TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
FINAL #1 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFPCBMIX
Lock Date: 11/04/02
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|
| 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
0 UG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 1 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Basophilic Focus, Multiple | X X X X X X |
Cholangiofibrosis | |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | |
Eosinophilic Focus | X X |
Eosinophilic Focus, Multiple | X X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 1 1 1 2 2|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X |
Necrosis | 1 1|
Pigmentation | 1 1 1 |
Bile Duct, Cyst | 3 3 1 |
Bile Duct, Fibrosis | 1 1 2 2|
Bile Duct, Hyperplasia | 1 1 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|
| 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
0 UG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Centrilobular, Degeneration | 2 |
Oval Cell, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fat, Necrosis | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 1 1 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Acinus, Atrophy | 1 |
Acinus, Hyperplasia, Focal | |
Acinus, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 2 1 |
Inflammation | 3 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 1 1 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 1 1 2 1 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 |
Coronary Artery, Inflammation, | |
Chronic Active | 1 |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|
| 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
0 UG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Epicardium, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 1 2 2 2 1 1 2 2 1 2 3 2 2 2 1 2 1 2 1|
Atrophy | |
Degeneration, Cystic | 2 2 2 2 3 2 2 |
Hematopoietic Cell Proliferation | 1|
Hyperplasia | 2 2 2 2 2 2 2 2 2|
Hypertrophy | 2 2 2 2 2 2 3 3 1 2 2 1 2 1 3 2 2 2 1 3 1 2 1|
Necrosis | |
Vacuolization Cytoplasmic | 1 3 1 1 1 1 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 3 1 1 2 3 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 3 3 2 2 2 2 2 2 1 |
Cyst | 2 |
Vacuolization Cytoplasmic | 2 |
Pars Distalis, Hyperplasia | 3 3 3 3 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
Follicular Cell, Hypertrophy | 1 1 2 1 1 1 2 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|
| 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
0 UG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation | 2 1 1 2 3 2 3 1 1 3 3 1 2 3 2 2 2 2 2 3 1 1 3|
Duct, Cyst | 1 3 2 3 3 2 3 3 3 3 2 2 2 2 2 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4|
Cyst | 2 2 2 3 2 2 2 2 3 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Cystic | 1 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 2 1 2 1 2 1 2 1 2 2 |
Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 3 2 2 1 1 3 2 2 2 4 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 3 2 3 3 4 4 3 2 4 4|
|__________________________________________________________________________|
Lymph Node | M + + + + + M M M M + M + M M M M M M + M + + + +|
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Lumbar, Hemorrhage | 2 |
Mediastinal, Ectasia | 1 1 2 1 |
Mediastinal, Hemorrhage | 1 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 |
Hyperplasia, Plasma Cell | 2 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Plasma Cell | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 1 1 2 3 2 2 2 3 1 2 2 2 3 2 4|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|
| 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
0 UG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pigmentation | 1 1 2 1 1 1 1 1 2 2 3 3 1 1 1 2 1 2 1 1 2 2 1 2 1|
Capsule, Fibrosis | |
Lymphoid Follicle, Atrophy | 2 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 2 2 3 4 2 4 2 4 3 4 4 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 1 2 1 2 1 1 2 1 1 1 2 2 1 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 1 2 2 2 2 1 2 2 1 2 1 2 2 2 2|
Inflammation | 1 4 |
Alveolar Epithelium, Hyperplasia | 1 3 1 1 1 1 1 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 |
Serosa, Fibrosis | 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6|
DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6|
| 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
0 UG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 3 |
Iris, Inflammation | 2 |
Retina, Atrophy | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X X |
Infarct | |
Inflammation, Chronic Active | 3 |
Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 3 1 1 1 2 1 2 1 1 1 1 1 2 1 |
Pelvis, Inflammation | 2 3 |
Renal Tubule, Hyperplasia | 2 1 |
Transitional Epithelium, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Ureter | + |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Edema | |
Inflammation | 2 2 2 |
Transitional Epithelium, Hyperplasia | 2 3 |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|
| 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|
0 UG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 3 2|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Basophilic Focus, Multiple | X X X X X X X |
Cholangiofibrosis | 3 |
Clear Cell Focus | X X X |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X X |
Eosinophilic Focus, Multiple | X X |
Fatty Change, Diffuse | 1 2 1 |
Fatty Change, Focal | 1 1 1 1 |
Hematopoietic Cell Proliferation | 1 1 2 2 1 2 1 1 1 1 2 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X X|
Necrosis | 2 |
Pigmentation | 1 1 |
Bile Duct, Cyst | 2 |
Bile Duct, Fibrosis | 2 2 |
Bile Duct, Hyperplasia | 1 1 |
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|
| 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|
0 UG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Centrilobular, Degeneration | 3 |
Oval Cell, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Acinus, Hyperplasia, Focal | 2 |
Acinus, Hyperplasia | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation | 3 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 1 1 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 1 2 2 1 2 1 2 1 2 1 2 3 2 1 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 1 2 |
Coronary Artery, Inflammation, | |
Chronic Active | |
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|
| 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|
0 UG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Epicardium, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 2 2 1 1 1 2 2 1 1 1 1 1 2 2 2 1 1 1|
Atrophy | 3 3 |
Degeneration, Cystic | 2 1 3 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 |
Hypertrophy | 3 3 3 3 2 1 2 1 2 2 2 2 2 2 3 2 2 2 1 1 |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 2 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 1 3 2 2 2 2 |
Cyst | |
Vacuolization Cytoplasmic | 2 |
Pars Distalis, Hyperplasia | 3 2 2 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 1 1 |
Follicle, Cyst | 3 |
Follicular Cell, Hypertrophy | 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|
| 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|
0 UG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation | 3 2 2 2 2 2 1 1 2 1 1 1 1 2 1 3 1 2 2 1 1 2 2|
Duct, Cyst | 3 2 3 2 2 2 2 2 1 1 2 3 1 2 3 3 2 2 2 3 1|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Cyst | 3 2 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hyperplasia, Cystic | |
Inflammation, Chronic Active | 1 1 |
Inflammation, Suppurative | 2 1 |
Metaplasia, Squamous | 2 1 2 1 2 4 1 1 2 1 4 1 |
Endometrium, Hyperplasia, Cystic | 3 1 2 1 1 4 2 2 1 3 3 2 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 3 3 3 3 3 3 2 3 3 2 3 4 4 2|
|__________________________________________________________________________|
Lymph Node | M M + + + M M + M + M + M + M M + + + M + M + + M|
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Lumbar, Hemorrhage | |
Mediastinal, Ectasia | 2 1 1 |
Mediastinal, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 3 2 2 2 2 3 3 2 2 3 2 2 2 2 3 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Histiocytic | 2 2 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 2 3 2 3 2 2 3 2 3 1 2 2 2 2 2 1 3 4 2|
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|
| 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|
0 UG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pigmentation | 1 2 2 2 2 2 1 1 1 2 2 1 2 3 1 2 2 2 2 2 2 1 1 2|
Capsule, Fibrosis | 3 |
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1 1 2 4 3 2 2 3 2 3 3 2 2 3 2 4 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 1 2 1 2 2 1 4 1 1 1 1|
Inflammation, Granulomatous | 2 3 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 1 1 1 1 2 1 2 2 2 2 2 1 1 2 2 2 2 1 2|
Inflammation | 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 2 1 1 1 1 1 1 1|
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | |
Serosa, Fibrosis | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3|
| 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG / | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9|
0 UG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Iris, Inflammation | |
Retina, Atrophy | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
Infarct | 3 4 |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation | 3 3 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Ureter | |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Edema | 3 |
Inflammation | 2 2 2 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 13
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 6| 6| 7| | |
DAY ON TEST | 2| 8| 2| | |
| 8| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG / | 9| 9| 9| | L |
0 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Muscularis, Inflammation | | 3 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Parasite Metazoan | | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + | 52 |
Parasite Metazoan | | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Basophilic Focus | X | 14 |
Basophilic Focus, Multiple | | 13 |
Cholangiofibrosis | | 1 3.0|
Clear Cell Focus | | 4 |
Clear Cell Focus, Multiple | | 1 |
Eosinophilic Focus | X | 5 |
Eosinophilic Focus, Multiple | | 5 |
Fatty Change, Diffuse | | 3 1.3|
Fatty Change, Focal | | 10 1.3|
Hematopoietic Cell Proliferation | 1 1 | 27 1.1|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation | 1 1 1 | 49 1.0|
Mixed Cell Focus | X | 5 |
Mixed Cell Focus, Multiple | | 33 |
Necrosis | | 3 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 6| 6| 7| | |
DAY ON TEST | 2| 8| 2| | |
| 8| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG / | 9| 9| 9| | L |
0 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pigmentation | | 5 1.0|
Bile Duct, Cyst | | 4 2.3|
Bile Duct, Fibrosis | | 6 1.7|
Bile Duct, Hyperplasia | 1 | 5 1.0|
Centrilobular, Degeneration | | 2 2.5|
Oval Cell, Hyperplasia | | 4 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + | 53 |
Fat, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + | 53 |
Gingival, Hyperplasia, Squamous | | 11 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Inflammation, Chronic Active | | 1 1.0|
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia, Focal | | 1 2.0|
Acinus, Hyperplasia | | 2 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperplasia, Squamous | | 4 1.5|
Inflammation | | 2 3.0|
Ulcer | | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Mineralization | | 12 1.3|
|__________________________________________________________________________|____________|
Tooth | + | 29 |
Peridontal Tissue, Inflammation | 4 | 29 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 6| 6| 7| | |
DAY ON TEST | 2| 8| 2| | |
| 8| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG / | 9| 9| 9| | L |
0 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | 1 1 1 | 20 1.2|
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 1.0|
Epicardium, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 42 1.6|
Atrophy | | 2 3.0|
Degeneration, Cystic | 3 | 12 2.2|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 13 2.0|
Hypertrophy | 1 3 | 45 2.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | | 14 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | 2 | 13 1.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + | 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 3 | 23 2.2|
Cyst | | 1 2.0|
Vacuolization Cytoplasmic | | 2 2.0|
Pars Distalis, Hyperplasia | 1 | 11 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 6| 6| 7| | |
DAY ON TEST | 2| 8| 2| | |
| 8| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG / | 9| 9| 9| | L |
0 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Hyperplasia | | 7 1.4|
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hypertrophy | 2 | 22 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Inflammation | 2 2 3 | 49 1.9|
Duct, Cyst | 2 1 2 | 40 2.2|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 3 3 3 | 46 3.0|
Cyst | | 19 2.2|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Congestion | | 1 1.0|
Hyperplasia, Cystic | | 1 1.0|
Inflammation, Chronic Active | | 2 1.0|
Inflammation, Suppurative | 2 | 4 1.5|
Metaplasia, Squamous | 1 | 23 1.7|
Endometrium, Hyperplasia, Cystic | 1 | 32 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 2 4 4 | 37 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 28 |
Deep Cervical, Hyperplasia, Plasma | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 6| 6| 7| | |
DAY ON TEST | 2| 8| 2| | |
| 8| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG / | 9| 9| 9| | L |
0 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Cell | 3 | 1 3.0|
Lumbar, Hemorrhage | | 1 2.0|
Mediastinal, Ectasia | | 7 1.3|
Mediastinal, Hemorrhage | | 2 1.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Ectasia | | 3 2.7|
Hyperplasia, Plasma Cell | 2 4 3 | 45 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Ectasia | | 1 2.0|
Hyperplasia, Histiocytic | | 2 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 2 3 4 | 49 2.2|
Pigmentation | 2 2 1 | 52 1.6|
Capsule, Fibrosis | | 1 3.0|
Lymphoid Follicle, Atrophy | 3 | 4 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + | 53 |
Atrophy | 4 2 | 40 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 1 3.0|
Hyperplasia | | 26 1.5|
Inflammation, Granulomatous | | 3 2.3|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 6| 6| 7| | |
DAY ON TEST | 2| 8| 2| | |
| 8| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG / | 9| 9| 9| | L |
0 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Infiltration Cellular, Histiocyte | 2 1 3 | 40 1.7|
Inflammation | | 5 1.6|
Alveolar Epithelium, Hyperplasia | 1 | 18 1.2|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | | 1 1.0|
Serosa, Fibrosis | | 3 1.3|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | 4 | 17 1.2|
Respiratory Epithelium, Hyperplasia | | 8 1.6|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Cataract | | 1 3.0|
Iris, Inflammation | | 1 2.0|
Retina, Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | 3 | 24 1.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 6| 6| 7| | |
DAY ON TEST | 2| 8| 2| | |
| 8| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG / | 9| 9| 9| | L |
0 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + + + | 53 |
Calculus Micro Observation Only | | 6 |
Infarct | | 2 3.5|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 1 | 46 1.0|
Nephropathy | 1 1 1 | 41 1.1|
Pelvis, Inflammation | | 4 2.8|
