TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 FINAL #1 RATS Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 86 98 86 98 86 Early Deaths Moribund Sacrifice 21 20 21 23 43 44 Natural Death 5 14 8 13 10 22 Dosing Accident 2 Survivors Terminal Sacrifice 27 17 24 15 Animals Examined Microscopically 53 51 53 53 53 66 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (53) (51) (53) (53) (53) (66) Degeneration 1 [3.0] Muscularis, Inflammation 3 [2.0] 2 [2.0] 3 [1.3] 3 [1.7] 2 [2.5] Intestine Large, Colon (53) (51) (53) (53) (52) (65) Parasite Metazoan 2 1 2 Artery, Inflammation, Chronic Active 1 [2.0] 1 [3.0] Intestine Large, Rectum (52) (51) (53) (53) (52) (66) Hyperplasia, Cystic 1 [2.0] Parasite Metazoan 3 2 2 2 1 Artery, Inflammation, Chronic Active 1 [3.0] 1 [3.0] 3 [3.0] 1 [3.0] Intestine Large, Cecum (53) (51) (53) (53) (52) (65) Edema 2 [2.0] Inflammation 2 [2.0] Artery, Inflammation, Chronic Active 2 [3.0] Intestine Small, Duodenum (53) (51) (53) (53) (53) (65) Dilatation 1 [3.0] Erosion 1 [2.0] Hyperplasia 1 [3.0] Artery, Inflammation, Chronic Active 1 [2.0] Intestine Small, Ileum (53) (51) (53) (53) (52) (65) Parasite Metazoan 1 Liver (53) (51) (53) (53) (53) (65) Angiectasis 1 [2.0] 2 [1.0] 1 [2.0] 3 [2.0] 2 [2.5] Basophilic Focus 14 8 6 5 4 Basophilic Focus, Multiple 13 8 4 3 Cholangiofibrosis 1 [3.0] 2 [1.0] 3 [1.0] 21 [2.2] 42 [3.4] 29 [3.2] Clear Cell Focus 4 1 Clear Cell Focus, Multiple 1 1 Degeneration, Cystic 1 [1.0] 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Eosinophilic Focus 5 5 11 1 2 Eosinophilic Focus, Multiple 5 16 12 14 4 10 Fatty Change, Diffuse 3 [1.3] 14 [1.0] 27 [1.2] 45 [1.5] 49 [1.7] 56 [1.8] Fatty Change, Focal 10 [1.3] 10 [1.4] 6 [1.7] 1 [2.0] 10 [2.6] 6 [2.2] Hematopoietic Cell Proliferation 27 [1.1] 27 [1.0] 30 [1.0] 32 [1.0] 22 [1.1] 11 [1.0] Hepatodiaphragmatic Nodule 2 2 2 Hyperplasia, Nodular 10 45 50 61 Inflammation 49 [1.0] 47 [1.2] 50 [1.1] 52 [1.4] 51 [1.2] 64 [1.4] Metaplasia 4 [1.0] 4 [2.0] Mineralization 1 [2.0] Mixed Cell Focus 5 5 4 1 3 Mixed Cell Focus, Multiple 33 23 28 16 1 Necrosis 3 [1.3] 13 [2.2] 6 [2.0] 26 [2.0] 17 [2.4] 27 [2.2] Pigmentation 5 [1.0] 18 [1.4] 38 [1.6] 52 [2.1] 53 [2.0] 60 [2.0] Thrombosis 1 [2.0] Toxic Hepatopathy 8 [1.1] 32 [1.2] 51 [2.6] 52 [3.5] 64 [3.6] Artery, Inflammation 1 [1.0] 1 [3.0] Bile Duct, Cyst 4 [2.3] 3 [3.0] 3 [2.3] 14 [2.1] 25 [2.2] 14 [1.9] Bile Duct, Dilatation 1 [2.0] Bile Duct, Fibrosis 6 [1.7] 2 [1.0] 3 [1.3] 10 [1.7] 3 [2.0] 4 [1.5] Bile Duct, Hyperplasia 5 [1.0] 5 [1.2] 7 [1.9] 46 [1.8] 52 [1.9] 60 [2.4] Centrilobular, Degeneration 2 [2.5] 3 [2.0] 8 [1.9] 8 [2.0] 3 [2.3] 8 [1.9] Centrilobular, Fibrosis 7 [1.0] 36 [1.6] 52 [1.9] 57 [2.1] Hepatocyte, Glandular Structures 1 [1.0] 5 [1.2] 25 [2.2] Hepatocyte, Hypertrophy 16 [1.1] 22 [1.4] 47 [2.6] 52 [3.2] 65 [3.5] Hepatocyte, Multinucleated 9 [1.3] 21 [1.2] 48 [1.8] 52 [1.9] 48 [1.7] Oval Cell, Hyperplasia 4 [1.0] 4 [1.0] 23 [1.2] 49 [2.1] 52 [3.0] 62 [3.0] Portal, Fibrosis 2 [1.0] 37 [1.8] 52 [2.7] 58 [2.9] Serosa, Inflammation 2 [2.5] Mesentery (53) (35) (45) (49) (52) (63) Inflammation 1 [3.0] Necrosis 1 [3.0] 1 [3.0] Artery, Inflammation, Chronic Active 1 [3.0] 1 [4.0] 9 [2.7] 9 [2.1] 3 [1.7] Fat, Necrosis 1 [3.0] 3 [2.3] 3 [2.7] Oral Mucosa (53) (51) (53) (53) (53) (66) Cyst 1 [2.0] Gingival, Hyperplasia, Squamous 11 [1.1] 10 [1.2] 20 [1.4] 24 [1.8] 27 [1.7] 18 [1.6] Pancreas (53) (51) (53) (53) (53) (65) Edema 1 [2.0] 4 [1.8] 19 [1.8] Hemorrhage 2 [2.5] Inflammation, Chronic Active 1 [1.0] 5 [1.8] 4 [1.5] 3 [1.3] 2 [1.5] 6 [1.8] Lipomatosis 1 [2.0] 1 [2.0] Acinus, Atrophy 1 [1.0] 5 [1.8] 3 [1.3] 5 [1.8] 9 [1.2] 8 [1.8] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Acinus, Hyperplasia 2 [1.5] Acinus, Hyperplasia, Focal 1 [2.0] Acinus, Vacuolization Cytoplasmic 1 [1.0] 8 [1.0] 39 [1.6] 49 [1.9] 43 [1.6] Artery, Inflammation, Chronic Active 2 [3.0] 2 [2.0] 21 [2.3] 14 [2.6] 4 [2.3] Duct, Dilatation 1 [2.0] 3 [3.0] Salivary Glands (53) (51) (53) (52) (52) (66) Atrophy 1 [2.0] Stomach, Forestomach (53) (51) (53) (53) (53) (65) Edema 2 [2.5] 1 [2.0] Erosion 1 [2.0] 1 [2.0] Hemorrhage 1 [2.0] Hyperplasia, Squamous 4 [1.5] 1 [2.0] 3 [2.3] 11 [2.0] 4 [1.8] 9 [1.9] Inflammation 2 [3.0] 2 [2.5] 4 [1.8] 1 [1.0] Mineralization 1 [1.0] 2 [1.0] Ulcer 2 [2.0] 1 [3.0] 1 [2.0] 1 [1.0] Artery, Inflammation, Chronic Active 2 [2.5] Stomach, Glandular (53) (51) (53) (53) (53) (65) Cyst 1 [2.0] Erosion 1 [2.0] 1 [2.0] 2 [2.0] Hemorrhage 1 [2.0] 3 [1.7] Inflammation 1 [1.0] Mineralization 12 [1.3] 6 [1.3] 6 [1.5] 1 [2.0] 6 [1.2] 5 [1.6] Glands, Cyst 1 [3.0] Tongue (1) Cyst 1 [2.0] Tooth (29) (26) (33) (34) (29) (25) Peridontal Tissue, Inflammation 29 [1.6] 26 [1.2] 33 [1.2] 34 [1.8] 29 [1.3] 25 [1.4] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (53) (51) (52) (53) (53) (66) Mineralization 1 [1.0] Aorta, Adventitia, Hemorrhage 1 [2.0] 1 [2.0] Aorta, Adventitia, Inflammation 1 [3.0] 2 [2.0] Heart (53) (51) (53) (53) (53) (65) Cardiomyopathy 20 [1.2] 13 [1.1] 17 [1.0] 34 [1.1] 14 [1.0] 19 [1.3] Atrium, Thrombosis 1 [3.0] Coronary Artery, Inflammation, Chronic Active 1 [1.0] 1 [2.0] 7 [2.0] 10 [2.7] 9 [2.4] Coronary Artery, Thrombosis 1 [2.0] Endocardium, Hyperplasia 1 [3.0] Epicardium, Hemorrhage 1 [2.0] Epicardium, Inflammation 1 [1.0] 1 [2.0] 6 [1.2] 13 [1.5] 6 [1.5] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - CONT Myocardium, Hemorrhage 3 [2.0] Myocardium, Inflammation 1 [2.0] Myocardium, Necrosis 2 [2.5] Pericardium, Inflammation, Chronic Active 1 [4.0] Valve, Fibrosis 1 [2.0] Valve, Hyperplasia 1 [4.0] Ventricle, Thrombosis 1 [3.0] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (53) (51) (53) (53) (53) (65) Angiectasis 42 [1.6] 35 [1.4] 39 [1.6] 25 [1.3] 4 [1.0] 6 [1.0] Atrophy 2 [3.0] 1 [4.0] 15 [2.4] 44 [2.4] 40 [2.4] Degeneration, Cystic 12 [2.2] 12 [2.3] 13 [1.8] 11 [2.1] 6 [2.2] 2 [1.5] Hematopoietic Cell Proliferation 1 [1.0] Hyperplasia 13 [2.0] 7 [2.1] 13 [2.1] 12 [2.1] 10 [2.2] 5 [2.0] Hypertrophy 45 [2.0] 40 [2.1] 47 [2.1] 44 [2.3] 45 [2.0] 27 [1.6] Inflammation 1 [3.0] Necrosis 1 [4.0] 2 [2.0] 4 [2.3] 1 [2.0] 4 [2.0] Vacuolization Cytoplasmic 14 [1.6] 16 [1.6] 13 [1.5] 24 [1.7] 27 [1.7] 12 [1.5] Adrenal Medulla (53) (51) (53) (53) (53) (64) Hyperplasia 13 [1.8] 4 [2.5] 9 [2.3] 12 [2.1] 2 [2.0] Islets, Pancreatic (53) (51) (53) (53) (53) (65) Hyperplasia 1 [2.0] Pituitary Gland (53) (51) (52) (53) (53) (65) Angiectasis 23 [2.2] 13 [2.2] 19 [2.3] 7 [2.4] Cyst 1 [2.0] Cytoplasmic Alteration 1 [1.0] 1 [1.0] Necrosis 1 [2.0] Vacuolization Cytoplasmic 2 [2.0] 1 [1.0] 5 [1.0] Pars Distalis, Hyperplasia 11 [2.4] 14 [2.6] 19 [2.1] 18 [2.3] 4 [2.3] 1 [2.0] Thyroid Gland (53) (51) (53) (52) (52) (66) Hemorrhage 1 [3.0] Inflammation 1 [3.0] Artery, Inflammation, Chronic Active 1 [3.0] C-Cell, Hyperplasia 7 [1.4] 11 [2.3] 13 [1.8] 10 [2.0] 15 [1.8] 3 [2.0] Follicle, Cyst 1 [3.0] Follicular Cell, Hyperplasia 2 [2.5] 1 [2.0] Follicular Cell, Hypertrophy 22 [1.2] 35 [1.4] 34 [1.8] 38 [1.8] 44 [1.9] 37 [1.7] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (53) (51) (51) (52) (52) (66) Inflammation 49 [1.9] 44 [1.6] 46 [1.4] 34 [1.2] 21 [1.1] 31 [1.1] Artery, Inflammation, Chronic Active 1 [3.0] Duct, Cyst 40 [2.2] 41 [2.2] 43 [2.1] 45 [2.3] 48 [2.4] 61 [2.4] Ovary (53) (51) (53) (53) (53) (65) Atrophy 46 [3.0] 34 [3.1] 43 [3.0] 42 [3.0] 7 [3.0] 9 [3.0] Cyst 19 [2.2] 12 [2.3] 15 [2.3] 19 [2.3] 8 [1.9] 13 [2.1] Inflammation 3 [3.3] 3 [3.3] Inflammation, Chronic Active 1 [3.0] 3 [4.0] 3 [4.0] Artery, Inflammation 1 [4.0] Periovarian Tissue, Inflammation, Chronic Active 1 [3.0] Oviduct (1) Cyst 1 [3.0] Inflammation 1 [3.0] Uterus (53) (51) (53) (53) (53) (66) Adenomyosis 1 [3.0] 3 [2.7] 1 [2.0] Congestion 1 [1.0] Hemorrhage 2 [3.5] 1 [3.0] Hyperplasia, Cystic 1 [1.0] Inflammation, Chronic Active 2 [1.0] 5 [1.8] 2 [3.0] 5 [3.2] Inflammation, Suppurative 4 [1.5] 3 [2.3] 5 [1.4] 7 [3.0] 2 [2.5] Metaplasia, Squamous 23 [1.7] 24 [2.4] 28 [2.4] 24 [2.5] Thrombosis 1 [2.0] Endometrium, Hyperplasia, Cystic 32 [2.1] 23 [2.0] 25 [2.2] 30 [2.2] 7 [2.4] 8 [2.0] Serosa, Inflammation, Chronic Active 1 [4.