TDMS Study 05135-05 Pathology Tables
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 1 |
Fibrosis | |
Fibrosis, Multifocal | 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation | |
Inflammation, Multifocal | 2 1 |
Necrosis, Multifocal | |
|__________________________________________________________________________|
Mesentery | + |
Necrosis | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Atrophy | 1 1 1 1 1 1 1|
Atrophy, Multifocal | 1 |
Infiltration Cellular, Focal, Mixed | |
Cell | 1 |
Infiltration Cellular, Mixed Cell | 1 1 |
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Focal | 1 1 |
Cardiomyopathy | |
Cardiomyopathy, Multifocal | 2 2 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic, Focal | 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 4 1 1 |
Pars Distalis, Cyst | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hypospermia | |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | X |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Interstitial Cell, Hyperplasia | 4 4 3 1 4 4 3 2 2 3 2 2 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Congestion | X |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + M M + + + + + + M + M + + + + + + +|
Congestion | X X X X X X X X X X X X|
Hyperplasia | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + + + + + + + + + + + + + + + + M +|
Congestion | X |
Hyperplasia | X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + + + + + + + M + + +|
Congestion | X X X X X X X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | X X X X X |
Pigmentation, Hemosiderin | X X X X X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + + M + M|
Hyperplasia | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | X |
Hemorrhage | 2 |
Hemorrhage, Multifocal | 3 3 2 2 3 4 4 3 2 3 3 1 1 2 2 1 1 4 3 1 1 2 2 1|
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Hyperplasia, | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 8| 6| 6| 6|
| 8| 8| 8| 6| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 6| 6| 8| 8| 6| 6| 8| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Multifocal | 1 2 |
Alveolus, Hemorrhage | 1 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 1 1 |
Peribronchial, Hyperplasia, Lymphoid,| |
Multifocal | 1 1 1 |
Perivascular, Hyperplasia, Focal, | |
Lymphoid | 2 |
Perivascular, Hyperplasia, Lymphoid, | |
Multifocal | 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Infiltration Cellular, | |
Mixed Cell | |
Turbinate, Inflammation, Suppurative | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + |
Hemorrhage | X |
Hyperplasia, Lymphoid | 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Nephropathy, Chronic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Fatty Change | | 1 1.0|
Fibrosis | 1 | 1 1.0|
Fibrosis, Multifocal | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation | 1 | 1 1.0|
Inflammation, Multifocal | | 2 1.5|
Necrosis, Multifocal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Necrosis | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Atrophy, Focal | | 1 1.0|
Atrophy | 1 | 8 1.0|
Atrophy, Multifocal | | 1 1.0|
Infiltration Cellular, Focal, Mixed | | |
Cell | | 1 1.0|
Infiltration Cellular, Mixed Cell | | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
Cardiomyopathy, Focal | | 2 1.0|
Cardiomyopathy | 1 | 1 1.0|
Cardiomyopathy, Multifocal | 1 1 1 1 | 14 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 40 |
Vacuolization Cytoplasmic, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 1 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 2 1 4 3 1 | 11 1.8|
Pars Distalis, Cyst | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | | 1 1.0|
Hypospermia | 4 | 1 4.0|
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + M + + + + + + + | 39 |
Hyperplasia | 4 | 1 4.0|
Infiltration Cellular, Mixed Cell | 1 1 | 2 1.0|
Inflammation, Suppurative | 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 40 |
Corpora Amylacea | | 1 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Degeneration | | 1 1.0|
Interstitial Cell, Hyperplasia | 1 4 1 2 2 1 1 2 2 4 1 3 | 26 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
Pancreatic, Congestion | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Bronchial | + M + + M + + + + + + + + + + | 32 |
Congestion | X X X X X | 17 |
Hyperplasia | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + M + | 35 |
Congestion | | 1 |
Hyperplasia | X | 8 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + M + + + + + | 35 |
Congestion | X X X X X X | 20 |
Hyperplasia | | 5 |
Pigmentation, Hemosiderin | X | 6 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
Accessory Spleen | | 2 |
|__________________________________________________________________________|____________|
Thymus | + + + M + M + + + + + + + + + | 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | 3 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 40 |
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Congestion | | 1 |
Hemorrhage | 1 1 1 2 | 5 1.4|
Hemorrhage, Multifocal | 1 2 1 1 1 2 1 3 2 1 2 | 35 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 | 3 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 2 1.5|