Renal Tubule, Hyperplasia | | 2 1.5|
Transitional Epithelium, Hyperplasia | | 4 2.3|
|__________________________________________________________________________|____________|
Ureter | | 1 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Calculus Gross Observation | | 1 |
Edema | | 1 3.0|
Inflammation | 2 1 | 8 1.9|
Transitional Epithelium, Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|
| 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
10 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X |
Basophilic Focus, Multiple | X X X |
Cholangiofibrosis | |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X X X X X X X X |
Fatty Change, Diffuse | 1 1 1 1 1 1 1 1 1|
Fatty Change, Focal | 1 1 1 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X|
Necrosis | 1 2 2 3 2 2 2 |
Pigmentation | 1 2 1 2 1 1 2 1 1 2|
Toxic Hepatopathy | 2 1 1 1 |
Artery, Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|
| 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
10 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Cyst | 3 3 3 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 2 1 |
Centrilobular, Degeneration | 1 2 |
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 2 1 |
Hepatocyte, Multinucleated | 1 2 2 2|
Oval Cell, Hyperplasia | 1 1 |
Serosa, Inflammation | 3 2 |
|__________________________________________________________________________|
Mesentery | + + M + + M + + + + M + + M + M M + M + M M + + M|
Inflammation | |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 3 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
Lipomatosis | 2 |
Acinus, Atrophy | 2 3 |
Acinus, Vacuolization Cytoplasmic | 1 |
Artery, Inflammation, Chronic Active | 3 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Squamous | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 1 4 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|
| 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
10 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 |
Coronary Artery, Inflammation, | |
Chronic Active | 2 |
Epicardium, Inflammation | 2 |
Pericardium, Inflammation, Chronic | |
Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 2 2 2 1 1 1 1 1 2 2 2 1|
Atrophy | |
Degeneration, Cystic | 2 2 3 2 2 2 3|
Hyperplasia | 2 2 2 2 2 2 |
Hypertrophy | 1 2 2 2 4 2 2 3 1 3 1 3 2 1 2 2 2 2 3 3|
Vacuolization Cytoplasmic | 1 2 1 2 3 2 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 2 1 2 |
Cytoplasmic Alteration | |
Vacuolization Cytoplasmic | 1 |
Pars Distalis, Hyperplasia | 2 4 1 3 3 3 2 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 3 3 2 3 |
Follicular Cell, Hypertrophy | 1 2 2 1 1 1 1 1 2 1 2 1 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|
| 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
10 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 1 3 1 2 2 2 2 1 2 2 2 1 2 2 1 1 2 1 2|
Duct, Cyst | 2 1 2 3 2 3 2 2 3 2 2 1 1 3 3 1 3 1 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3|
Cyst | 2 2 3 2 2 2 2 |
Inflammation, Chronic Active | 3 |
Periovarian Tissue, Inflammation, | |
Chronic Active | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 3 |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 4 |
Metaplasia, Squamous | 1 1 2 2 2 1 4 2 2|
Endometrium, Hyperplasia, Cystic | 1 3 2 4 2 1 2 1 2 2 4 1|
Serosa, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 2 2 3 4 2 3 2 2 3 3 3 3 2 2 3 4 3 2 2 |
|__________________________________________________________________________|
Lymph Node | + M M M + M M M M + M M + M M M + + + + M + M + M|
Lumbar, Ectasia | 3 |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Ectasia | 2 1 1 2 2 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 2 2 2 |
Renal, Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|
| 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
10 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 3 2 2 2 3 3 2 2 2 3 2 4 1 3 1 3 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 2 3 1 1 1 3 1 1 1 1 1 1 1 1|
Lymphoid Follicle, Atrophy | 2 2 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 2 4 2 4 2 4 3 2 2 1 4 2 4 2|
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Hyperplasia | 1 2 1 1 2 1 2 1 1 1 |
Inflammation, Granulomatous | 2 2 |
Inflammation | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2|
| 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
10 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Infiltration Cellular, Histiocyte | 2 2 2 1 2 2 2 2 2 1 2 2 1 2 3 1 2 1 |
Inflammation | 1 1 1 1 2 |
Metaplasia, Squamous | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 2 2 1 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 2 1 1 2 1 1 1 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 2 2 2 1 1 1 1 |
Olfactory Epithelium, Metaplasia | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 3 2 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 3 |
Cornea, Inflammation | |
Retina, Atrophy | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 1 3 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X |
Cyst | 2 |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1|
Nephropathy | 1 2 1 1 1 2 1 1 1 1 2 1 1 1 1 4 1 1 1 1 1|
Pelvis, Inflammation | 2 2 1 |
Transitional Epithelium, Hyperplasia | 2 1 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 |
Transitional Epithelium, Hyperplasia | 2 1 |
__________________________________________|__________________________________________________________________________
Page 26
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|
DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|
| 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
10 UG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X|
Cholangiofibrosis | 1 1 |
Clear Cell Focus | |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X X X X X X |
Fatty Change, Diffuse | 1 1 1 1 1 |
Fatty Change, Focal | 2 1 2 1 2 1|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 2 3 1|
Mixed Cell Focus | X X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X|
Necrosis | 2 2 3 3 2 |
Pigmentation | 1 1 1 1 1 2 2 3 |
Toxic Hepatopathy | 1 1 1 1 |
Artery, Inflammation | 1 |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|
DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|
| 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
10 UG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Cyst | |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 1 1 1 |
Centrilobular, Degeneration | 3 |
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1|
Hepatocyte, Multinucleated | 1 1 1 1 1 |
Oval Cell, Hyperplasia | 1 1 |
Serosa, Inflammation | |
|__________________________________________________________________________|
Mesentery | M + + + + M M + + + + + + + + + + M M + M + + + +|
Inflammation | 3 |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 |
Lipomatosis | |
Acinus, Atrophy | 2 1 1 |
Acinus, Vacuolization Cytoplasmic | |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 1 2 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|
DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|
| 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
10 UG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 |
Coronary Artery, Inflammation, | |
Chronic Active | |
Epicardium, Inflammation | |
Pericardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 1 2 1 2 1 2 3 1 1 1 2 1 1|
Atrophy | 4 |
Degeneration, Cystic | 1 3 3 3 2 |
Hyperplasia | 3 |
Hypertrophy | 1 1 2 2 2 3 1 3 1 1 3 3 2 2 2 2 1 2 3 2|
Vacuolization Cytoplasmic | 3 1 1 1 1 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + M + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 2 3 4 |
Cytoplasmic Alteration | 1 |
Vacuolization Cytoplasmic | |
Pars Distalis, Hyperplasia | 2 3 3 3 3 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 2 2 2 |
Follicular Cell, Hypertrophy | 2 2 1 1 1 2 1 2 2 1 2 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|
DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|
| 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
10 UG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 1 2 2 1 2 2 1 1 2 2 2 1 1 1 1 2 2 2 1|
Duct, Cyst | 3 1 2 1 3 3 2 3 1 2 3 2 3 3 3 2 2 2 1 2 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3|
Cyst | 2 2 4 2 2 |
Inflammation, Chronic Active | |
Periovarian Tissue, Inflammation, | |
Chronic Active | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Inflammation, Chronic Active | 2 2 2 2 |
Inflammation, Suppurative | 1 2 |
Metaplasia, Squamous | 4 4 1 4 2 2 2 3 4 4 2 1 2 4 |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 1 3 3 2 2 2|
Serosa, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 4 3 2 2 3 4 2 4 4 2 1 3 3 2 3|
|__________________________________________________________________________|
Lymph Node | M M + + + M M M + M M M + M M M M M M M M M M M M|
Lumbar, Ectasia | |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Ectasia | 1 1 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Renal, Ectasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 3 3 2 2 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|
DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|
| 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
10 UG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 4 2 1 2 2 2 2 2 2 3 3 2 1 1 2 2 3 2 2|
Pigmentation | 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 3 2 2 2 1 1 1|
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 4 3 2 2 2 2 2 2 2 2 3 1 2 3 3 3 2 2 2|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 2 1 2 2 1 3 |
Inflammation, Granulomatous | |
Inflammation | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5|
DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3|
| 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
80 NG / | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
10 UG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Infiltration Cellular, Histiocyte | 1 2 2 3 1 1 2 2 1 1 2 1 1 1 1 |
Inflammation | 2 1 1 3 |
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 2 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 4 |
Cornea, Inflammation | 2 |
Retina, Atrophy | 2 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X |
Cyst | 3 |
Inflammation, Suppurative | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1|
Pelvis, Inflammation | 2 2 1|
Transitional Epithelium, Hyperplasia | 2 2 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 32
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 1| | A |
80 NG / | 7| | L |
10 UG | 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 51 |
Degeneration | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
Parasite Metazoan | | 2 |
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 51 |
|__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 1 2.0|
Basophilic Focus | X | 8 |
Basophilic Focus, Multiple | | 8 |
Cholangiofibrosis | | 2 1.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 5 |
Eosinophilic Focus, Multiple | | 16 |
Fatty Change, Diffuse | | 14 1.0|
Fatty Change, Focal | | 10 1.4|
Hematopoietic Cell Proliferation | 1 | 27 1.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation | 2 | 47 1.2|
Mixed Cell Focus | | 5 |
Mixed Cell Focus, Multiple | | 23 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 1| | A |
80 NG / | 7| | L |
10 UG | 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Necrosis | 2 | 13 2.2|
Pigmentation | | 18 1.4|
Toxic Hepatopathy | | 8 1.1|
Artery, Inflammation | | 1 1.0|
Bile Duct, Cyst | | 3 3.0|
Bile Duct, Fibrosis | | 2 1.0|
Bile Duct, Hyperplasia | | 5 1.2|
Centrilobular, Degeneration | | 3 2.0|
Hepatocyte, Hypertrophy | | 16 1.1|
Hepatocyte, Multinucleated | | 9 1.3|
Oval Cell, Hyperplasia | | 4 1.0|
Serosa, Inflammation | | 2 2.5|
|__________________________________________________________________________|____________|
Mesentery | + | 35 |
Inflammation | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 51 |
Gingival, Hyperplasia, Squamous | | 10 1.2|
|__________________________________________________________________________|____________|
Pancreas | + | 51 |
Inflammation, Chronic Active | | 5 1.8|
Lipomatosis | | 1 2.0|
Acinus, Atrophy | | 5 1.8|
Acinus, Vacuolization Cytoplasmic | | 1 1.0|
Artery, Inflammation, Chronic Active | | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Erosion | | 1 2.0|
Hyperplasia, Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 1| | A |
80 NG / | 7| | L |
10 UG | 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Erosion | 2 | 1 2.0|
Mineralization | | 6 1.3|
|__________________________________________________________________________|____________|
Tooth | | 26 |
Peridontal Tissue, Inflammation | | 26 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
|__________________________________________________________________________|____________|
Heart | + | 51 |
Cardiomyopathy | | 13 1.1|
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 2.0|
Epicardium, Inflammation | | 1 2.0|
Pericardium, Inflammation, Chronic | | |
Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Angiectasis | | 35 1.4|
Atrophy | | 1 4.0|
Degeneration, Cystic | | 12 2.3|
Hyperplasia | | 7 2.1|
Hypertrophy | | 40 2.1|
Vacuolization Cytoplasmic | | 16 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia | | 4 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + | 45 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 1| | A |
80 NG / | 7| | L |
10 UG | 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Angiectasis | | 13 2.2|
Cytoplasmic Alteration | | 1 1.0|
Vacuolization Cytoplasmic | | 1 1.0|
Pars Distalis, Hyperplasia | | 14 2.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
C-Cell, Hyperplasia | | 11 2.3|
Follicular Cell, Hypertrophy | 3 | 35 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + | 51 |
Inflammation | 1 | 44 1.6|
Duct, Cyst | 2 | 41 2.2|
|__________________________________________________________________________|____________|
Ovary | + | 51 |
Atrophy | 3 | 34 3.1|
Cyst | | 12 2.3|
Inflammation, Chronic Active | | 1 3.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + | 51 |
Adenomyosis | | 1 3.0|
Inflammation, Chronic Active | | 5 1.8|
Inflammation, Suppurative | | 3 2.3|
Metaplasia, Squamous | 1 | 24 2.4|
Endometrium, Hyperplasia, Cystic | | 23 2.0|
Serosa, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 1| | A |
80 NG / | 7| | L |
10 UG | 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hyperplasia | 4 | 41 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + | 16 |
Lumbar, Ectasia | | 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Ectasia | | 7 1.4|
Mediastinal, Hemorrhage | | 2 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 3 2.0|
Renal, Ectasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
Ectasia | | 2 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 35 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Ectasia | | 1 3.0|
Hemorrhage | | 2 1.5|
|__________________________________________________________________________|____________|
Spleen | + | 51 |
Hematopoietic Cell Proliferation | 4 | 44 2.3|
Pigmentation | 1 | 50 1.3|
Lymphoid Follicle, Atrophy | | 5 2.0|
|__________________________________________________________________________|____________|
Thymus | + | 51 |
Atrophy | 3 | 44 2.5|
Artery, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Cyst | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 1| | A |
80 NG / | 7| | L |
10 UG | 7| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperplasia | | 17 1.5|
