TDMS Study 05135-05 Pathology Tables
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + M M + + + + + + M + M + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + + M + M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | X X X | 6 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + M + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Interstitial Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + + + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + M + | 35 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + M + + + + + | 35 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Thymus | + + + M + M + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | 3 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Spinal Cord | + + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + |
|__________________________________________________________________________|
Pharynx | + + + + + + + + |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + |
|__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adrenal Cortex | + + + + + + + + |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + +|
Adenoma | X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
|__________________________________________________________________________|
Prostate | + + + + + + + + |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Bronchial | + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
|__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + |
|__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + | 15 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + | 10 |
|__________________________________________________________________________|____________|
Pharynx | + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 18 |
Adenoma | X X | 7 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + | 10 |
|__________________________________________________________________________|____________|
Preputial Gland | + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node | + | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + | 13 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Thymus | + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + | 11 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 10 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + | 10 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + |
|__________________________________________________________________________|
Pharynx | + + + + + + + + + |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adrenal Cortex | + + + + + + + + + |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + |
Ganglioneuroma | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + |
Adenoma | X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + |
Mesothelioma Benign | |
|__________________________________________________________________________|
Preputial Gland | + + + + + M + + + |
|__________________________________________________________________________|
Prostate | + + + + + + + + + |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + M + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + |
|__________________________________________________________________________|
Thymus | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + M + + + |
|__________________________________________________________________________|
Skin | + + + + + M + + + +|
Sarcoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + M + + + |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + M + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + M + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + A + + + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Nose | + + + + + + + + + |
|__________________________________________________________________________|
Trachea | + + + + + A + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 11 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + | 22 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + | 11 |
|__________________________________________________________________________|____________|
Pharynx | + + | 11 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 11 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 11 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + | 11 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + | 12 |
Ganglioneuroma | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 11 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 14 |
Adenoma | X | 3 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + | 12 |
Mesothelioma Benign | X | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + | 11 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + | 11 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Testes | + + + + + + + + + + + + + + + | 40 |
Interstitial Cell, Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 12 |
|__________________________________________________________________________|____________|
Spleen | + + | 12 |
|__________________________________________________________________________|____________|
Thymus | + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + | 11 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 11 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + | 11 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Nose | + + | 11 |
|__________________________________________________________________________|____________|
Trachea | + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + | 12 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Mesothelioma Benign | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
|__________________________________________________________________________|
Liver | + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Pancreas | + + + + + |
|__________________________________________________________________________|
Pharynx | + + + + + |
|__________________________________________________________________________|
Salivary Glands | + + + + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + |
|__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adrenal Cortex | + + + + + |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + |
Adenoma | X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + |
|__________________________________________________________________________|
Prostate | + + + + + |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + |
|__________________________________________________________________________|
Spleen | + + + + + + |
|__________________________________________________________________________|
Thymus | + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + |
Fibroadenoma | X |
|__________________________________________________________________________|
Skin | + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Nose | + + + + + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + | 15 |
|__________________________________________________________________________|____________|
Mesentery | + + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 14 |
Adenoma | X X | 4 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 10 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Interstitial Cell, Adenoma | X X X | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 11 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thymus | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 11 |
Fibroadenoma | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 10 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + | 12 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + +|
|__________________________________________________________________________|
Pharynx | + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + +|
|__________________________________________________________________________|
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adrenal Cortex | + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + +|
Adenoma | X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + +|
Mesothelioma NOS | X |
|__________________________________________________________________________|
Preputial Gland | + + + + +|
|__________________________________________________________________________|
Prostate | + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + +|
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mandibular | + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + +|
|__________________________________________________________________________|
Skin | + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Nose | + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | X |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + | 17 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 14 |
Adenoma | X | 3 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 11 |
Mesothelioma NOS | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Adenoma | X X X X | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thymus | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Peripheral Nerve | + + + + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + | 16 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Palate, Papilloma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X X X X X |
Interstitial Cell, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + + + M + + + M + + + + + + + M + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
Palate, Papilloma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | X X | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
Mesothelioma Benign | X | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Testes | + + + + + + + + + + + + + + + | 40 |
Interstitial Cell, Adenoma | X X | 8 |
Interstitial Cell, Adenoma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + M + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + + M M + + + + | 30 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + + + + + | 36 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M M M M | 3 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05135-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:14:18
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Brain | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Mesothelioma Benign | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------