TDMS Study 88138-03 Pathology Tables
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
FINAL #1 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 10 9 13
Natural Death 2 2 4 3
Survivors
Terminal Sacrifice 32 38 37 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Inflammation 1 [2.0]
Periesophageal Tissue, Necrosis, Fatty 1 [2.0]
Intestine Large, Colon (50) (50) (50) (50)
Inflammation 1 [2.0]
Metaplasia, Mucous 1 [3.0]
Parasite Metazoan 1 [1.0] 3 [1.0] 2 [1.0] 3 [1.0]
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 8 [1.1] 8 [1.1] 14 [1.2] 6 [1.0]
Ulcer 1 [3.0]
Intestine Large, Cecum (50) (50) (50) (50)
Inflammation 1 [3.0]
Mineralization 1 [1.0]
Intestine Small, Duodenum (50) (50) (50) (50)
Hyperplasia 1 [3.0]
Intestine Small, Jejunum (50) (50) (50) (50)
Inflammation 1 [2.0] 2 [1.0]
Liver (50) (50) (50) (50)
Angiectasis 2 [1.0] 2 [1.0] 5 [1.4] 1 [1.0]
Basophilic Focus 48 48 41 43
Clear Cell Focus 15 13 10 10
Degeneration, Cystic 1 [1.0] 3 [1.7] 4 [1.3]
Eosinophilic Focus 6 6 9
Fatty Change, Diffuse 11 [1.5] 8 [2.1] 9 [2.1] 20 [1.5]
Fibrosis 1 [3.0]
Hematopoietic Cell Proliferation 1 [1.0] 6 [1.2] 4 [1.0] 2 [1.5]
Hepatodiaphragmatic Nodule 5 6 6 6
Inflammation, Chronic Active 46 [1.5] 38 [1.5] 29 [1.3] 30 [1.4]
Mixed Cell Focus 10 11 5 5
Necrosis 12 [1.1] 6 [1.3] 11 [1.7] 12 [1.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Cyst 1
Bile Duct, Hyperplasia 10 [1.3] 35 [1.2] 39 [1.4] 40 [1.6]
Hepatocyte, Centrilobular, Hypertrophy 27 [1.0] 30 [1.3] 33 [2.0]
Oval Cell, Hyperplasia 3 [2.0]
Mesentery (12) (18) (10) (6)
Fat, Necrosis 11 [1.4] 18 [2.0] 10 [1.8] 4 [2.0]
Oral Mucosa (4) (8) (4) (4)
Hyperplasia, Squamous 1 [2.0]
Gingival, Inflammation 4 [1.5] 7 [1.1] 4 [1.0] 4 [1.3]
Pancreas (50) (50) (50) (50)
Basophilic Focus 1 [1.0] 1 [1.0]
Inflammation 12 [1.2] 3 [1.0] 2 [1.0] 6 [1.0]
Acinus, Atrophy 17 [1.2] 10 [1.0] 11 [1.5] 12 [1.5]
Salivary Glands (50) (50) (50) (50)
Atrophy 2 [1.0] 1 [1.0] 1 [2.0]
Basophilic Focus 1 [1.0] 1 [1.0]
Inflammation 1 [2.0]
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 2 [2.0] 2 [2.5] 2 [2.0] 4 [2.3]
Inflammation 4 [1.3] 2 [1.5] 2 [1.5] 3 [2.3]
Ulcer 1 [3.0] 1 [2.0] 2 [3.5]
Stomach, Glandular (50) (50) (50) (50)
Erosion 1 [2.0] 1 [2.0] 1 [2.0]
Inflammation 2 [1.5] 3 [1.7]
Mineralization 2 [1.0] 2 [1.0]
Ulcer 1 [1.0] 1 [3.0]
Epithelium, Atrophy 1 [2.0]
Tooth (3) (3)
Inflammation 3 [2.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Mineralization 1 [1.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 46 [1.3] 46 [1.4] 48 [1.3] 46 [1.4]