Inflammation, Granulomatous | | 2 2.0|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + | 51 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 51 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + | 51 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + | 51 |
Infiltration Cellular, Histiocyte | | 33 1.6|
Inflammation | | 9 1.4|
Metaplasia, Squamous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 10 1.2|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | | 14 1.3|
|__________________________________________________________________________|____________|
Nose | + | 51 |
Inflammation | 1 | 15 1.4|
Olfactory Epithelium, Metaplasia | | 2 2.0|
Respiratory Epithelium, Hyperplasia | | 11 1.8|
|__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 6| | |
| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 1| | A |
80 NG / | 7| | L |
10 UG | 7| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 51 |
Cataract | | 3 3.0|
Cornea, Inflammation | | 1 2.0|
Retina, Atrophy | | 3 2.7|
|__________________________________________________________________________|____________|
Harderian Gland | + | 51 |
Inflammation | | 7 1.4|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 51 |
Calculus Micro Observation Only | | 6 |
Cyst | | 2 2.5|
Inflammation, Suppurative | | 1 1.0|
Mineralization | 1 | 34 1.1|
Nephropathy | | 37 1.2|
Pelvis, Inflammation | | 6 1.7|
Transitional Epithelium, Hyperplasia | | 6 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Inflammation | | 3 1.3|
Transitional Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|
DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|
| 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
30 UG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 1 |
Degeneration, Cystic | |
Eosinophilic Focus | X X X X X |
Eosinophilic Focus, Multiple | X X X X X X |
Fatty Change, Diffuse | 1 2 1 1 1 1 1 2 2 1 1 1 1 |
Fatty Change, Focal | 1 1 |
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperplasia, Nodular | X X X X X X |
Inflammation | 2 1 2 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 2 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X |
Necrosis | 3 2 |
Pigmentation | 2 1 1 2 3 1 1 2 2 1 1 1 1 1 1 2 1 1 |
Toxic Hepatopathy | 3 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|
DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|
| 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
30 UG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Cyst | 3 2 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 3 3 1 2 1 |
Centrilobular, Degeneration | 1 2 2 2 3 |
Centrilobular, Fibrosis | 1 1 |
Hepatocyte, Hypertrophy | 4 1 2 1 1 2 1 1 2 1 1 |
Hepatocyte, Multinucleated | 2 1 1 1 1 1 1 1 1 2 |
Oval Cell, Hyperplasia | 3 2 1 1 1 1 1 1 1 1 1 1 |
Portal, Fibrosis | 1 |
|__________________________________________________________________________|
Mesentery | + + + + + M + + M + + + + + + + M + + + + + M + +|
Necrosis | |
Artery, Inflammation, Chronic Active | 4 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 2 2 1 1 1 2 2 2 2 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic Active | 2 1 1 |
Lipomatosis | |
Acinus, Atrophy | 1 1 |
Acinus, Vacuolization Cytoplasmic | 1 1 |
Artery, Inflammation, Chronic Active | 3 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation | 3 |
Ulcer | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
|__________________________________________________________________________|
Tongue | + |
Cyst | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|
DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|
| 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
30 UG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Tooth | + + + + + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 2 2 1 1 2 1 1 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 |
Valve, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 3 2 2 2 2 2 2 1 1 1 1 2 1 2 1 1 |
Degeneration, Cystic | 2 1 1 2 2 1 2 |
Hyperplasia | 2 3 2 2 2 2 2 3 |
Hypertrophy | 1 2 2 2 2 1 2 2 3 2 2 1 2 3 3 1 1 1 4 3 2 1 |
Necrosis | 2 2 |
Vacuolization Cytoplasmic | 1 2 2 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 3 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | 3 2 3 3 2 2 2 1 |
Cytoplasmic Alteration | 1 |
Pars Distalis, Hyperplasia | 3 2 2 1 1 2 2 2 1 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 2 2 1 |
Follicular Cell, Hypertrophy | 3 1 2 2 2 2 2 2 2 2 2 4 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|
DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|
| 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
30 UG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation | 2 1 1 1 2 2 3 1 2 1 1 2 1 1 2 2 2 2 3 2 1|
Duct, Cyst | 1 1 2 3 2 2 1 2 1 3 1 3 2 2 3 3 3 3 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Cyst | 2 2 2 2 2 3 2 2 |
Inflammation, Chronic Active | 4 4 |
Inflammation | 4 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3|
Inflammation, Suppurative | 1 1 |
Metaplasia, Squamous | 3 4 2 3 4 2 2 2 2 2 1 3 3 2 2 2 2 |
Endometrium, Hyperplasia, Cystic | 1 2 1 2 1 3 3 1 3 2 2 2 3 3 4|
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 3 3 3 3 3 4 2 2 3 3 3 3|
|__________________________________________________________________________|
Lymph Node | M + + M M M + M M M M M M + M M M M M + + + M M +|
Mediastinal, Ectasia | 2 1 1 1 |
Mediastinal, Hemorrhage | 2 1 |
Mediastinal, Hyperplasia, Lymphoid | 4 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 3 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Histiocytic | |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|
DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|
| 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
30 UG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 3 2 1 2 2 2 2 2 2 2 2 2 2 1 3 2 3 1 2 3 |
Pigmentation | 1 1 1 2 2 2 2 2 2 3 2 2 1 1 1 2 2 1 1 1 1 1 2 1 1|
Lymphoid Follicle, Atrophy | 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | 4 4 4 3 2 2 2 2 4 2 3 3 3 4 4 2 3 3 3 4|
Hemorrhage | 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 1 |
Inflammation, Granulomatous | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 2 1 2 2 3 2 2 2 2 2 1 2 2 1 1 1 2 2 2 |
Inflammation | 1 |
Metaplasia, Squamous | |
Necrosis | 3 |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5|
DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5|
| 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
30 UG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 2 2 2 2 1 2 1 2 1 1 2 1 1 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Squamous Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1|
Nephropathy | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 3 2 1 |
Pelvis, Dilatation | 2 |
Pelvis, Inflammation | |
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________|__________________________________________________________________________
Page 45
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|
DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|
| 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
30 UG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X X |
Cholangiofibrosis | 1 1 |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X X X X X |
Fatty Change, Diffuse | 1 1 1 1 2 2 1 1 1 1 1 1|
Fatty Change, Focal | 2 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperplasia, Nodular | X X X X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X|
Necrosis | 3 2 1 |
Pigmentation | 1 1 1 2 2 2 1 2 1 2 2 1 1 2 2 2 2 2|
Toxic Hepatopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|
DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|
| 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
30 UG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Cyst | 2 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration | 1 2 |
Centrilobular, Fibrosis | 1 1 1 1|
Hepatocyte, Hypertrophy | 2 1 2 1 1 1 1 1 2 1 |
Hepatocyte, Multinucleated | 1 1 1 1 1 2 1 1 1|
Oval Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 |
Portal, Fibrosis | 1 |
|__________________________________________________________________________|
Mesentery | + M + + + M + + + + + + + M + + + + + + + M + + +|
Necrosis | 3 |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 2 1 1 1 1 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic Active | 2 |
Lipomatosis | 2|
Acinus, Atrophy | 2|
Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation | 2 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 2 2 1 |
|__________________________________________________________________________|
Tongue | |
Cyst | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|
DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|
| 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
30 UG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Tooth | + + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1|
Valve, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 1 2 2 1 2 1 1 2 2 1 1 2 1 1 2 2|
Degeneration, Cystic | 2 1 3 3 2|
Hyperplasia | 2 2 1 2 2|
Hypertrophy | 4 2 1 2 2 1 2 2 1 3 1 1 3 3 3 3 2 2 2 2 3 3|
Necrosis | |
Vacuolization Cytoplasmic | 1 1 2 1 1 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 2 3 2 2 2 3 2|
Cytoplasmic Alteration | |
Pars Distalis, Hyperplasia | 2 3 1 2 4 3 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 1 1 2 |
Follicular Cell, Hypertrophy | 2 2 2 2 1 1 2 2 2 2 2 1 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|
DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|
| 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
30 UG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Inflammation | 1 1 2 1 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Duct, Cyst | 2 2 3 2 2 2 3 3 2 2 2 2 2 3 2 2 1 2 2 2 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3|
Cyst | 2 3 2 2 4 2 3 |
Inflammation, Chronic Active | 4 |
Inflammation | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 1 1 3 |
Metaplasia, Squamous | 2 1 1 2 2 2 3 4 4 2 3|
Endometrium, Hyperplasia, Cystic | 2 2 1 4 4 2 2 1 2 1 |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 1 3 2 2 3 3 2 4 4 4 2 2 3 3 4 2|
|__________________________________________________________________________|
Lymph Node | + M M M + M M + M M + M M M M M M M M + M M + + M|
Mediastinal, Ectasia | 2 1 |
Mediastinal, Hemorrhage | 2 1 |
Mediastinal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 2 3 2 2 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | 2 |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|
DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|
| 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
30 UG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 1 3 3 2 1 2 1 2 2 2 2 2 2 2 1|
Pigmentation | 1 1 1 1 2 1 2 2 2 1 2 1 1 3 1 2 1 1 1 1 1 1 1 1|
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 2 4 2 4 3 4 2 3 4 3 2 2 3 2 2 2 4 4|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Hyperplasia | 1 2 2 1 1 1 2 1 2 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 2 2 2 1 1 2 1 1 2 2 3 2 2 2 2 1 1|
Inflammation | 1 1 1 2 1 1 |
Metaplasia, Squamous | 1 2 |
Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7|
DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2|
| 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 NG / | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
30 UG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 1 1 2 1 2 2 1 1 1 1 1 2 2 3 2 2 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 3 1 2 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 2 1 2 1 |
Squamous Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
Inflammation, Suppurative | 1 2 2 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1|
Pelvis, Dilatation | |
Pelvis, Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 3 1 1 1 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________|__________________________________________________________________________
Page 51
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 2| 2| 0| | |
| 6| 6| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
240 NG / | 9| 9| 9| | L |
30 UG | 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Muscularis, Inflammation | | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Artery, Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | | 2 |
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Artery, Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 2 1.0|
Basophilic Focus | | 6 |
Basophilic Focus, Multiple | | 4 |
Cholangiofibrosis | | 3 1.0|
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | | 11 |
Eosinophilic Focus, Multiple | X | 12 |
Fatty Change, Diffuse | 1 1 | 27 1.2|
Fatty Change, Focal | 2 2 | 6 1.7|
Hematopoietic Cell Proliferation | 1 1 | 30 1.0|
Hyperplasia, Nodular | | 10 |
Inflammation | 1 1 1 | 50 1.1|
Mixed Cell Focus | | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 2| 2| 0| | |
| 6| 6| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
240 NG / | 9| 9| 9| | L |
30 UG | 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mixed Cell Focus, Multiple | X | 28 |
Necrosis | 1 | 6 2.0|
Pigmentation | 3 2 | 38 1.6|
Toxic Hepatopathy | 1 1 | 32 1.2|
Bile Duct, Cyst | | 3 2.3|
Bile Duct, Fibrosis | 2 | 3 1.3|
Bile Duct, Hyperplasia | 1 | 7 1.9|
Centrilobular, Degeneration | 2 | 8 1.9|
Centrilobular, Fibrosis | 1 | 7 1.0|
Hepatocyte, Hypertrophy | 1 | 22 1.4|
Hepatocyte, Multinucleated | 1 2 | 21 1.2|
Oval Cell, Hyperplasia | 1 1 | 23 1.2|
Portal, Fibrosis | | 2 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + | 45 |
Necrosis | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + | 53 |
Gingival, Hyperplasia, Squamous | | 20 1.4|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Edema | | 1 2.0|
Inflammation, Chronic Active | | 4 1.5|
Lipomatosis | | 1 2.0|
Acinus, Atrophy | | 3 1.3|
Acinus, Vacuolization Cytoplasmic | | 8 1.0|
Artery, Inflammation, Chronic Active | | 2 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperplasia, Squamous | 2 | 3 2.3|
Inflammation | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 2| 2| 0| | |
| 6| 6| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
240 NG / | 9| 9| 9| | L |
30 UG | 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Mineralization | | 6 1.5|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + | 33 |
Peridontal Tissue, Inflammation | 1 1 | 33 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 52 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | | 17 1.0|
Valve, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 2 | 39 1.6|
Degeneration, Cystic | 2 | 13 1.8|
Hyperplasia | | 13 2.1|
Hypertrophy | 3 2 2 | 47 2.1|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | | 13 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | | 9 2.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 2| 2| 0| | |
| 6| 6| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
240 NG / | 9| 9| 9| | L |
30 UG | 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Angiectasis | 3 | 19 2.3|
Cytoplasmic Alteration | | 1 1.0|
Pars Distalis, Hyperplasia | 1 | 19 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Hyperplasia | | 13 1.8|
Follicular Cell, Hypertrophy | 1 | 34 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
Inflammation | 1 1 1 | 46 1.4|
Duct, Cyst | 2 2 | 43 2.1|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 3 | 43 3.0|
Cyst | | 15 2.3|
Inflammation, Chronic Active | | 3 4.0|
Inflammation | | 3 3.3|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Inflammation, Chronic Active | | 2 3.0|
Inflammation, Suppurative | | 5 1.4|
