              1  3   |             
      Necrosis                             |                                                             2            |             
      Vacuolization Cytoplasmic            |             1                 1                    1  1           1  2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|             
                             DAY ON TEST   | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|             
                                           | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Necrosis                             |                                                             2            |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                         3|             
      C-Cell, Hyperplasia                  |                                           2                              |             
      Follicular Cell, Hyperplasia         |                                                                      2   |             
      Follicular Cell, Hypertrophy         | 2  2  1  1     2     1  1  1        1  1  1     2  1  3              2  4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1  1     1  1        1     1     2     1  1     1           2   |             
      Duct, Cyst                           | 3  2  2  3  3  3  3  2  2  2  1  2  2  2  3  3  2  3  2  3  2  3  2  3  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3              2        3                    4                           |             
      Cyst                                 |                2                          2        1              2      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                        1              2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|             
                             DAY ON TEST   | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|             
                                           | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          | 2  3  2     2  3  3  3  3  3     2  2  2  2     3     2  2     3  2  2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  M  +|             
      Mediastinal, Ectasia                 |    2  1     1     2     2  1  1  2     2  2           1        2         |             
      Mediastinal, Hemorrhage              |    2  1           1                                   1     2  2        1|             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Pigmentation            |                   2                                                      |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |                                                    2                     |             
      Pancreatic, Hyperplasia, Histiocytic |                         3                          2              2      |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                       2        2         |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Hyperplasia, Plasma Cell             | 2  2     2  2  2        2  2                                      2      |             
      Necrosis, Lymphoid                   |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                                            |             
      Hemorrhage                           |                2                    3           2     2        2        3|             
      Hyperplasia, Lymphoid                |                            3                                             |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2  2  1     2  1  1  2           2  1  2     1  2  1        2        1|             
      Pigmentation                         | 1  1  1  1     1  1  1  1  2  1  1     1  1     1  1  1  1  1  1  1  1  1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                  3                                       |             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Atrophy                              |    4  4  4  4  4  4  4  4  4  3  3  4  3  4     4     4  4  4     4  4  4|             
      Artery, Inflammation, Chronic Active |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|             
                             DAY ON TEST   | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|             
                                           | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                                |             
      Inflammation                         |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                          +               |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          1               |             
      Infiltration Cellular, Histiocyte    | 1  1           1  1     1        1     1  1  1  1  1  1     1  1         |             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |                         2  2           2                       2         |             
      Alveolar Epithelium, Hyperplasia     |                                           1                              |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                                                    1  1                  |             
      Artery, Thrombosis                   |                   2                                                      |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Serosa, Fibrosis                     |                                                    2              2      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2           1                          1                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|             
                             DAY ON TEST   | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|             
                                           | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |    3     1     2                          1                              |             
      Squamous Epithelium, Hyperplasia     |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 1  1              1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                          3               |             
      Inflammation, Suppurative            |                                                          1               |             
      Mineralization                       |    1        1  1  1  1  1           1  1     1  1  1           1  1     1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          |    1           1  1     1  1              1  2  1  2  1  1  1  1  1  1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|             
                             DAY ON TEST   | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|             
                                           | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                      3              2                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2              2                     |             
      Inflammation                         |       2                                            2                     |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                    2                                                   |             
      Cholangiofibrosis                    |          3     1     3  3  4                 3  4  3  3     2  4        4|             
      Eosinophilic Focus, Multiple         |                X                                         X              X|             
      Fatty Change, Diffuse                | 1  2     2  1  3  2  2  2  2  2  2  1     3  1  2     2  2  2  2  1  2   |             
      Fatty Change, Focal                  |                                        2                                2|             
      Hematopoietic Cell Proliferation     |       1              1  1                                1     1        1|             
      Hyperplasia, Nodular                 | X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Inflammation                         | 1  1  2  1  2  1  1  1  2  2  2  1  1  1  2  2  1  1  2  1  2  2  1  1  2|             