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (53) (51) (53) (53) (53) (66) Atrophy 2 [2.5] 12 [2.3] Hyperplasia 37 [2.8] 41 [2.8] 36 [2.8] 48 [2.9] 47 [2.9] 49 [2.6] Lymph Node (28) (16) (16) (25) (20) (45) Hemorrhage 1 [2.0] Deep Cervical, Congestion 1 [2.0] Deep Cervical, Ectasia 1 [1.0] Deep Cervical, Hemorrhage 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 6 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Deep Cervical, Hyperplasia, Histiocytic 1 [2.0] Deep Cervical, Hyperplasia, Plasma Cell 1 [3.0] Lumbar, Ectasia 1 [3.0] 1 [3.0] Lumbar, Hemorrhage 1 [2.0] Lumbar, Hyperplasia, Plasma Cell 1 [3.0] Mediastinal, Congestion 1 [2.0] Mediastinal, Ectasia 7 [1.3] 7 [1.4] 7 [1.3] 7 [1.4] 7 [1.7] 27 [1.6] Mediastinal, Hemorrhage 2 [1.5] 2 [2.0] 4 [1.5] 15 [1.9] 7 [1.9] 25 [1.8] Mediastinal, Hyperplasia, Histiocytic 2 [2.0] 2 [2.0] 2 [2.5] Mediastinal, Hyperplasia, Lymphoid 2 [4.0] Mediastinal, Hyperplasia, Plasma Cell 3 [2.0] 1 [3.0] Mediastinal, Pigmentation 2 [2.0] Pancreatic, Ectasia 1 [2.0] 1 [2.0] Pancreatic, Hemorrhage 1 [2.0] 4 [1.8] Pancreatic, Hyperplasia, Histiocytic 1 [2.0] 4 [2.5] 3 [2.3] Pancreatic, Hyperplasia, Lymphoid 2 [3.0] 1 [2.0] Renal, Ectasia 1 [3.0] 1 [3.0] 1 [2.0] Renal, Hemorrhage 1 [2.0] Renal, Hyperplasia 1 [2.0] Renal, Hyperplasia, Histiocytic 1 [3.0] 2 [3.0] Lymph Node, Mandibular (53) (51) (53) (52) (52) (66) Atrophy 1 [4.0] Ectasia 3 [2.7] 2 [2.0] 3 [2.0] 4 [2.3] 4 [2.0] 1 [2.0] Hemorrhage 1 [2.0] 2 [1.5] 7 [2.0] Hyperplasia, Histiocytic 1 [2.0] Hyperplasia, Lymphoid 1 [3.0] 3 [2.7] 2 [3.5] 1 [2.0] Hyperplasia, Plasma Cell 45 [2.2] 35 [2.1] 34 [2.1] 27 [2.2] 22 [2.2] 20 [2.1] Necrosis 1 [1.0] Necrosis, Lymphoid 1 [1.0] Pigmentation 1 [2.0] Lymph Node, Mesenteric (53) (51) (53) (53) (52) (65) Ectasia 1 [2.0] 1 [3.0] 2 [2.0] 1 [2.0] 2 [2.0] Hemorrhage 2 [1.5] 2 [2.0] 2 [2.0] 4 [1.5] 14 [2.1] Hyperplasia, Histiocytic 2 [2.0] 1 [2.0] 6 [1.8] 5 [2.2] Hyperplasia, Lymphoid 1 [4.0] 1 [3.0] Hyperplasia, Plasma Cell 1 [2.0] Spleen (53) (51) (53) (53) (53) (65) Hematopoietic Cell Proliferation 49 [2.2] 44 [2.3] 49 [2.0] 52 [2.0] 50 [1.9] 43 [1.5] Pigmentation 52 [1.6] 50 [1.3] 52 [1.4] 50 [1.4] 50 [1.3] 59 [1.1] Artery, Inflammation, Chronic Active 1 [3.0] Capsule, Fibrosis 1 [3.0] Lymphoid