TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
FINAL #1 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFPCBMIX
Lock Date: 11/04/02
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 86 98 86
Early Deaths
Moribund Sacrifice 21 20 21 23 43 44
Natural Death 5 14 8 13 10 22
Dosing Accident 2
Survivors
Terminal Sacrifice 27 17 24 15
Animals Examined Microscopically 53 51 53 53 53 66
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (53) (51) (53) (53) (53) (66)
Degeneration 1 [3.0]
Muscularis, Inflammation 3 [2.0] 2 [2.0] 3 [1.3] 3 [1.7] 2 [2.5]
Intestine Large, Colon (53) (51) (53) (53) (52) (65)
Parasite Metazoan 2 1 2
Artery, Inflammation, Chronic Active 1 [2.0] 1 [3.0]
Intestine Large, Rectum (52) (51) (53) (53) (52) (66)
Hyperplasia, Cystic 1 [2.0]
Parasite Metazoan 3 2 2 2 1
Artery, Inflammation, Chronic Active 1 [3.0] 1 [3.0] 3 [3.0] 1 [3.0]
Intestine Large, Cecum (53) (51) (53) (53) (52) (65)
Edema 2 [2.0]
Inflammation 2 [2.0]
Artery, Inflammation, Chronic Active 2 [3.0]
Intestine Small, Duodenum (53) (51) (53) (53) (53) (65)
Dilatation 1 [3.0]
Erosion 1 [2.0]
Hyperplasia 1 [3.0]
Artery, Inflammation, Chronic Active 1 [2.0]
Intestine Small, Ileum (53) (51) (53) (53) (52) (65)
Parasite Metazoan 1
Liver (53) (51) (53) (53) (53) (65)
Angiectasis 1 [2.0] 2 [1.0] 1 [2.0] 3 [2.0] 2 [2.5]
Basophilic Focus 14 8 6 5 4
Basophilic Focus, Multiple 13 8 4 3
Cholangiofibrosis 1 [3.0] 2 [1.0] 3 [1.0] 21 [2.2] 42 [3.4] 29 [3.2]
Clear Cell Focus 4 1
Clear Cell Focus, Multiple 1 1
Degeneration, Cystic 1 [1.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Eosinophilic Focus 5 5 11 1 2
Eosinophilic Focus, Multiple 5 16 12 14 4 10
Fatty Change, Diffuse 3 [1.3] 14 [1.0] 27 [1.2] 45 [1.5] 49 [1.7] 56 [1.8]
Fatty Change, Focal 10 [1.3] 10 [1.4] 6 [1.7] 1 [2.0] 10 [2.6] 6 [2.2]
Hematopoietic Cell Proliferation 27 [1.1] 27 [1.0] 30 [1.0] 32 [1.0] 22 [1.1] 11 [1.0]
Hepatodiaphragmatic Nodule 2 2 2
Hyperplasia, Nodular 10 45 50 61
Inflammation 49 [1.0] 47 [1.2] 50 [1.1] 52 [1.4] 51 [1.2] 64 [1.4]
Metaplasia 4 [1.0] 4 [2.0]
Mineralization 1 [2.0]
Mixed Cell Focus 5 5 4 1 3
Mixed Cell Focus, Multiple 33 23 28 16 1
Necrosis 3 [1.3] 13 [2.2] 6 [2.0] 26 [2.0] 17 [2.4] 27 [2.2]
Pigmentation 5 [1.0] 18 [1.4] 38 [1.6] 52 [2.1] 53 [2.0] 60 [2.0]
Thrombosis 1 [2.0]
Toxic Hepatopathy 8 [1.1] 32 [1.2] 51 [2.6] 52 [3.5] 64 [3.6]
Artery, Inflammation 1 [1.0] 1 [3.0]
Bile Duct, Cyst 4 [2.3] 3 [3.0] 3 [2.3] 14 [2.1] 25 [2.2] 14 [1.9]
Bile Duct, Dilatation 1 [2.0]
Bile Duct, Fibrosis 6 [1.7] 2 [1.0] 3 [1.3] 10 [1.7] 3 [2.0] 4 [1.5]