Metaplasia, Squamous | | 28 2.4|
Endometrium, Hyperplasia, Cystic | | 25 2.2|
|__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 2| 2| 0| | |
| 6| 6| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
240 NG / | 9| 9| 9| | L |
30 UG | 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 2 3 | 36 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + M M | 16 |
Mediastinal, Ectasia | 1 | 7 1.3|
Mediastinal, Hemorrhage | | 4 1.5|
Mediastinal, Hyperplasia, Lymphoid | | 2 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Ectasia | | 3 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 3 2.7|
Hyperplasia, Plasma Cell | 1 | 34 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Hemorrhage | | 2 2.0|
Hyperplasia, Histiocytic | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 2 1 3 | 49 2.0|
Pigmentation | 1 2 1 | 52 1.4|
Lymphoid Follicle, Atrophy | | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + | 51 |
Atrophy | 2 4 4 | 44 3.0|
Hemorrhage | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 2 3.0|
Hyperplasia | 2 1 | 13 1.4|
Inflammation, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 2| 2| 0| | |
| 6| 6| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
240 NG / | 9| 9| 9| | L |
30 UG | 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | | 1 1.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Infiltration Cellular, Histiocyte | 1 2 | 46 1.7|
Inflammation | | 7 1.1|
Metaplasia, Squamous | | 2 1.5|
Necrosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 | 39 1.4|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | 3 | 16 1.3|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 5 1.4|
Squamous Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 2| 2| 0| | |
| 6| 6| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
240 NG / | 9| 9| 9| | L |
30 UG | 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | | 20 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | X | 6 |
Inflammation, Suppurative | | 4 1.8|
Mineralization | 1 1 | 38 1.1|
Nephropathy | 1 1 | 37 1.2|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 6 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|
DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|
| 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|
100 UG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 1 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Erosion | |
Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 1 2 1 3 1 1 3 3 4|
Clear Cell Focus, Multiple | |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | X X X X X X X X |
Fatty Change, Diffuse | 2 1 2 1 2 1 1 2 2 2 2 2 1 1 2 1 2 1 1 2 1|
Fatty Change, Focal | 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X|
Inflammation | 2 2 2 1 1 1 2 2 1 1 1 1 2 1 1 1 3 1 1 1 1 1 3 2 1|
Mixed Cell Focus, Multiple | X X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|
DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|
| 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|
100 UG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Necrosis | 3 1 1 1 3 1 2 3 2 2 2 2 2 3 |
Pigmentation | 2 2 2 2 2 1 2 2 2 1 2 3 2 2 2 3 2 2 2 2 2 2 2 2 2|
Toxic Hepatopathy | 3 3 2 3 2 2 3 2 2 2 2 3 3 3 3 3 3 3 3 3 2 3 2 3|
Artery, Inflammation | |
Bile Duct, Cyst | 1 2 3 2 2 2 |
Bile Duct, Fibrosis | 2 2 1 2 1 |
Bile Duct, Hyperplasia | 1 2 2 3 4 2 3 2 2 1 2 2 2 1 1 3 1 2 2|
Centrilobular, Degeneration | 3 2 1 |
Centrilobular, Fibrosis | 1 1 1 2 2 2 2 1 2 2 1 1 1 1 2 2 1 |
Hepatocyte, Glandular Structures | |
Hepatocyte, Hypertrophy | 3 3 2 3 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 2 3 3|
Hepatocyte, Multinucleated | 2 2 2 2 1 2 2 2 2 2 2 2 1 2 3 2 2 1 2 1 2 2 2 2|
Oval Cell, Hyperplasia | 2 2 2 2 1 1 1 2 2 2 3 2 2 3 2 2 2 3 3 2 2 3|
Portal, Fibrosis | 1 1 2 2 2 1 3 1 2 2 1 1 1 1 3 2 2|
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + M + + +|
Necrosis | |
Artery, Inflammation, Chronic Active | 3 3 1 3|
Fat, Necrosis | 2 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 2 2 1 2 3 2 1 3 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Acinus, Atrophy | 2 2 2 |
Acinus, Vacuolization Cytoplasmic | 2 2 2 1 2 1 2 2 1 1 1 2 2 1 2 1 2|
Artery, Inflammation, Chronic Active | 3 2 2 2 3 4 2 3 2 1 3|
Duct, Dilatation | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Hyperplasia, Squamous | 1 2 2 1 |
Inflammation | |
Mineralization | 1 |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|
DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|
| 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|
100 UG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 1 3 2 1 1 2 2 1 1 1 4 4 1 2 3 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 2 |
Coronary Artery, Inflammation, | |
Chronic Active | 3 3 2 1|
Endocardium, Hyperplasia | 3 |
Epicardium, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 3 1 1 1 2 3 1 1 1|
Atrophy | 2 2 2|
Degeneration, Cystic | 2 1 1 3 |
Hyperplasia | 2 2 2 3 2|
Hypertrophy | 1 2 3 3 2 1 2 2 2 1 3 2 3 2 2 3 2 2 3 |
Inflammation | 3 |
Necrosis | 3 2 |
Vacuolization Cytoplasmic | 1 2 1 1 1 2 2 1 3 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M M + + + + + + + + + + + + M + + +|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|
DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|
| 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|
100 UG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
Pars Distalis, Hyperplasia | 2 1 2 3 3 2 3 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 |
Follicular Cell, Hypertrophy | 2 2 2 1 2 3 1 1 1 1 3 2 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Inflammation | 1 1 1 2 1 1 1 1 2 1 1 2|
Artery, Inflammation, Chronic Active | 3|
Duct, Cyst | 3 2 2 3 3 1 3 2 3 2 3 2 2 2 2 3 2 3 1 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 3 4 3 3 3 4 3 3 3 3 3 3 3 3|
Cyst | 3 2 3 2 2 2|
Inflammation, Chronic Active | 4 |
Inflammation | 4 |
Artery, Inflammation | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Hemorrhage | 4 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 3 3 4 |
Metaplasia, Squamous | 2 2 2 3 3 3 4 3 |
Endometrium, Hyperplasia, Cystic | 2 2 3 4 2 3 4 3 4 1 1 3 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|
DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|
| 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|
100 UG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 2 3 2 3 3 2 4 2 2 2 3 3 4 3 2 3 4 3 3 3 4 3|
|__________________________________________________________________________|
Lymph Node | + M M + M M M + + M M + + M + + + M M + M M + + +|
Hemorrhage | 2 |
Deep Cervical, Congestion | 2 |
Deep Cervical, Ectasia | 1 |
Deep Cervical, Hemorrhage | 2 |
Deep Cervical, Hyperplasia, | |
Histiocytic | 2 |
Lumbar, Ectasia | |
Mediastinal, Congestion | 2 |
Mediastinal, Ectasia | 2 2 1 1 |
Mediastinal, Hemorrhage | 2 2 2 2 2 1 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Hyperplasia, Histiocytic | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Ectasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Plasma Cell | 3 2 2 2 2 2 2 2 2 2 2 3 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 2 |
Hyperplasia, Histiocytic | 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 2 1 2 2 1 3 1 1 2 1 2 3 2 3 2 3 3 2|
Pigmentation | 1 2 2 1 1 1 2 2 2 2 1 2 3 1 1 2 1 1 1 1 1 1 1|
Lymphoid Follicle, Atrophy | 2 2 1 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3|
Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|
DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|
| 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|
100 UG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 2 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 1 |
Inflammation | 1 3 |
Necrosis | 3 3 |
Cerebrum, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 2 2 1 2 2 1 2 1 1 2 1 1 1 2 2 2 2 1 2 1 1|
Inflammation | 3 3 |
Metaplasia, Squamous | 2 2 2 3 2 2 2|
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 2 2 2 2 3 1 1 2 3 2 1 1 1 1 2 1 2 2 1 1 2|
Serosa, Fibrosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 2 3 1 |
Olfactory Epithelium, Degeneration | 2 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7|
DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2|
| 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|
100 UG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation | 3 |
Retina, Atrophy | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 3 3 1 1 1 1 1 1 3 2 1 1 3 2 3 2 3 4 2 1 2|
Artery, Inflammation, Chronic Active | |
Pelvis, Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 4 1 3 2 1 2 4 3 |
Transitional Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Metaplasia, Squamous | |
Artery, Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 65
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|
DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|
| 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
100 UG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 1|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
Artery, Inflammation, Chronic Active | 3 3 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Erosion | 2 |
Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 1 3 2 3 3 3 3 3 3 1|
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X X X X |
Fatty Change, Diffuse | 1 2 2 1 1 2 2 1 1 2 1 2 1 2 2 1 2 1 1 2 2|
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X|
Inflammation | 1 1 1 2 2 2 2 1 1 2 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus, Multiple | X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|
DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|
| 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
100 UG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Necrosis | 2 1 3 2 2 2 2 1 2 1 2 3 |
Pigmentation | 2 2 2 2 3 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2|
Toxic Hepatopathy | 1 3 2 3 3 2 2 3 2 4 2 2 3 2 3 3 3 4 2 3 2 3 4 2|
Artery, Inflammation | |
Bile Duct, Cyst | 3 3 2 1 3 2 2 2 |
Bile Duct, Fibrosis | 2 2 2 2 |
Bile Duct, Hyperplasia | 1 1 1 3 2 2 1 2 1 2 2 2 2 1 2 3 2 2 2 1 1 2 2 1|
Centrilobular, Degeneration | 2 2 2 2 2 |
Centrilobular, Fibrosis | 2 2 2 1 2 1 2 2 1 2 1 1 1 1 2 2 |
Hepatocyte, Glandular Structures | 1 |
Hepatocyte, Hypertrophy | 2 2 2 2 3 3 2 2 2 3 3 2 3 3 3 2 3 3 2 2 3 4 |
Hepatocyte, Multinucleated | 1 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 1 1|
Oval Cell, Hyperplasia | 1 2 2 3 2 1 2 2 2 3 3 2 3 2 2 3 2 3 1 2 3 3 3 1|
Portal, Fibrosis | 2 1 2 2 1 2 1 3 2 2 2 2 1 2 2 3 3 3 2|
|__________________________________________________________________________|
Mesentery | M + + + + M + + + + + + + + + + + M + + + + + + +|
Necrosis | 3 |
Artery, Inflammation, Chronic Active | 2 2 3 4 3 |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 2 1 1 2 3 2 1 1 1 2 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Acinus, Atrophy | 2 1 |
Acinus, Vacuolization Cytoplasmic | 3 1 1 2 2 1 2 1 1 1 2 2 2 2 1 2 2 2 1 2|
Artery, Inflammation, Chronic Active | 4 2 3 3 1 2 2 2 2 |
Duct, Dilatation | 2 |
|__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Erosion | |
Hyperplasia, Squamous | 3 3 2 1 2 1 4 |
Inflammation | 3 2 1 1 |
Mineralization | |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|
DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|
| 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
100 UG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 2 |
Artery, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 2 1 1 2 1 4 1 1 1 1 1 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Coronary Artery, Inflammation, | |
Chronic Active | 3 1 |
Endocardium, Hyperplasia | |
Epicardium, Inflammation | 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 2 1 1 1 1|
Atrophy | 4 2 2 2 3 2 2 2 2 3 3 3 |
Degeneration, Cystic | 2 2 2 3 3 1 3 |
Hyperplasia | 1 3 2 1 2 2 3 |
Hypertrophy | 1 3 3 2 3 2 3 2 3 3 2 2 1 3 3 3 3 3 2 1 1 3 2|
Inflammation | |
Necrosis | 3 1 |
Vacuolization Cytoplasmic | 2 2 3 2 1 2 1 2 2 1 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 2 2 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|
DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|
| 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
100 UG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 3 |
Vacuolization Cytoplasmic | |
Pars Distalis, Hyperplasia | 3 4 2 2 1 3 2 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2|
Follicular Cell, Hypertrophy | 1 2 1 2 3 2 2 1 2 2 1 2 2 2 2 3 2 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 2 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1|
Artery, Inflammation, Chronic Active | |
Duct, Cyst | 2 2 1 2 2 1 3 3 2 2 2 1 2 3 3 3 2 3 3 3 3 1 3 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Cyst | 3 2 2 2 2 3 2 2 2 2 2 3 |
Inflammation, Chronic Active | 4 |
Inflammation | 4 2 |
Artery, Inflammation | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 2 3 3 |
Hemorrhage | 3 |
Inflammation, Chronic Active | 3 4 3 |
Inflammation, Suppurative | 2 4 |
Metaplasia, Squamous | 3 3 2 2 1 1 2 2 4 4 4 2 3 2|
Endometrium, Hyperplasia, Cystic | 1 3 3 1 1 2 3 3 1 1 2 1 1 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|
DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|
| 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
100 UG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 2 3 3 3 2 3 3 2 4 4 3 4 4 3 3 3 3 2 3 3 3 3 2|
|__________________________________________________________________________|
Lymph Node | + + + + + + + M + + M M + M M M + M M M M M M M M|
Hemorrhage | |
Deep Cervical, Congestion | |
Deep Cervical, Ectasia | |
Deep Cervical, Hemorrhage | |
Deep Cervical, Hyperplasia, | |
Histiocytic | |
Lumbar, Ectasia | 3 |
Mediastinal, Congestion | |
Mediastinal, Ectasia | 2 1 1 |
Mediastinal, Hemorrhage | 1 2 2 1 2 3 2 2 2 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Pancreatic, Hyperplasia, Histiocytic | 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Plasma Cell | 2 3 2 3 2 2 2 2 2 2 2 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hemorrhage | |
Hyperplasia, Histiocytic | 2 1 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 1 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2|
Pigmentation | 1 1 2 2 1 2 1 2 1 1 1 1 1 1 1 2 1 2 2 2 1 1 1 1|
Lymphoid Follicle, Atrophy | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Necrosis | 3 |
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|
DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|
| 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
100 UG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
Necrosis | |
Cerebrum, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 2 1 2 1 1 1 1 1 2 1 1 1 2 1 2 1 2 1 2 2 2 2|
Inflammation | |
Metaplasia, Squamous | 2 1 2 3 2 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 2 2 1 1 1 2 1 1 1 2 2 1 2 1 2 2 3 3 2|
Serosa, Fibrosis | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 2 1 2 |
Olfactory Epithelium, Degeneration | |
Olfactory Epithelium, Metaplasia | 3 2 |
Respiratory Epithelium, Hyperplasia | 1 3 2 2 |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7|
DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2|
| 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 NG / | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
100 UG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation | |
Retina, Atrophy | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 4 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 3 2 1 2 1 3 3 2 3 4 3 1 3 3 2 4 1 1 2 3 1 3 1|