Atrium, Thrombosis 1 [1.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Angiectasis 42 [1.4] 36 [1.1] 18 [1.0] 24 [1.0]
Atrophy 1 [1.0] 1 [2.0]
Degeneration, Cystic 3 [1.0] 2 [1.0] 2 [1.0]
Hematopoietic Cell Proliferation 3 [1.0] 1 [1.0] 2 [1.0] 2 [1.0]
Hyperplasia 6 [1.2] 10 [1.1] 6 [2.0] 6 [1.2]
Hypertrophy 7 [1.0] 5 [1.4] 5 [1.0] 8 [1.0]
Karyomegaly 1 [1.0]
Necrosis 5 [1.4] 7 [1.4] 5 [1.4] 2 [2.5]
Vacuolization Cytoplasmic 14 [1.3] 16 [1.4] 15 [1.7] 20 [1.3]
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 [1.0] 2 [2.5]
Necrosis 2 [2.0]
Vacuolization Cytoplasmic 1 [1.0]
Parathyroid Gland (47) (48) (44) (48)
Hyperplasia 1 [1.0] 1 [2.0]
Pituitary Gland (50) (50) (50) (50)
Angiectasis 30 [2.2] 30 [2.3] 23 [2.3] 23 [2.0]
Cyst 2 [1.0] 1 [2.0] 1 [1.0] 2 [2.0]
Hyperplasia 23 [2.2] 24 [2.5] 20 [2.8] 18 [1.9]
Inflammation 1 [1.0]
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 34 [1.8] 11 [1.8] 13 [1.7] 8 [1.9]
Follicle, Cyst 1 [2.0] 1 [1.0] 1 [2.0]
Follicle, Hyperplasia 2 [1.0]
Follicular Cell, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Atrophy 1 [4.0]
Cyst 3 [2.3] 2 [2.5] 1 [3.0]
Hyperplasia 6 [2.2] 1 [2.0] 2 [2.5]
Hyperplasia, Squamous 1 [2.0]
Inflammation 2 [3.0] 2 [2.5] 2 [3.0]
Metaplasia, Squamous 1 [2.0]
Ovary (50) (50) (50) (50)
Cyst 6 13 10 9
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Interstitial Cell, Hyperplasia 1 [2.0]
Uterus (50) (50) (50) (50)
Angiectasis, Focal 1 [2.0]
Inflammation 1 [2.0]
Cervix, Hypertrophy 1 [3.0]
Endometrium, Hyperplasia, Cystic 12 [1.8] 20 [1.9] 20 [2.2] 20 [2.3]
Endometrium, Hyperplasia, Adenomatous 1 [2.0] 1 [3.0] 1 [3.0]
Serosa, Inflammation, Granulomatous 2 [1.0]
Vagina (1) (1)
Inflammation 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Inflammation, Granulomatous 1 [2.0] 1 [2.0] 1 [1.0] 1 [1.0]
Myelofibrosis 2 [1.0] 2 [1.5] 6 [1.5]
Necrosis 1 [2.0] 1 [2.0]
Erythroid Cell, Hyperplasia 8 [1.1] 6 [1.0] 7 [1.9] 2 [1.5]
Myeloid Cell, Hyperplasia 11 [1.7] 13 [2.5] 20 [2.5] 13 [2.6]
Lymph Node (8) (8) (11) (12)
Axillary, Right, Ectasia 1 [3.0]
Axillary, Right, Infiltration Cellular,
Plasma Cell 1 [4.0]
Deep Cervical, Ectasia 1 [1.0]
Deep Cervical, Hemorrhage 1 [2.0]
Deep Cervical, Infiltration Cellular, Plasma
Cell 3 [1.7] 2 [1.5]
Deep Cervical, Infiltration Cellular,
Histiocyte 3 [1.7]
Mediastinal, Hemorrhage 2 [3.0]
Mediastinal, Infiltration Cellular, Plasma
Cell 2 [1.5] 1 [2.0] 4 [2.3] 2 [2.0]
Mediastinal, Infiltration Cellular,
Histiocyte 1 [1.0] 1 [1.0]
Pancreatic, Hemorrhage 2 [2.0]
Pancreatic, Infiltration Cellular, Histiocyte 3 [2.3] 1 [2.0]