Follicle, Atrophy 4 [2.5] 5 [2.0] 2 [2.5] 5 [2.2] 3 [2.3] 9 [2.6] Red Pulp, Atrophy 1 [2.0] 2 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 7 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Thymus (53) (51) (51) (51) (51) (59) Atrophy 40 [2.7] 44 [2.5] 44 [3.0] 49 [3.9] 50 [3.8] 57 [3.8] Hemorrhage 2 [3.0] Necrosis 1 [3.0] Artery, Inflammation, Chronic Active 1 [3.0] 1 [3.0] 1 [2.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (53) (51) (53) (53) (53) (66) Cyst 1 [3.0] 2 [2.5] 2 [3.0] 2 [2.0] Hyperplasia 26 [1.5] 17 [1.5] 13 [1.4] 6 [1.8] 6 [1.2] Inflammation 1 [3.0] Inflammation, Granulomatous 3 [2.3] 2 [2.0] 1 [3.0] Skin (53) (51) (53) (53) (53) (66) Cyst Epithelial Inclusion 1 2 1 Hemorrhage 1 [2.0] Inflammation 1 [3.0] 1 [2.0] Ulcer 1 [3.0] Subcutaneous Tissue, Inflammation, Chronic Active 1 [3.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (53) (51) (53) (53) (53) (66) Hemorrhage 1 [1.0] 1 [1.0] 4 [1.3] 5 [2.0] 14 [2.2] Hydrocephalus 1 [2.0] Inflammation 2 [2.0] 1 [3.0] Mineralization 1 [1.0] Necrosis 2 [3.0] 1 [3.0] Artery, Inflammation, Chronic Active 1 [2.0] Cerebrum, Degeneration 1 [2.0] Meninges, Inflammation 1 [3.0] Meninges, Vein, Thrombosis 1 [2.0] ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 8 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (53) (51) (53) (53) (53) (66) Congestion 2 [2.5] Hemorrhage 1 [3.0] 2 [1.0] 4 [1.3] Infiltration Cellular, Histiocyte 40 [1.7] 33 [1.6] 46 [1.7] 48 [1.5] 46 [1.1] 33 [1.0] Inflammation 5 [1.6] 9 [1.4] 7 [1.1] 3 [3.3] 2 [3.0] 2 [1.5] Metaplasia, Squamous 1 [1.0] 2 [1.5] 14 [2.1] 16 [2.3] 7 [2.6] Necrosis 1 [3.0] Alveolar Epithelium, Hyperplasia 18 [1.2] 10 [1.2] 2 [1.0] 1 [1.0] 1 [1.0] 4 [1.3] Alveolar Epithelium, Metaplasia, Bronchiolar 1 [1.0] 14 [1.3] 39 [1.4] 46 [1.6] 35 [1.1] 8 [1.0] Artery, Thrombosis 1 [2.0] Artery, Mediastinum, Inflammation, Chronic Active 1 [3.0] Mediastinum, Inflammation 1 [3.0] Serosa, Fibrosis 3 [1.3] 1 [3.0] 16 [1.6] 8 [1.8] Nose (53) (51) (53) (53) (53) (66) Inflammation 17 [1.2] 15 [1.4] 16 [1.3] 10 [1.7] 22 [1.7] 11 [1.4] Necrosis 1 [4.0] Ulcer 1 [2.0] Glands, Hyperplasia 2 [3.0] Olfactory Epithelium, Degeneration 1 [2.0] Olfactory Epithelium, Metaplasia 2 [2.0] 1 [2.0] 3 [2.3] 8 [2.3] 1 [2.0] Respiratory Epithelium, Hyperplasia 8 [1.6] 11 [1.8] 5 [1.4] 8 [2.0] 16 [2.4] 9 [1.9] Squamous Epithelium, Hyperplasia 1 [1.0] 2 [2.