TDMS Study 05206-05 Pathology Tables
NTP Experiment-Test: 05206-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CUPRIC SULFATE Date: 10/15/04
Route: DOSED FEED Time: 08:19:29
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7758-99-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 001 0 PPM
Include 006 500 PPM
Include 005 500 PPM
Include 010 1000 PPM
Include 009 1000 PPM
Include 014 2000 PPM
Include 013 2000 PPM
Include 018 4000 PPM
Include 017 4000 PPM
Include 022 8000 PPM
Include 021 8000 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05206-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CUPRIC SULFATE Date: 10/15/04
Route: DOSED FEED Time: 08:19:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Accidently Killed 1
Survivors
Terminal Sacrifice 10 10 9 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (10) (1) (10)
Inflammation, Acute 1 (10%)
Liver (10) (1) (2) (10) (10) (10)
Hepatodiaphragmatic Nodule 2 (20%) 1 (100%) 2 (100%) 2 (20%)
Inflammation, Chronic Active 6 (60%) 10 (100%)
Inflammation, Focal 2 (20%)
Mesentery (1)
Fat, Necrosis 1 (100%)
Pancreas (10) (1) (10)
Atrophy 1 (10%) 1 (10%)
Stomach, Forestomach (10) (10) (10) (10) (10)
Cyst Epithelial Inclusion 1 (10%)
Hyperplasia 7 (70%) 10 (100%) 10 (100%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10)
Inflammation, Chronic Active 1 (10%)
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ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05206-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CUPRIC SULFATE Date: 10/15/04
Route: DOSED FEED Time: 08:19:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (1) (10)
Inflammation, Chronic Active 9 (90%) 10 (100%)
Ovary (10) (1) (1) (10)
Cyst 1 (100%)
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HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (10) (1) (10)
Gliosis 1 (10%)
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RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Chronic Active 1 (10%) 1 (10%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Cyst 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05206-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CUPRIC SULFATE Date: 10/15/04
Route: DOSED FEED Time: 08:19:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cytoplasmic Alteration 1 (10%) 9 (90%) 10 (100%) 10 (100%)
Mineralization 1 (10%)
Nephropathy 1 (10%) 1 (10%) 2 (20%)
Pigmentation 2 (20%)
Proximal Convoluted Renal Tubule, Karyomegaly 10 (100%)
Renal Tubule, Degeneration 3 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05206-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CUPRIC SULFATE Date: 10/15/04
Route: DOSED FEED Time: 08:19:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 1 (10%) 10 (100%) 10 (100%)
Pancreas (10) (10)
Atrophy 2 (20%) 1 (10%)
Stomach, Forestomach (10) (1) (10) (10) (10) (10)
Hyperplasia 10 (100%) 10 (100%) 10 (100%)
Stomach, Glandular (10) (10) (10) (10) (10)
Mineralization 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Inflammation, Chronic Active 10 (100%) 5 (50%)
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ENDOCRINE SYSTEM
Pituitary Gland (10) (10)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10)
Inflammation, Chronic Active 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05206-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CUPRIC SULFATE Date: 10/15/04
Route: DOSED FEED Time: 08:19:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Preputial Gland (10) (10)
Inflammation, Chronic Active 7 (70%) 8 (80%)
Prostate (10) (10)
Inflammation, Chronic Active 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (9) (10) (10) (10) (10)
Cytoplasmic Alteration 3 (30%) 10 (100%) 10 (100%)
Nephropathy 10 (100%) 9 (100%) 10 (100%) 8 (80%) 9 (90%) 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05206-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY CUPRIC SULFATE Date: 10/15/04
Route: DOSED FEED Time: 08:19:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Proximal Convoluted Renal Tubule, Karyomegaly 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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