Pancreatic, Pigmentation, Hemosiderin 2 [3.0]
Renal, Infiltration Cellular, Histiocyte 1 [3.0] 1 [3.0]
Renal, Pigmentation 1 [2.0]
Lymph Node, Mesenteric (50) (50) (50) (50)
Infiltration Cellular, Plasma Cell 1 [2.0] 1 [2.0] 2 [2.0]
Infiltration Cellular, Histiocyte 50 [1.6] 49 [1.4] 48 [1.5] 49 [1.4]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (49) (50) (50) (50)
Accessory Spleen 1 [1.4] 1 [2.0]
Autolysis 2
Fibrosis 1 [3.0] 1 [1.0]
Hematopoietic Cell Proliferation 47 [1.1] 45 [1.0] 40 [1.2] 45 [1.1]
Hyperplasia, Lymphoid 1 [2.0] 1 [3.0] 2 [2.5]
Infarct 1 [4.0]
Inflammation, Granulomatous 1 [2.0] 1 [4.0]
Pigmentation, Hemosiderin 48 [1.1] 50 [1.0] 49 [1.0] 49 [1.0]
Lymphoid Follicle, Atrophy 5 [1.6]
Red Pulp, Hyperplasia 1 [2.0]
Thymus (50) (49) (46) (50)
Atrophy 49 [3.3] 48 [3.4] 44 [3.4] 49 [3.3]
Cyst 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Atrophy 1 [3.0]
Galactocele 7 3 2 2
Hyperplasia 3 [1.0] 4 [2.0] 1 [3.0] 3 [2.0]
Inflammation 1 [3.0] 1 [1.0] 1 [2.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 1
Sebaceous Gland, Hyperplasia 1 [3.0]
Subcutaneous Tissue, Necrosis 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 [1.0]
Skeletal Muscle (1) (1) (3) (1)
Inflammation 1 [3.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 [1.0]
Hemorrhage 2 [3.0] 1 [1.0] 2 [1.0]
Hydrocephalus 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Inflammation 1 [1.0] 1 [1.0] 1 [1.0]
Mineralization 1 [2.0]
Necrosis 1 [1.0] 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Inflammation, Acute 2 [1.0] 1 [2.0]
Inflammation, Granulomatous 12 [1.1] 5 [1.0] 9 [1.4] 7 [1.4]
Metaplasia, Squamous 1 [1.0]
Alveolar Epithelium, Hyperplasia 18 [1.5] 18 [1.4] 13 [1.2] 15 [1.3]
Alveolus, Infiltration Cellular, Histiocyte 50 [2.0] 50 [2.0] 50 [2.0] 50 [1.9]
Interstitium, Fibrosis 1 [3.0]
Nose (50) (50) (50) (50)
Inflammation 2 [2.5] 1 [1.0] 3 [1.3] 1 [1.0]
Thrombosis 2 [2.0]
Trachea (50) (50) (50) (50)
Inflammation 4 [1.3] 2 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Inflammation 1 [1.0] 1 [3.0] 2 [2.0] 1 [1.0]
Lens, Cataract 1 [3.0] 1 [2.0] 2 [1.5] 2 [3.5]
Optic Nerve, Fibrosis 1 [2.0]
Retina, Degeneration 2 [2.5] 2 [2.5] 4 [3.0] 4 [3.0]
Retina, Dysplasia 1 [2.0]
Harderian Gland (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 14 [1.0] 10 [1.0] 6 [1.0] 9 [1.1]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 2 [2.5] 1 [4.0]
Fibrosis 1 [4.0]
Infarct 1 2 1
Inflammation, Chronic Active 1 [2.0]
Nephropathy 47 [1.1] 49 [1.4] 48 [1.7] 49 [2.0]
Cortex, Inflammation 1 [2.0]
