TDMS Study 99022-02 Pathology Tables
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
FINAL #2; REVISION #1 MICE
Facility: Southern Research Institute
Chemical CAS #: 30516-87-1
Lock Date: 06/20/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Merge 006 006,016
Merge 007 007,017
Merge 008 008,018
Merge 009 009,019
Merge 010 010,020
Merge 001 001,011
Merge 002 002,012
Merge 003 003,013
Merge 004 004,014
Merge 005 005,015
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE FEMALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 40 42
Early Deaths
Moribund Sacrifice 16 18 11 11 15
Natural Death 14 13 15 9 8
Accidently Killed 1
Survivors
Moribund Sacrifice 1 1
Terminal Sacrifice 19 17 24 19 18
Natural Death 1 1
Animals Examined Microscopically 50 50 50 40 42
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (49) (39) (42)
Edema 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Cecum (47) (48) (45) (38) (40)
Amyloid Deposition 1 (2%)
Edema 3 (6%) 3 (6%) 4 (9%) 4 (11%) 8 (20%)
Intestine Small, Duodenum (50) (50) (48) (40) (42)
Amyloid Deposition 1 (2%)
Erosion 1 (2%) 1 (2%) 2 (5%)
Ulcer 2 (4%) 1 (2%)
Epithelium, Hyperplasia 12 (24%) 7 (14%) 12 (25%) 4 (10%) 9 (21%)
Intestine Small, Jejunum (46) (49) (46) (40) (40)
Amyloid Deposition 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (3%)
Intestine Small, Ileum (47) (48) (45) (38) (40)
Amyloid Deposition 1 (2%)
Liver (50) (50) (50) (40) (42)
Amyloid Deposition 1 (2%) 1 (3%)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Cyst 2 (4%) 1 (2%) 1 (3%)
Eosinophilic Focus 1 (2%) 2 (4%) 3 (6%) 1 (3%) 3 (7%)
Hematopoietic Cell Proliferation 8 (16%) 5 (10%) 5 (10%) 5 (13%) 8 (19%)
Hyperplasia, Lymphoid 3 (8%)
Infiltration Cellular, Mixed Cell 7 (14%) 6 (12%) 6 (12%) 9 (23%) 9 (21%)
Necrosis, Focal 6 (12%) 8 (16%) 5 (10%) 4 (10%) 6 (14%)
Regeneration 1 (2%) 1 (2%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE FEMALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Hypertrophy 1 (2%) 6 (12%) 3 (6%) 2 (5%) 2 (5%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 3 (6%) 2 (5%)
Kupffer Cell, Hyperplasia 1 (2%) 1 (2%) 1 (3%) 2 (5%)
Kupffer Cell, Pigmentation 4 (8%) 4 (8%) 2 (4%) 6 (15%) 6 (14%)
Mesentery (4) (8) (7) (3) (5)
Angiectasis 1 (14%)
Hemorrhage 1 (25%) 1 (13%) 1 (33%)
Thrombosis 1 (25%)
Fat, Necrosis 5 (63%) 4 (57%) 2 (67%) 3 (60%)
Pancreas (50) (49) (49) (40) (41)
Atrophy 1 (2%) 1 (3%)
Edema 2 (4%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Acinus, Cytoplasmic Alteration 4 (8%) 2 (5%) 4 (10%)
Salivary Glands (50) (49) (49) (40) (42)
Hyperplasia, Lymphoid 2 (4%) 6 (12%) 3 (6%) 1 (3%) 4 (10%)