Artery, Inflammation, Chronic Active | |
Pelvis, Inflammation | 4 2 3 2 2 |
Transitional Epithelium, Hyperplasia | 1 1 4 1 2 3 3 2 |
Transitional Epithelium, Metaplasia, | |
Squamous | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 1 3 |
Metaplasia, Squamous | 3 |
Artery, Inflammation, Chronic Active | 3 |
Transitional Epithelium, Hyperplasia | 3 2 2 |
__________________________________________|__________________________________________________________________________
Page 72
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Muscularis, Inflammation | | 3 1.3|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | | 2 |
Artery, Inflammation, Chronic Active | 3 | 3 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Artery, Inflammation, Chronic Active | | 2 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Dilatation | | 1 3.0|
Erosion | | 1 2.0|
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 5 |
Basophilic Focus, Multiple | X | 3 |
Cholangiofibrosis | 1 1 | 21 2.2|
Clear Cell Focus, Multiple | | 1 |
Eosinophilic Focus | | 1 |
Eosinophilic Focus, Multiple | | 14 |
Fatty Change, Diffuse | 2 2 1 | 45 1.5|
Fatty Change, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 32 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia, Nodular | X X X | 45 |
Inflammation | 1 1 | 52 1.4|
Mixed Cell Focus, Multiple | X | 16 |
Necrosis | | 26 2.0|
Pigmentation | 2 2 2 | 52 2.1|
Toxic Hepatopathy | 2 2 1 | 51 2.6|
Artery, Inflammation | 3 | 1 3.0|
Bile Duct, Cyst | | 14 2.1|
Bile Duct, Fibrosis | 1 | 10 1.7|
Bile Duct, Hyperplasia | 2 2 2 | 46 1.8|
Centrilobular, Degeneration | | 8 2.0|
Centrilobular, Fibrosis | 2 2 2 | 36 1.6|
Hepatocyte, Glandular Structures | | 1 1.0|
Hepatocyte, Hypertrophy | 3 2 3 | 47 2.6|
Hepatocyte, Multinucleated | 2 1 1 | 48 1.8|
Oval Cell, Hyperplasia | 2 1 2 | 49 2.1|
Portal, Fibrosis | 2 | 37 1.8|
|__________________________________________________________________________|____________|
Mesentery | + + + | 49 |
Necrosis | | 1 3.0|
Artery, Inflammation, Chronic Active | | 9 2.7|
Fat, Necrosis | | 3 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + | 53 |
Gingival, Hyperplasia, Squamous | 2 | 24 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Inflammation, Chronic Active | | 3 1.3|
Acinus, Atrophy | | 5 1.8|
Acinus, Vacuolization Cytoplasmic | 2 1 | 39 1.6|
Artery, Inflammation, Chronic Active | 1 | 21 2.3|
Duct, Dilatation | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Edema | | 2 2.5|
Erosion | | 1 2.0|
Hyperplasia, Squamous | | 11 2.0|
Inflammation | | 4 1.8|
Mineralization | | 1 1.0|
Ulcer | | 1 2.0|
Artery, Inflammation, Chronic Active | | 2 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + | 34 |
Peridontal Tissue, Inflammation | 3 3 2 | 34 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | 1 1 2 | 34 1.1|
Coronary Artery, Inflammation, | | |
Chronic Active | 1 | 7 2.0|
Endocardium, Hyperplasia | | 1 3.0|
Epicardium, Inflammation | | 6 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 1 | 25 1.3|
Atrophy | | 15 2.4|
Degeneration, Cystic | | 11 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | | 12 2.1|
Hypertrophy | 2 3 | 44 2.3|
Inflammation | | 1 3.0|
Necrosis | | 4 2.3|
Vacuolization Cytoplasmic | 1 2 | 24 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | 2 | 12 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | | 7 2.4|
Vacuolization Cytoplasmic | | 5 1.0|
Pars Distalis, Hyperplasia | | 18 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
C-Cell, Hyperplasia | 2 | 10 2.0|
Follicular Cell, Hypertrophy | 2 2 | 38 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
Inflammation | 1 2 | 34 1.2|
Artery, Inflammation, Chronic Active | | 1 3.0|
Duct, Cyst | 2 | 45 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 3 3 | 42 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cyst | 2 | 19 2.3|
Inflammation, Chronic Active | 4 | 3 4.0|
Inflammation | | 3 3.3|
Artery, Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Adenomyosis | | 3 2.7|
Hemorrhage | | 2 3.5|
Inflammation, Chronic Active | 3 | 5 3.2|
Inflammation, Suppurative | 3 | 7 3.0|
Metaplasia, Squamous | 1 2 | 24 2.5|
Endometrium, Hyperplasia, Cystic | | 30 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 4 3 3 | 48 2.9|
|__________________________________________________________________________|____________|
Lymph Node | M + M | 25 |
Hemorrhage | | 1 2.0|
Deep Cervical, Congestion | | 1 2.0|
Deep Cervical, Ectasia | | 1 1.0|
Deep Cervical, Hemorrhage | | 1 2.0|
Deep Cervical, Hyperplasia, | | |
Histiocytic | | 1 2.0|
Lumbar, Ectasia | | 1 3.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Ectasia | | 7 1.4|
Mediastinal, Hemorrhage | | 15 1.9|
Mediastinal, Hyperplasia, Histiocytic| | 2 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Pancreatic, Hyperplasia, Histiocytic | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 2 3.0|
Renal, Ectasia | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Ectasia | | 4 2.3|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Plasma Cell | 2 | 27 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Ectasia | | 2 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Histiocytic | | 6 1.8|
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 2 2 2 | 52 2.0|
Pigmentation | 1 2 1 | 50 1.4|
Lymphoid Follicle, Atrophy | | 5 2.2|
|__________________________________________________________________________|____________|
Thymus | + M + | 51 |
Atrophy | 3 3 | 49 3.9|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 2 2.0|
Hyperplasia | 3 | 6 1.8|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Cyst Epithelial Inclusion | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | | 4 1.3|
Inflammation | | 2 2.0|
Necrosis | | 2 3.0|
Cerebrum, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Congestion | | 2 2.5|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 2 1 | 48 1.5|
Inflammation | 4 | 3 3.3|
Metaplasia, Squamous | 2 | 14 2.1|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 | 46 1.6|
Serosa, Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | | 10 1.7|
Olfactory Epithelium, Degeneration | | 1 2.0|
Olfactory Epithelium, Metaplasia | | 3 2.3|
Respiratory Epithelium, Hyperplasia | | 8 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Cornea, Inflammation | | 1 3.0|
Retina, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| | |
DAY ON TEST | 5| 3| 2| | |
| 5| 9| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
800 NG / | 8| 8| 8| | L |
100 UG | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Harderian Gland | + + + | 53 |
Inflammation | | 13 1.2|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Inflammation, Suppurative | | 3 2.3|
Mineralization | 1 1 | 44 1.0|
Nephropathy | 1 1 2 | 48 2.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Pelvis, Inflammation | | 6 2.5|
Transitional Epithelium, Hyperplasia | | 16 2.3|
Transitional Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 4 2.3|
Metaplasia, Squamous | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|
DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|
| 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 UG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 2|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Cholangiofibrosis | 3 4 4 3 4 4 3 4 4 4 2 4 4 4 4 2 4 4|
Degeneration, Cystic | |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X |
Fatty Change, Diffuse | 2 1 2 3 2 3 2 1 1 2 1 3 2 2 2 2 2 2 2 1 1 3 2 1|
Fatty Change, Focal | 3 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 2 1 1 |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X|
Inflammation | 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia | 1 1 |
Mixed Cell Focus | X |
Mixed Cell Focus, Multiple | X |
Necrosis | 2 3 2 2 2 |
Pigmentation | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2|
Toxic Hepatopathy | 3 4 4 4 4 3 4 4 3 3 4 3 3 4 4 4 4 4 4 3 4 2 3 4 3|
Bile Duct, Cyst | 2 2 3 2 2 3 2 2 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|
DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|
| 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 UG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Fibrosis | 2 2 |
Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 2 1 1 2 1 2 2 2 3 2 2 2 2 2 2 1 3 1|
Centrilobular, Degeneration | 2 2 |
Centrilobular, Fibrosis | 2 2 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Hepatocyte, Glandular Structures | 2 |
Hepatocyte, Hypertrophy | 3 3 3 3 3 4 3 4 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 4 3|
Hepatocyte, Multinucleated | 3 2 1 2 1 2 2 1 3 2 2 3 2 2 1 1 2 2 2 3 2 2 3 3|
Oval Cell, Hyperplasia | 3 3 3 3 3 3 3 4 2 3 3 2 3 3 3 4 3 3 3 2 3 3 3 4 3|
Portal, Fibrosis | 2 3 3 3 3 1 3 3 3 2 2 2 3 3 3 3 3 3 3 2 3 2 2 3 3|
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + M + + + + +|
Artery, Inflammation, Chronic Active | 3 2 1 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 2 1 2 1 1 3 2 1 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic Active | 1 2 |
Acinus, Atrophy | 1 1 1 1 |
Acinus, Vacuolization Cytoplasmic | 2 2 1 1 3 2 1 2 2 2 2 1 2 2 2 2 2 2 2 1 1 2 1|
Artery, Inflammation, Chronic Active | 3 3 3 2 |
Duct, Dilatation | 3 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Squamous | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Erosion | 2 |
Hemorrhage | 2 |
Mineralization | 1 1 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 2 1 4 1 1 1 1 1 1 2 3 1 1|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|
DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|
| 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 UG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Adventitia, Hemorrhage | |
Aorta, Adventitia, Inflammation | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 |
Coronary Artery, Inflammation, | |
Chronic Active | 3 4 3 3 |
Coronary Artery, Thrombosis | |
Epicardium, Inflammation | 3 2 2 1 1 2 1 1 1 |
Valve, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Atrophy | 2 3 2 2 2 2 2 2 3 3 2 3 2 2 2 2 2 2 2 3 |
Degeneration, Cystic | 2 2 3 2 2 |
Hyperplasia | 3 2 2 |
Hypertrophy | 3 1 1 2 2 3 2 2 2 1 3 4 3 2 1 2 3 1 3 2 1 1 1|
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 2 2 1 2 1 1 2 1 1 2 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Artery, Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 1 3 2 3 2 1 3|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|
DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|
| 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 UG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicular Cell, Hyperplasia | |
Follicular Cell, Hypertrophy | 3 2 1 1 1 2 2 2 3 1 2 2 2 2 1 2 2 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1 2|
Duct, Cyst | 2 2 2 3 2 2 2 2 2 3 2 3 2 4 3 3 3 3 3 4 3 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 |
Cyst | 1 2 2 2 2 2 |
|__________________________________________________________________________|
Oviduct | |
Cyst | |
Inflammation | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 3 2 3 3 3 3 3 3 3 3 2 4 3 3 3 2 3 3 2 2 2|
|__________________________________________________________________________|
Lymph Node | + M M M + M M + M + M + M + M M M M + + M M + + +|
Mediastinal, Ectasia | 2 2 1 |
Mediastinal, Hemorrhage | 2 2 1 2 2 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Histiocytic | 2 |
Renal, Ectasia | |
Renal, Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|
DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|
| 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 UG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Renal, Hyperplasia, Histiocytic | 3 |
Renal, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Ectasia | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | 2 2 3 2 3 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Ectasia | |
Hemorrhage | 2 1 |
Hyperplasia, Histiocytic | 2 2 |
Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 2 1 2 2 1 1 2 |
Pigmentation | 1 1 1 1 2 2 2 1 2 2 1 2 1 2 1 1 2 1 1 1 1 2 1 1 1|
Lymphoid Follicle, Atrophy | 2 3 |
Red Pulp, Atrophy | 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 4 3 4 2 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 3 4|
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation | 3 |
Ulcer | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|
DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|
| 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 UG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 2 |
Inflammation | 3 |
Necrosis | 3 |
Artery, Inflammation, Chronic Active | 2 |
Meninges, Inflammation | 3 |
Meninges, Vein, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation | 2 |
Metaplasia, Squamous | 2 2 2 2 1 4 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1|
Mediastinum, Inflammation | 3 |
Serosa, Fibrosis | 1 2 1 2 2 1 1 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 4 2 3 1 1 1 1 2 |
Necrosis | 4 |
Ulcer | |
Glands, Hyperplasia | |
Olfactory Epithelium, Metaplasia | 3 2 2 |
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 3 2 2 3 |
Squamous Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3|
DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7|
| 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
300 UG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 1 3 3 3 3 1 1 1 2 2 1 1 3 3 2 3 2 3 3 1 1 3 1|
Pigmentation | |
Transitional Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 87
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|
DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|
| 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|
300 UG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 1 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X |
Cholangiofibrosis | 4 3 2 4 2 4 4 3 3 4 3 4 3 3 4 3 3 3 3 2 3|
Degeneration, Cystic | 2 |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | X X X|
Fatty Change, Diffuse | 1 1 2 2 1 1 2 2 2 1 1 1 2 1 2 2 2 2 2 2 1 2|
Fatty Change, Focal | 2 3 4 3 2 2 2 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X X|
Inflammation | 2 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 2 1 1|
Metaplasia | 1 1 |
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | |
Necrosis | 2 3 2 3 3 2 3 2 2 3 2|
Pigmentation | 2 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2|
Toxic Hepatopathy | 4 4 4 3 4 3 3 4 3 3 3 3 3 4 4 4 4 3 3 3 3 4 3 4|
Bile Duct, Cyst | 2 2 2 2 2 2 3 3 3 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|
DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|
| 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|
300 UG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Fibrosis | 2 |
Bile Duct, Hyperplasia | 3 1 2 3 2 1 1 2 2 2 2 2 2 2 2 2 3 2 2 3 2 3 2 2|
Centrilobular, Degeneration | 3 |
Centrilobular, Fibrosis | 2 2 2 2 2 2 1 1 1 1 1 2 2 2 3 2 2 2 2 3 2 4 2 2|
Hepatocyte, Glandular Structures | 1 1 1 |
Hepatocyte, Hypertrophy | 4 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3 4 3 3 4 3 3|
Hepatocyte, Multinucleated | 2 2 2 2 1 3 2 3 2 2 2 2 1 3 2 1 1 1 1 1 1 3 1 2 2|
Oval Cell, Hyperplasia | 3 3 4 3 3 3 3 3 3 3 3 3 2 3 4 3 3 3 3 3 3 4 3 3|
Portal, Fibrosis | 3 3 3 2 3 2 3 3 3 3 3 3 2 3 3 2 2 3 3 3 2 4 2 2|
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 2 3 1 2 2 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 2 2 3 2 1 1 1 3 2 1 1 2 2 2 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 1 |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 2 1 |
Acinus, Vacuolization Cytoplasmic | 1 1 1 2 2 2 2 1 2 2 2 2 1 2 2 3 2 2 2 3 3 2 3 |
