TDMS Study 05206-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus CUPRIC SULFATE DATE: 10/15/04
EXPERIMENT: 05206 TEST: 05 TIME: 08:22:38
TEST TYPE: SUBCHRON 90-DAY PAGE: 1
CONT: NO1ES75169 ROUTE: DOSED FEED NTP C#: 62191B
PATHOLOGIST: A. SINGER CAS: 7758-99-8
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 PPM
INCLUDE 002 0 PPM
INCLUDE 005 500 PPM
INCLUDE 006 500 PPM
INCLUDE 009 1000 PPM
INCLUDE 010 1000 PPM
INCLUDE 013 2000 PPM
INCLUDE 014 2000 PPM
INCLUDE 017 4000 PPM
INCLUDE 018 4000 PPM
INCLUDE 021 8000 PPM
INCLUDE 022 8000 PPM
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus CUPRIC SULFATE DATE: 10/15/04
EXPERIMENT: 05206 TEST: 05 TIME: 08:22:38
TEST TYPE: SUBCHRON 90-DAY
CONT: NO1ES75169 ROUTE: DOSED FEED NTP C#: 62191B
PATHOLOGIST: A. SINGER CAS: 7758-99-8
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF CUPRIC SULFATE
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Heart Adrenal Gland Cortex
Kidney Cytoplasmic Alteration
Nephropathy
Kidney: Proximal Convoluted Renal Tubule
Karyomegaly
Liver Adrenal Gland Cortex
Stomach Forestomach Hyperplasia
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Kidney Cytoplasmic Alteration
Pigmentation
Kidney: Proximal Convoluted Renal Tubule
Karyomegaly
Kidney: Renal Tubule Degeneration
Liver Adrenal Gland Cortex
Hepatodiaphragmatic Nodule
Inflammation Focal
Stomach Forestomach Hyperplasia
===============================================================
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/10 (90%) 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|POLY-3 RATE (b) | 9/10.00 0/0.00 0/0.00 0/0.00 0/0.00 10/10.00 |
|POLY-3 PERCENT (g) | 90.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 9/10 (90%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.309 P=1.000 P=1.000 P=1.000 P=1.000N P=0.500 |
|POLY 3 | (e) (e) P=0.943N (e) (e) P=0.500 |
|POLY 1.5 | (e) (e) P=0.933N (e) (e) P=0.500 |
|POLY 6 | (e) (e) P=0.943N (e) (e) P=0.500 |
|LOGISTIC REGRESSION| P=0.304 (e) (e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.188 P=1.000 P=0.182N P=1.000 P=1.000 P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Heart |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/10 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 5/10 (50%) |
|POLY-3 RATE (b) | 10/10.00 0/0.00 0/0.00 0/0.00 0/0.00 5/10.00 |
|POLY-3 PERCENT (g) | 100.0% 0.0% 0.0% 0.0% 0.0% 50.0% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 5/10 (50%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.012N* (e) (e) (e) (e) P=0.022N* |
|POLY 3 | (e) (e) (e) (e) (e) P=0.008N** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.008N** |
|POLY 6 | (e) (e) (e) (e) (e) P=0.008N** |
|LOGISTIC REGRESSION| P=0.012N* (e) (e) (e) (e) P=0.022N* |
|COCH-ARM / FISHERS | P=0.010N* (e) (e) (e) (e) P=0.016N* |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Heart |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 10.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.309 (e) (e) (e) (e) P=0.500 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.500 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.500 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.500 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.304 (e) (e) (e) (e) P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 3/10 (30%) 10/10 (100%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/9.00 0/10.00 3/10.00 10/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 30.0% 100.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 3/10 (30%) 10/10 (100%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- --- 92 (T) 92 (T) 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.111 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.095 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.095 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.095 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.111 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.105 P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 9/10 (90%) 10/10 (100%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 1/9.00 9/10.00 10/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 11.1% 90.0% 100.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 1/9 (11%) 9/10 (90%) 10/10 (100%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- 92 (T) 92 (T) 92 (T) 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.479 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.479 P<0.001 ** P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001 ** (e) P=0.480 P<0.001 ** P<0.001N** P<0.001N** |
|POLY 6 | P<0.001 ** (e) P=0.479 P<0.001 ** P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| (e) (e) P=0.479 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/10 (100%) 9/9 (100%) 10/10 (100%) 8/10 (80%) 9/10 (90%) 6/10 (60%) |
|POLY-3 RATE (b) | 10/10.00 9/9.00 10/10.00 8/10.00 9/10.00 6/10.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% 100.0% 80.0% 90.0% 60.0% |
|TERMINAL (d) | 10/10 (100%) 9/9 (100%) 10/10 (100%) 8/10 (80%) 9/10 (90%) 6/10 (60%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002N** (e) (e) P=0.234N P=0.500N P=0.051N |