Stomach, Forestomach (50) (50) (49) (40) (42)
Edema 1 (2%) 5 (10%) 3 (6%) 2 (5%) 4 (10%)
Erosion 2 (5%)
Epithelium, Hyperplasia 4 (8%) 3 (6%) 2 (5%) 4 (10%)
Stomach, Glandular (50) (50) (49) (40) (42)
Amyloid Deposition 1 (2%)
Cyst 2 (4%)
Edema 2 (4%) 1 (2%) 2 (5%)
Erosion 1 (2%) 2 (4%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Glands, Hyperplasia, Cystic 6 (12%) 12 (24%) 8 (16%) 10 (25%) 6 (14%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (2)
Inflammation, Chronic 1 (33%)
Heart (50) (49) (50) (40) (42)
Amyloid Deposition 1 (2%)
Cardiomyopathy 3 (6%) 2 (4%) 6 (12%) 1 (3%) 2 (5%)
Inflammation, Chronic 7 (14%) 1 (2%) 2 (4%) 2 (5%) 2 (5%)
Mineralization 2 (4%) 3 (6%) 2 (4%) 1 (3%) 2 (5%)
Thrombosis 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE FEMALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Cortex (50) (49) (50) (38) (42)
Accessory Adrenal Cortical Nodule 10 (20%) 8 (16%) 11 (22%) 7 (18%) 6 (14%)
Amyloid Deposition 1 (2%)
Hyperplasia, Diffuse 2 (4%) 1 (2%)
Hypertrophy, Focal 1 (2%)
Capsule, Hyperplasia 1 (2%) 1 (2%) 2 (5%) 2 (5%)
Adrenal Medulla (50) (49) (50) (38) (42)
Hyperplasia 1 (2%) 3 (6%) 1 (2%)
Islets, Pancreatic (50) (49) (49) (40) (41)
Hyperplasia 2 (4%) 5 (10%) 6 (12%) 7 (18%) 10 (24%)
Pituitary Gland (50) (49) (50) (40) (42)
Pars Distalis, Angiectasis 1 (2%) 1 (3%) 2 (5%)
Pars Distalis, Cyst 3 (6%) 3 (8%)
Pars Distalis, Hyperplasia, Focal 3 (6%) 4 (8%) 1 (2%) 2 (5%) 4 (10%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (50) (49) (50) (40) (42)
Amyloid Deposition 1 (2%) 1 (3%)
Degeneration, Cystic 26 (52%) 18 (37%) 39 (78%) 24 (60%) 29 (69%)
Follicular Cell, Hyperplasia 4 (8%) 2 (4%) 5 (10%) 4 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (40) (42)
Cyst 22 (44%) 18 (36%) 25 (50%) 14 (35%) 12 (29%)
Infiltration Cellular, Lymphocyte 1 (3%)
Inflammation, Chronic 23 (46%) 19 (38%) 17 (34%) 14 (35%) 16 (38%)
Ovary (50) (50) (49) (40) (42)
Amyloid Deposition 1 (2%) 1 (2%)
Angiectasis 1 (2%) 1 (2%) 4 (8%) 3 (8%) 4 (10%)
Cyst 38 (76%) 35 (70%) 37 (76%) 28 (70%) 29 (69%)
Hematocyst 1 (2%)
Hemorrhage 2 (4%) 2 (4%) 7 (14%) 5 (13%) 4 (10%)
Thrombosis 2 (4%) 1 (3%) 1 (2%)
Bilateral, Cyst 1 (3%)
Corpus Luteum, Hyperplasia 1 (2%) 1 (2%) 1 (3%) 1 (2%)
Uterus (50) (50) (49) (40) (42)
Angiectasis 1 (2%) 4 (8%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE FEMALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Thrombosis 2 (4%) 3 (6%) 1 (2%)
Endometrium, Hyperplasia, Cystic 22 (44%) 27 (54%) 29 (59%) 24 (60%) 22 (52%)
Vagina (49) (49) (47) (40) (41)
Cyst 2 (4%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (40) (42)