Artery, Inflammation, Chronic Active | 4 3 4 2 3 2 1 2 3 |
Duct, Dilatation | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Squamous | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion | |
Hemorrhage | |
Mineralization | 1 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 2 1 1 1 1 1 1 1 2 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|
DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|
| 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|
300 UG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Adventitia, Hemorrhage | 2 |
Aorta, Adventitia, Inflammation | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 |
Coronary Artery, Inflammation, | |
Chronic Active | 2 2 3 3 2 |
Coronary Artery, Thrombosis | |
Epicardium, Inflammation | 1 2 2 1 |
Valve, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Atrophy | 3 3 2 2 2 2 3 3 3 3 4 2 2 3 2 3 4 3 2 2 3 |
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 3 2 2 2 |
Hypertrophy | 2 3 2 3 2 1 1 1 3 3 2 2 2 1 3 1 2 3 2|
Necrosis | |
Vacuolization Cytoplasmic | 2 1 1 2 2 2 2 3 3 1 3 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Artery, Inflammation, Chronic Active | 3 |
C-Cell, Hyperplasia | 1 1 1 1 2 2 |
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|
DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|
| 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|
300 UG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicular Cell, Hyperplasia | 2 3 |
Follicular Cell, Hypertrophy | 1 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 2 1 1 |
Duct, Cyst | 3 1 3 2 2 2 1 2 1 3 3 3 2 2 2 3 2 1 2 3 3 2 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 |
Cyst | 2 2 |
|__________________________________________________________________________|
Oviduct | + |
Cyst | 3 |
Inflammation | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 3 3 4 3 3 4 3 2 3 2 3 3 3 3 3 3 3 3 3 3 3 2 2 3|
|__________________________________________________________________________|
Lymph Node | + M + M M M M M + M M M M M + + M + M + M M + M M|
Mediastinal, Ectasia | 2 1 2 2 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Pancreatic, Ectasia | 2 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Histiocytic | 3 2 3 |
Renal, Ectasia | |
Renal, Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|
DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|
| 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|
300 UG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Renal, Hyperplasia, Histiocytic | |
Renal, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 2 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 2 2 2 2 3 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 2 |
Hyperplasia, Histiocytic | 2 2 3 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 3 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2|
Pigmentation | 1 1 1 1 1 2 1 2 1 2 1 1 1 1 1 1 1 2 2 1 2 1|
Lymphoid Follicle, Atrophy | 2 |
Red Pulp, Atrophy | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3 4 4 2 4 4 4 4|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation | |
Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|
DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|
| 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|
300 UG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
Necrosis | |
Artery, Inflammation, Chronic Active | |
Meninges, Inflammation | |
Meninges, Vein, Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1 1 2 1 1 1 1|
Inflammation | 4 |
Metaplasia, Squamous | 3 2 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Mediastinum, Inflammation | |
Serosa, Fibrosis | 2 1 2 3 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 1 2 1 1 3 2 1|
Necrosis | |
Ulcer | |
Glands, Hyperplasia | 3 3 |
Olfactory Epithelium, Metaplasia | 1 3 3 2 |
Respiratory Epithelium, Hyperplasia | 2 2 3 3 3 |
Squamous Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4|
DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7|
| 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 NG/ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|
300 UG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 3 1 2 3 2 1 1 2 2 2 2 3 1 3 1 2 3 2 2 3 1 1 1 |
Pigmentation | 2 |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 94
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Muscularis, Inflammation | | 3 1.7|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
Parasite Metazoan | | 1 |
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | 2 | 3 2.0|
Basophilic Focus | | 4 |
Cholangiofibrosis | 4 4 4 | 42 3.4|
Degeneration, Cystic | | 1 2.0|
Eosinophilic Focus | X | 2 |
Eosinophilic Focus, Multiple | | 4 |
Fatty Change, Diffuse | 2 1 2 | 49 1.7|
Fatty Change, Focal | 3 | 10 2.6|
Hematopoietic Cell Proliferation | 1 1 | 22 1.1|
Hyperplasia, Nodular | X X X | 50 |
Inflammation | 1 1 | 51 1.2|
Metaplasia | | 4 1.0|
Mixed Cell Focus | | 1 |
Mixed Cell Focus, Multiple | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Necrosis | 2 | 17 2.4|
Pigmentation | 3 2 2 | 53 2.0|
Toxic Hepatopathy | 4 4 4 | 52 3.5|
Bile Duct, Cyst | 2 3 | 25 2.2|
Bile Duct, Fibrosis | | 3 2.0|
Bile Duct, Hyperplasia | 2 3 2 | 52 1.9|
Centrilobular, Degeneration | | 3 2.3|
Centrilobular, Fibrosis | 3 2 3 | 52 1.9|
Hepatocyte, Glandular Structures | 1 | 5 1.2|
Hepatocyte, Hypertrophy | 3 4 3 | 52 3.2|
Hepatocyte, Multinucleated | 2 1 2 | 52 1.9|
Oval Cell, Hyperplasia | 3 3 3 | 52 3.0|
Portal, Fibrosis | 3 3 3 | 52 2.7|
|__________________________________________________________________________|____________|
Mesentery | + + + | 52 |
Artery, Inflammation, Chronic Active | | 9 2.1|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + | 53 |
Gingival, Hyperplasia, Squamous | 1 | 27 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Edema | 2 | 4 1.8|
Inflammation, Chronic Active | | 2 1.5|
Acinus, Atrophy | 2 1 | 9 1.2|
Acinus, Vacuolization Cytoplasmic | 1 2 3 | 49 1.9|
Artery, Inflammation, Chronic Active | 2 | 14 2.6|
Duct, Dilatation | | 3 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Edema | | 1 2.0|
Hyperplasia, Squamous | 1 | 4 1.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Glandular | + + + | 53 |
Cyst | | 1 2.0|
Erosion | | 1 2.0|
Hemorrhage | | 1 2.0|
Mineralization | 1 | 6 1.2|
|__________________________________________________________________________|____________|
Tooth | + + | 29 |
Peridontal Tissue, Inflammation | 1 1 | 29 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Aorta, Adventitia, Hemorrhage | | 1 2.0|
Aorta, Adventitia, Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | 1 | 14 1.0|
Coronary Artery, Inflammation, | | |
Chronic Active | 2 | 10 2.7|
Coronary Artery, Thrombosis | 2 | 1 2.0|
Epicardium, Inflammation | | 13 1.5|
Valve, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 4 1.0|
Atrophy | 2 2 2 | 44 2.4|
Degeneration, Cystic | | 6 2.2|
Hyperplasia | 2 | 10 2.2|
Hypertrophy | 2 1 1 | 45 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 1 | 27 1.7|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + | 53 |
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Hyperplasia | 3 | 4 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Inflammation | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
C-Cell, Hyperplasia | 2 2 | 15 1.8|
Follicular Cell, Hyperplasia | | 2 2.5|
Follicular Cell, Hypertrophy | 1 3 1 | 44 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
Inflammation | | 21 1.1|
Duct, Cyst | 2 3 2 | 48 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 3 | 7 3.0|
Cyst | | 8 1.9|
|__________________________________________________________________________|____________|
Oviduct | | 1 |
Cyst | | 1 3.0|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Uterus | + + + | 53 |
Endometrium, Hyperplasia, Cystic | | 7 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Atrophy | 3 | 2 2.5|
Hyperplasia | 4 2 | 47 2.9|
|__________________________________________________________________________|____________|
Lymph Node | M + M | 20 |
Mediastinal, Ectasia | | 7 1.7|
Mediastinal, Hemorrhage | | 7 1.9|
Mediastinal, Hyperplasia, Histiocytic| | 2 2.0|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia, Histiocytic | | 4 2.5|
Renal, Ectasia | 2 | 1 2.0|
Renal, Hemorrhage | 2 | 1 2.0|
Renal, Hyperplasia, Histiocytic | | 1 3.0|
Renal, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Atrophy | | 1 4.0|
Ectasia | 2 | 4 2.0|
Hemorrhage | 1 | 2 1.5|
Hyperplasia, Lymphoid | | 2 3.5|
Hyperplasia, Plasma Cell | 3 | 22 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Ectasia | | 1 2.0|
Hemorrhage | | 4 1.5|
Hyperplasia, Histiocytic | | 5 2.2|
Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 3 2 2 | 50 1.9|
Pigmentation | 1 1 2 | 50 1.3|
Lymphoid Follicle, Atrophy | | 3 2.3|
Red Pulp, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + | 51 |
Atrophy | 4 4 4 | 50 3.8|
Artery, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Hyperplasia | | 6 1.2|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Cyst Epithelial Inclusion | | 1 |
Inflammation | | 1 3.0|
Ulcer | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | 2 | 5 2.0|
Inflammation | | 1 3.0|
Necrosis | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
Meninges, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Meninges, Vein, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Hemorrhage | | 2 1.0|
Infiltration Cellular, Histiocyte | 1 1 | 46 1.1|
Inflammation | | 2 3.0|
Metaplasia, Squamous | 2 4 | 16 2.3|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 | 35 1.1|
Mediastinum, Inflammation | | 1 3.0|
Serosa, Fibrosis | 2 | 16 1.6|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | 1 3 | 22 1.7|
Necrosis | | 1 4.0|
Ulcer | 2 | 1 2.0|
Glands, Hyperplasia | | 2 3.0|
Olfactory Epithelium, Metaplasia | 2 | 8 2.3|
Respiratory Epithelium, Hyperplasia | 2 3 | 16 2.4|
Squamous Epithelium, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Cornea, Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | | 7 1.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 3| 6| 5| | |
DAY ON TEST | 8| 3| 6| | |
| 3| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
2400 NG/ | 9| 9| 9| | L |
300 UG | 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Mineralization | 1 1 | 34 1.1|
Nephropathy | 1 3 3 | 50 2.0|
Pigmentation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|
DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|
| 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cholangiofibrosis | 4 4 3 2 4 3 4 3 4 3 |
Eosinophilic Focus, Multiple | X X X X |
Fatty Change, Diffuse | 2 1 2 2 1 2 1 2 1 1 2 1 3 2 2 2 1 2 1 1 2 |
Fatty Change, Focal | 2 3 2 |
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X X|
Inflammation | 1 2 2 2 1 1 2 1 1 2 2 2 1 1 2 2 1 1 1 1 1 2 1 1|
Metaplasia | 2 2 |
Mineralization | 2 |
Mixed Cell Focus | X X |
Necrosis | 3 3 3 2 2 3 3 3 |
Pigmentation | 1 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1|
Thrombosis | |
Toxic Hepatopathy | 4 4 2 4 4 4 4 4 4 3 4 3 4 3 4 4 4 4 4 3 3 4 4 4 4|
Bile Duct, Cyst | 2 2 2 1 2 2 2 2 |
Bile Duct, Dilatation | 2 |
__________________________________________|__________________________________________________________________________|
Page 103
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|
DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|
| 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Fibrosis | 2 |
Bile Duct, Hyperplasia | 3 3 1 3 3 3 3 3 3 1 3 1 3 1 3 3 2 2 2 1 3 2 2 3|
Centrilobular, Degeneration | 2 |
Centrilobular, Fibrosis | 2 2 2 2 2 2 2 2 2 3 2 3 2 3 2 2 2 2 2 2 2 2|
Hepatocyte, Glandular Structures | 2 3 1 1 3 4 1 2 1 2 3|
Hepatocyte, Hypertrophy | 4 4 2 4 4 3 4 3 4 3 4 2 4 3 4 4 3 3 3 4 4 4 4 4 4|
Hepatocyte, Multinucleated | 1 1 2 1 1 2 1 1 3 2 3 3 1 1 2 2 2 2 2 1 |
Oval Cell, Hyperplasia | 3 4 1 4 3 4 4 4 4 2 3 2 3 2 4 4 3 4 2 2 2 4 3 3 3|
Portal, Fibrosis | 3 3 4 3 3 3 3 3 3 2 4 2 3 3 3 3 2 3 3 4 3 3 4|
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 3 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Gingival, Hyperplasia, Squamous | 2 2 1 1 1 1 1 4 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 1 2 2 2|
Hemorrhage | |
Inflammation, Chronic Active | 3 1|
Acinus, Atrophy | 1 3 2|
Acinus, Vacuolization Cytoplasmic | 2 1 2 2 2 1 2 1 1 3 3 1 1 3 1 1 3 1 |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Squamous | 2 1 2 |
Inflammation | |
Mineralization | 1 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Erosion | |
Hemorrhage | 2 |
__________________________________________|__________________________________________________________________________|
Page 104
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|
DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|
| 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation | |
Mineralization | 2 2|
Glands, Cyst | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + |
Peridontal Tissue, Inflammation | 2 1 2 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Adventitia, Hemorrhage | |
Aorta, Adventitia, Inflammation | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 1 |
Atrium, Thrombosis | 3 |
Coronary Artery, Inflammation, | |
Chronic Active | 3 3 2 3 |
Epicardium, Hemorrhage | 2 |
Epicardium, Inflammation | 2 2 1 |
Myocardium, Hemorrhage | 2 |
Myocardium, Inflammation | |
Myocardium, Necrosis | 3 |
Ventricle, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 |
Atrophy | 2 3 2 2 3 2 2 2 2 2 2 2 4 3 2 2 2 3 |
Degeneration, Cystic | 1 2 |
Hyperplasia | 2 |
Hypertrophy | 2 3 1 1 2 1 1 1 2 3 2 1 2 1 3 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 105
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|
DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|
| 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Necrosis | 2 |
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3|
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | 2 |
Follicular Cell, Hypertrophy | 2 2 1 1 2 1 1 1 1 1 1 2 1 3 2 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 2 1 1 1 2 |
Duct, Cyst | 3 2 2 3 3 3 3 2 2 2 1 2 2 2 3 3 2 3 2 3 2 3 2 3 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 4 |
Cyst | 2 2 1 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Hemorrhage | |
Inflammation, Suppurative | |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________|__________________________________________________________________________|
Page 106
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|
DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|
| 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 2 3 2 2 3 3 3 3 3 2 2 2 2 3 2 2 3 2 2 3|
|__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + M + + M M + + + + + + M +|
Mediastinal, Ectasia | 2 1 1 2 2 1 1 2 2 2 1 2 |
Mediastinal, Hemorrhage | 2 1 1 1 2 2 1|
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Pigmentation | 2 |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Histiocytic | 3 2 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Histiocytic | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 |
Necrosis, Lymphoid | |
Necrosis | |
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 3 2 2 2 3|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 2 1 1 2 2 1 2 1 2 1 2 1|
Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | |
Lymphoid Follicle, Atrophy | 3 |
Red Pulp, Atrophy | |
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + + M + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 3 3 4 3 4 4 4 4 4 4 4 4|
Artery, Inflammation, Chronic Active | |