Cortex, Mineralization 2 [1.0] 1 [1.0] 4 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Medulla, Fibrosis 1 [2.0]
Medulla, Mineralization 43 [1.0] 49 [1.1] 49 [1.1] 46 [1.1]
Pelvis, Inflammation 1 [3.0] 4 [1.8] 2 [1.5]
Pelvis, Transitional Epithelium, Hyperplasia 1 [1.0] 2 [1.5] 2 [2.0] 4 [1.0]
Renal Tubule, Cyst 1
Renal Tubule, Hyperplasia 1 [4.0] 1 [3.0] 1 [4.0]
Renal Tubule, Pigmentation 1 [2.0]
Renal Tubule, Vacuolization Cytoplasmic 1 [2.0]
Urinary Bladder (50) (50) (50) (50)
Hyperplasia 1 [3.0] 1 [3.0]
Inflammation 1 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 25 12 16 44
Natural Death 3 11 3 4
Survivors
Terminal Sacrifice 22 27 31 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Erosion 1 [2.0]
Inflammation 1 [2.0]
Parasite Metazoan 1 [1.0] 1 [1.0] 1 [1.0]
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 6 [1.0] 6 [1.2] 8 [1.0] 5 [1.0]
Intestine Large, Cecum (50) (50) (50) (50)
Erosion 1 [2.0] 1 [1.0] 1 [4.0]
Inflammation 4 [3.0]
Mineralization 2 [2.0]
Ulcer 1 [3.0]
Intestine Small, Duodenum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 [3.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [3.0]
Basophilic Focus 24 25 32 19
Clear Cell Focus 19 19 18
Congestion 1 [2.0]
Degeneration, Cystic 8 [1.3] 11 [1.0] 20 [1.3] 15 [1.2]
Eosinophilic Focus 5 14 10 9
Fatty Change, Diffuse 22 [2.3] 20 [1.7] 22 [1.5] 15 [1.7]
Hematopoietic Cell Proliferation 4 [1.3] 1 [2.0] 2 [1.0] 4 [1.0]
Hepatodiaphragmatic Nodule 2 6 1 1
Infarct 1
Inflammation, Chronic Active 22 [1.9] 21 [1.6] 35 [1.9] 33 [1.8]
Inflammation, Granulomatous 1 [4.0] 2 [2.5]
Mineralization 1 [1.0]
Mixed Cell Focus 9 17 22 4
Necrosis 19 [1.5] 19 [1.6] 9 [1.7] 14 [1.7]
Bile Duct, Cyst 1
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 49 [2.1] 46 [2.1] 48 [2.1] 50 [1.5]
Hepatocyte, Multinucleated 1 [1.0] 1 [1.0]
Hepatocyte, Centrilobular, Hypertrophy 17 [1.3] 31 [1.8] 19 [1.5]
Hepatocyte, Centrilobular, Necrosis 1 [1.0]
Vein, Inflammation 1 [2.0]
Mesentery (9) (12) (8) (4)
Inflammation 1 [2.0] 1 [2.0] 1 [1.0]
Fat, Necrosis 7 [2.3] 7 [1.9] 7 [2.0] 3 [2.0]
Oral Mucosa (8) (8) (5) (7)
Gingival, Hyperplasia 1 [4.0]
Gingival, Inflammation 8 [1.0] 6 [1.0] 5 [1.8] 5 [1.2]
Pharyngeal, Inflammation 1 [1.0]
Pancreas (50) (50) (50) (50)
Basophilic Focus 1 [3.0]
Cyst 3 [1.0]
Inflammation 14 [1.5] 16 [1.2] 6 [1.0] 9 [1.0]
Metaplasia, Hepatocyte 1 [1.0]
Acinus, Atrophy 20 [1.3] 21 [1.1] 22 [1.3] 10 [1.2]
Acinus, Hyperplasia 1 [3.0]
Salivary Glands (49) (50) (50) (49)
Atrophy 1 [1.0] 1 [1.0] 3 [1.3]
Inflammation 2 [3.0]