Hyperplasia 33 (66%) 24 (48%) 30 (60%) 22 (55%) 26 (62%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (14) (23) (16) (12) (16)
Hematopoietic Cell Proliferation 1 (7%) 1 (4%) 2 (13%)
Hemorrhage 1 (6%)
Hyperplasia, Lymphoid 1 (7%) 3 (13%) 1 (8%)
Hyperplasia, Plasma Cell 2 (14%) 1 (6%)
Pigmentation 1 (6%)
Bronchial, Hemorrhage 1 (4%)
Iliac, Hematopoietic Cell Proliferation 1 (7%) 1 (4%) 1 (6%)
Iliac, Hemorrhage 1 (6%)
Iliac, Hyperplasia, Lymphoid 2 (9%) 2 (13%)
Inguinal, Hematopoietic Cell Proliferation 1 (4%) 1 (6%)
Inguinal, Hyperplasia, Lymphoid 2 (14%) 4 (17%) 2 (13%) 1 (8%) 2 (13%)
Inguinal, Hyperplasia, Plasma Cell 1 (7%)
Inguinal, Pigmentation 1 (4%)
Lumbar, Hematopoietic Cell Proliferation 1 (7%)
Lumbar, Hyperplasia, Lymphoid 1 (4%) 1 (6%)
Mediastinal, Hematopoietic Cell Proliferation 1 (7%)
Mediastinal, Hemorrhage 1 (7%) 1 (4%) 2 (13%) 1 (6%)
Mediastinal, Hyperplasia, Lymphoid 1 (7%) 2 (9%) 1 (8%)
Mediastinal, Pigmentation 1 (4%)
Pancreatic, Hyperplasia, Lymphoid 1 (8%)
Popliteal, Hyperplasia 1 (6%)
Popliteal, Hyperplasia, Lymphoid 1 (8%)
Renal, Ectasia 1 (4%)
Renal, Hematopoietic Cell Proliferation 1 (4%)
Renal, Hemorrhage 2 (9%) 1 (6%)
Renal, Hyperplasia, Lymphoid 3 (13%) 2 (13%)
Lymph Node, Mandibular (49) (47) (49) (40) (42)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE FEMALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Amyloid Deposition 1 (2%)
Atrophy 2 (4%) 2 (4%) 1 (2%) 4 (10%)
Ectasia 2 (4%) 1 (2%) 3 (8%) 2 (5%)
Hematopoietic Cell Proliferation 7 (14%) 3 (6%) 2 (4%) 4 (10%) 6 (14%)
Hemorrhage 3 (6%) 4 (9%) 5 (10%) 5 (13%) 7 (17%)
Hyperplasia, Lymphoid 9 (18%) 10 (21%) 17 (35%) 10 (25%) 4 (10%)
Hyperplasia, Plasma Cell 5 (10%) 3 (7%)
Infiltration Cellular, Plasma Cell 2 (4%)
Pigmentation 5 (10%) 4 (9%) 2 (4%) 4 (10%) 6 (14%)
Lymph Node, Mesenteric (50) (48) (46) (40) (42)
Atrophy 2 (4%) 4 (8%) 2 (4%) 1 (3%) 5 (12%)
Ectasia 2 (4%) 3 (6%) 2 (4%) 3 (8%) 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 6 (13%) 2 (4%) 3 (8%) 8 (19%)
Hemorrhage 12 (24%) 10 (21%) 9 (20%) 9 (23%) 11 (26%)
Hyperplasia, Lymphoid 6 (12%) 7 (15%) 9 (20%) 10 (25%) 7 (17%)
Pigmentation 2 (4%) 7 (15%) 3 (7%) 2 (5%) 4 (10%)
Spleen (50) (50) (49) (40) (42)
Amyloid Deposition 1 (3%)
Hematopoietic Cell Proliferation 31 (62%) 21 (42%) 32 (65%) 26 (65%) 29 (69%)
Pigmentation 13 (26%) 24 (48%) 12 (24%) 10 (25%) 12 (29%)
Lymphoid Follicle, Atrophy 4 (8%) 6 (12%) 5 (10%) 6 (15%) 4 (10%)
Lymphoid Follicle, Hyperplasia 7 (14%) 3 (6%) 7 (14%) 6 (15%) 7 (17%)
Thymus (49) (44) (46) (36) (42)
Atrophy 7 (14%) 3 (7%) 5 (11%) 2 (6%) 4 (10%)
Hemorrhage 1 (2%) 4 (9%) 2 (4%) 3 (7%)
Hyperplasia, Lymphoid 7 (14%) 3 (7%) 3 (7%) 7 (19%) 2 (5%)