Bile Duct, Hyperplasia 5 [1.0] 5 [1.2] 7 [1.9] 46 [1.8] 52 [1.9] 60 [2.4]
Centrilobular, Degeneration 2 [2.5] 3 [2.0] 8 [1.9] 8 [2.0] 3 [2.3] 8 [1.9]
Centrilobular, Fibrosis 7 [1.0] 36 [1.6] 52 [1.9] 57 [2.1]
Hepatocyte, Glandular Structures 1 [1.0] 5 [1.2] 25 [2.2]
Hepatocyte, Hypertrophy 16 [1.1] 22 [1.4] 47 [2.6] 52 [3.2] 65 [3.5]
Hepatocyte, Multinucleated 9 [1.3] 21 [1.2] 48 [1.8] 52 [1.9] 48 [1.7]
Oval Cell, Hyperplasia 4 [1.0] 4 [1.0] 23 [1.2] 49 [2.1] 52 [3.0] 62 [3.0]
Portal, Fibrosis 2 [1.0] 37 [1.8] 52 [2.7] 58 [2.9]
Serosa, Inflammation 2 [2.5]
Mesentery (53) (35) (45) (49) (52) (63)
Inflammation 1 [3.0]
Necrosis 1 [3.0] 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0] 1 [4.0] 9 [2.7] 9 [2.1] 3 [1.7]
Fat, Necrosis 1 [3.0] 3 [2.3] 3 [2.7]
Oral Mucosa (53) (51) (53) (53) (53) (66)
Cyst 1 [2.0]
Gingival, Hyperplasia, Squamous 11 [1.1] 10 [1.2] 20 [1.4] 24 [1.8] 27 [1.7] 18 [1.6]
Pancreas (53) (51) (53) (53) (53) (65)
Edema 1 [2.0] 4 [1.8] 19 [1.8]
Hemorrhage 2 [2.5]
Inflammation, Chronic Active 1 [1.0] 5 [1.8] 4 [1.5] 3 [1.3] 2 [1.5] 6 [1.8]
Lipomatosis 1 [2.0] 1 [2.0]
Acinus, Atrophy 1 [1.0] 5 [1.8] 3 [1.3] 5 [1.8] 9 [1.2] 8 [1.8]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Hyperplasia 2 [1.5]
Acinus, Hyperplasia, Focal 1 [2.0]
Acinus, Vacuolization Cytoplasmic 1 [1.0] 8 [1.0] 39 [1.6] 49 [1.9] 43 [1.6]
Artery, Inflammation, Chronic Active 2 [3.0] 2 [2.0] 21 [2.3] 14 [2.6] 4 [2.3]
Duct, Dilatation 1 [2.0] 3 [3.0]
Salivary Glands (53) (51) (53) (52) (52) (66)
Atrophy 1 [2.0]
Stomach, Forestomach (53) (51) (53) (53) (53) (65)
Edema 2 [2.5] 1 [2.0]
Erosion 1 [2.0] 1 [2.0]
Hemorrhage 1 [2.0]
Hyperplasia, Squamous 4 [1.5] 1 [2.0] 3 [2.3] 11 [2.0] 4 [1.8] 9 [1.9]
Inflammation 2 [3.0] 2 [2.5] 4 [1.8] 1 [1.0]
Mineralization 1 [1.0] 2 [1.0]
Ulcer 2 [2.0] 1 [3.0] 1 [2.0] 1 [1.0]
Artery, Inflammation, Chronic Active 2 [2.5]
Stomach, Glandular (53) (51) (53) (53) (53) (65)
Cyst 1 [2.0]
Erosion 1 [2.0] 1 [2.0] 2 [2.0]
Hemorrhage 1 [2.0] 3 [1.7]
Inflammation 1 [1.0]
Mineralization 12 [1.3] 6 [1.3] 6 [1.5] 1 [2.0] 6 [1.2] 5 [1.6]
Glands, Cyst 1 [3.0]
Tongue (1)
Cyst 1 [2.0]
Tooth (29) (26) (33) (34) (29) (25)
Peridontal Tissue, Inflammation 29 [1.6] 26 [1.2] 33 [1.2] 34 [1.8] 29 [1.3] 25 [1.4]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (53) (51) (52) (53) (53) (66)
Mineralization 1 [1.0]
Aorta, Adventitia, Hemorrhage 1 [2.0] 1 [2.0]
Aorta, Adventitia, Inflammation 1 [3.0] 2 [2.0]
Heart (53) (51) (53) (53) (53) (65)
Cardiomyopathy 20 [1.2] 13 [1.1] 17 [1.0] 34 [1.1] 14 [1.0] 19 [1.3]