Stomach, Forestomach (50) (49) (49) (50)
Autolysis 1
Hyperplasia, Squamous 7 [2.0] 4 [1.8] 10 [2.4] 17 [2.6]
Inflammation 8 [2.0] 6 [2.0] 8 [3.4] 12 [2.6]
Mineralization 1 [1.0] 1 [2.0] 3 [2.7]
Ulcer 4 [2.5] 1 [1.0] 8 [3.1] 8 [3.0]
Stomach, Glandular (50) (50) (49) (50)
Erosion 5 [1.4] 2 [2.0] 3 [1.7] 3 [2.3]
Hyperplasia 1 [2.0]
Inflammation 5 [2.2] 5 [1.8] 4 [1.8] 7 [1.7]
Mineralization 5 [2.6] 15 [2.7]
Ulcer 1 [3.0] 1 [3.0] 4 [2.3]
Tooth (3) (5) (2) (3)
Inflammation 1 [1.0] 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Inflammation 1 [1.0]
Mineralization 1 [1.0] 1 [4.0] 11 [3.1]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Pulmonary Artery, Pulmonary Vein, Hypertrophy 1 [2.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 48 [1.9] 48 [2.0] 47 [2.1] 49 [1.9]
Mineralization 2 [1.5] 6 [2.3]
Aorta, Tunic, Media, Mineralization 1 [1.0]
Atrium, Thrombosis 3 [3.0] 5 [2.2] 2 [1.5] 1 [1.0]
Endocardium, Hyperplasia 2 [4.0]
Valve, Thrombosis 1 [2.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Angiectasis 4 [1.0] 4 [1.3] 2 [1.5] 1 [1.0]
Atrophy 1 [3.0]
Cytoplasmic Alteration 1 [2.0]
Degeneration, Cystic 1 [1.0]
Hematopoietic Cell Proliferation 5 [1.0] 2 [1.0]
Hyperplasia 1 [1.0] 4 [1.3] 11 [1.2] 4 [1.3]
Hypertrophy 8 [1.4] 2 [1.0] 3 [2.0] 3 [1.0]
Necrosis 1 [4.0] 4 [1.8] 1 [1.0]
Vacuolization Cytoplasmic 27 [1.6] 27 [1.7] 31 [1.4] 27 [1.4]
Adrenal Medulla (50) (49) (50) (50)
Angiectasis 1 [1.0]
Hyperplasia 6 [2.5] 8 [2.1] 11 [2.1] 5 [1.8]
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 [2.0]
Parathyroid Gland (49) (45) (48) (49)
Hyperplasia 2 [1.5] 1 [1.0] 19 [2.0] 32 [2.2]
Pituitary Gland (50) (50) (50) (50)
Angiectasis 4 [2.0] 10 [2.0] 11 [2.2] 3 [1.7]
Cyst 6 [1.0] 3 [1.0] 1 [1.0] 5 [1.0]
Hyperplasia 16 [2.1] 21 [2.3] 12 [1.8] 13 [1.8]
Inflammation 1 [2.0] 1 [1.0]
Pigmentation, Hemosiderin 1 [2.0]
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 [1.0]
Ultimobranchial Cyst 2 [1.5] 1 [1.0]
C-Cell, Hyperplasia 17 [2.0] 8 [2.0] 8 [2.1] 5 [1.4]
Follicle, Cyst 1 [2.0]
Follicle, Degeneration 1 [1.0] 2 [1.0]
Follicular Cell, Hyperplasia 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 [1.0] 1 [1.0] 2 [1.5]
Inflammation 3 [2.0] 4 [1.3] 1 [1.0]
Preputial Gland (50) (50) (50) (49)
Atrophy 1 [4.0]
Hyperplasia 1 [3.0] 1 [3.0] 1 [2.0]
Inflammation 2 [4.0] 2 [2.5] 1 [2.0] 1 [2.0]
Duct, Cyst 1 [2.0] 1 [4.0]
Prostate (50) (50) (50) (50)
Atrophy 4 [2.3] 7 [1.1] 8 [1.4] 4 [1.3]
Hyperplasia 2 [1.0] 3 [1.3] 4 [1.8]
Inflammation 18 [1.6] 17 [1.2] 26 [1.5] 26 [1.6]
Seminal Vesicle (50) (50) (50) (49)