Alveolus, Hemorrhage | 1 | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 1 | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | | 2 1.0|
Peribronchial, Hyperplasia, Lymphoid,| | |
Multifocal | 1 1 | 5 1.0|
Perivascular, Hyperplasia, Focal, | | |
Lymphoid | | 1 2.0|
Perivascular, Hyperplasia, Lymphoid, | | |
Multifocal | 1 1 1 1 1 1 | 15 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Turbinate, Infiltration Cellular, | | |
Mixed Cell | 2 | 1 2.0|
Turbinate, Inflammation, Suppurative | | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| | |
| 8| 8| 8| 8| 8| 6| 8| 8| 8| 6| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
Hemorrhage | | 1 |
Hyperplasia, Lymphoid | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
Bilateral, Nephropathy, Chronic | 1 1 1 1 1 1 2 2 2 | 23 1.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
Calculus Micro Observation Only | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Hepatodiaphragmatic Nodule | X X X X X X |
|__________________________________________________________________________|
Mesentery | + + |
Necrosis | X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + |
|__________________________________________________________________________|
Pharynx | + + + + + + + + |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + |
|__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
|__________________________________________________________________________|
Prostate | + + + + + + + + |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 4 1 1 4 2 4 1 1 2 2 2 2 4 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
|__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Congestion | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + |
Congestion | X X X |
Hyperplasia | X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Accessory Spleen | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
|__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + |
Hemorrhage | 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 1| 3| 1| 3| 1| 1| 3| 3|
DAY ON TEST | 6| 6| 8| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 8| 6| 8| 8| 6| 6|
| 8| 8| 6| 8| 6| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 8| 8| 6| 8| 6| 8| 6| 6| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage | 2 1 2 1 1 1 2 1 |
Hemorrhage, Multifocal | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 2 2 2 1 3 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 1 1 1 2 2 2 3 |
Peribronchial, Hyperplasia, Focal, | |
Lymphoid | 1 1 |
Peribronchial, Hyperplasia, Lymphoid,| |
Multifocal | 1 1 1 |
Perivascular, Hyperplasia, Focal, | |
Lymphoid | 1 |
Perivascular, Hyperplasia, Lymphoid, | |
Multifocal | 1 1 2 1 3 3 2 3 1|
|__________________________________________________________________________|
Nose | + + + + + + + + |
|__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
__________________________________________|__________________________________________________________________________
Page 16
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + | 15 |
Hepatodiaphragmatic Nodule | X X X | 9 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Necrosis | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + | 10 |
|__________________________________________________________________________|____________|
Pharynx | + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 18 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + | 10 |
|__________________________________________________________________________|____________|
Preputial Gland | + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Interstitial Cell, Hyperplasia | 1 3 2 1 4 1 2 2 1 1 4 3 1 | 31 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Pancreatic, Congestion | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 15 |
Congestion | | 3 |
Hyperplasia | X | 4 |
|__________________________________________________________________________|____________|
Spleen | + + | 13 |
Accessory Spleen | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | 1 2 | 10 1.4|
Hemorrhage, Multifocal | 1 1 1 1 1 1 1 2 1 1 1 1 2 | 30 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 3 2 3 1 3 3 1 1 | 15 2.1|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 3 3 3 3 1 1 3 3 1 1 | 17 2.0|
Peribronchial, Hyperplasia, Focal, | | |
Lymphoid | | 2 1.0|
Peribronchial, Hyperplasia, Lymphoid,| | |
Multifocal | 1 1 1 1 1 | 8 1.0|
Perivascular, Hyperplasia, Focal, | | |
Lymphoid | | 1 1.0|
Perivascular, Hyperplasia, Lymphoid, | | |
Multifocal | 1 3 3 3 3 1 1 1 1 3 3 1 1 3 | 23 2.0|
|__________________________________________________________________________|____________|
Nose | + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 10 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + | 10 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Clear Cell Focus | |
Fatty Change | 1 1 |
Fatty Change, Multifocal | 2 |
Fibrosis, Multifocal | |
Hepatodiaphragmatic Nodule | X X X |
Necrosis, Focal | |
Necrosis, Multifocal | |
|__________________________________________________________________________|
Mesentery | + + |
Congestion | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + |
|__________________________________________________________________________|
Pharynx | + + + + + + + + + |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + |
Pars Distalis, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + M + + + |
|__________________________________________________________________________|
Prostate | + + + + + + + + + |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 4|
Granuloma | X|
Inflammation | 4|
Interstitial Cell, Hyperplasia | 1 1 2 2 3 2 4 2 1 1 1 3 1 3 2 1 4 |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + M + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + |
Hyperplasia | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + |
Congestion | |
Hyperplasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Accessory Spleen | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + M + + + |
|__________________________________________________________________________|
Skin | + + + + + M + + + +|
Subcutaneous Tissue, Hemorrhage | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + M + + + |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + M + + + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Spinal Cord | + + + + + M + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + A + + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Multifocal | 1 |
Hemorrhage | 2 2 2 2 2 3 2 2 |
Hemorrhage, Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 1 2 2 2 1 1 2 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 1 1 2 2 2 1 2 1 1 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Peribronchial, Hyperplasia, Focal, | |
Lymphoid | 1 |
Peribronchial, Hyperplasia, Lymphoid,| |
Multifocal | 1 2 2 2 1 2 1 |
Perivascular, Hyperplasia, Lymphoid, | |
Multifocal | 2 1 1 3 1 2 2 1 1 2 1 1 3 3 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + |
Turbinate, Hemorrhage | X |
|__________________________________________________________________________|
Trachea | + + + + + A + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 1| 1| 3| 3| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 8| 8| 6| 6| 8| 8| 6| 6| 6| 6| 8| 6| 8| 6| 6| 8| 6| 6|
| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Bilateral, Nephropathy, Chronic | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + |
Calculus Micro Observation Only | X X |
__________________________________________|__________________________________________________________________________
Page 26
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 11 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + | 22 |
Clear Cell Focus | 1 | 1 1.0|
Fatty Change | 1 | 3 1.0|
Fatty Change, Multifocal | 1 | 2 1.5|
Fibrosis, Multifocal | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X | 8 |
Necrosis, Focal | 1 | 1 1.0|
Necrosis, Multifocal | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Congestion | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + | 11 |
|__________________________________________________________________________|____________|
Pharynx | + + | 11 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 11 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 11 |
|__________________________________________________________________________|____________|
Heart | + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + | 11 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + | 12 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 11 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 14 |
Pars Distalis, Cyst | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + | 12 |
|__________________________________________________________________________|____________|
Preputial Gland | + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + | 11 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Degeneration | | 1 4.0|
Granuloma | | 1 |
Inflammation | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 2 2 1 3 3 4 4 4 1 1 1 2 2 | 31 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 12 |
Hyperplasia | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 12 |
Congestion | X | 1 |
Hyperplasia | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + | 12 |
Accessory Spleen | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Subcutaneous Tissue, Hemorrhage | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 11 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + | 11 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Congestion | | 1 2.0|
Fibrosis, Multifocal | | 1 1.0|
Hemorrhage | 2 1 3 | 11 2.1|
Hemorrhage, Multifocal | 1 1 1 1 1 2 3 1 1 1 1 | 26 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 1 1 3 3 | 13 1.8|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 1 1 2 1 3 3 | 18 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Peribronchial, Hyperplasia, Focal, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| | |
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lymphoid | 2 1 | 3 1.3|
Peribronchial, Hyperplasia, Lymphoid,| | |
Multifocal | | 7 1.6|
Perivascular, Hyperplasia, Lymphoid, | | |
Multifocal | 1 1 1 1 2 1 2 1 3 3 | 25 1.6|
|__________________________________________________________________________|____________|
Nose | + + | 11 |
Turbinate, Hemorrhage | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + | 12 |
