TDMS Study 99022-02 Pathology Tables
NTP EXP/TEST: 99022-02 AZT TRANSPLACENTAL CARCINOGENESIS STUDY PAGE: 1
TEST TYPE: PERINATAL EXPOS INITIAL AND CURRENT BODY WEIGHT DATE: 10/08/03
ROUTE: IN-UTERO TIME: 16:02:30
EIS REPORT 03
FINAL/MICE
FACILITY: Southern Research Institute
NTP C#: C99022
CONTRACT NUMBER: N01-ES-15328
CAS NUMBER: 30516-87-1
ANIMAL SUPPLIER: TACONIC FARMS
CAGE RANGE: ALL
DATE RANGE: ALL
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: MERGE 001 001,011 0 MG/KG/DY
MERGE 002 002,012 50 MG/KG/DY
MERGE 003 003,013 100 MG/KG/DY
MERGE 004 004,014 200 MG/KG/DY
MERGE 005 005,015 300 MG/KG/DY
MERGE 006 006,016 0 MG/KG/DY
MERGE 007 007,017 50 MG/KG/DY
MERGE 008 008,018 100 MG/KG/DY
MERGE 009 009,019 200 MG/KG/DY
MERGE 010 010,020 300 MG/KG/DY
NTP EXP/TEST: 99022-02 AZT TRANSPLACENTAL CARCINOGENESIS STUDY PAGE: 2
TEST TYPE: PERINATAL EXPOS INITIAL AND CURRENT BODY WEIGHT DATE: 10/08/03
ROUTE: IN-UTERO EISRPT03 TIME: 16:02:30
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SPECIES-STRAIN: SWISS-MICE SEX: FEMALE WEEK ON DOSE: 97 FIRST DOSE: 06/19/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
0 MG/KG/DY 50 21.8 3.6 19 55.3 9.1 19 34.2 8.4
50 MG/KG/DY 50 21.1 3.6 17 58.2 8.9 105.2 17 36.7 10.3
100 MG/KG/DY 50 21.3 4.2 24 57.6 11.7 104.1 24 36.6 11.6
200 MG/KG/DY 40 22.3 2.0 19 51.1 8.2 92.4 19 28.8 7.8
300 MG/KG/DY 42 19.4 2.4 18 59.7 16.4 107.9 18 39.5 15.1
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SPECIES-STRAIN: SWISS-MICE SEX: MALE WEEK ON DOSE: 97 FIRST DOSE: 06/19/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
0 MG/KG/DY 50 28.5 4.0 19 55.5 5.2 19 26.9 5.3
50 MG/KG/DY 50 28.1 5.8 20 52.1 8.1 93.8 20 25.7 7.9
100 MG/KG/DY 50 26.9 3.6 13 53.8 7.8 96.9 13 26.1 7.9
200 MG/KG/DY 37 26.9 2.7 7 49.9 5.7 89.9 7 23.2 6.5
300 MG/KG/DY 32 25.6 4.2 7 54.9 5.4 98.9 7 29.2 2.9
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