Atrophy 3 [1.7] 7 [1.0] 8 [1.5] 4 [1.3]
Inflammation 1 [3.0] 1 [3.0] 1 [2.0]
Mineralization 4 [2.8]
Testes (50) (50) (50) (50)
Inflammation 1 [4.0] 1 [1.0]
Necrosis 2 [4.0]
Germinal Epithelium, Degeneration 6 [2.8] 5 [3.6] 6 [2.0] 7 [2.9]
Interstitial Cell, Hyperplasia 15 [1.9] 12 [2.3] 14 [2.0] 22 [1.9]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Hyperplasia, Megakaryocyte 1 [2.0]
Inflammation, Granulomatous 1 [2.0] 2 [2.0]
Myelofibrosis 1 [2.0] 2 [2.0] 2 [1.0]
Necrosis 1 [2.0]
Erythroid Cell, Hyperplasia 13 [1.8] 3 [1.3] 10 [1.4] 10 [1.7]
Myeloid Cell, Hyperplasia 21 [2.8] 27 [2.5] 20 [2.8] 14 [2.7]
Lymph Node (19) (20) (16) (19)
Deep Cervical, Ectasia 2 [2.0] 1 [2.0]
Deep Cervical, Infiltration Cellular, Plasma
Cell 1 [2.0] 2 [2.0] 2 [1.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Ectasia 3 [2.3] 4 [1.5] 3 [1.0]
Mediastinal, Hemorrhage 1 [1.0] 1 [2.0] 2 [2.0]
Mediastinal, Hyperplasia 1 [2.0] 2 [2.0]
Mediastinal, Infiltration Cellular, Plasma
Cell 1 [2.0] 2 [1.5] 3 [2.0]
Mediastinal, Infiltration Cellular,
Histiocyte 2 [1.5]
Mediastinal, Inflammation 1 [2.0]
Pancreatic, Ectasia 2 [1.5] 2 [2.0]
Pancreatic, Hemorrhage 1 [2.0] 1 [1.0]
Pancreatic, Infiltration Cellular, Histiocyte 1 [3.0] 1 [2.0] 2 [3.0]
Pancreatic, Inflammation 3 [2.3] 1 [3.0]
Renal, Ectasia 1 [2.0]
Renal, Infiltration Cellular, Histiocyte 1 [3.0]
Lymph Node, Mandibular (5) (1) (2)
Ectasia 1 [4.0]
Lymph Node, Mesenteric (50) (50) (50) (50)
Atrophy 1 [1.0] 6 [2.0]
Ectasia 4 [2.0] 2 [1.0] 5 [1.6] 4 [1.8]
Infiltration Cellular, Histiocyte 47 [1.2] 41 [1.5] 48 [1.6] 46 [1.5]
Inflammation 1 [4.0]
Spleen (50) (50) (50) (50)
Accessory Spleen 1
Autolysis 1
Fibrosis 1 [2.0] 3 [2.3] 1 [3.0]
Hematopoietic Cell Proliferation 45 [1.2] 42 [1.2] 45 [1.2] 41 [1.2]
Hemorrhage 1 [1.0] 1 [3.0]
Hyperplasia, Lymphoid 6 [2.0] 2 [2.0] 9 [2.7] 4 [2.0]
Inflammation, Granulomatous 1 [2.0] 3 [3.0] 7 [3.3] 1 [4.0]
Necrosis 1 [2.0] 2 [2.5] 1 [2.0]
Pigmentation, Hemosiderin 39 [1.1] 43 [1.0] 44 [1.0] 43 [1.0]
Lymphoid Follicle, Atrophy 1 [1.0] 1 [2.0] 2 [2.5]
Thymus (48) (48) (48) (48)
Atrophy 44 [3.6] 42 [3.6] 47 [3.8] 46 [3.8]
Ectopic Parathyroid Gland 1 [3.0] 4 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (50) (50)
Fibrosis 1 [3.0]
Galactocele 2 [1.0] 1 [1.0]
Inflammation 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (50) (50) (50) (50)
Hyperplasia 1 [2.0]
Inflammation 2 [1.5]
Subcutaneous Tissue, Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 [2.0] 4 [1.8]
Osteosclerosis 1 [2.0]
Skeletal Muscle (2) (2) (1)