Atrium, Thrombosis 1 [3.0]
Coronary Artery, Inflammation, Chronic Active 1 [1.0] 1 [2.0] 7 [2.0] 10 [2.7] 9 [2.4]
Coronary Artery, Thrombosis 1 [2.0]
Endocardium, Hyperplasia 1 [3.0]
Epicardium, Hemorrhage 1 [2.0]
Epicardium, Inflammation 1 [1.0] 1 [2.0] 6 [1.2] 13 [1.5] 6 [1.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Myocardium, Hemorrhage 3 [2.0]
Myocardium, Inflammation 1 [2.0]
Myocardium, Necrosis 2 [2.5]
Pericardium, Inflammation, Chronic Active 1 [4.0]
Valve, Fibrosis 1 [2.0]
Valve, Hyperplasia 1 [4.0]
Ventricle, Thrombosis 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (53) (51) (53) (53) (53) (65)
Angiectasis 42 [1.6] 35 [1.4] 39 [1.6] 25 [1.3] 4 [1.0] 6 [1.0]
Atrophy 2 [3.0] 1 [4.0] 15 [2.4] 44 [2.4] 40 [2.4]
Degeneration, Cystic 12 [2.2] 12 [2.3] 13 [1.8] 11 [2.1] 6 [2.2] 2 [1.5]
Hematopoietic Cell Proliferation 1 [1.0]
Hyperplasia 13 [2.0] 7 [2.1] 13 [2.1] 12 [2.1] 10 [2.2] 5 [2.0]
Hypertrophy 45 [2.0] 40 [2.1] 47 [2.1] 44 [2.3] 45 [2.0] 27 [1.6]
Inflammation 1 [3.0]
Necrosis 1 [4.0] 2 [2.0] 4 [2.3] 1 [2.0] 4 [2.0]
Vacuolization Cytoplasmic 14 [1.6] 16 [1.6] 13 [1.5] 24 [1.7] 27 [1.7] 12 [1.5]
Adrenal Medulla (53) (51) (53) (53) (53) (64)
Hyperplasia 13 [1.8] 4 [2.5] 9 [2.3] 12 [2.1] 2 [2.0]
Islets, Pancreatic (53) (51) (53) (53) (53) (65)
Hyperplasia 1 [2.0]
Pituitary Gland (53) (51) (52) (53) (53) (65)
Angiectasis 23 [2.2] 13 [2.2] 19 [2.3] 7 [2.4]
Cyst 1 [2.0]
Cytoplasmic Alteration 1 [1.0] 1 [1.0]
Necrosis 1 [2.0]
Vacuolization Cytoplasmic 2 [2.0] 1 [1.0] 5 [1.0]
Pars Distalis, Hyperplasia 11 [2.4] 14 [2.6] 19 [2.1] 18 [2.3] 4 [2.3] 1 [2.0]
Thyroid Gland (53) (51) (53) (52) (52) (66)
Hemorrhage 1 [3.0]
Inflammation 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0]
C-Cell, Hyperplasia 7 [1.4] 11 [2.3] 13 [1.8] 10 [2.0] 15 [1.8] 3 [2.0]
Follicle, Cyst 1 [3.0]
Follicular Cell, Hyperplasia 2 [2.5] 1 [2.0]
Follicular Cell, Hypertrophy 22 [1.2] 35 [1.4] 34 [1.8] 38 [1.8] 44 [1.9] 37 [1.7]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (53) (51) (51) (52) (52) (66)
Inflammation 49 [1.9] 44 [1.6] 46 [1.4] 34 [1.2] 21 [1.1] 31 [1.1]
Artery, Inflammation, Chronic Active 1 [3.0]
Duct, Cyst 40 [2.2] 41 [2.2] 43 [2.1] 45 [2.3] 48 [2.4] 61 [2.4]
Ovary (53) (51) (53) (53) (53) (65)
Atrophy 46 [3.0] 34 [3.1] 43 [3.0] 42 [3.0] 7 [3.0] 9 [3.0]
Cyst 19 [2.2] 12 [2.3] 15 [2.3] 19 [2.3] 8 [1.9] 13 [2.1]
Inflammation 3 [3.3] 3 [3.3]
Inflammation, Chronic Active 1 [3.0] 3 [4.0] 3 [4.0]
Artery, Inflammation 1 [4.0]
Periovarian Tissue, Inflammation, Chronic
Active 1 [3.0]
Oviduct (1)
Cyst 1 [3.0]