__________________________________________|__________________________________________________________________________|
Page 107
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|
DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|
| 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Mineralization | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation | |
Metaplasia, Squamous | 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 |
Artery, Thrombosis | 2 |
Artery, Mediastinum, Inflammation, | |
Chronic Active | |
Serosa, Fibrosis | 2 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 1 1 |
__________________________________________|__________________________________________________________________________|
Page 108
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2|
DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7|
| 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 3 1 2 1 |
Squamous Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Inflammation, Suppurative | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | |
Nephropathy | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 109
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|
DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|
| 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 3 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Inflammation | 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Cholangiofibrosis | 3 1 3 3 4 3 4 3 3 2 4 4|
Eosinophilic Focus, Multiple | X X X|
Fatty Change, Diffuse | 1 2 2 1 3 2 2 2 2 2 2 1 3 1 2 2 2 2 2 1 2 |
Fatty Change, Focal | 2 2|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1|
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X X|
Inflammation | 1 1 2 1 2 1 1 1 2 2 2 1 1 1 2 2 1 1 2 1 2 2 1 1 2|
Metaplasia | 2 2 |
Mineralization | |
Mixed Cell Focus | X |
Necrosis | 1 2 1 2 3 2 3 2 2 2 1 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2|
Thrombosis | 2 |
Toxic Hepatopathy | 4 3 4 4 4 3 3 4 4 4 4 3 4 4 3 4 4 4 4 3 4 4 4 4 4|
Bile Duct, Cyst | 1 2 1 2 |
Bile Duct, Dilatation | |
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|
DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|
| 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Fibrosis | 2 1 |
Bile Duct, Hyperplasia | 2 2 3 2 3 1 2 4 3 2 1 3 2 1 2 2 3 3 1 3 4 3 3 2|
Centrilobular, Degeneration | 2 2 3 1 2 |
Centrilobular, Fibrosis | 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Hepatocyte, Glandular Structures | 3 4 3 2 2 2 1 3 2 2 3 2 |
Hepatocyte, Hypertrophy | 3 3 4 4 4 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 3|
Hepatocyte, Multinucleated | 1 1 2 2 1 1 1 2 2 1 1 1 1 1 1 2|
Oval Cell, Hyperplasia | 3 3 4 3 3 1 3 4 3 3 2 3 3 3 3 4 3 4 2 4 4 3 3 3|
Portal, Fibrosis | 2 2 3 3 4 3 4 3 3 2 3 3 2 3 3 3 4 2 4 3 3 3 3|
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 1 1 3 |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Gingival, Hyperplasia, Squamous | 2 1 2 1 2 1 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 1 2 2 2 2 2 2 1 |
Hemorrhage | 3 |
Inflammation, Chronic Active | 2 1 2 |
Acinus, Atrophy | 1 1 1 3 |
Acinus, Vacuolization Cytoplasmic | 1 2 3 2 2 1 1 2 1 1 1 1 1 1 2|
Artery, Inflammation, Chronic Active | 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Squamous | 2 2 2 2 |
Inflammation | |
Mineralization | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hemorrhage | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 111
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|
DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|
| 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation | |
Mineralization | 2 1 |
Glands, Cyst | 3 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + +|
Peridontal Tissue, Inflammation | 2 1 1 2 1 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Adventitia, Hemorrhage | 2 |
Aorta, Adventitia, Inflammation | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 2 1 2 1 |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic Active | 2 3 3 1 |
Epicardium, Hemorrhage | |
Epicardium, Inflammation | 2 1 1|
Myocardium, Hemorrhage | 2 2 |
Myocardium, Inflammation | 2 |
Myocardium, Necrosis | 2 |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 3 2 3 3 2 3 2 2 2 2|
Degeneration, Cystic | |
Hyperplasia | 3 2 1 |
Hypertrophy | 1 1 3 1 1 1 1 2 1 2|
Necrosis | 2 2 |
Vacuolization Cytoplasmic | 1 1 2 3 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 112
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|
DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|
| 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + M M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Pars Distalis, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | |
Follicular Cell, Hypertrophy | 1 2 2 1 1 2 1 2 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 2 1 1 1 |
Duct, Cyst | 2 2 3 2 3 3 3 3 2 2 3 3 2 3 3 3 2 3 2 2 3 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 |
Cyst | 2 2 3 3 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 |
Thrombosis | 2 |
Endometrium, Hyperplasia, Cystic | 1 3 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 3 2 3 |
__________________________________________|__________________________________________________________________________|
Page 113
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|
DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|
| 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 2 3 2 2 3 3 3 2 3 3 3 2 3 3 3 4 3|
|__________________________________________________________________________|
Lymph Node | + + M M + + + + + M M + + + + + + + + + + + + + M|
Mediastinal, Ectasia | 1 2 1 2 2 2 1 2 1 1 |
Mediastinal, Hemorrhage | 2 2 2 2 3 3 2 3 3 1 2 2 1 1 2 |
Mediastinal, Hyperplasia, Histiocytic| 3 2 |
Mediastinal, Pigmentation | |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 2 2 |
Pancreatic, Hyperplasia, Histiocytic | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Histiocytic | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 2 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 |
Necrosis, Lymphoid | 1 |
Necrosis | |
Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 2 1 3 2 2 2 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 1 1 1 1 1 1 1 1 3 1 2 2 1 2|
Pigmentation | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | 3 |
Lymphoid Follicle, Atrophy | 3 3 2 3 2 |
Red Pulp, Atrophy | 2 2 |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + M M +|
Atrophy | 3 4 4 4 4 4 4 3 4 4 4 3 4 4 4 4 4 4 4 3 4 3|
Artery, Inflammation, Chronic Active | 2 |
__________________________________________|__________________________________________________________________________|
Page 114
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|
DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|
| 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 2 1 2 3 2 1 3 |
Mineralization | 1 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation | 1 2 |
Metaplasia, Squamous | 4 3 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 |
Artery, Thrombosis | |
Artery, Mediastinum, Inflammation, | |
Chronic Active | 3 |
Serosa, Fibrosis | 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 115
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3|
DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8|
| 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4000 NG/ | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 |
Squamous Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | 2 |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1|
Necrosis | 3 |
Nephropathy | 1 1 3 2 1 2 1 2 1 1 1 1 1 1 2 2 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 116
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 66 |
Muscularis, Inflammation | | 2 2.5|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + | 65 |
Parasite Metazoan | | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Cystic | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + | 65 |
Edema | | 2 2.0|
Inflammation | | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 65 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | 66 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + | 65 |
|__________________________________________________________________________|____________|
Liver | + + + + + M + + + + + + + + + + | 65 |
Angiectasis | | 2 2.5|
Cholangiofibrosis | 4 3 4 2 3 2 4 | 29 3.2|
Eosinophilic Focus, Multiple | X X X | 10 |
Fatty Change, Diffuse | 1 3 2 1 3 2 2 1 1 1 1 3 2 2 | 56 1.8|
Fatty Change, Focal | 2 | 6 2.2|
Hematopoietic Cell Proliferation | 1 1 1 | 11 1.0|
Hyperplasia, Nodular | X X X X X X X X X X X X X | 61 |
Inflammation | 1 1 2 1 1 1 1 2 1 2 2 1 1 1 1 | 64 1.4|
Metaplasia | | 4 2.0|
Mineralization | | 1 2.0|
Mixed Cell Focus | | 3 |
Necrosis | 2 2 3 3 1 2 2 2 | 27 2.2|
Pigmentation | 2 2 2 2 3 2 2 1 2 2 1 3 2 2 | 60 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Thrombosis | | 1 2.0|
Toxic Hepatopathy | 4 3 4 3 4 4 4 1 2 3 3 3 3 4 | 64 3.6|
Bile Duct, Cyst | 2 3 | 14 1.9|
Bile Duct, Dilatation | | 1 2.0|
Bile Duct, Fibrosis | 1 | 4 1.5|
Bile Duct, Hyperplasia | 3 2 2 2 2 3 3 1 2 2 2 3 | 60 2.4|
Centrilobular, Degeneration | 2 1 | 8 1.9|
Centrilobular, Fibrosis | 2 2 2 2 2 2 2 1 2 2 2 2 | 57 2.1|
Hepatocyte, Glandular Structures | 2 2 | 25 2.2|
Hepatocyte, Hypertrophy | 4 3 3 3 3 4 4 2 3 3 4 3 3 2 4 | 65 3.5|
Hepatocyte, Multinucleated | 1 2 2 2 2 2 3 1 2 2 3 3 | 48 1.7|
Oval Cell, Hyperplasia | 3 2 3 3 3 4 4 2 3 3 3 2 3 | 62 3.0|
Portal, Fibrosis | 3 2 3 2 3 3 3 3 3 2 2 3 | 58 2.9|
|__________________________________________________________________________|____________|
Mesentery | + + M + M M + + + + + + + + + + | 63 |
Artery, Inflammation, Chronic Active | | 3 1.7|
Fat, Necrosis | | 3 2.7|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + + | 66 |
Cyst | 2 | 1 2.0|
Gingival, Hyperplasia, Squamous | 2 2 | 18 1.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + M + + + + + + + + + + | 65 |
Edema | 2 2 1 | 19 1.8|
Hemorrhage | 2 | 2 2.5|
Inflammation, Chronic Active | 2 | 6 1.8|
Acinus, Atrophy | 2 | 8 1.8|
Acinus, Vacuolization Cytoplasmic | 1 1 2 1 3 1 2 2 2 1 | 43 1.6|
Artery, Inflammation, Chronic Active | 3 | 4 2.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 66 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 65 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hyperplasia, Squamous | 2 2 | 9 1.9|
Inflammation | 1 | 1 1.0|
Mineralization | 1 | 2 1.0|
Ulcer | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 65 |
Erosion | 2 | 2 2.0|
Hemorrhage | | 3 1.7|
Inflammation | 1 | 1 1.0|
Mineralization | 1 | 5 1.6|
Glands, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + | 25 |
Peridontal Tissue, Inflammation | 1 4 2 1 1 | 25 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + | 66 |
Aorta, Adventitia, Hemorrhage | | 1 2.0|
Aorta, Adventitia, Inflammation | | 2 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + M + + + + + + + + + + | 65 |
Cardiomyopathy | 1 1 1 1 1 1 | 19 1.3|
Atrium, Thrombosis | | 1 3.0|
Coronary Artery, Inflammation, | | |
Chronic Active | 2 | 9 2.4|
Epicardium, Hemorrhage | | 1 2.0|
Epicardium, Inflammation | | 6 1.5|
Myocardium, Hemorrhage | | 3 2.0|
Myocardium, Inflammation | | 1 2.0|
Myocardium, Necrosis | | 2 2.5|
Ventricle, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + M + + + + + + + + + + | 65 |
Angiectasis | 1 1 1 | 6 1.0|
Atrophy | 2 2 2 3 2 2 2 2 3 2 4 | 40 2.4|
Degeneration, Cystic | | 2 1.5|
Hyperplasia | 2 | 5 2.0|
Hypertrophy | 2 1 | 27 1.6|
Necrosis | 2 | 4 2.0|
Vacuolization Cytoplasmic | 3 | 12 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + + | 64 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + | 65 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + | 62 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 65 |
Necrosis | | 1 2.0|
Pars Distalis, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 66 |
Hemorrhage | | 1 3.0|
C-Cell, Hyperplasia | 2 | 3 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
Follicular Cell, Hypertrophy | 2 2 1 2 2 1 2 2 2 3 2 | 37 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + | 66 |
Inflammation | 1 1 1 1 2 1 1 1 1 1 | 31 1.1|
Duct, Cyst | 2 2 2 3 2 2 2 1 2 3 3 3 2 3 | 61 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 120
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + M + + + + + + + + + + | 65 |
Atrophy | 3 3 | 9 3.0|
Cyst | 2 2 2 2 | 13 2.1|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + | 66 |
Adenomyosis | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 3 | 2 2.5|
Thrombosis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 3 | 8 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 66 |
Atrophy | 2 2 2 2 | 12 2.3|
Hyperplasia | 3 3 3 2 2 3 2 4 3 2 2 3 | 49 2.6|
|__________________________________________________________________________|____________|
Lymph Node | M M + M + M M + + + M M M M M M | 45 |
Mediastinal, Ectasia | 1 3 2 1 2 | 27 1.6|
Mediastinal, Hemorrhage | 2 1 1 | 25 1.8|
Mediastinal, Hyperplasia, Histiocytic| | 2 2.5|
Mediastinal, Pigmentation | 2 | 2 2.0|
Pancreatic, Ectasia | 2 | 1 2.0|
Pancreatic, Hemorrhage | 1 | 4 1.8|
Pancreatic, Hyperplasia, Histiocytic | | 3 2.3|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Histiocytic | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | 66 |
Ectasia | 2 | 1 2.0|
Hemorrhage | 2 | 7 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 2 3 2 3 | 20 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Necrosis, Lymphoid | | 1 1.0|
Necrosis | 1 | 1 1.0|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + | 65 |
Ectasia | 2 | 2 2.0|
Hemorrhage | 1 | 14 2.1|
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + M + + + + + + + + + + | 65 |
Hematopoietic Cell Proliferation | 2 2 1 1 3 1 1 1 2 2 1 | 43 1.5|
Pigmentation | 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 | 59 1.1|
Artery, Inflammation, Chronic Active | | 1 3.0|
Lymphoid Follicle, Atrophy | 3 2 2 | 9 2.6|
Red Pulp, Atrophy | | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + | 59 |
Atrophy | 4 4 4 4 4 4 4 2 4 4 3 4 4 4 | 57 3.8|
Artery, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + | 66 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 66 |
Hemorrhage | | 1 2.0|
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 122
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + + + + + + + | 66 |
Hemorrhage | 3 1 2 2 | 14 2.2|
Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 66 |
Hemorrhage | | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 33 1.0|
Inflammation | | 2 1.5|
Metaplasia, Squamous | 3 | 7 2.6|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.3|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 1 | 8 1.0|
Artery, Thrombosis | | 1 2.0|
Artery, Mediastinum, Inflammation, | | |
Chronic Active | | 1 3.0|
Serosa, Fibrosis | 2 2 1 1 2 | 8 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 66 |
Inflammation | 2 1 1 | 11 1.4|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 2 2 | 9 1.9|
Squamous Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 123
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | |
DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | |
| 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4000 NG/ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L |
500 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Retina, Atrophy | | 1 2.0|
Retina, Degeneration | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + | 66 |
Inflammation | 1 1 | 9 1.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + M + + + + + + + + + + | 65 |