Degeneration 1 [2.0] 1 [2.0] 1 [2.0]
Inflammation 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 5 [1.8] 5 [1.8] 2 [2.5] 5 [2.2]
Necrosis 2 [2.0] 4 [1.8]
Peripheral Nerve (1)
Infiltration Cellular, Mononuclear Cell 1 [1.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Inflammation, Acute 2 [1.0] 2 [2.0] 5 [1.2] 7 [1.3]
Inflammation, Granulomatous 2 [1.0] 4 [2.3] 5 [2.0] 2 [2.0]
Metaplasia, Squamous 1 [1.0]
Mineralization 2 [2.5] 10 [2.7]
Necrosis 1 [2.0]
Thrombosis 1 [2.0] 1 [3.0]
Alveolar Epithelium, Hyperplasia 16 [1.4] 5 [2.0] 13 [1.6] 7 [1.3]
Alveolus, Infiltration Cellular, Histiocyte 46 [1.7] 47 [1.5] 49 [1.5] 50 [1.8]
Bronchiole, Hyperplasia 1 [1.0] 3 [2.0]
Interstitium, Fibrosis 2 [1.5]
Nose (50) (50) (50) (50)
Inflammation 7 [2.0] 7 [1.9] 8 [1.9] 9 [1.9]
Thrombosis 1 [2.0] 2 [3.0] 1 [3.0]
Olfactory Epithelium, Degeneration 1 [1.0]
Olfactory Epithelium, Metaplasia 1 [2.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 14
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/21/03
Route: DOSED FEED BENZOPHENONE Time: 16:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Hyperplasia 1 [2.0] 1 [1.0]
Trachea (50) (50) (50) (50)
Inflammation 2 [1.0] 1 [1.0] 8 [1.0] 3 [2.3]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Anterior Chamber, Inflammation 1 [3.0]
Ciliary Body, Inflammation 1 [1.0]
Cornea, Inflammation 1 [1.0]
Iris, Fibrosis 1 [3.0] 1 [3.0]
Iris, Inflammation 1 [1.0] 1 [2.0]
Lens, Cataract 2 [3.0] 1 [4.0]
Lens, Mineralization 1 [2.0]
Retina, Atrophy 1 [2.0]
Retina, Degeneration 5 [2.2] 2 [1.0] 5 [1.8]
Harderian Gland (50) (50) (50) (50)
Hyperplasia 1 [1.0] 1 [3.0] 1 [1.0]
Infiltration Cellular, Lymphoid 9 [1.2] 4 [1.0] 9 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 4 [1.8] 1 [2.0] 4 [1.5] 2 [2.5]
Hyperplasia, Oncocytic 1 [2.0]
Infarct 1 3
Nephropathy 50 [1.3] 45 [2.4] 50 [3.3] 50 [3.8]
Artery, Inflammation 1 [2.0]
Cortex, Mineralization 1 [1.0] 4 [2.5] 14 [2.8]
Medulla, Mineralization 47 [1.0] 49 [1.2] 47 [1.1] 49 [1.2]
Papilla, Transitional Epithelium, Hyperplasia 1 [1.0]
Pelvis, Inflammation 1 [1.0] 1 [2.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [1.0] 11 [1.2] 29 [1.5] 34 [1.7]
Renal Tubule, Cyst 1 9
Renal Tubule, Hyperplasia 1 [1.0] 5 [1.4] 20 [1.5] 23 [1.3]
Renal Tubule, Pigmentation 1 [4.0] 1 [1.0] 2 [3.0]
Urinary Bladder (50) (50) (50) (50)
Calculus Gross Observation 1 1
Inflammation 3 [1.7] 2 [2.5] 2 [1.5]
Muscularis, Degeneration 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 15
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