Thrombosis 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (40) (42)
Hyperplasia 9 (18%) 9 (18%) 8 (16%) 6 (15%) 7 (17%)
Skin (50) (50) (49) (40) (42)
Cyst Epithelial Inclusion 1 (3%) 2 (5%)
Edema 3 (6%) 7 (14%) 7 (14%) 6 (15%) 5 (12%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (3%) 1 (2%)
Ulcer 8 (16%) 5 (10%) 1 (2%) 5 (13%) 3 (7%)
Epidermis, Hyperplasia 7 (14%) 5 (10%) 3 (6%) 4 (10%) 3 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE FEMALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Bone (50) (50) (50) (40) (42)
Fibrous Osteodystrophy 2 (4%) 7 (14%) 9 (18%) 6 (15%) 4 (10%)
Hyperostosis 1 (2%) 1 (3%)
Myelofibrosis 1 (3%)
Cranium, Hyperostosis 1 (2%)
Femur, Callus 1 (2%)
Femur, Hyperostosis 1 (3%)
Skeletal Muscle (5) (2) (1) (1) (4)
Inflammation, Chronic 1 (20%) 1 (100%)
Thrombosis 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (40) (42)
Compression 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 1 (2%)
Peripheral Nerve (7) (5) (3) (5) (6)
Atrophy 1 (20%) 1 (33%) 1 (20%)
Spinal Cord (50) (50) (50) (40) (42)
Cyst Epithelial Inclusion 1 (2%) 1 (3%) 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (40) (42)
Amyloid Deposition 1 (2%)
Edema 1 (2%) 3 (6%) 4 (8%) 1 (3%) 3 (7%)
Fibrosis, Focal 1 (2%)
Foreign Body 3 (6%)
Hemorrhage 7 (14%) 6 (12%) 6 (12%) 2 (5%) 8 (19%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 3 (6%) 4 (10%) 1 (2%)
Infiltration Cellular, Histiocyte 12 (24%) 11 (22%) 21 (42%) 12 (30%) 10 (24%)
Infiltration Cellular, Mixed Cell 2 (4%) 1 (3%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (5%) 2 (5%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (4%) 10 (20%) 3 (8%) 2 (5%)
Nose (50) (50) (50) (40) (42)
Foreign Body 2 (4%)
Inflammation, Chronic 11 (22%) 2 (4%) 7 (14%) 2 (5%) 4 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE FEMALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2)
Atrophy 1 (50%) 1 (100%)
Cataract 1 (50%)
Inflammation, Chronic 1 (50%)
Harderian Gland (49) (49) (50) (40) (41)
Atrophy 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (40) (42)
Amyloid Deposition 2 (4%) 1 (2%) 2 (5%)
Cyst 2 (4%) 7 (14%) 5 (10%) 7 (18%) 5 (12%)
Hydronephrosis 2 (4%) 7 (14%) 5 (10%) 5 (13%) 3 (7%)
Infarct 1 (2%) 3 (6%) 2 (5%)
Infiltration Cellular, Mixed Cell 10 (20%) 20 (40%) 15 (30%) 14 (35%) 15 (36%)
Inflammation, Chronic 3 (6%)
Metaplasia, Osseous 1 (2%) 2 (5%)
Nephropathy 29 (58%) 31 (62%) 41 (82%) 26 (65%) 33 (79%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 2 (4%) 2 (4%) 3 (8%) 3 (7%)
Renal Tubule, Dilatation 1 (2%) 3 (6%) 1 (3%)
Renal Tubule, Necrosis 1 (2%) 1 (3%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 1 (2%) 2 (5%) 2 (5%)