Infarct | | 1 3.0|
Inflammation, Suppurative | | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 | 37 1.1|
Necrosis | | 1 3.0|
Nephropathy | 1 1 1 1 3 1 1 2 3 1 2 | 43 1.4|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 124
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|
DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|
| 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500UG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Artery, Inflammation, Chronic Active | 3 3 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation | 2 |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 |
Basophilic Focus | |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 2 2 3 1 4 1 3 2 1 1 1 1 1 1 |
Clear Cell Focus | X |
Degeneration, Cystic | |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X X X X X X X X |
Fatty Change, Diffuse | 2 2 1 1 2 1 1 1 1 1 1 1 3 1 3 1 1 2 1 1 |
Fatty Change, Focal | 2 2 2 1 2 1 |
Hematopoietic Cell Proliferation | 2 1 2 1 1 1 1 1 1 2 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X|
Inflammation | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 125
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|
DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|
| 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500UG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Metaplasia | 2 |
Mixed Cell Focus | X |
Mixed Cell Focus, Multiple | X X X X X X X X X X |
Necrosis | 2 2 2 2 |
Pigmentation | 2 2 2 2 2 1 1 2 1 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2|
Toxic Hepatopathy | 2 2 2 2 2 2 2 2 2 1 2 2 3 3 3 2 3 2 3 4 3 2 3 2 3|
Bile Duct, Cyst | 3 4 2 2 3 4 3 2 3 |
Bile Duct, Fibrosis | 2 2 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 3 1 1 1 3 3 2 2 1 3|
Centrilobular, Degeneration | 2 1 2 |
Centrilobular, Fibrosis | 2 1 2 1 3 1 2 3 2 3 2 2 1 2 2 2 2 2 2 3|
Hepatocyte, Glandular Structures | 3 2 1 2 3|
Hepatocyte, Hypertrophy | 4 3 1 4 2 2 3 4 3 4 3 3 3 4 4 1 2 3|
Hepatocyte, Multinucleated | 3 2 2 2 2 1 1 1 1 2 1 1 1 1 2 3 1|
Oval Cell, Hyperplasia | 2 2 2 2 2 2 1 1 1 2 3 3 2 1 3 3 3 3 2 3 1 3|
Portal, Fibrosis | 1 2 3 2 2 1 1 3 3 2 3 2 3 3 3 3 3 1 3|
Serosa, Fibrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + + M M + + + M M + + + M M + + + + + + +|
Necrosis | 3 |
Artery, Inflammation, Chronic Active | 2 1 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 2 1 2 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 2 2|
Hemorrhage | |
Inflammation, Chronic Active | 1 2 3 |
Acinus, Atrophy | 2 4 3 |
Acinus, Vacuolization Cytoplasmic | 2 2 3 2 3 1 1 1 2 2 2 2 2 1 1 1 1 1|
Artery, Inflammation, Chronic Active | 2 2 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Squamous | 2 |
__________________________________________|__________________________________________________________________________|
Page 126
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|
DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|
| 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500UG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation | 1 |
Mineralization | 2 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 2 2 1 2 2 3 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Adventitia, Hemorrhage | 3 |
Aorta, Adventitia, Inflammation | 1 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 |
Atrium, Thrombosis | 1 |
Coronary Artery, Inflammation, | |
Chronic Active | 3 |
Epicardium, Inflammation | 1 |
Myocardium, Hemorrhage | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 2 1 1 1 1 1 1 1 1 |
Atrophy | 2 2 3 2|
Degeneration, Cystic | 3 2 2 3 3 |
Hyperplasia | 2 2 2 2 |
Hypertrophy | 1 3 2 2 3 3 3 2 3 3 2 2 3 1 |
Inflammation | 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 2 2 2 2 3 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 127
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|
DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|
| 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500UG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 |
Cyst | 2 |
Cytoplasmic Alteration | |
Pars Distalis, Hyperplasia | 2 2 1 |
Pars Intermedia, Hyperplasia | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 3 |
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hypertrophy | 2 1 2 1 3 2 2 1 2 1 4 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 1 1 1 1 1 1 1 1 1 2 1 |
Duct, Cyst | 2 3 3 3 2 2 2 3 1 2 2 1 3 2 2 3 3 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 |
Cyst | 3 2 2 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 3 |
Metaplasia, Squamous | 2 1 2 |
Cervix, Stromal Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 128
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|
DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|
| 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500UG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Endometrium, Hyperplasia, Cystic | 2 1 1 2 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 |
Hyperplasia | 2 2 3 4 3 3 4 1 2 3 1 3 1 3 3 3 2 3 3|
|__________________________________________________________________________|
Lymph Node | + M M M M M M M M M M M M + M + M + M M M + M + M|
Lumbar, Hemorrhage | 1 |
Lumbar, Hyperplasia, Histiocytic | 2 |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | 2 2 3 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Histiocytic | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Ectasia | 3 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Histiocytic | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 2|
Hemorrhage | 2 2 1 |
Hyperplasia, Plasma Cell | 2 2 3 2 3 3 2 2 3 2 3 2 3 3 2 2|
Inflammation | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 2 2 3 2 2|
Hyperplasia, Histiocytic | |
Hyperplasia, Plasma Cell | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 1 1 2 1 2 2 2 2 2 1 2 1 1 1|
Pigmentation | 1 2 1 1 1 2 2 2 1 2 1 1 2 2 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 129
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|
DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|
| 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500UG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymphoid Follicle, Atrophy | 2 3 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + M + + + + +|
Atrophy | 4 2 3 2 4 3 2 4 3 2 3 4 4 4 3 4 4 4 4 4 3 4 4|
Hemorrhage | 3 |
Artery, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 1 1 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 3 1 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 1 1 2 |
Inflammation, Granulomatous | 3 |
Inflammation | 2 3 3 |
Keratin Cyst | 4 4 |
Metaplasia, Squamous | 2 1 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Alveolar Epithelium, Metaplasia, | |
__________________________________________|__________________________________________________________________________|
Page 130
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
_____________________________________________________________________________________________________________________
| 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2|
DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4|
| 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
4000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
500UG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Bronchiolar | 2 2 1 1 1 1 1 1 1 |
Serosa, Fibrosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 2 1 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 2 3 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Cyst | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 2 3 2 3 1 1 2 2 2 1 2 2 3 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________|__________________________________________________________________________
Page 131
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
Artery, Inflammation, Chronic Active | 2 1 | 4 2.3|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Inflammation | | 1 2.0|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 4 2.3|
Basophilic Focus | X X | 2 |
Basophilic Focus, Multiple | X X | 3 |
Cholangiofibrosis | 3 2 3 2 3 3 1 3 3 3 2 1 2 | 27 2.0|
Clear Cell Focus | | 1 |
Degeneration, Cystic | 2 | 1 2.0|
Eosinophilic Focus | | 1 |
Eosinophilic Focus, Multiple | X X X X | 14 |
Fatty Change, Diffuse | 2 2 1 1 2 1 1 1 2 1 1 2 1 1 1| 35 1.4|
Fatty Change, Focal | 3 2 2 2 2 3 3 3 | 14 2.1|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 | 22 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 132
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X| 34 |
Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0|
Metaplasia | 1 | 2 1.5|
Mixed Cell Focus | | 1 |
Mixed Cell Focus, Multiple | X X X X X X X X X | 19 |
Necrosis | 2 2 | 6 2.0|
Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 50 1.9|
Toxic Hepatopathy | 3 3 2 4 3 3 3 3 3 2 3 3 1 3 3 3 2 3 4 3 2 4 3 4 3| 50 2.6|
Bile Duct, Cyst | 2 2 3 3 2 3 2 3 4 2 2 3 | 21 2.7|
Bile Duct, Fibrosis | 2 2 2 2 2 2 1 2 | 12 1.9|
Bile Duct, Hyperplasia | 3 2 1 3 2 1 2 2 2 2 1 1 3 2 2 3 1 2 1 3 1| 37 1.8|
Centrilobular, Degeneration | 2 2 3 | 6 2.0|
Centrilobular, Fibrosis | 3 1 1 2 2 1 2 2 2 2 2 1 1 1 2 1 2 2 2 3 2 2 2| 43 1.9|
Hepatocyte, Glandular Structures | 3 1 3 3 | 9 2.3|
Hepatocyte, Hypertrophy | 3 1 2 3 3 3 2 3 2 1 2 1 4 2 3 3 3 3| 36 2.7|
Hepatocyte, Multinucleated | 2 1 2 2 1 2 1 1 2 2 2 2 1 1 2 2 1 1 1 2 3| 38 1.6|
Oval Cell, Hyperplasia | 3 2 3 4 2 2 2 3 3 2 3 2 2 1 2 2 3 2 3 2 3 | 43 2.3|
Portal, Fibrosis | 3 2 3 4 3 1 3 3 2 2 2 1 2 1 2 1 2 3 4 3 2 3 1| 42 2.3|
Serosa, Fibrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + M + + + + + + + + +| 43 |
Necrosis | | 1 3.0|
Artery, Inflammation, Chronic Active | 2 2 1 4 | 7 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gingival, Hyperplasia, Squamous | 2 2 2 3 1 1 1 1 1 2 | 18 1.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 1 1 1 2 1 2 | 12 1.7|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 | 5 1.6|
Acinus, Atrophy | 2 2 2 2 2 | 8 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 133
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Acinus, Vacuolization Cytoplasmic | 2 2 2 2 1 1 1 1 2 1 1 2 2 1 1 2 2 1 1 2 1 1 2| 41 1.6|
Artery, Inflammation, Chronic Active | 2 2 2 3 2 | 10 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Hyperplasia, Squamous | 1 | 2 1.5|
Inflammation | 3 | 2 2.0|
Mineralization | | 1 2.0|
Ulcer | 3 1 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + | 23 |
Peridontal Tissue, Inflammation | 3 3 2 1 1 1 1 2 1 1 1 2 1 | 23 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Adventitia, Hemorrhage | 2 | 2 2.5|
Aorta, Adventitia, Inflammation | | 2 1.5|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 1 1 | 15 1.1|
Atrium, Thrombosis | | 1 1.0|
Coronary Artery, Inflammation, | | |
Chronic Active | 1 1 1 3 3| 6 2.0|
Epicardium, Inflammation | | 1 1.0|
Myocardium, Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 134
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 2 1 1 1 | 21 1.2|
Atrophy | 2 2 2 4 2 2 2 2 | 12 2.3|
Degeneration, Cystic | 2 3 2 2 | 9 2.4|
Hyperplasia | 3 2 2 2 2 3 | 10 2.2|
Hypertrophy | 2 3 3 1 1 4 3 1 1 1 3 3 2 2 2 | 29 2.2|
Inflammation | 2 | 2 2.0|
Necrosis | 2 | 2 2.0|
Vacuolization Cytoplasmic | 1 1 1 3 1 1 2 1 1 | 16 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 | 8 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + M + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 3 1.3|
Cyst | 3 2 | 3 2.3|
Cytoplasmic Alteration | 3 2 | 2 2.5|
Pars Distalis, Hyperplasia | 3 2 2 2 2 | 8 2.0|
Pars Intermedia, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphoid | 3 | 2 3.0|
C-Cell, Hyperplasia | 2 4 1 1 3 | 6 2.2|
Follicular Cell, Hypertrophy | 1 4 2 1 1 1 1 1 1 2 2 3 1 1 1| 29 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 135
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 1 2 2 1 2 1 1 2 2 1 1 1 | 30 1.2|
Duct, Cyst | 2 1 2 2 1 3 1 1 2 2 2 1 2 3 3 2 2 3 2 2 1| 40 2.1|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 3 3 3 2 2 2 | 15 2.7|
Cyst | 2 2 3 | 7 2.3|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | 2 2 | 4 2.3|
Metaplasia, Squamous | 3 1 1 1 2 | 8 1.6|
Cervix, Stromal Hyperplasia | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 4 4 2 4 4 4 1 3 3 1| 17 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 4 2.0|
Hyperplasia | 2 1 3 3 2 2 3 3 2 3 3 2 2 4 3 3 3 2 3 3 3| 40 2.6|
|__________________________________________________________________________|____________|
Lymph Node | + + + + M + + M M M M + M + M + + M + + + + + + M| 22 |
Lumbar, Hemorrhage | | 1 1.0|
Lumbar, Hyperplasia, Histiocytic | | 1 2.0|
Mediastinal, Ectasia | 2 2 | 3 2.0|
Mediastinal, Hemorrhage | 1 2 2 2 2 2 2 2 | 11 2.0|
Mediastinal, Hyperplasia, Histiocytic| 3 2 2 | 4 2.3|
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Pancreatic, Hemorrhage | 2 2 | 3 2.0|
Pancreatic, Hyperplasia, Histiocytic | 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 136
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Ectasia | | 1 3.0|
Renal, Hemorrhage | 2 2 | 2 2.0|
Renal, Hyperplasia, Histiocytic | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Ectasia | 3 2 2 2 2 2 3 | 11 2.3|
Hemorrhage | 2 | 4 1.8|
Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 2 2 2 2 | 28 2.3|
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
Hemorrhage | 1 2 1 2 | 10 1.9|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 2 3 3 2 2 2 1 3 2 2 2 2 2 2 3 2 3 2 1 3 1| 45 1.9|
Pigmentation | 1 2 2 1 2 1 1 3 1 1 2 2 2 1 2 1 1 1 1 1 1| 41 1.4|
Lymphoid Follicle, Atrophy | 2 | 4 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + + M + + +| 46 |
Atrophy | 4 4 4 3 4 4 3 3 4 4 3 4 3 2 4 2 4 2 2 4 4 4| 45 3.4|
Hemorrhage | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Hyperplasia | 2 2 1 2 1 2 2 | 11 1.6|
Inflammation, Granulomatous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 137
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 2 | 8 1.8|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 3 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 2 2 1 1 | 24 1.2|
Inflammation, Granulomatous | 3 3 3 | 4 3.0|
Inflammation | 3 1 1 | 6 2.2|
Keratin Cyst | 3 3 4 3 3 3 3 | 9 3.3|
Metaplasia, Squamous | 3 1 2 2 2 | 8 1.9|
Alveolar Epithelium, Hyperplasia | 1 1 | 5 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 2 1 1 | 15 1.2|
Serosa, Fibrosis | 1| 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 3 2 1 2 2 | 11 1.7|
Olfactory Epithelium, Metaplasia | 2 3 2 3 | 5 2.4|
Respiratory Epithelium, Hyperplasia | 2 3 2 3 3 3 2 | 10 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 138
NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 04/29/04
Route: GAVAGE Time: 14:29:22
__________________________________________________________________________________________________________________________________
| 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| |
DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| |
| 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
4000 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
500UG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Retina, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 1 | 12 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 | 1 1.0|
Cyst | | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0|
Nephropathy | 3 2 1 3 3 2 3 3 2 2 2 2 2 3 2 1 1 1| 34 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 139
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