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (53) (51) (53) (53) (53) (66) Cataract 1 [3.0] 3 [3.0] Cornea, Inflammation 1 [2.0] 1 [3.0] 1 [3.0] Iris, Inflammation 1 [2.0] Retina, Atrophy 1 [3.0] 3 [2.7] 1 [2.0] 1 [2.0] Retina, Degeneration 1 [2.0] Harderian Gland (53) (51) (53) (53) (53) (66) Inflammation 24 [1.1] 7 [1.4] 20 [1.0] 13 [1.2] 7 [1.0] 9 [1.1] ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (53) (51) (53) (53) (53) (65) Calculus Micro Observation Only 6 6 6 Cyst 2 [2.5] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 9 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Infarct 2 [3.5] 1 [3.0] Inflammation, Chronic Active 1 [3.0] Inflammation, Suppurative 1 [1.0] 4 [1.8] 3 [2.3] 1 [1.0] Mineralization 46 [1.0] 34 [1.1] 38 [1.1] 44 [1.0] 34 [1.1] 37 [1.1] Necrosis 1 [3.0] Nephropathy 41 [1.1] 37 [1.2] 37 [1.2] 48 [2.0] 50 [2.0] 43 [1.4] Pigmentation 1 [2.0] Artery, Inflammation, Chronic Active 1 [3.0] Pelvis, Dilatation 1 [2.0] Pelvis, Inflammation 4 [2.8] 6 [1.7] 1 [2.0] 6 [2.5] Renal Tubule, Hyperplasia 2 [1.5] Transitional Epithelium, Hyperplasia 4 [2.3] 6 [1.8] 6 [1.5] 16 [2.3] 1 [3.0] Transitional Epithelium, Metaplasia, Squamous 1 [3.0] Ureter (1) Transitional Epithelium, Hyperplasia 1 [2.0] Urinary Bladder (53) (51) (53) (53) (52) (66) Calculus Gross Observation 1 Edema 1 [3.0] Inflammation 8 [1.9] 3 [1.3] 2 [1.5] 4 [2.3] 1 [2.0] Metaplasia, Squamous 1 [3.0] Artery, Inflammation, Chronic Active 1 [3.0] Transitional Epithelium, Hyperplasia 4 [2.3] 2 [1.5] 4 [2.3] 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 10 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 4000 NG/ 500UG ST ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 Early Deaths Moribund Sacrifice 28 Natural Death 12 Survivors Terminal Sacrifice 10 Animals Examined Microscopically 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) Parasite Metazoan 1 Intestine Large, Rectum (50) Parasite Metazoan 1 Artery, Inflammation, Chronic Active 4 [2.3] Intestine Large, Cecum (50) Edema 1 [2.0] Inflammation 1 [2.0] Artery, Inflammation, Chronic Active 1 [2.0] Intestine Small, Ileum (50) Parasite Metazoan 1 Liver (50) Angiectasis 4 [2.3] Basophilic Focus 2 Basophilic Focus, Multiple 3 Cholangiofibrosis 27 [2.0] Clear Cell Focus 1 Degeneration, Cystic 1 [2.0] Eosinophilic Focus 1 Eosinophilic Focus, Multiple 14 Fatty Change, Diffuse 35 [1.4] Fatty Change, Focal 14 [2.1] Hematopoietic Cell Proliferation 22 [1.1] Hemorrhage 1 [2.0] Hepatodiaphragmatic Nodule 1 Hyperplasia, Nodular 34 Inflammation 48 [1.0] Metaplasia 2 [1.5] Mixed Cell Focus 1 Mixed Cell Focus, Multiple 19 a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 11 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 4000 NG/ 500UG ST ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Necrosis 