Urinary Bladder (50) (50) (49) (40) (42)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 3 (6%) 2 (5%) 3 (7%)
Inflammation, Chronic 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE MALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 37 32
Early Deaths
Moribund Sacrifice 24 20 25 23 12
Natural Death 7 9 11 5 10
Accidently Killed 1 1 2
Survivors
Terminal Sacrifice 19 20 13 7 7
Moribund Sacrifice 1
Natural Death 1
Other 1
Animals Examined Microscopically 50 50 50 37 32
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (50) (49) (37) (32)
Edema 2 (4%) 1 (3%)
Intestine Large, Cecum (49) (49) (48) (35) (30)
Edema 13 (27%) 11 (22%) 8 (17%) 14 (40%) 2 (7%)
Infiltration Cellular, Lymphocyte 1 (2%)
Intestine Small, Duodenum (49) (50) (49) (36) (32)
Amyloid Deposition 1 (2%)
Epithelium, Hyperplasia 3 (6%) 4 (8%) 4 (8%) 1 (3%) 1 (3%)
Intestine Small, Jejunum (49) (50) (46) (36) (29)
Amyloid Deposition 1 (2%)
Epithelium, Hyperplasia 4 (8%) 2 (4%) 1 (3%) 1 (3%)
Intestine Small, Ileum (49) (48) (47) (35) (30)
Amyloid Deposition 1 (2%)
Liver (50) (50) (50) (37) (32)
Amyloid Deposition 1 (3%)
Angiectasis 1 (2%) 1 (2%) 1 (3%)
Basophilic Focus 2 (4%) 4 (8%) 2 (4%) 2 (5%)
Cholangiofibrosis 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%)
Cyst 2 (4%) 1 (3%)
Eosinophilic Focus 3 (6%) 2 (4%) 2 (4%) 1 (3%) 2 (6%)
Hematopoietic Cell Proliferation 9 (18%) 7 (14%) 12 (24%) 6 (16%) 5 (16%)
Hemorrhage 1 (2%) 1 (2%) 1 (3%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 1 (3%)
Infiltration Cellular, Mixed Cell 10 (20%) 7 (14%) 2 (4%) 5 (14%) 2 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE MALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis, Focal 8 (16%) 9 (18%) 7 (14%) 4 (11%) 3 (9%)
Regeneration 1 (2%) 1 (3%)
Tension Lipidosis 1 (2%) 1 (3%)
Centrilobular, Necrosis 2 (4%) 1 (2%)
Hepatocyte, Hypertrophy 15 (30%) 15 (30%) 9 (18%) 6 (16%) 15 (47%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 1 (2%) 2 (4%) 1 (3%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 (3%)
Kupffer Cell, Hyperplasia 2 (4%) 1 (3%) 1 (3%)
Kupffer Cell, Pigmentation 2 (4%) 3 (6%) 2 (5%) 3 (9%)
Mesentery (1) (2) (3) (1)
Hemorrhage 1 (50%) 1 (100%)
Fat, Necrosis 1 (50%) 3 (100%)
Pancreas (50) (50) (50) (37) (31)
Atrophy 1 (2%)
Cyst 1 (3%)
Edema 1 (2%) 2 (4%) 2 (5%)
Infiltration Cellular, Mixed Cell 1 (3%)
Acinus, Cytoplasmic Alteration 1 (2%) 2 (4%) 1 (2%) 1 (3%) 1 (3%)
Salivary Glands (50) (50) (50) (37) (32)
Atrophy 1 (2%) 1 (3%)
Hyperplasia, Lymphoid 1 (3%)
Infiltration Cellular, Lymphoid 1 (2%) 5 (16%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%) 2 (5%)