      Metaplasia                           |             2           2                                                |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                         X                                                |             
      Necrosis                             |    1        2  1  2  3  2                    3        2     2  2     1   |             
      Pigmentation                         |    2  2  2     2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2|             
      Thrombosis                           |                      2                                                   |             
      Toxic Hepatopathy                    | 4  3  4  4  4  3  3  4  4  4  4  3  4  4  3  4  4  4  4  3  4  4  4  4  4|             
      Bile Duct, Cyst                      |                      1  2  1     2                                       |             
      Bile Duct, Dilatation                |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|             
                             DAY ON TEST   | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|             
                                           | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                2        1                                                |             
      Bile Duct, Hyperplasia               | 2  2  3  2  3     1  2  4  3  2  1  3  2  1  2  2  3  3  1  3  4  3  3  2|             
      Centrilobular, Degeneration          |    2           2  3              1        2                              |             
      Centrilobular, Fibrosis              | 2  2  3  2  3  2  2  2     2  2  2  2  2  2  2  2  2     2  2  2  2  3  2|             
      Hepatocyte, Glandular Structures     | 3     4     3        2     2        2        1     3     2  2     3  2   |             
      Hepatocyte, Hypertrophy              | 3  3  4  4  4  3  3  3  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4  4  3|             
      Hepatocyte, Multinucleated           |    1  1        2  2  1  1  1  2  2        1     1        1  1  1     1  2|             
      Oval Cell, Hyperplasia               | 3  3  4  3  3     1  3  4  3  3  2  3  3  3  3  4  3  4  2  4  4  3  3  3|             
      Portal, Fibrosis                     | 2  2  3  3  4        3  4  3  3  2  3  3  2  3  3  3  4  2  4  3  3  3  3|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                         1              1           3                     |             
      Fat, Necrosis                        |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Gingival, Hyperplasia, Squamous      |          2           1  2  1                                2  1        1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2     2                             2  1     2  2  2  2        2  2  1   |             
      Hemorrhage                           |                                              3                           |             
      Inflammation, Chronic Active         |       2                                1                       2         |             
      Acinus, Atrophy                      |       1                                1              1        3         |             
      Acinus, Vacuolization Cytoplasmic    |    1     2           3  2  2  1  1     2  1     1  1  1        1     1  2|             
      Artery, Inflammation, Chronic Active |                         2              1                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      2   |             
      Hyperplasia, Squamous                |                         2                                2        2  2   |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   2      |             
      Hemorrhage                           |       1                                                           2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|             
                             DAY ON TEST   | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|             
                                           | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |          2                                                     1         |             
      Glands, Cyst                         |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +                 +  +  +  +  +              +           +  +        +|             
      Peridontal Tissue, Inflammation      |    2                 1  1  2  1  1              2           2  2        1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Adventitia, Hemorrhage        |                                              2                           |             
      Aorta, Adventitia, Inflammation      |                                              2                           |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2                 1  1  1     2              1              2  1      |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |             2           3     3  1                                       |             
      Epicardium, Hemorrhage               |                                                                          |             
      Epicardium, Inflammation             |                      2                                1                 1|             
      Myocardium, Hemorrhage               |                                              2  2                        |             
      Myocardium, Inflammation             |                                              2                           |             
      Myocardium, Necrosis                 |                                              2                           |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |    2     3           2  3  3                 2        3  2  2  2        2|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                            3  2                 1                        |             
      Hypertrophy                          |          1  1           3  1     1           1  1           2  1        2|             
      Necrosis                             |                2                          2                              |             
      Vacuolization Cytoplasmic            |                1  1     2              3                    1            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|             
                             DAY ON TEST   | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|             
                                           | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Pars Distalis, Hyperplasia           |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                 2                        |             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         | 1        2        2     1  1  2        1              2        1        3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                 1        1  1  1  1  2  1                 1  1      |             
      Duct, Cyst                           | 2  2  3     2     3  3  3  3  2     2  3  3  2  3  3  3  2  3  2  2  3  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                             3              3               |             
      Cyst                                 |                2        2     3        3                       2         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hemorrhage                           |                                                                3         |             
      Inflammation, Suppurative            |                      2                                                   |             
      Thrombosis                           |                      2                                                   |             
      Endometrium, Hyperplasia, Cystic     |    1                 3     3                                   2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3  2              2        3     3        2           3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|             
