TDMS Study 05195-03 Pathology Tables
NTP Experiment-Test: 05195-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:16:35
Facility: TSI Mason Research
Chemical CAS #: 13410-01-0
Lock Date: 02/16/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 001 0 PPM
Include 004 3.75 PPM
Include 003 3.75 PPM
Include 006 7.5 PPM
Include 005 7.5 PPM
Include 008 15 PPM
Include 007 15 PPM
Include 010 30 PPM
Include 009 30 PPM
Include 012 60 PPM
Include 011 60 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05195-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 9
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (8) (7) (10) (10) (10)
Hematopoietic Cell Proliferation, Focal 7 (70%) 5 (63%) 3 (43%) 2 (20%) 3 (30%)
Hepatodiaphragmatic Nodule 3 (38%) 5 (71%) 1 (10%) 1 (10%)
Inflammation, Focal 2 (25%) 1 (10%) 4 (40%)
Necrosis, Multifocal 2 (20%) 9 (90%)
Hepatocyte, Inclusion Body Intracytoplasmic,
Focal 1 (10%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Pancreas (10) (10) (10)
Atrophy 8 (80%)
Salivary Glands (10) (10) (9)
Atrophy 9 (100%)
Stomach, Forestomach (10) (1) (1) (10) (10)
Submucosa, Ectopic Tissue, Focal 1 (100%)
Stomach, Glandular (10) (10) (10)
Mucosa, Hemorrhage, Focal 7 (70%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (10) (9)
Pars Nervosa, Developmental Malformation 1 (10%)
Thyroid Gland (10) (10) (10)
Ectopic Thymus 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05195-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (1) (1) (10) (10)
Atrophy 10 (100%)
Ovary (10) (1) (10) (10) (9)
Cyst 2 (20%) 1 (100%) 2 (20%)
Interstitium, Atrophy 5 (50%) 9 (100%)
Uterus (10) (2) (9) (10) (10)
Endometrium, Atrophy 10 (100%) 6 (60%)
Lumen, Dilatation 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10)
Femoral, Depletion Cellular 3 (30%) 10 (100%) 10 (100%)
Femoral, Inflammation, Focal, Subacute 1 (10%)
Femoral, Pigmentation, Hemosiderin 3 (30%)
Sternal, Depletion Cellular 1 (10%)
Lymph Node (1) (1) (1)
Mediastinal, Hyperplasia, Lymphoid 1 (100%)
Pancreatic, Hyperplasia, Lymphoid 1 (100%) 1 (100%)
Lymph Node, Mandibular (10) (10) (10) (10) (10) (9)
Congestion 1 (10%) 1 (10%)
Hyperplasia, Lymphoid 2 (20%) 1 (10%)
Lymphocyte, Depletion Cellular 8 (89%)
Lymph Node, Mesenteric (10) (10) (10) (10) (10) (9)
Hyperplasia, Lymphoid 2 (20%) 2 (20%)
Lymphocyte, Depletion Cellular 9 (100%)
Spleen (10) (10) (10)
Lymphocyte, Depletion Cellular 10 (100%)
Thymus (10) (10) (9)
Depletion Lymphoid 9 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (6)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05195-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Atrophy 6 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (10) (10) (10) (10) (10)
Distal, Femur, Metaphysis, Atrophy 9 (90%) 10 (100%)
Sternum, Developmental Malformation 1 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (2) (1) (10) (10)
Edema 1 (10%)
Inflammation, Acute, Focal 1 (50%)
Inflammation, Focal, Subacute 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (5) (8) (10) (10)
Mineralization, Focal 9 (90%) 4 (40%) 4 (40%)
Papilla, Degeneration 1 (10%) 1 (100%) 5 (100%) 8 (100%) 7 (70%) 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05195-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 20 20 20 20 20
Early Deaths
Natural Death 16
Moribund Sacrifice 4
Accidently Killed 1
Survivors
Terminal Sacrifice 20 20 19 20 20
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (6) (8) (10) (10) (10)
Fatty Change 1 (10%) 1 (10%)
Hematopoietic Cell Proliferation, Focal 4 (40%) 2 (33%) 4 (50%) 2 (20%) 4 (40%)
Hepatodiaphragmatic Nodule 2 (20%) 3 (50%) 3 (38%) 1 (10%)
Inflammation, Focal 1 (17%) 1 (13%) 1 (10%)
Necrosis, Multifocal 3 (30%) 2 (20%)
Pancreas (10) (10) (9)
Atrophy 6 (67%)
Salivary Glands (10) (9) (9)
Atrophy 8 (89%)
Stomach, Forestomach (10) (3) (1) (10) (10)
Mucosa, Erosion, Focal 2 (67%) 1 (100%)
Mucosa, Hyperplasia 1 (100%)
Mucosa, Ulcer, Focal 1 (33%)
Stomach, Glandular (10) (10) (10)
Mucosa, Hemorrhage, Focal 2 (20%)
Submucosa, Hemorrhage, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10)
Cardiomyopathy 5 (50%) 3 (30%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10)
Hyperplasia 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05195-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 10 (100%) 8 (80%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10)
Lumen, Degeneration 9 (90%)
Penis (1)
Hemorrhage, Focal 1 (100%)
Preputial Gland (10) (1) (10) (10)
Atrophy 9 (90%)
Seminal Vesicle (10) (10) (10)
Atrophy 10 (100%)
Testes (10) (10) (10)
Germinal Epithelium, Degeneration 4 (40%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10)
Femoral, Depletion Cellular 9 (90%) 9 (90%)
Femoral, Pigmentation, Hemosiderin 5 (50%)
Lymph Node, Mandibular (10) (10) (10) (10) (9) (9)
Congestion 3 (30%) 1 (10%) 2 (20%) 2 (20%)
Hyperplasia, Lymphoid 1 (10%) 1 (10%) 1 (11%)
Lymphocyte, Depletion Cellular 7 (78%)
Lymph Node, Mesenteric (10) (10) (10) (10) (10) (6)
Congestion 1 (10%)
Hyperplasia, Lymphoid 1 (10%)
Lymphocyte, Depletion Cellular 5 (83%)
Spleen (10) (10) (10)
Lymphocyte, Depletion Cellular 7 (70%)
Thymus (10) (10) (8)
Depletion Lymphoid 8 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05195-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY SODIUM SELENATE Date: 10/18/04
Route: DOSED WATER Time: 14:16:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 3.75 7.5 15 30 60
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (10) (10) (10) (10)
Distal, Femur, Metaphysis, Atrophy 3 (30%) 9 (90%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Infiltration Cellular, Polymorphonuclear 1 (50%)
Lens, Cataract 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (3) (6) (10) (10)
Mineralization, Focal 1 (10%)
Papilla, Degeneration 3 (100%) 6 (100%) 6 (60%) 7 (70%)
Renal Tubule, Dilatation, Focal 1 (10%) 1 (10%) 2 (20%)
Urinary Bladder (10) (1) (10) (10)
Calculus Gross Observation 1 (100%)
Calculus Micro Observation Only 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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