Stomach, Forestomach (49) (50) (50) (37) (32)
Diverticulum 1 (3%)
Edema 1 (2%) 2 (4%) 1 (3%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 2 (4%) 1 (2%) 1 (3%) 1 (3%)
Stomach, Glandular (49) (50) (50) (37) (32)
Edema 1 (2%) 2 (4%) 2 (5%)
Erosion 2 (4%) 2 (4%) 1 (2%) 1 (3%)
Glands, Hyperplasia, Cystic 9 (18%) 13 (26%) 10 (20%) 15 (41%) 6 (19%)
Tooth (1)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (1)
Inflammation, Chronic 1 (100%)
Heart (50) (50) (50) (37) (32)
Amyloid Deposition 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE MALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Cardiomyopathy 12 (24%) 7 (14%) 19 (38%) 13 (35%) 7 (22%)
Inflammation 1 (2%)
Inflammation, Chronic 1 (2%) 5 (10%) 3 (6%) 2 (5%) 1 (3%)
Mineralization 2 (4%) 1 (2%) 1 (3%)
Thrombosis 2 (4%) 4 (8%) 5 (10%) 3 (8%) 3 (9%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (37) (32)
Accessory Adrenal Cortical Nodule 8 (16%) 9 (18%) 7 (14%) 6 (16%) 6 (19%)
Amyloid Deposition 1 (2%)
Hyperplasia, Focal 2 (4%) 5 (10%) 3 (6%) 2 (5%)
Hypertrophy, Focal 6 (12%) 5 (10%) 4 (8%) 4 (11%) 4 (13%)
Capsule, Hyperplasia 2 (4%) 2 (4%) 1 (2%) 3 (8%) 2 (6%)
Adrenal Medulla (50) (50) (49) (37) (32)
Hyperplasia 2 (4%) 1 (2%) 1 (3%)
Islets, Pancreatic (50) (50) (50) (36) (31)
Hyperplasia 15 (30%) 13 (26%) 12 (24%) 6 (17%) 6 (19%)
Pituitary Gland (48) (49) (49) (36) (31)
Pars Distalis, Cyst 1 (2%) 2 (4%) 3 (6%) 2 (6%) 1 (3%)
Thyroid Gland (50) (50) (50) (37) (32)
Amyloid Deposition 1 (2%)
Degeneration, Cystic 29 (58%) 23 (46%) 33 (66%) 15 (41%) 15 (47%)
Follicular Cell, Hyperplasia 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (2) (1) (1)
Bilateral, Dilatation 1 (50%)
Epididymis (50) (50) (50) (37) (32)
Atypia Cellular 1 (2%) 3 (6%) 3 (6%) 3 (8%) 3 (9%)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Spermatocele 2 (4%) 1 (3%)
Penis (2) (1) (3) (1)
Inflammation, Chronic Active 2 (100%) 1 (100%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE MALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Preputial Gland (50) (50) (50) (37) (32)
Cyst 6 (12%) 7 (14%) 6 (12%) 6 (16%) 2 (6%)
Inflammation, Chronic 11 (22%) 11 (22%) 18 (36%) 8 (22%) 9 (28%)
Prostate (50) (50) (50) (37) (32)
Inflammation, Chronic 8 (16%) 3 (6%) 12 (24%) 6 (16%) 5 (16%)
Seminal Vesicle (50) (50) (50) (37) (32)
Degeneration 1 (2%) 1 (3%) 1 (3%)
Dilatation 2 (4%) 3 (9%)
Inflammation, Chronic 2 (4%) 3 (6%) 3 (8%)
Testes (50) (50) (50) (37) (32)
Germinal Epithelium, Atrophy 4 (8%) 7 (14%) 5 (10%) 3 (8%) 4 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (37) (32)
Hyperplasia 43 (86%) 29 (58%) 35 (70%) 27 (73%) 24 (75%)