|POLY 3 | P<0.001N** (e) (e) P=0.227N P=0.500N P=0.033N* |
|POLY 1.5 | P<0.001N** (e) (e) P=0.227N P=0.500N P=0.033N* |
|POLY 6 | P<0.001N** (e) (e) P=0.227N P=0.500N P=0.033N* |
|LOGISTIC REGRESSION| P=0.002N** (e) (e) P=0.234N P=0.500N P=0.051N |
|COCH-ARM / FISHERS | P=0.002N** (e) (e) P=0.237N P=0.500N P=0.043N* |
|ORDER RESTRICTED | P=0.002N** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 1/9.00 1/10.00 0/10.00 2/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 11.1% 10.0% 0.0% 20.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 1/9 (11%) 1/10 (10%) 0/10 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- 92 (T) 92 (T) --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.111 (e) P=0.479 P=0.500 (e) P=0.234 |
|POLY 3 | P=0.106 (e) P=0.479 P=0.500 (e) P=0.227 |
|POLY 1.5 | P=0.106 (e) P=0.480 P=0.500 (e) P=0.227 |
|POLY 6 | P=0.106 (e) P=0.479 P=0.500 (e) P=0.227 |
|LOGISTIC REGRESSION| (e) (e) P=0.479 P=0.500 (e) P=0.234 |
|COCH-ARM / FISHERS | P=0.104 (e) P=0.500 P=0.500 (e) P=0.237 |
|ORDER RESTRICTED | P=0.055 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/9.00 0/10.00 0/10.00 0/10.00 0/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/9.00 0/10.00 0/10.00 2/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 20.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.012 * (e) (e) (e) (e) P=0.234 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.227 |
|POLY 1.5 | P=0.008 ** (e) (e) (e) (e) P=0.227 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.227 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.234 |
|COCH-ARM / FISHERS | P=0.010 * (e) (e) (e) (e) P=0.237 |
|ORDER RESTRICTED | P=0.007 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Proximal Convoluted Renal Tubule |
| Karyomegaly |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/9.00 0/10.00 0/10.00 0/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | P<0.001N** (e) (e) (e) (e) P<0.001N** |
|POLY 1.5 | P<0.001N** (e) (e) (e) (e) P<0.001N** |
|POLY 6 | P<0.001N** (e) (e) (e) (e) P<0.001N** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Proximal Convoluted Renal Tubule |
| Karyomegaly |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/9.00 0/10.00 0/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/9.00 0/10.00 0/10.00 0/10.00 0/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/9.00 0/10.00 0/10.00 3/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 30.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.111 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.095 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.095 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.095 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.111 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.105 |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/10 (0%) 1/10 (10%) 10/10 (100%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/10.00 1/10.00 10/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 10.0% 100.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/10 (0%) 1/10 (10%) 10/10 (100%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- --- 92 (T) 92 (T) 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.500 P<0.001 ** P<0.001 ** |
|POLY 3 | (e) (e) (e) P=0.500 P<0.001N** P<0.001 ** |
|POLY 1.5 | (e) (e) (e) P=0.500 P<0.001N** P<0.001 ** |
|POLY 6 | (e) (e) (e) P=0.500 P<0.001N** P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.500 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.500 P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/1 (0%) 0/2 (0%) 0/10 (0%) 6/10 (60%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/1.00 0/2.00 0/10.00 6/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 60.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/1 (0%) 0/2 (0%) 0/10 (0%) 6/10 (60%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.009 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.009 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.005 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/10 (10%) 0/0 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 1/10.00 0/0.00 1/10.00 1/10.00 0/10.00 0/10.00 |
|POLY-3 PERCENT (g) | 10.0% 0.0% 10.0% 10.0% 0.0% 0.0% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (T) --- 92 (T) 92 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.202N P=1.000N P=0.766 P=0.766 P=0.500N P=0.500N |
|POLY 3 | (e) (e) P=0.760 P=0.760 P=0.500N P=0.500N |
|POLY 1.5 | (e) (e) P=0.760 P=0.760 P=0.500N P=0.500N |
|POLY 6 | (e) (e) P=0.760 P=0.760 P=0.500N P=0.500N |
|LOGISTIC REGRESSION| P=0.202N (e) P=0.766 P=0.766 (e) (e) |
|COCH-ARM / FISHERS | P=0.200N P=1.000 P=0.763N P=0.763N P=0.500N P=0.500N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/10 (20%) 1/1 (100%) 2/2 (100%) 2/10 (20%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 2/10.00 1/1.00 2/2.00 2/10.00 0/10.00 0/10.00 |
|POLY-3 PERCENT (g) | 20.0% 100.0% 100.0% 20.0% 0.0% 0.0% |
|TERMINAL (d) | 2/10 (20%) 1/1 (100%) 2/2 (100%) 2/10 (20%) 0/10 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.020N* P=0.305 P=0.095 P=0.707 P=0.234N P=0.234N |
|POLY 3 | P=0.005N** P=0.286 P=0.053 P=0.702 P=0.227N P=0.227N |
