TDMS Study 05135-06 Pathology Tables
NTP Experiment-Test: 05135-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:53
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05135-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:53
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B6C3F1 MICE MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
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DISPOSITION SUMMARY
Animals Initially in Study 40 40 40 40 40 40
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 1 1 1 1 1 5
Natural Death 1 1 1 2 3 4
Accidently Killed 1
Survivors
Terminal Sacrifice 27 28 28 27 26 21
Animals Examined Microscopically 40 40 40 40 40 40
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ALIMENTARY SYSTEM
Liver (40) (40) (39) (40) (40) (38)
Hemangioma 2 (5%)
Hepatocellular Carcinoma 3 (8%) 1 (3%) 3 (8%) 4 (10%) 1 (3%) 9 (24%)
Hepatocellular Carcinoma, Multiple 1 (3%) 1 (3%) 3 (8%)
Hepatocellular Adenoma 4 (10%) 3 (8%) 3 (8%) 12 (30%) 13 (33%) 5 (13%)
Hepatocellular Adenoma, Multiple 1 (3%) 3 (8%) 3 (8%) 5 (13%) 11 (29%)
Lymphoma Malignant Histiocytic 1 (3%)
Lymphoma Malignant Lymphocytic 1 (3%) 1 (3%) 1 (3%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (3%)
Mesentery (1) (2) (2) (4) (2)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (25%)
Stomach, Forestomach (40) (40) (39) (40) (40) (38)
Squamous Cell Carcinoma 2 (5%) 1 (3%)
Squamous Cell Papilloma 2 (5%) 2 (5%) 4 (11%)
Squamous Cell Papilloma, Multiple 1 (3%)
Tooth (1) (2)
Odontoma 1 (100%) 1 (50%)
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NTP Experiment-Test: 05135-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (40) (12) (11) (13) (40) (38)
Lymphoma Malignant Lymphocytic 1 (3%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
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HEMATOPOIETIC SYSTEM
Bone Marrow (40) (12) (11) (13) (40) (38)
Lymphoma Malignant Lymphocytic 1 (8%) 1 (3%)
Lymph Node, Bronchial (32) (11) (10) (11) (35) (32)
Lymphoma Malignant Histiocytic 1 (9%)
Lymphoma Malignant Lymphocytic 1 (3%) 1 (9%) 1 (3%) 1 (3%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (3%)
Lymph Node, Mandibular (24) (7) (10) (11) (33) (23)
Lymphoma Malignant Lymphocytic 1 (3%) 1 (4%)
Lymph Node, Mesenteric (40) (13) (9) (13) (39) (37)
Lymphoma Malignant Histiocytic 1 (3%)
Lymphoma Malignant Lymphocytic 1 (8%) 1 (3%) 1 (3%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (3%)
Lymph Node, Mediastinal (19) (10) (7) (9) (20) (22)
Lymphoma Malignant Histiocytic 1 (11%)
Lymphoma Malignant Lymphocytic 1 (5%) 1 (11%) 1 (5%) 1 (5%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (5%)
Spleen (40) (15) (11) (13) (40) (38)
Lymphoma Malignant Histiocytic 1 (8%)
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NTP Experiment-Test: 05135-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymphoma Malignant Lymphocytic 1 (8%) 1 (3%) 1 (3%)
Thymus (40) (12) (11) (13) (39) (36)
Lymphoma Malignant Histiocytic 1 (8%)
Lymphoma Malignant Lymphocytic 1 (3%) 1 (8%) 1 (3%) 1 (3%)
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INTEGUMENTARY SYSTEM
Skin (40) (14) (11) (14) (40) (39)
Squamous Cell Papilloma 1 (7%)
Sebaceous Gland, Adenoma 1 (7%)
Subcutaneous Tissue, Sarcoma 1 (3%)
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MUSCULOSKELETAL SYSTEM
Skeletal Muscle (40) (40) (39) (40) (40) (38)
Lymphoma Malignant Lymphocytic 1 (3%)
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NERVOUS SYSTEM
Brain (40) (12) (11) (13) (40) (38)
Meningioma Malignant, Metastatic, Spinal Cord 1 (3%)
Spinal Cord (40) (40) (39) (40) (39) (38)
Meningioma Malignant 1 (3%)
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RESPIRATORY SYSTEM
Lung (40) (40) (39) (40) (40) (38)
Alveolar/Bronchiolar Adenoma 2 (5%) 2 (5%) 1 (3%) 4 (10%) 8 (20%) 5 (13%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (5%) 4 (11%)
Alveolar/Bronchiolar Carcinoma 1 (3%) 3 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (3%)
Lymphoma Malignant Histiocytic 1 (3%)
Lymphoma Malignant Lymphocytic 1 (3%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (3%)
Nose (40) (40) (39) (40) (40) (38)
Turbinate, Olfactory Epithelium, Lymphoma
Malignant 1 (3%)
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NTP Experiment-Test: 05135-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (40) (40) (39) (40) (40) (38)
Adenoma 2 (5%) 6 (15%) 4 (10%) 13 (33%) 11 (28%) 7 (18%)
Adenoma, Multiple 1 (3%) 2 (5%) 5 (13%)
Carcinoma 1 (3%)
Lymphoma Malignant 1 (3%)
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URINARY SYSTEM
Kidney (40) (13) (11) (14) (40) (38)
Bilateral, Lymphoma Malignant Lymphocytic 1 (7%) 1 (3%) 1 (3%)
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SYSTEMIC LESIONS
Multiple Organs *(40) *(40) *(40) *(40) *(40) *(40)
Lymphoma Malignant 1 (3%)
Lymphoma Malignant Histiocytic 1 (3%) 1 (3%)
Lymphoma Malignant Lymphocytic 1 (3%) 1 (3%) 1 (3%) 1 (3%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05135-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 12 12 11 25 26 25
Total Primary Neoplasms 14 13 15 45 55 59
Total Animals with Benign Neoplasms 9 11 10 23 25 24
Total Benign Neoplasms 9 12 12 37 45 42
Total Animals with Malignant Neoplasms 5 1 3 8 9 14
Total Malignant Neoplasms 5 1 3 8 10 17
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 6 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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