Infiltration Cellular, Mast Cell 1 (2%)
Myelofibrosis 1 (3%)
Lymph Node (12) (10) (15) (6) (2)
Hematopoietic Cell Proliferation 3 (25%) 2 (20%) 1 (7%)
Hyperplasia, Lymphoid 1 (8%) 3 (30%) 2 (13%) 2 (33%)
Hyperplasia, Plasma Cell 3 (25%) 2 (100%)
Bronchial, Hyperplasia, Lymphoid 1 (10%)
Iliac, Hyperplasia, Lymphoid 1 (7%) 1 (17%)
Iliac, Pigmentation 1 (7%)
Inguinal, Hematopoietic Cell Proliferation 1 (8%) 1 (7%) 1 (17%)
Inguinal, Hyperplasia, Lymphoid 2 (17%) 1 (10%) 6 (40%) 1 (17%)
Inguinal, Hyperplasia, Plasma Cell 2 (17%)
Inguinal, Pigmentation 1 (7%)
Lumbar, Pigmentation 1 (7%)
Mediastinal, Hemorrhage 1 (8%)
Mediastinal, Hyperplasia, Lymphoid 3 (20%)
Renal, Hyperplasia, Lymphoid 1 (8%) 1 (17%)
Renal, Hyperplasia, Plasma Cell 1 (8%)
Lymph Node, Mandibular (50) (50) (49) (37) (32)
Atrophy 1 (2%) 3 (8%)
Ectasia 2 (4%) 1 (2%) 1 (3%) 2 (6%)
Hematopoietic Cell Proliferation 7 (14%) 6 (12%) 4 (11%) 5 (16%)
Hemorrhage 3 (6%)
Hyperplasia, Lymphoid 11 (22%) 7 (14%) 9 (18%) 6 (16%) 9 (28%)
Hyperplasia, Plasma Cell 11 (22%) 9 (18%) 6 (12%) 3 (8%) 4 (13%)
Pigmentation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE MALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mesenteric (50) (49) (49) (36) (32)
Atrophy 1 (2%) 2 (4%) 3 (8%)
Ectasia 2 (4%) 7 (14%) 3 (6%) 6 (17%) 2 (6%)
Hematopoietic Cell Proliferation 12 (24%) 3 (6%) 8 (16%) 3 (8%) 4 (13%)
Hemorrhage 7 (14%) 14 (29%) 17 (35%) 8 (22%) 9 (28%)
Hyperplasia, Lymphoid 15 (30%) 16 (33%) 9 (18%) 10 (28%) 6 (19%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (2%) 1 (2%) 3 (6%)
Pigmentation 1 (2%) 1 (2%) 1 (2%) 1 (3%)
Spleen (49) (50) (50) (37) (32)
Hematopoietic Cell Proliferation 31 (63%) 29 (58%) 27 (54%) 18 (49%) 20 (63%)
Pigmentation 2 (4%) 3 (6%) 4 (8%) 2 (5%)
Lymphoid Follicle, Atrophy 4 (8%) 5 (10%) 5 (10%) 7 (19%) 2 (6%)
Lymphoid Follicle, Hyperplasia 6 (12%) 5 (10%) 2 (5%) 1 (3%)
Thymus (48) (45) (47) (33) (32)
Atrophy 15 (31%) 12 (27%) 15 (32%) 13 (39%) 7 (22%)
Cyst 2 (4%) 1 (2%) 2 (4%) 1 (3%) 1 (3%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 6 (13%) 1 (3%) 6 (19%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (37) (32)
Cyst Epithelial Inclusion 2 (4%) 1 (3%)
Edema 10 (20%) 2 (4%) 7 (14%) 7 (19%) 1 (3%)
Ulcer 14 (28%) 14 (28%) 13 (26%) 7 (19%) 6 (19%)
Epidermis, Hyperplasia 13 (26%) 12 (24%) 12 (24%) 8 (22%) 5 (16%)
Epidermis, Inflammation 1 (2%) 1 (2%)
Epidermis, Ulcer 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (37) (32)
Fibrous Osteodystrophy 1 (2%) 1 (3%) 1 (3%)
Fracture 1 (3%)
Femur, Osteopetrosis 1 (2%) 2 (6%)
Scapula, Osteopetrosis 1 (3%)
Skeletal Muscle (1) (2) (1) (3) (2)