                             DAY ON TEST   | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|             
                                           | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia                          | 2     3  2  2        3  3  3  2  3  3  3     2     3  3     3  4        3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Mediastinal, Ectasia                 |    1                    2           1  2        2  2     1     2  1  1   |             
      Mediastinal, Hemorrhage              | 2  2        2  2  3  3           2  3     3  1  2  2  1           1  2   |             
      Mediastinal, Hyperplasia, Histiocytic|                      3  2                                                |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               | 2                                         2                              |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                  2                                       |             
      Renal, Hyperplasia, Histiocytic      |                         3                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                2  2                             2                    2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |    2     2     2                          2     2        2     2  2      |             
      Necrosis, Lymphoid                   |                                                                      1   |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |    2  2        1                    3           2                 2  2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2     2           2  1  1  1  1  1  1  1  1  3  1        2  2  1     2|             
      Pigmentation                         | 1  2     1     1  2  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1|             
      Artery, Inflammation, Chronic Active |                         3                                                |             
      Lymphoid Follicle, Atrophy           |             3  3                                      2           3  2   |             
      Red Pulp, Atrophy                    |                2  2                                                      |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
      Atrophy                              | 3     4  4  4  4  4  4  3  4  4  4  3  4  4  4  4  4  4  4  3  4        3|             
      Artery, Inflammation, Chronic Active |                                                    2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|             
                             DAY ON TEST   | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|             
                                           | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3           3  2              1        2  3  2                 1  3   |             
      Mineralization                       |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1                                   1           2            |             
      Infiltration Cellular, Histiocyte    |          1     1  1           1  1        1     1        1  1  1     1   |             
      Inflammation                         | 1                                                           2            |             
      Metaplasia, Squamous                 |                         4  3                                             |             
      Alveolar Epithelium, Hyperplasia     |                            1                                   1         |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    1     1                                                               |             
      Artery, Thrombosis                   |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic Active                  |                         3                                                |             
      Serosa, Fibrosis                     |                                                                         2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                    1                    1  2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|             
                             DAY ON TEST   | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|             
                                           | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    4000 NG/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                2         |             
      Respiratory Epithelium, Hyperplasia  |                                                             2  2         |             
      Squamous Epithelium, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                         2                                                |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1           1        1              2               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |       1  1        1  1  1     1     1           1  1  1  1  1  1  3  1  1|             
      Necrosis                             |                                                                   3      |             
      Nephropathy                          | 1                 1  3  2  1  2  1     2  1     1  1  1  1  1  2  2     2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Muscularis, Inflammation             |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Edema                                |                                                                          |      2  2.0|
      Inflammation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Angiectasis                          |                                                                          |      2  2.5|
      Cholangiofibrosis                    |       4  3        4              2  3  2     4                           |     29  3.2|
      Eosinophilic Focus, Multiple         |                            X     X     X                                 |     10     |
      Fatty Change, Diffuse                | 1  3  2  1  3     2  2  1  1  1  1  3  2     2                           |     56  1.8|
      Fatty Change, Focal                  |                               2                                          |      6  2.2|
      Hematopoietic Cell Proliferation     |          1              1                    1                           |     11  1.0|
      Hyperplasia, Nodular                 | X  X  X  X  X     X  X     X  X  X  X  X     X                           |     61     |
      Inflammation                         | 1  1  2  1  1     1  1  2  1  2  2  1  1  1  1                           |     64  1.4|
      Metaplasia                           |                                                                          |      4  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis                             |    2  2           3           3  1     2  2  2                           |     27  2.2|
      Pigmentation                         | 2  2  2  2  3     2  2  1  2  2  1  3  2     2                           |     60  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Thrombosis                           |                                                                          |      1  2.0|
      Toxic Hepatopathy                    | 4  3  4  3  4     4  4  1  2  3  3  3  3     4                           |     64  3.6|
      Bile Duct, Cyst                      |       2           3                                                      |     14  1.9|
      Bile Duct, Dilatation                |                                                                          |      1  2.0|
      Bile Duct, Fibrosis                  |                                  1                                       |      4  1.5|
      Bile Duct, Hyperplasia               | 3  2  2  2  2     3  3        1  2  2  2     3                           |     60  2.4|
      Centrilobular, Degeneration          |    2                       1                                             |      8  1.9|
      Centrilobular, Fibrosis              | 2  2  2  2  2     2  2     1  2     2  2     2                           |     57  2.1|