Bilateral, Nephropathy, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 13 |
Calculus Micro Observation Only | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
|__________________________________________________________________________|
Liver | + + + + + + + + +|
Fatty Change | 1 1 1 1|
Fatty Change, Multifocal | |
Hepatodiaphragmatic Nodule | X X X X |
|__________________________________________________________________________|
Mesentery | |
Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + |
|__________________________________________________________________________|
Pharynx | + + + + + |
|__________________________________________________________________________|
Salivary Glands | + + + + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + |
|__________________________________________________________________________|
Heart | + + + + + |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + |
Hemorrhage, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + |
Infiltration Cellular, Mixed Cell | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Prostate | + + + + + |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 4 2 3 4 4 2 3 1 2 2 4 4 2 1 3 2 4 1 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | + + + + + |
Congestion | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + |
Hyperplasia | X |
|__________________________________________________________________________|
Spleen | + + + + + + |
Accessory Spleen | X |
Capsule, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Thymus | + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + |
|__________________________________________________________________________|
Skin | + + + + + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6|
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage | 2 2 2 3 1 |
Hemorrhage, Multifocal | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 2 1 1 2 1 2|
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 2 1 1 1 1 1 2 1 2|
Peribronchial, Hyperplasia, Lymphoid,| |
Multifocal | 1 1 1 |
Perivascular, Hyperplasia, Focal, | |
Lymphoid | 1 2 |
Perivascular, Hyperplasia, Lymphoid, | |
Multifocal | 3 2 1 2 1 1 1 1 2 2 2|
|__________________________________________________________________________|
Nose | + + + + + |
|__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + |
Nephropathy, Chronic | 1 |
Bilateral, Cyst | X |
Bilateral, Nephropathy, Chronic | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + |
__________________________________________|__________________________________________________________________________
Page 35
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + | 15 |
Fatty Change | | 4 1.0|
Fatty Change, Multifocal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 4 |
|__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Necrosis | X X | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 14 |
Hemorrhage, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 10 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 12 |
Infiltration Cellular, Mixed Cell | 2 4 | 2 3.0|
Inflammation, Suppurative | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Interstitial Cell, Hyperplasia | 3 1 1 4 4 4 2 3 2 2 3 | 31 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 11 |
Congestion | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 11 |
Hyperplasia | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + | 13 |
Accessory Spleen | X | 2 |
Capsule, Hyperplasia, Lymphoid | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 11 |
|__________________________________________________________________________|____________|
Skin | + + + + + + | 12 |
Inflammation, Chronic | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 10 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | 2 2 3 2 2 | 10 2.1|
Hemorrhage, Multifocal | 1 1 1 1 1 2 1 1 1 | 24 1.1|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 1 1 2 2 | 11 1.5|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 1 1 1 2 2 2 | 16 1.4|
Peribronchial, Hyperplasia, Lymphoid,| | |
Multifocal | 1 1 1 1 | 7 1.0|
Perivascular, Hyperplasia, Focal, | | |
Lymphoid | | 2 1.5|
Perivascular, Hyperplasia, Lymphoid, | | |
Multifocal | 2 1 1 1 3 1 1 2 2 | 20 1.6|
|__________________________________________________________________________|____________|
Nose | + + + + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 1| | |
DAY ON TEST | 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 8| 6| 8| | |
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + + + + + + | 11 |
Cataract | X | 1 |
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + | 12 |
Nephropathy, Chronic | | 1 1.0|
Bilateral, Cyst | | 1 |
Bilateral, Nephropathy, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + +|
Fatty Change, Focal | 1 |
Fibrosis, Focal | 1 |
Fibrosis | 1 |
Hepatodiaphragmatic Nodule | X X X X X |
|__________________________________________________________________________|
Mesentery | + + |
Necrosis | X X |
|__________________________________________________________________________|
Pancreas | + + + + +|
|__________________________________________________________________________|