Hemorrhage 1 (100%)
Pigmentation 1 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE MALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (37) (32)
Hydrocephalus 1 (2%)
Necrosis 1 (3%)
Spinal Cord (50) (50) (50) (37) (32)
Cyst Epithelial Inclusion 1 (2%) 1 (3%)
Demyelination 1 (3%)
Infiltration Cellular, Mast Cell 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (37) (32)
Congestion 1 (3%)
Edema 1 (2%) 2 (4%) 4 (11%)
Fibrosis, Focal 1 (2%)
Foreign Body 1 (2%) 1 (2%) 1 (3%) 1 (3%)
Hemorrhage 5 (10%) 3 (6%) 7 (14%) 5 (14%) 2 (6%)
Hyperplasia, Lymphoid 1 (2%) 1 (3%) 1 (3%)
Infiltration Cellular, Histiocyte 12 (24%) 16 (32%) 13 (26%) 16 (43%) 14 (44%)
Inflammation, Chronic 2 (4%) 1 (2%) 5 (10%) 2 (5%) 1 (3%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 3 (6%) 1 (3%) 4 (13%)
Nose (50) (50) (50) (36) (32)
Foreign Body 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 5 (10%) 5 (10%) 5 (10%) 3 (8%) 4 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (50) (50) (49) (37) (32)
Hyperplasia, Focal 2 (4%) 1 (2%) 1 (3%) 1 (3%)
Hypertrophy, Focal 1 (2%)
Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (37) (32)
Amyloid Deposition 3 (6%)
Cyst 27 (54%) 23 (46%) 26 (52%) 24 (65%) 17 (53%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 99022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:32
____________________________________________________________________________________________________________________________________
SWISS MICE MALE 0 50 100 200 300
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hydronephrosis 30 (60%) 20 (40%) 17 (34%) 16 (43%) 14 (44%)
Infarct 1 (2%) 1 (3%) 1 (3%)
Infiltration Cellular, Mixed Cell 9 (18%) 11 (22%) 17 (34%) 9 (24%) 12 (38%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%) 2 (5%)
Inflammation, Suppurative 4 (8%)
Metaplasia, Osseous 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (3%)
Nephropathy 40 (80%) 40 (80%) 42 (84%) 30 (81%) 23 (72%)
Renal Tubule, Dilatation 1 (2%) 5 (10%) 2 (5%) 1 (3%)
Renal Tubule, Necrosis 3 (6%) 1 (3%)
Renal Tubule, Pigmentation 1 (2%) 2 (4%) 2 (5%)
Ureter (3) (1) (1)
Dilatation 2 (67%) 1 (100%) 1 (100%)
Urethra (1) (4) (5) (3) (3)
Angiectasis 1 (100%) 3 (60%) 1 (33%) 1 (33%)
Inflammation, Chronic 1 (100%) 1 (25%) 3 (60%) 1 (33%)
Bulbourethral Gland, Cyst 1 (25%) 2 (40%) 1 (33%) 2 (67%)
Urinary Bladder (50) (50) (50) (37) (32)
Edema 1 (2%) 2 (6%)
Hemorrhage 3 (6%) 2 (5%) 2 (6%)
Inflammation, Chronic 4 (8%) 2 (4%) 1 (3%) 1 (3%)
Transitional Epithelium, Hyperplasia 4 (8%) 1 (2%) 3 (6%) 1 (3%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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