      Hepatocyte, Glandular Structures     | 2           2                                                            |     25  2.2|
      Hepatocyte, Hypertrophy              | 4  3  3  3  3     4  4  2  3  3  4  3  3  2  4                           |     65  3.5|
      Hepatocyte, Multinucleated           | 1  2  2  2  2           2  3  1  2  2  3     3                           |     48  1.7|
      Oval Cell, Hyperplasia               | 3  2  3  3  3     4  4     2  3  3  3  2     3                           |     62  3.0|
      Portal, Fibrosis                     | 3  2  3  2  3     3  3        3  3  2  2     3                           |     58  2.9|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +                           |  63        |
      Artery, Inflammation, Chronic Active |                                                                          |      3  1.7|
      Fat, Necrosis                        |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Cyst                                 | 2                                                                        |      1  2.0|
      Gingival, Hyperplasia, Squamous      |       2                                      2                           |     18  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Edema                                | 2                    2                       1                           |     19  1.8|
      Hemorrhage                           |                                        2                                 |      2  2.5|
      Inflammation, Chronic Active         |                                        2                                 |      6  1.8|
      Acinus, Atrophy                      |                                        2                                 |      8  1.8|
      Acinus, Vacuolization Cytoplasmic    | 1  1     2  1     3  1     2     2  2        1                           |     43  1.6|
      Artery, Inflammation, Chronic Active |                                     3                                    |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia, Squamous                |       2                                      2                           |      9  1.9|
      Inflammation                         |                   1                                                      |      1  1.0|
      Mineralization                       |                                        1                                 |      2  1.0|
      Ulcer                                |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Erosion                              |                   2                                                      |      2  2.0|
      Hemorrhage                           |                                                                          |      3  1.7|
      Inflammation                         |                   1                                                      |      1  1.0|
      Mineralization                       |                      1                                                   |      5  1.6|
      Glands, Cyst                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +     +           +                 +        +                           |  25        |
      Peridontal Tissue, Inflammation      | 1     4           2                 1        1                           |     25  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Aorta, Adventitia, Hemorrhage        |                                                                          |      1  2.0|
      Aorta, Adventitia, Inflammation      |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Cardiomyopathy                       |       1              1        1  1  1        1                           |     19  1.3|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                  2                                       |      9  2.4|
      Epicardium, Hemorrhage               |                                                                          |      1  2.0|
      Epicardium, Inflammation             |                                                                          |      6  1.5|
      Myocardium, Hemorrhage               |                                                                          |      3  2.0|
      Myocardium, Inflammation             |                                                                          |      1  2.0|
      Myocardium, Necrosis                 |                                                                          |      2  2.5|
      Ventricle, Thrombosis                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Angiectasis                          |          1                    1           1                              |      6  1.0|
      Atrophy                              | 2     2  2  3     2  2     2  2  3  2        4                           |     40  2.4|
      Degeneration, Cystic                 |                                                                          |      2  1.5|
      Hyperplasia                          |                   2                                                      |      5  2.0|
      Hypertrophy                          |                               2              1                           |     27  1.6|
      Necrosis                             |    2                                                                     |      4  2.0|
      Vacuolization Cytoplasmic            |                                              3                           |     12  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  64        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  62        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Necrosis                             |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hemorrhage                           |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |                               2                                          |      3  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
      Follicular Cell, Hypertrophy         | 2     2           1  2  2  1     2  2  2  3  2                           |     37  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Inflammation                         |    1     1  1  1        2  1     1  1     1  1                           |     31  1.1|
      Duct, Cyst                           | 2  2  2  3  2     2  2     1  2  3  3  3  2  3                           |     61  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Atrophy                              |       3     3                                                            |      9  3.0|
      Cyst                                 | 2           2     2        2                                             |     13  2.1|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Adenomyosis                          |                                  2                                       |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                  3                                       |      2  2.5|
      Thrombosis                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |    1                             3                                       |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Atrophy                              | 2  2        2        2                                                   |     12  2.3|
      Hyperplasia                          |       3  3     3  2     2  3  2  4  3  2  2  3                           |     49  2.6|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | M  M  +  M  +  M  M  +  +  +  M  M  M  M  M  M                           |  45        |
      Mediastinal, Ectasia                 |       1     3        2  1  2                                             |     27  1.6|
      Mediastinal, Hemorrhage              |             2        1     1                                             |     25  1.8|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      2  2.5|
      Mediastinal, Pigmentation            |             2                                                            |      2  2.0|