Pharynx | + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + +|
|__________________________________________________________________________|
Prostate | + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 1 4 1 3 2 2 2 1 3 2 3 3 2 2 3 4 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + +|
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + +|
Congestion | X |
|__________________________________________________________________________|
Spleen | + + + + + + +|
Accessory Spleen | X X |
|__________________________________________________________________________|
Thymus | + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + +|
|__________________________________________________________________________|
Skin | + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 1 2|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 1| 3| 3| 1|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 6| 8| 8| 6| 6| 8|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage, Multifocal | 1 2 1 2 1 1 1 1 2 1 2 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 2 2 2 1 2 |
Alveolus, Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 1 2 1 1 2 2 2 2 1 |
Peribronchial, Hyperplasia, Lymphoid,| |
Multifocal | 1 2 1 2 |
Perivascular, Hyperplasia, Focal, | |
Lymphoid | 1 1 |
Perivascular, Hyperplasia, Lymphoid, | |
Multifocal | 2 1 1 3 1 3 2 2 1 |
|__________________________________________________________________________|
Nose | + + + + +|
|__________________________________________________________________________|
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + +|
Cataract | X |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + +|
Bilateral, Nephropathy, Chronic | 1 1 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + +|
Calculus Micro Observation Only | X X X X |
__________________________________________|__________________________________________________________________________
Page 44
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + | 17 |
Fatty Change, Focal | | 1 1.0|
Fibrosis, Focal | | 1 1.0|
Fibrosis | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 8 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Necrosis | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 14 |
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + | 11 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Interstitial Cell, Hyperplasia | 1 2 4 2 1 1 3 2 1 1 1 2 | 32 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 11 |
Hyperplasia | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 10 |
Congestion | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + | 13 |
Accessory Spleen | X | 3 |
|__________________________________________________________________________|____________|
Thymus | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | 2 2 2 2 2 | 10 1.8|
Hemorrhage, Multifocal | 1 2 1 1 1 1 1 | 22 1.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 1 2 1 2 2 | 11 1.6|
Alveolus, Hemorrhage | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 1 1 2 2 2 1 | 15 1.5|
Peribronchial, Hyperplasia, Lymphoid,| | |
Multifocal | | 4 1.5|
Perivascular, Hyperplasia, Focal, | | |
Lymphoid | | 2 1.0|
Perivascular, Hyperplasia, Lymphoid, | | |
Multifocal | 3 1 1 2 1 2 3 1 | 17 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 3| 1| 3| 1| 3| 3| 3| 1| 3| | |
DAY ON TEST | 6| 6| 6| 6| 8| 8| 6| 8| 6| 8| 6| 6| 6| 8| 6| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + + + + + | 11 |
Cataract | | 1 |
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + | 16 |
Bilateral, Nephropathy, Chronic | 1 1 | 6 1.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 17 |
Calculus Micro Observation Only | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 1|
Inflammation, Multifocal, Suppurative| 1|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Fibrosis, Multifocal | 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Focal | |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 2 |
Sinusoid, Congestion, Focal | 1 |
|__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Atrophy | 1 1 1 1 1 1|
Atrophy, Multifocal | 1 |
Infiltration Cellular, Mixed Cell | 1 1 |
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 |
Cardiomyopathy, Multifocal | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 2 1 1 |
Pars Distalis, Cyst | X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | X X |
Inflammation, Suppurative | 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 4 4 2 4 4 1 4 1 2 1 3 2 2 3 1 1 4 2 2 1 4 3 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | X X X X X X X X X X X X X |
Hyperplasia | X X|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | X X X |
Hyperplasia | X X|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + + + M + + + M + + + + + + + M + + + + +|
Congestion | X X X X X X X X X X X X X|
Hyperplasia | X X X X X|
Pigmentation, Hemosiderin | X X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
|__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + M M M M M M M M M M M M M M M M M M M M M M M|
Hyperplasia | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 1 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 2 1 |