Inflammation 1 [3.0]
Uterus (53) (51) (53) (53) (53) (66)
Adenomyosis 1 [3.0] 3 [2.7] 1 [2.0]
Congestion 1 [1.0]
Hemorrhage 2 [3.5] 1 [3.0]
Hyperplasia, Cystic 1 [1.0]
Inflammation, Chronic Active 2 [1.0] 5 [1.8] 2 [3.0] 5 [3.2]
Inflammation, Suppurative 4 [1.5] 3 [2.3] 5 [1.4] 7 [3.0] 2 [2.5]
Metaplasia, Squamous 23 [1.7] 24 [2.4] 28 [2.4] 24 [2.5]
Thrombosis 1 [2.0]
Endometrium, Hyperplasia, Cystic 32 [2.1] 23 [2.0] 25 [2.2] 30 [2.2] 7 [2.4] 8 [2.0]
Serosa, Inflammation, Chronic Active 1 [4.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (53) (51) (53) (53) (53) (66)
Atrophy 2 [2.5] 12 [2.3]
Hyperplasia 37 [2.8] 41 [2.8] 36 [2.8] 48 [2.9] 47 [2.9] 49 [2.6]
Lymph Node (28) (16) (16) (25) (20) (45)
Hemorrhage 1 [2.0]
Deep Cervical, Congestion 1 [2.0]
Deep Cervical, Ectasia 1 [1.0]
Deep Cervical, Hemorrhage 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Deep Cervical, Hyperplasia, Histiocytic 1 [2.0]
Deep Cervical, Hyperplasia, Plasma Cell 1 [3.0]
Lumbar, Ectasia 1 [3.0] 1 [3.0]
Lumbar, Hemorrhage 1 [2.0]
Lumbar, Hyperplasia, Plasma Cell 1 [3.0]
Mediastinal, Congestion 1 [2.0]
Mediastinal, Ectasia 7 [1.3] 7 [1.4] 7 [1.3] 7 [1.4] 7 [1.7] 27 [1.6]
Mediastinal, Hemorrhage 2 [1.5] 2 [2.0] 4 [1.5] 15 [1.9] 7 [1.9] 25 [1.8]
Mediastinal, Hyperplasia, Histiocytic 2 [2.0] 2 [2.0] 2 [2.5]
Mediastinal, Hyperplasia, Lymphoid 2 [4.0]
Mediastinal, Hyperplasia, Plasma Cell 3 [2.0] 1 [3.0]
Mediastinal, Pigmentation 2 [2.0]
Pancreatic, Ectasia 1 [2.0] 1 [2.0]
Pancreatic, Hemorrhage 1 [2.0] 4 [1.8]
Pancreatic, Hyperplasia, Histiocytic 1 [2.0] 4 [2.5] 3 [2.3]
Pancreatic, Hyperplasia, Lymphoid 2 [3.0] 1 [2.0]
Renal, Ectasia 1 [3.0] 1 [3.0] 1 [2.0]
Renal, Hemorrhage 1 [2.0]
Renal, Hyperplasia 1 [2.0]
Renal, Hyperplasia, Histiocytic 1 [3.0] 2 [3.0]
Lymph Node, Mandibular (53) (51) (53) (52) (52) (66)
Atrophy 1 [4.0]
Ectasia 3 [2.7] 2 [2.0] 3 [2.0] 4 [2.3] 4 [2.0] 1 [2.0]
Hemorrhage 1 [2.0] 2 [1.5] 7 [2.0]
Hyperplasia, Histiocytic 1 [2.0]
Hyperplasia, Lymphoid 1 [3.0] 3 [2.7] 2 [3.5] 1 [2.0]
Hyperplasia, Plasma Cell 45 [2.2] 35 [2.1] 34 [2.1] 27 [2.2] 22 [2.2] 20 [2.1]
Necrosis 1 [1.0]
Necrosis, Lymphoid 1 [1.0]
Pigmentation 1 [2.0]
Lymph Node, Mesenteric (53) (51) (53) (53) (52) (65)
Ectasia 1 [2.0] 1 [3.0] 2 [2.0] 1 [2.0] 2 [2.0]
Hemorrhage 2 [1.5] 2 [2.0] 2 [2.0] 4 [1.5] 14 [2.1]
Hyperplasia, Histiocytic 2 [2.0] 1 [2.0] 6 [1.8] 5 [2.2]
Hyperplasia, Lymphoid 1 [4.0] 1 [3.0]
Hyperplasia, Plasma Cell 1 [2.0]
Spleen (53) (51) (53) (53) (53) (65)
Hematopoietic Cell Proliferation 49 [2.2] 44 [2.3] 49 [2.0] 52 [2.0] 50 [1.9] 43 [1.5]