6 [2.0] Pigmentation 50 [1.9] Toxic Hepatopathy 50 [2.6] Bile Duct, Cyst 21 [2.7] Bile Duct, Fibrosis 12 [1.9] Bile Duct, Hyperplasia 37 [1.8] Centrilobular, Degeneration 6 [2.0] Centrilobular, Fibrosis 43 [1.9] Hepatocyte, Glandular Structures 9 [2.3] Hepatocyte, Hypertrophy 36 [2.7] Hepatocyte, Multinucleated 38 [1.6] Oval Cell, Hyperplasia 43 [2.3] Portal, Fibrosis 42 [2.3] Serosa, Fibrosis 1 [1.0] Mesentery (43) Necrosis 1 [3.0] Artery, Inflammation, Chronic Active 7 [2.0] Oral Mucosa (50) Gingival, Hyperplasia, Squamous 18 [1.4] Pancreas (50) Edema 12 [1.7] Hemorrhage 1 [2.0] Inflammation, Chronic Active 5 [1.6] Acinus, Atrophy 8 [2.4] Acinus, Vacuolization Cytoplasmic 41 [1.6] Artery, Inflammation, Chronic Active 10 [1.8] Stomach, Forestomach (50) Edema 1 [2.0] Hyperplasia, Squamous 2 [1.5] Inflammation 2 [2.0] Mineralization 1 [2.0] Ulcer 2 [2.0] Stomach, Glandular (50) Mineralization 1 [1.0] Artery, Inflammation, Chronic Active 1 [3.0] Tooth (23) Peridontal Tissue, Inflammation 23 [1.6] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) Aorta, Adventitia, Hemorrhage 2 [2.5] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 12 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 4000 NG/ 500UG ST ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - CONT Aorta, Adventitia, Inflammation 2 [1.5] Heart (50) Cardiomyopathy 15 [1.1] Atrium, Thrombosis 1 [1.0] Coronary Artery, Inflammation, Chronic Active 6 [2.0] Epicardium, Inflammation 1 [1.0] Myocardium, Hemorrhage 1 [1.0] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) Angiectasis 21 [1.2] Atrophy 12 [2.3] Degeneration, Cystic 9 [2.4] Hyperplasia 10 [2.2] Hypertrophy 29 [2.2] Inflammation 2 [2.0] Necrosis 2 [2.0] Vacuolization Cytoplasmic 16 [1.6] Adrenal Medulla (49) Hyperplasia 8 [2.0] Pituitary Gland (50) Angiectasis 3 [1.3] Cyst 3 [2.3] Cytoplasmic Alteration 2 [2.5] Pars Distalis, Hyperplasia 8 [2.0] Pars Intermedia, Hyperplasia 1 [3.0] Thyroid Gland (49) Infiltration Cellular, Lymphoid 2 [3.0] C-Cell, Hyperplasia 6 [2.2] Follicular Cell, Hypertrophy 29 [1.7] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) Inflammation 30 [1.2] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 13 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 4000 NG/ 500UG ST ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Duct, Cyst 40 [2.1] Ovary (50) Atrophy 15 [2.7] Cyst 7 [2.3] Uterus (50) Congestion 1 [2.0] Hemorrhage 1 [2.0] Inflammation, Chronic Active 1 [2.0] Inflammation, Suppurative 4 [2.3] Metaplasia, Squamous 8 [1.6] Cervix, Stromal Hyperplasia 1 [3.0] Endometrium, Hyperplasia, Cystic 