      Pancreatic, Ectasia                  |       2                                                                  |      1  2.0|
      Pancreatic, Hemorrhage               |       1                                                                  |      4  1.8|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      3  2.3|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Histiocytic      |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Ectasia                              |                      2                                                   |      1  2.0|
      Hemorrhage                           |                      2                                                   |      7  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 2     3  2                             3                                 |     20  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Necrosis, Lymphoid                   |                                                                          |      1  1.0|
      Necrosis                             |    1                                                                     |      1  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Ectasia                              |       2                                                                  |      2  2.0|
      Hemorrhage                           |       1                                                                  |     14  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Hematopoietic Cell Proliferation     | 2     2  1  1        3  1  1     1  2  2     1                           |     43  1.5|
      Pigmentation                         | 1  2  1  1  1     1  1  1  1  1  1  1  1  2  1                           |     59  1.1|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Lymphoid Follicle, Atrophy           |    3              2           2                                          |      9  2.6|
      Red Pulp, Atrophy                    |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  59        |
      Atrophy                              | 4  4  4  4  4     4  4  2  4  4  3  4  4     4                           |     57  3.8|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hemorrhage                           |    3     1  2                             2                              |     14  2.2|
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hemorrhage                           |                                                                          |      4  1.3|
      Infiltration Cellular, Histiocyte    |    1  1  1  1     1              1  1        1                           |     33  1.0|
      Inflammation                         |                                                                          |      2  1.5|
      Metaplasia, Squamous                 |             3                                                            |      7  2.6|
      Alveolar Epithelium, Hyperplasia     |                            2                                             |      4  1.3|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |          1        1                    1     1                           |      8  1.0|
      Artery, Thrombosis                   |                                                                          |      1  2.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Serosa, Fibrosis                     |                            2     2  1  1     2                           |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Inflammation                         |       2           1        1                                             |     11  1.4|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |       2           2                          2                           |      9  1.9|
      Squamous Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4|                          |            |
                             DAY ON TEST   | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4|                          |            |
                                           | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                          |      A     |
    4000 NG/                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|                          |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Retina, Atrophy                      |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Inflammation                         |    1     1                                                               |      9  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 1        1        1  1        1  1     1                                 |     37  1.1|
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy                          |    1  1  1  1     3  1  1        2  3  1     2                           |     43  1.4|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|             
                             DAY ON TEST   | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|             
                                           | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    500UG ST                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation, Chronic Active |       3                       3                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             2            |             
      Inflammation                         |                                                             2            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2        3           2                                          |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                   X                                                      |             
      Cholangiofibrosis                    |          2  2     3  1  4  1  3  2        1     1  1  1  1           1   |             
      Clear Cell Focus                     |                   X                                                      |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   | X                                                                        |             
      Eosinophilic Focus, Multiple         |    X     X  X  X  X           X     X        X     X                 X   |             
      Fatty Change, Diffuse                | 2  2  1  1  2  1     1     1  1  1  1  1  3     1     3  1  1  2  1  1   |             
      Fatty Change, Focal                  |       2  2  2           1                                      2     1   |             
      Hematopoietic Cell Proliferation     | 2        1  2  1  1        1  1              1     1                 2   |             
      Hemorrhage                           |                                              2                           |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 | X           X  X  X  X  X           X  X  X     X  X     X  X  X  X  X  X|             
      Inflammation                         | 2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|             
                             DAY ON TEST   | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|             
                                           | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    500UG ST                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Metaplasia                           |                                                             2            |             
      Mixed Cell Focus                     |             X                                                            |             
      Mixed Cell Focus, Multiple           |    X  X  X     X  X     X  X  X                    X                 X   |             
      Necrosis                             | 2              2                          2  2                           |             
      Pigmentation                         | 2  2  2  2  2  1  1  2  1  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2|             
      Toxic Hepatopathy                    | 2  2  2  2  2  2  2  2  2  1  2  2  3  3  3  2  3  2  3  4  3  2  3  2  3|             