Pigmentation 52 [1.6] 50 [1.3] 52 [1.4] 50 [1.4] 50 [1.3] 59 [1.1]
Artery, Inflammation, Chronic Active 1 [3.0]
Capsule, Fibrosis 1 [3.0]
Lymphoid Follicle, Atrophy 4 [2.5] 5 [2.0] 2 [2.5] 5 [2.2] 3 [2.3] 9 [2.6]
Red Pulp, Atrophy 1 [2.0] 2 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (53) (51) (51) (51) (51) (59)
Atrophy 40 [2.7] 44 [2.5] 44 [3.0] 49 [3.9] 50 [3.8] 57 [3.8]
Hemorrhage 2 [3.0]
Necrosis 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0] 1 [3.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (51) (53) (53) (53) (66)
Cyst 1 [3.0] 2 [2.5] 2 [3.0] 2 [2.0]
Hyperplasia 26 [1.5] 17 [1.5] 13 [1.4] 6 [1.8] 6 [1.2]
Inflammation 1 [3.0]
Inflammation, Granulomatous 3 [2.3] 2 [2.0] 1 [3.0]
Skin (53) (51) (53) (53) (53) (66)
Cyst Epithelial Inclusion 1 2 1
Hemorrhage 1 [2.0]
Inflammation 1 [3.0] 1 [2.0]
Ulcer 1 [3.0]
Subcutaneous Tissue, Inflammation, Chronic
Active 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (53) (51) (53) (53) (53) (66)
Hemorrhage 1 [1.0] 1 [1.0] 4 [1.3] 5 [2.0] 14 [2.2]
Hydrocephalus 1 [2.0]
Inflammation 2 [2.0] 1 [3.0]
Mineralization 1 [1.0]
Necrosis 2 [3.0] 1 [3.0]
Artery, Inflammation, Chronic Active 1 [2.0]
Cerebrum, Degeneration 1 [2.0]
Meninges, Inflammation 1 [3.0]
Meninges, Vein, Thrombosis 1 [2.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (53) (51) (53) (53) (53) (66)
Congestion 2 [2.5]
Hemorrhage 1 [3.0] 2 [1.0] 4 [1.3]
Infiltration Cellular, Histiocyte 40 [1.7] 33 [1.6] 46 [1.7] 48 [1.5] 46 [1.1] 33 [1.0]
Inflammation 5 [1.6] 9 [1.4] 7 [1.1] 3 [3.3] 2 [3.0] 2 [1.5]
Metaplasia, Squamous 1 [1.0] 2 [1.5] 14 [2.1] 16 [2.3] 7 [2.6]
Necrosis 1 [3.0]
Alveolar Epithelium, Hyperplasia 18 [1.2] 10 [1.2] 2 [1.0] 1 [1.0] 1 [1.0] 4 [1.3]
Alveolar Epithelium, Metaplasia, Bronchiolar 1 [1.0] 14 [1.3] 39 [1.4] 46 [1.6] 35 [1.1] 8 [1.0]
Artery, Thrombosis 1 [2.0]
Artery, Mediastinum, Inflammation, Chronic
Active 1 [3.0]
Mediastinum, Inflammation 1 [3.0]
Serosa, Fibrosis 3 [1.3] 1 [3.0] 16 [1.6] 8 [1.8]
Nose (53) (51) (53) (53) (53) (66)
Inflammation 17 [1.2] 15 [1.4] 16 [1.3] 10 [1.7] 22 [1.7] 11 [1.4]
Necrosis 1 [4.0]
Ulcer 1 [2.0]
Glands, Hyperplasia 2 [3.0]
Olfactory Epithelium, Degeneration 1 [2.0]
Olfactory Epithelium, Metaplasia 2 [2.0] 1 [2.0] 3 [2.3] 8 [2.3] 1 [2.0]
Respiratory Epithelium, Hyperplasia 8 [1.6] 11 [1.8] 5 [1.4] 8 [2.0] 16 [2.4] 9 [1.9]
Squamous Epithelium, Hyperplasia 1 [1.0] 2 [2.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (53) (51) (53) (53) (53) (66)
Cataract 1 [3.0] 3 [3.0]
Cornea, Inflammation 1 [2.0] 1 [3.0] 1 [3.0]
