TDMS Study 88138-03 Pathology Tables
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
FINAL #2/RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 10 9 13
Natural Death 2 2 4 3
Survivors
Terminal Sacrifice 32 38 37 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Carcinoma 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Mesentery (12) (18) (10) (6)
Histiocytic Sarcoma 1 (17%)
Oral Mucosa (4) (8) (4) (4)
Gingival, Squamous Cell Carcinoma 1 (13%)
Pancreas (50) (50) (50) (50)
Salivary Glands (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Tooth (3) (3)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Heart (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Endocardium, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Benign 2 (4%) 2 (4%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 2 (4%) 1 (2%)
Parathyroid Gland (47) (48) (44) (48)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 17 (34%) 17 (34%) 11 (22%) 13 (26%)
Thyroid Gland (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 4 (8%) 6 (12%) 3 (6%) 6 (12%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Adenoma 2 (4%) 5 (10%) 6 (12%)
Carcinoma 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
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NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Uterus (50) (50) (50) (50)
Polyp Stromal 6 (12%) 9 (18%) 10 (20%) 10 (20%)
Cervix, Histiocytic Sarcoma 1 (2%)
Cervix, Schwannoma Malignant 1 (2%)
Vagina (1) (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (8) (8) (11) (12)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (9%)
Lymph Node, Mandibular (1) (1) (1)
Lymph Node, Mesenteric (50) (50) (50) (50)
Spleen (49) (50) (50) (50)
Thymus (50) (49) (46) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 2 (4%) 2 (4%) 3 (6%)
Carcinoma 1 (2%) 1 (2%)
Fibroadenoma 21 (42%) 20 (40%) 12 (24%) 7 (14%)
Fibroadenoma, Multiple 6 (12%) 4 (8%) 3 (6%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 3 (6%) 2 (4%)
Lipoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (3) (1)
Histiocytic Sarcoma 1 (33%) 1 (100%)
Rhabdomyosarcoma 1 (33%)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Nose (50) (50) (50) (50)
Adenoma 1 (2%)
Trachea (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Iris, Melanoma Benign 1 (2%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Adenoma, Multiple 2 (4%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Page 5
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Leukemia Mononuclear 19 (38%) 25 (50%) 30 (60%) 29 (58%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 46 45 44
Total Primary Neoplasms 93 95 97 85
Total Animals with Benign Neoplasms 42 40 37 33
Total Benign Neoplasms 71 62 59 48
Total Animals with Malignant Neoplasms 20 29 32 32
Total Malignant Neoplasms 22 33 38 37
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 4 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 25 12 16 44
Natural Death 3 11 3 4
Survivors
Terminal Sacrifice 22 27 31 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Intestine Large, Colon (50) (50) (50) (50)
Intestine Large, Rectum (50) (50) (50) (50)
Leiomyoma 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50)
Intestine Small, Jejunum (50) (50) (50) (50)
Intestine Small, Ileum (50) (50) (50) (50)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 2 (4%) 1 (2%)
Mesentery (9) (12) (8) (4)
Oral Mucosa (8) (8) (5) (7)
Gingival, Squamous Cell Papilloma 1 (13%)
Pharyngeal, Squamous Cell Papilloma 1 (14%)
Pancreas (50) (50) (50) (50)
Mixed Tumor Benign 1 (2%)
Salivary Glands (49) (50) (50) (49)
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (50) (49) (49) (50)
Stomach, Glandular (50) (50) (49) (50)
Tongue (1) (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%) 1 (100%)
Tooth (3) (5) (2) (3)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Heart (50) (50) (50) (50)
Chordoma, Metastatic, Bone 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Benign 8 (16%) 5 (10%) 6 (12%) 3 (6%)
Bilateral, Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Parathyroid Gland (49) (45) (48) (49)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 10 (20%) 6 (12%) 12 (24%) 5 (10%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 3 (6%)
C-Cell, Adenoma 10 (20%) 6 (12%) 6 (12%) 4 (8%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 2 (4%) 2 (4%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (49)
Adenoma 3 (6%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 3 (6%) 3 (6%) 1 (2%)
Prostate (50) (50) (50) (50)
Seminal Vesicle (50) (50) (50) (49)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 43 (86%) 41 (82%) 40 (80%) 42 (84%)
Page 9
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Interstitial Cell, Adenoma 2 (4%) 5 (10%) 6 (12%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Lymph Node (19) (20) (16) (19)
Lymph Node, Mandibular (5) (1) (2)
Lymph Node, Mesenteric (50) (50) (50) (50)
Chordoma, Metastatic, Bone 1 (2%)
Spleen (50) (50) (50) (50)
Thymus (48) (48) (48) (48)
Chordoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (50) (50)
Fibroadenoma 2 (4%) 2 (4%) 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 3 (6%) 1 (2%)
Fibrous Histiocytoma 1 (2%)
Keratoacanthoma 10 (20%) 3 (6%) 3 (6%) 3 (6%)
Osteosarcoma 1 (2%) 2 (4%)
Schwannoma Malignant 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Chordoma 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (2) (2) (1)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Chordoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Skin 2 (4%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 2 (4%) 1 (2%)
Mediastinum, Myxosarcoma 1 (2%)
Nose (50) (50) (50) (50)
Trachea (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Harderian Gland (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 2 (4%) 4 (8%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 27 (54%) 41 (82%) 39 (78%) 24 (48%)
Mesothelioma Malignant 2 (4%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 88138-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 08/23/04
Route: DOSED FEED Time: 08:33:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 50
Total Primary Neoplasms 139 139 143 109
Total Animals with Benign Neoplasms 49 47 49 50
Total Benign Neoplasms 103 86 92 77
Total Animals with Malignant Neoplasms 33 42 40 26
Total Malignant Neoplasms 36 53 51 32
Total Animals with Metastatic Neoplasms 2 5 4 1
Total Metastatic Neoplasm 9 12 6 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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