|POLY 1.5 | P=0.005N** P=0.286 P=0.053 P=0.702 P=0.227N P=0.227N |
|POLY 6 | P=0.005N** P=0.286 P=0.053 P=0.702 P=0.227N P=0.227N |
|LOGISTIC REGRESSION| P=0.020N* P=0.305 P=0.095 P=0.707 (e) (e) |
|COCH-ARM / FISHERS | P=0.019N* P=0.273 P=0.091 P=0.709N P=0.237N P=0.237N |
|ORDER RESTRICTED | P=0.003N** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/10.00 0/10.00 0/10.00 0/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/10 (20%) 0/1 (0%) 0/2 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 2/10.00 0/1.00 0/2.00 0/10.00 0/10.00 0/10.00 |
|POLY-3 PERCENT (g) | 20.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/10 (20%) 0/1 (0%) 0/2 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.129N P=0.795N P=0.630N P=0.234N P=0.234N P=0.234N |
|POLY 3 | P=0.124N P=0.786N P=0.627N P=0.227N P=0.227N P=0.227N |
|POLY 1.5 | P=0.124N P=0.786N P=0.627N P=0.227N P=0.227N P=0.227N |
|POLY 6 | P=0.124N P=0.786N P=0.627N P=0.227N P=0.227N P=0.227N |
|LOGISTIC REGRESSION| P=0.129N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.127N P=0.818N P=0.682N P=0.237N P=0.237N P=0.237N |
|ORDER RESTRICTED | P=0.007N** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Pancreas |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/10 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 2/10.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00 |
|POLY-3 PERCENT (g) | 20.0% 0.0% 0.0% 0.0% 0.0% 10.0% |
|TERMINAL (d) | 2/10 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.380N P=1.000N P=1.000N P=1.000 P=1.000 P=0.500N |
|POLY 3 | (e) (e) (e) (e) (e) P=0.500N |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.500N |
|POLY 6 | (e) (e) (e) (e) (e) P=0.500N |
|LOGISTIC REGRESSION| P=0.380N (e) (e) (e) (e) P=0.500N |
|COCH-ARM / FISHERS | P=0.377N P=1.000 P=1.000 P=1.000 P=1.000 P=0.500N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Pancreas |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/10 (10%) 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 1/10.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00 |
|POLY-3 PERCENT (g) | 10.0% 0.0% 0.0% 0.0% 0.0% 10.0% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.642 P=1.000 P=1.000 P=1.000 P=1.000 P=0.766 |
|POLY 3 | (e) (e) P=0.943N (e) (e) P=0.760 |
|POLY 1.5 | (e) (e) P=0.943N (e) (e) P=0.760 |
|POLY 6 | (e) (e) P=0.943N (e) (e) P=0.760 |
|LOGISTIC REGRESSION| P=0.645N (e) (e) (e) (e) P=0.766 |
|COCH-ARM / FISHERS | P=0.626 P=1.000 P=0.909N P=1.000 P=1.000 P=0.763N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/10 (70%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 8/10 (80%) |
|POLY-3 RATE (b) | 7/10.00 0/0.00 0/0.00 0/0.00 0/0.00 8/10.00 |
|POLY-3 PERCENT (g) | 70.0% 0.0% 0.0% 0.0% 0.0% 80.0% |
|TERMINAL (d) | 7/10 (70%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 8/10 (80%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.401 P=1.000N P=1.000N P=1.000 P=1.000 P=0.500 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.500 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.500 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.500 |
|LOGISTIC REGRESSION| P=0.401 (e) (e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.398 P=1.000 P=1.000 P=1.000 P=1.000 P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Adrenal Gland Cortex |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
Date: 10/15/04 EXPERIMENT: 05206 TEST: 05 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - CUPRIC SULFATE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Stomach Forestomach |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/1 (0%) 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/1.00 0/10.00 10/10.00 10/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/1 (0%) 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- --- 92 (T) 92 (T) 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001N** (e) (e) P<0.001 ** P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001N** (e) (e) P<0.001 ** P<0.001N** P<0.001N** |
|POLY 6 | P<0.001N** (e) (e) P<0.001 ** P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| (e) (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 PPM 500 PPM 1000 PPM 2000 PPM 4000 PPM 8000 PPM |
| | |
|=================================================================================================================================|
| |
|Stomach Forestomach |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/10 (0%) 7/10 (70%) 10/10 (100%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/9.00 7/10.00 10/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 70.0% 100.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/9 (0%) 7/10 (70%) 10/10 (100%) 10/10 (100%) |
|FIRST INCIDENCE | --- --- --- 92 (T) 92 (T) 92 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.003 ** P<0.001 ** P<0.001 ** |
|POLY 3 | (e) (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | (e) (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | (e) (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.003 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.002 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).