Iris, Inflammation 1 [2.0]
Retina, Atrophy 1 [3.0] 3 [2.7] 1 [2.0] 1 [2.0]
Retina, Degeneration 1 [2.0]
Harderian Gland (53) (51) (53) (53) (53) (66)
Inflammation 24 [1.1] 7 [1.4] 20 [1.0] 13 [1.2] 7 [1.0] 9 [1.1]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (51) (53) (53) (53) (65)
Calculus Micro Observation Only 6 6 6
Cyst 2 [2.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/
0 UG 10 UG 30 UG 100 UG 300 UG 500 UG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Infarct 2 [3.5] 1 [3.0]
Inflammation, Chronic Active 1 [3.0]
Inflammation, Suppurative 1 [1.0] 4 [1.8] 3 [2.3] 1 [1.0]
Mineralization 46 [1.0] 34 [1.1] 38 [1.1] 44 [1.0] 34 [1.1] 37 [1.1]
Necrosis 1 [3.0]
Nephropathy 41 [1.1] 37 [1.2] 37 [1.2] 48 [2.0] 50 [2.0] 43 [1.4]
Pigmentation 1 [2.0]
Artery, Inflammation, Chronic Active 1 [3.0]
Pelvis, Dilatation 1 [2.0]
Pelvis, Inflammation 4 [2.8] 6 [1.7] 1 [2.0] 6 [2.5]
Renal Tubule, Hyperplasia 2 [1.5]
Transitional Epithelium, Hyperplasia 4 [2.3] 6 [1.8] 6 [1.5] 16 [2.3] 1 [3.0]
Transitional Epithelium, Metaplasia, Squamous 1 [3.0]
Ureter (1)
Transitional Epithelium, Hyperplasia 1 [2.0]
Urinary Bladder (53) (51) (53) (53) (52) (66)
Calculus Gross Observation 1
Edema 1 [3.0]
Inflammation 8 [1.9] 3 [1.3] 2 [1.5] 4 [2.3] 1 [2.0]
Metaplasia, Squamous 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0]
Transitional Epithelium, Hyperplasia 4 [2.3] 2 [1.5] 4 [2.3] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 4000 NG/
500UG ST
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50
Early Deaths
Moribund Sacrifice 28
Natural Death 12
Survivors
Terminal Sacrifice 10
Animals Examined Microscopically 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50)
Parasite Metazoan 1
Intestine Large, Rectum (50)
Parasite Metazoan 1
Artery, Inflammation, Chronic Active 4 [2.3]
Intestine Large, Cecum (50)
Edema 1 [2.0]
Inflammation 1 [2.0]
Artery, Inflammation, Chronic Active 1 [2.0]
Intestine Small, Ileum (50)
Parasite Metazoan 1
Liver (50)
Angiectasis 4 [2.3]
Basophilic Focus 2
Basophilic Focus, Multiple 3
Cholangiofibrosis 27 [2.0]
Clear Cell Focus 1
Degeneration, Cystic 1 [2.0]
Eosinophilic Focus 1
Eosinophilic Focus, Multiple 14
Fatty Change, Diffuse 35 [1.4]
Fatty Change, Focal 14 [2.1]
Hematopoietic Cell Proliferation 22 [1.1]
Hemorrhage 1 [2.0]
Hepatodiaphragmatic Nodule 1
Hyperplasia, Nodular 34
Inflammation 48 [1.0]
Metaplasia 2 [1.5]
Mixed Cell Focus 1
Mixed Cell Focus, Multiple 19
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 4000 NG/
500UG ST
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 6 [2.0]