      Bile Duct, Cyst                      |       3  4  2  2  3     4     3              2                 3         |             
      Bile Duct, Fibrosis                  |                               2              2                 2  2      |             
      Bile Duct, Hyperplasia               | 1           1  1  1     1     1     3  1        1     1  3  3  2  2  1  3|             
      Centrilobular, Degeneration          |                      2                    1           2                  |             
      Centrilobular, Fibrosis              | 2  1        2  1     3     1     2  3  2  3  2  2  1  2  2  2  2  2  2  3|             
      Hepatocyte, Glandular Structures     |                                        3        2        1  2           3|             
      Hepatocyte, Hypertrophy              | 4  3  1     4  2  2              3  4  3  4     3  3  3  4  4     1  2  3|             
      Hepatocyte, Multinucleated           | 3  2     2  2  2     1     1  1        1  2        1  1     1  1  2  3  1|             
      Oval Cell, Hyperplasia               | 2  2        2  2  2  2  1  1  1  2  3  3  2  1  3     3  3  3  2  3  1  3|             
      Portal, Fibrosis                     | 1     2     3  2  2  1     1        3  3  2     3  2  3  3  3  3  3  1  3|             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  M  M  +  +  +  M  M  +  +  +  M  M  +  +  +  +  +  +  +|             
      Necrosis                             |                3                                                         |             
      Artery, Inflammation, Chronic Active |             2                 1                                2         |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      | 1  1           1  2        1     2                 1        1            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        2        2        2  2           2|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                1              2  3                                       |             
      Acinus, Atrophy                      |                               2  4                             3         |             
      Acinus, Vacuolization Cytoplasmic    | 2  2  3  2  3  1  1  1  2  2  2              2     2  1        1  1  1  1|             
      Artery, Inflammation, Chronic Active |    2  2  1  1                                                  1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                2         |             
      Hyperplasia, Squamous                |             2                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|             
                             DAY ON TEST   | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|             
                                           | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    500UG ST                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation                         |                                                                1         |             
      Mineralization                       |             2                                                            |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            1                                             |             
      Artery, Inflammation, Chronic Active |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +           +  +     +  +  +  +                 +        +            |             
      Peridontal Tissue, Inflammation      | 1  1           2  2     1  2  2  3                 2        1            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Adventitia, Hemorrhage        |                                                 3                        |             
      Aorta, Adventitia, Inflammation      |                                     1           2                        |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1     1                 1        1        1              1         |             
      Atrium, Thrombosis                   |             1                                                            |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                      3   |             
      Epicardium, Inflammation             |             1                                                            |             
      Myocardium, Hemorrhage               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2  2  1     2     1  1  1     1        1     1        1        1   |             
      Atrophy                              |                                                 2     2  3              2|             
      Degeneration, Cystic                 |          3        2     2  3                                   3         |             
      Hyperplasia                          |    2        2     2                                2                     |             
      Hypertrophy                          |       1  3  2  2  3     3  3  2        3     3     2  2        3     1   |             
      Inflammation                         |                                                       2                  |             
      Necrosis                             |                   2                                                      |             
      Vacuolization Cytoplasmic            |          2  2     2                       2  2                 3        1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|             
                             DAY ON TEST   | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|             
                                           | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    500UG ST                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |             2     2              2                                       |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1           2           1                                          |             
      Cyst                                 |                                                                      2   |             
      Cytoplasmic Alteration               |                                                                          |             
      Pars Distalis, Hyperplasia           |       2           2                                            1         |             
      Pars Intermedia, Hyperplasia         |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      |                                                          3               |             
      C-Cell, Hyperplasia                  |                2                                                         |             
      Follicular Cell, Hypertrophy         | 2  1  2        1  3        2  2  1           2     1     4     1  1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1  2     1  1  1     1     1  1     1     1     1           2     1   |             
      Duct, Cyst                           |    2  3  3  3     2  2  2     3  1  2  2     1  3  2  2  3     3  2     2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3     3  3     3     3                       3  3               |             
      Cyst                                 |                               3              2     2           2         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Hemorrhage                           |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                2                 3                                       |             
      Metaplasia, Squamous                 |                2  1     2                                                |             
      Cervix, Stromal Hyperplasia          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|             
                             DAY ON TEST   | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|             
                                           | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    500UG ST                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       2  1        1     2     1  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                 2  2     2                        |             