Hemorrhage, Multifocal | 2 3 2 1 1 1 1 2 1 2 1 2 1 2 2 1 2 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 1 1|
Alveolus, Hemorrhage | 1 1 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
_____________________________________________________________________________________________________________________
| 3| 1| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 1| 3| 3|
DAY ON TEST | 6| 8| 8| 6| 6| 6| 6| 6| 6| 8| 6| 6| 6| 8| 6| 6| 6| 6| 6| 8| 6| 6| 8| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolus, Inflammation, Granulomatous| 1 |
Peribronchial, Hyperplasia, Focal, | |
Lymphoid | 1 1 1 |
Peribronchial, Hyperplasia, Lymphoid | 1 |
Peribronchial, Hyperplasia, Lymphoid,| |
Multifocal | |
Perivascular, Hyperplasia, Focal, | |
Lymphoid | 2 1 |
Perivascular, Hyperplasia, Lymphoid, | |
Multifocal | 1 1 1 1 1 1 2 1 1 1 2 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Infiltration Cellular, | |
Multifocal, Mixed Cell | 1 |
Turbinate, Infiltration Cellular, | |
Mixed Cell | |
Turbinate, Inflammation, Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + |
Hyperplasia, Lymphoid | 1 1 1 |
Hyperplasia, Lymphoid, Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Nephropathy, Chronic | 1 2 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X X X X X X X|
__________________________________________|__________________________________________________________________________
Page 54
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
Hemorrhage, Multifocal | | 1 1.0|
Inflammation, Multifocal, Suppurative| | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 40 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Fibrosis | 1 | 1 1.0|
Fibrosis, Multifocal | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 6 |
Inflammation, Focal | 1 | 1 1.0|
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | 1 1 | 3 1.3|
Sinusoid, Congestion, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Accessory Spleen | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Accessory Spleen | | 1 |
Atrophy | 1 1 1 | 9 1.0|
Atrophy, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Infiltration Cellular, Mixed Cell | | 2 1.0|
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
Cardiomyopathy | 1 1 1 | 12 1.0|
Cardiomyopathy, Multifocal | | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 2 2 1 | 11 1.4|
Pars Distalis, Cyst | | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
Cyst | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
Inflammation, Chronic | | 1 4.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 40 |
Infiltration Cellular, Mixed Cell | | 1 1.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 40 |
Corpora Amylacea | | 2 |
Inflammation, Suppurative | | 2 1.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
Interstitial Cell, Hyperplasia | 1 2 3 4 2 1 1 4 2 3 2 4 4 4 2 | 40 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + M + + + + + + + | 37 |
Congestion | X X X X X X | 19 |
Hyperplasia | X X X X | 6 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 40 |
Congestion | | 3 |
Hyperplasia | X X X | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + + M M + + + + | 30 |
Congestion | X X X X | 17 |
Hyperplasia | X X X | 8 |
Pigmentation, Hemosiderin | | 2 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
Accessory Spleen | X | 2 |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + + + + + | 36 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M M M M | 3 |
Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Larynx | + + + + + + + + + + + + + + + | 40 |
Infiltration Cellular, Mixed Cell | | 3 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | | 5 1.8|
Hemorrhage, Multifocal | 1 1 3 2 1 3 2 1 2 1 2 1 1 1 3 | 35 1.6|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 | 3 1.3|
Alveolus, Hemorrhage | 1 | 3 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 1 1 1 1 1 2 | 18 1.1|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 1.5|
Alveolus, Inflammation, Granulomatous| | 1 1.0|
Peribronchial, Hyperplasia, Focal, | | |
Lymphoid | 1 | 4 1.0|
Peribronchial, Hyperplasia, Lymphoid | | 1 1.0|
Peribronchial, Hyperplasia, Lymphoid,| | |
Multifocal | 1 | 1 1.0|
Perivascular, Hyperplasia, Focal, | | |
Lymphoid | | 2 1.5|
Perivascular, Hyperplasia, Lymphoid, | | |
Multifocal | 1 1 1 1 1 1 1 2 2 | 23 1.2|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Turbinate, Infiltration Cellular, | | |
Multifocal, Mixed Cell | | 1 1.0|
Turbinate, Infiltration Cellular, | | |
Mixed Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05135-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:16:09
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 6| 6| 6| 6| 8| 8| 6| 6| 6| 6| 6| 6| 6| 8| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Turbinate, Inflammation, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
Hyperplasia, Lymphoid | | 3 1.0|
Hyperplasia, Lymphoid, Multifocal | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
Bilateral, Nephropathy, Chronic | 1 1 1 2 2 1 1 2 1 1 1 | 29 1.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
Calculus Micro Observation Only | X X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
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