17 [2.4] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) Atrophy 4 [2.0] Hyperplasia 40 [2.6] Lymph Node (22) Lumbar, Hemorrhage 1 [1.0] Lumbar, Hyperplasia, Histiocytic 1 [2.0] Mediastinal, Ectasia 3 [2.0] Mediastinal, Hemorrhage 11 [2.0] Mediastinal, Hyperplasia, Histiocytic 4 [2.3] Mediastinal, Hyperplasia, Lymphoid 1 [4.0] Mediastinal, Hyperplasia, Plasma Cell 1 [2.0] Pancreatic, Hemorrhage 3 [2.0] Pancreatic, Hyperplasia, Histiocytic 3 [2.3] Pancreatic, Hyperplasia, Lymphoid 1 [3.0] Renal, Ectasia 1 [3.0] Renal, Hemorrhage 2 [2.0] Renal, Hyperplasia, Histiocytic 3 [2.0] Lymph Node, Mandibular (49) Ectasia 11 [2.3] Hemorrhage 4 [1.8] Hyperplasia, Plasma Cell 28 [2.3] Inflammation 1 [2.0] Lymph Node, Mesenteric (50) Ectasia 1 [2.0] Hemorrhage 10 [1.9] Hyperplasia, Histiocytic 1 [3.0] Hyperplasia, Plasma Cell 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 14 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 4000 NG/ 500UG ST ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Spleen (50) Hematopoietic Cell Proliferation 45 [1.9] Pigmentation 41 [1.4] Lymphoid Follicle, Atrophy 4 [2.5] Thymus (46) Atrophy 45 [3.4] Hemorrhage 1 [3.0] Artery, Inflammation, Chronic Active 1 [4.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) Cyst 1 [3.0] Hyperplasia 11 [1.6] Inflammation, Granulomatous 1 [2.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) Tarsal, Inflammation 1 [3.0] ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) Hemorrhage 8 [1.8] Mineralization 1 [1.0] ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) Hemorrhage 3 [1.3] Infiltration Cellular, Histiocyte 24 [1.2] Inflammation 6 [2.2] Inflammation, Granulomatous 4 [3.0] Keratin Cyst 9 [3.3] Metaplasia, Squamous 8 [1.9] Alveolar Epithelium, Hyperplasia 5 [1.0] Alveolar Epithelium, Metaplasia, Bronchiolar 15 [1.2] Serosa, Fibrosis 1 [1.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 15 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 4000 NG/ 500UG ST ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Nose (50) Inflammation 11 [1.7] Olfactory Epithelium, Metaplasia 5 [2.4] Respiratory Epithelium, Hyperplasia 10 [2.5] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) Retina, Atrophy 1 [2.0] Harderian Gland (50) Inflammation 12 [1.0] ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) Accumulation, Hyaline Droplet 1 [1.0] Cyst 1 [2.0] Mineralization 32 [1.0] Nephropathy 34 [2.0] Urinary Bladder (50) Inflammation 1 [1.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 16 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------