      Hyperplasia                          | 2  2        3  4        3  3     4  1  2     3  1  3  1  3  3  3  2  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  M  M  M  M  M  M  M  M  M  M  M  M  +  M  +  M  +  M  M  M  +  M  +  M|             
      Lumbar, Hemorrhage                   |                                              1                           |             
      Lumbar, Hyperplasia, Histiocytic     |                                              2                           |             
      Mediastinal, Ectasia                 |                                                                2         |             
      Mediastinal, Hemorrhage              |                                        2                       2     3   |             
      Mediastinal, Hyperplasia, Histiocytic|                                              2                           |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                              2                           |             
      Pancreatic, Hemorrhage               |                                        2                                 |             
      Pancreatic, Hyperplasia, Histiocytic |                                        2                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Ectasia                       |                                              3                           |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                              2                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         3                    2                 2        2|             
      Hemorrhage                           |                                        2        2     1                  |             
      Hyperplasia, Plasma Cell             | 2  2  3  2     3  3     2  2  3  2     3           2     3     3     2  2|             
      Inflammation                         |                                                                2         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                2         |             
      Hemorrhage                           |                                                 2     2  2  3  2        2|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  2  2  2  2  2     2  2  1  1  2  1     2  2  2  2  2  1  2  1  1  1|             
      Pigmentation                         | 1  2  1  1  1     2  2  2  1  2     1  1  2  2     1  1        1  1  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|             
                             DAY ON TEST   | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|             
                                           | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    500UG ST                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                  2     3  3                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              | 4  2  3  2  4  3  2  4  3  2  3     4  4  4  3  4  4  4     4  4  3  4  4|             
      Hemorrhage                           |                                                 3                        |             
      Artery, Inflammation, Chronic Active |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |       2                    2                 1                       1   |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      2                 2  3     1     1                  |             
      Mineralization                       |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2        1                                               1   |             
      Infiltration Cellular, Histiocyte    |       1  1  2  1     1     1  1  1                 1  1        1  1  2   |             
      Inflammation, Granulomatous          |       3                                                                  |             
      Inflammation                         |             2                 3              3                           |             
      Keratin Cyst                         |                                              4     4                     |             
      Metaplasia, Squamous                 |       2           1              2                                       |             
      Alveolar Epithelium, Hyperplasia     |          1                    1                                   1      |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|             
                             DAY ON TEST   | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|             
                                           | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4000 NG/                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    500UG ST                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
           Bronchiolar                     |       2     2  1     1  1  1     1                 1                 1   |             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1           2  2           1                 1                           |             
      Olfactory Epithelium, Metaplasia     |                2                                                         |             
      Respiratory Epithelium, Hyperplasia  |             2  3           2                                             |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                            2                                             |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     1     1     1     1                                         1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Cyst                                 |                                                                      2   |             
      Mineralization                       |       1  1              1  1  1  1        1     1  1  1  1  1     1  1  1|             
      Nephropathy                          | 1  2  3  2  3  1  1     2  2  2  1           2     2           3  1  1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2|            |
                             DAY ON TEST   | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7|            |
                                           | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    4000 NG/                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    500UG ST                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                   X      |      1     |
      Artery, Inflammation, Chronic Active |                2                 1                                       |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                           |      4  2.3|
      Basophilic Focus                     |                                                    X        X            |      2     |
      Basophilic Focus, Multiple           |                X                             X                           |      3     |
      Cholangiofibrosis                    |       3  2        3     2  3     3  1  3     3  3  2        1        2   |     27  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                2                                                         |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Eosinophilic Focus, Multiple         |                X           X     X           X                           |     14     |
      Fatty Change, Diffuse                |    2              2  1  1     2     1     1     1  2  1  1  2  1  1     1|     35  1.4|
      Fatty Change, Focal                  |                         3  2     2  2  2     3     3        3            |     14  2.1|
      Hematopoietic Cell Proliferation     |       1  1     1  1        1        1  1  1        1     1  1     1      |     22  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2|            |
                             DAY ON TEST   | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7|            |