Pigmentation 50 [1.9]
Toxic Hepatopathy 50 [2.6]
Bile Duct, Cyst 21 [2.7]
Bile Duct, Fibrosis 12 [1.9]
Bile Duct, Hyperplasia 37 [1.8]
Centrilobular, Degeneration 6 [2.0]
Centrilobular, Fibrosis 43 [1.9]
Hepatocyte, Glandular Structures 9 [2.3]
Hepatocyte, Hypertrophy 36 [2.7]
Hepatocyte, Multinucleated 38 [1.6]
Oval Cell, Hyperplasia 43 [2.3]
Portal, Fibrosis 42 [2.3]
Serosa, Fibrosis 1 [1.0]
Mesentery (43)
Necrosis 1 [3.0]
Artery, Inflammation, Chronic Active 7 [2.0]
Oral Mucosa (50)
Gingival, Hyperplasia, Squamous 18 [1.4]
Pancreas (50)
Edema 12 [1.7]
Hemorrhage 1 [2.0]
Inflammation, Chronic Active 5 [1.6]
Acinus, Atrophy 8 [2.4]
Acinus, Vacuolization Cytoplasmic 41 [1.6]
Artery, Inflammation, Chronic Active 10 [1.8]
Stomach, Forestomach (50)
Edema 1 [2.0]
Hyperplasia, Squamous 2 [1.5]
Inflammation 2 [2.0]
Mineralization 1 [2.0]
Ulcer 2 [2.0]
Stomach, Glandular (50)
Mineralization 1 [1.0]
Artery, Inflammation, Chronic Active 1 [3.0]
Tooth (23)
Peridontal Tissue, Inflammation 23 [1.6]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50)
Aorta, Adventitia, Hemorrhage 2 [2.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 4000 NG/
500UG ST
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Aorta, Adventitia, Inflammation 2 [1.5]
Heart (50)
Cardiomyopathy 15 [1.1]
Atrium, Thrombosis 1 [1.0]
Coronary Artery, Inflammation, Chronic Active 6 [2.0]
Epicardium, Inflammation 1 [1.0]
Myocardium, Hemorrhage 1 [1.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50)
Angiectasis 21 [1.2]
Atrophy 12 [2.3]
Degeneration, Cystic 9 [2.4]
Hyperplasia 10 [2.2]
Hypertrophy 29 [2.2]
Inflammation 2 [2.0]
Necrosis 2 [2.0]
Vacuolization Cytoplasmic 16 [1.6]
Adrenal Medulla (49)
Hyperplasia 8 [2.0]
Pituitary Gland (50)
Angiectasis 3 [1.3]
Cyst 3 [2.3]
Cytoplasmic Alteration 2 [2.5]
Pars Distalis, Hyperplasia 8 [2.0]
Pars Intermedia, Hyperplasia 1 [3.0]
Thyroid Gland (49)
Infiltration Cellular, Lymphoid 2 [3.0]
C-Cell, Hyperplasia 6 [2.2]
Follicular Cell, Hypertrophy 29 [1.7]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50)
Inflammation 30 [1.2]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 4000 NG/
500UG ST
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Duct, Cyst 40 [2.1]
Ovary (50)
Atrophy 15 [2.7]
Cyst 7 [2.3]
Uterus (50)
Congestion 1 [2.0]
Hemorrhage 1 [2.0]
Inflammation, Chronic Active 1 [2.0]
Inflammation, Suppurative 4 [2.3]
Metaplasia, Squamous 8 [1.6]
Cervix, Stromal Hyperplasia 1 [3.0]
Endometrium, Hyperplasia, Cystic 17 [2.4]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50)