                                           | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    4000 NG/                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    500UG ST                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                         X                                                |      1     |
      Hyperplasia, Nodular                 | X     X  X  X     X  X  X     X        X     X     X  X  X     X  X  X  X|     34     |
      Inflammation                         | 1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1|     48  1.0|
      Metaplasia                           |                      1                                                   |      2  1.5|
      Mixed Cell Focus                     |                                                                          |      1     |
      Mixed Cell Focus, Multiple           |                X           X     X  X  X  X  X     X        X            |     19     |
      Necrosis                             |          2                                                     2         |      6  2.0|
      Pigmentation                         | 2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2|     50  1.9|
      Toxic Hepatopathy                    | 3  3  2  4  3  3  3  3  3  2  3  3  1  3  3  3  2  3  4  3  2  4  3  4  3|     50  2.6|
      Bile Duct, Cyst                      |    2  2        3        3  2        3  2  3  4     2     2           3   |     21  2.7|
      Bile Duct, Fibrosis                  |    2  2                 2  2     2        2        1     2               |     12  1.9|
      Bile Duct, Hyperplasia               | 3  2  1  3  2  1  2  2  2  2  1  1     3  2  2        3  1     2  1  3  1|     37  1.8|
      Centrilobular, Degeneration          |                               2                    2              3      |      6  2.0|
      Centrilobular, Fibrosis              | 3  1  1  2  2  1  2  2  2  2  2  1     1  1  2  1  2  2  2     3  2  2  2|     43  1.9|
      Hepatocyte, Glandular Structures     | 3           1                                         3        3         |      9  2.3|
      Hepatocyte, Hypertrophy              | 3  1  2  3  3        3     2  3  2     1        2  1  4     2  3  3  3  3|     36  2.7|
      Hepatocyte, Multinucleated           | 2  1  2  2  1  2  1  1  2  2  2  2  1        1  2  2     1  1  1  2     3|     38  1.6|
      Oval Cell, Hyperplasia               | 3  2  3  4  2  2  2  3  3  2  3  2     2  1  2  2     3  2     3  2  3   |     43  2.3|
      Portal, Fibrosis                     | 3  2  3  4  3  1  3  3  2  2  2  1     2  1  2  1  2  3  4     3  2  3  1|     42  2.3|
      Serosa, Fibrosis                     |                                     1                                    |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
      Necrosis                             |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                2  2              1                       4               |      7  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gingival, Hyperplasia, Squamous      |       2        2  2     3        1  1  1     1           1           2   |     18  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                | 2        1           1                       1  2     1        2         |     12  1.7|
      Hemorrhage                           |                                                       2                  |      1  2.0|
      Inflammation, Chronic Active         |                                           1  1                           |      5  1.6|
      Acinus, Atrophy                      |                                     2     2  2  2              2         |      8  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 133                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2|            |
                             DAY ON TEST   | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7|            |
                                           | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    4000 NG/                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    500UG ST                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Acinus, Vacuolization Cytoplasmic    | 2  2  2     2  1  1  1  1  2  1  1  2  2  1  1  2  2  1  1  2     1  1  2|     41  1.6|
      Artery, Inflammation, Chronic Active |                2  2              2        3              2               |     10  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |    1                                                                     |      2  1.5|
      Inflammation                         |       3                                                                  |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |       3                 1                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +        +  +     +        +  +  +     +     +  +  +  +        +   |  23        |
      Peridontal Tissue, Inflammation      |       3        3  2     1        1  1  1     2     1  1  1  2        1   |     23  1.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Adventitia, Hemorrhage        |                                                                2         |      2  2.5|
      Aorta, Adventitia, Inflammation      |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                1           2     1     1     1           1        1  1   |     15  1.1|
      Atrium, Thrombosis                   |                                                                          |      1  1.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                1  1              1                       3              3|      6  2.0|
      Epicardium, Inflammation             |                                                                          |      1  1.0|
      Myocardium, Hemorrhage               |                                                                1         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 134                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/29/04    
Route: GAVAGE                                                                                                     Time: 14:29:22    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2|            |
                             DAY ON TEST   | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7|            |
                                           | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    4000 NG/                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    500UG ST                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    1           1        1           1  2  1  1              1            |     21  1.2|
      Atrophy                              | 2           2        2     4           2     2        2        2         |     12  2.3|
      Degeneration, Cystic                 |       2                    3     2                 2                     |      9  2.4|
      Hyperplasia                          |                      3              2  2  2           2  3               |     10  2.2|
      Hypertrophy                          |    2  3  3     1  1        4     3  1  1  1  3     3        2  2     2   |     29  2.2|
      Inflammation                         |                            2                                             |      2  2.0|
      Necrosis                             |                               2                                          |      2  2.0|
      Vacuolization Cytoplasmic            |       1        1  1        3           1  1  2     1                 1   |     16  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2              2                       2  2                          2   |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      3  1.3|
      Cyst                                 |                                                 3     2                  |      3  2.3|
      Cytoplasmic Alteration               |             3                                      2                     |      2  2.5|
      Pars Distalis, Hyperplasia           |                                  3