Atrophy 4 [2.0]
Hyperplasia 40 [2.6]
Lymph Node (22)
Lumbar, Hemorrhage 1 [1.0]
Lumbar, Hyperplasia, Histiocytic 1 [2.0]
Mediastinal, Ectasia 3 [2.0]
Mediastinal, Hemorrhage 11 [2.0]
Mediastinal, Hyperplasia, Histiocytic 4 [2.3]
Mediastinal, Hyperplasia, Lymphoid 1 [4.0]
Mediastinal, Hyperplasia, Plasma Cell 1 [2.0]
Pancreatic, Hemorrhage 3 [2.0]
Pancreatic, Hyperplasia, Histiocytic 3 [2.3]
Pancreatic, Hyperplasia, Lymphoid 1 [3.0]
Renal, Ectasia 1 [3.0]
Renal, Hemorrhage 2 [2.0]
Renal, Hyperplasia, Histiocytic 3 [2.0]
Lymph Node, Mandibular (49)
Ectasia 11 [2.3]
Hemorrhage 4 [1.8]
Hyperplasia, Plasma Cell 28 [2.3]
Inflammation 1 [2.0]
Lymph Node, Mesenteric (50)
Ectasia 1 [2.0]
Hemorrhage 10 [1.9]
Hyperplasia, Histiocytic 1 [3.0]
Hyperplasia, Plasma Cell 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 14
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 4000 NG/
500UG ST
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (50)
Hematopoietic Cell Proliferation 45 [1.9]
Pigmentation 41 [1.4]
Lymphoid Follicle, Atrophy 4 [2.5]
Thymus (46)
Atrophy 45 [3.4]
Hemorrhage 1 [3.0]
Artery, Inflammation, Chronic Active 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50)
Cyst 1 [3.0]
Hyperplasia 11 [1.6]
Inflammation, Granulomatous 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50)
Tarsal, Inflammation 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50)
Hemorrhage 8 [1.8]
Mineralization 1 [1.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50)
Hemorrhage 3 [1.3]
Infiltration Cellular, Histiocyte 24 [1.2]
Inflammation 6 [2.2]
Inflammation, Granulomatous 4 [3.0]
Keratin Cyst 9 [3.3]
Metaplasia, Squamous 8 [1.9]
Alveolar Epithelium, Hyperplasia 5 [1.0]
Alveolar Epithelium, Metaplasia, Bronchiolar 15 [1.2]
Serosa, Fibrosis 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 15
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 17:03:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 4000 NG/
500UG ST
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (50)
Inflammation 11 [1.7]
Olfactory Epithelium, Metaplasia 5 [2.4]
Respiratory Epithelium, Hyperplasia 10 [2.5]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50)
Retina, Atrophy 1 [2.0]
Harderian Gland (50)
Inflammation 12 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50)
Accumulation, Hyaline Droplet 1 [1.0]
Cyst 1 [2.0]
Mineralization 32 [1.0]
Nephropathy 34 [2.0]
Urinary Bladder (50)
Inflammation 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 16
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