Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/16729

TDMS Study 05135-06 Pathology Tables

NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53




       Facility:  Battelle Northwest

       Chemical CAS #:  78-79-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          40           40           40           40           40           40           
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            1            1            1            1            5           
    Natural Death                                      1            1            1            2            3            4           
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           28           28           27           26           21           
                                                                                                                                    
  Animals Examined Microscopically                    40           40           40           40           40           40           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (40)         (40)         (39)         (40)         (40)         (38)         
      Hemangioma                                                                                           2 (5%)                   
      Hepatocellular Carcinoma                         3 (8%)       1 (3%)       3 (8%)       4 (10%)      1 (3%)       9 (24%)     
      Hepatocellular Carcinoma, Multiple               1 (3%)                                 1 (3%)       3 (8%)                   
      Hepatocellular Adenoma                           4 (10%)      3 (8%)       3 (8%)      12 (30%)     13 (33%)      5 (13%)     
      Hepatocellular Adenoma, Multiple                              1 (3%)       3 (8%)       3 (8%)       5 (13%)     11 (29%)     
      Lymphoma Malignant Histiocytic                                                          1 (3%)                                
      Lymphoma Malignant Lymphocytic                                                          1 (3%)       1 (3%)       1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Mesentery                                          (1)          (2)                       (2)          (4)          (2)          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (25%)                  
   Stomach, Forestomach                               (40)         (40)         (39)         (40)         (40)         (38)         
      Squamous Cell Carcinoma                                                                              2 (5%)       1 (3%)      
      Squamous Cell Papilloma                                                                 2 (5%)       2 (5%)       4 (11%)     
      Squamous Cell Papilloma, Multiple                                                                                 1 (3%)      
   Tooth                                              (1)                       (2)                                                 
      Odontoma                                         1 (100%)                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (40)         (12)         (11)         (13)         (40)         (38)         
      Lymphoma Malignant Lymphocytic                                                                                    1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (40)         (12)         (11)         (13)         (40)         (38)         
      Lymphoma Malignant Lymphocytic                                                          1 (8%)       1 (3%)                   
   Lymph Node, Bronchial                              (32)         (11)         (10)         (11)         (35)         (32)         
      Lymphoma Malignant Histiocytic                                                          1 (9%)                                
      Lymphoma Malignant Lymphocytic                   1 (3%)                                 1 (9%)       1 (3%)       1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Lymph Node, Mandibular                             (24)         (7)          (10)         (11)         (33)         (23)         
      Lymphoma Malignant Lymphocytic                                                                       1 (3%)       1 (4%)      
   Lymph Node, Mesenteric                             (40)         (13)         (9)          (13)         (39)         (37)         
      Lymphoma Malignant Histiocytic                                                                                    1 (3%)      
      Lymphoma Malignant Lymphocytic                                                          1 (8%)       1 (3%)       1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Lymph Node, Mediastinal                            (19)         (10)         (7)          (9)          (20)         (22)         
      Lymphoma Malignant Histiocytic                                                          1 (11%)                               
      Lymphoma Malignant Lymphocytic                   1 (5%)                                 1 (11%)      1 (5%)       1 (5%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (5%)                   
   Spleen                                             (40)         (15)         (11)         (13)         (40)         (38)         
      Lymphoma Malignant Histiocytic                                                          1 (8%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Lymphoma Malignant Lymphocytic                                                          1 (8%)       1 (3%)       1 (3%)      
   Thymus                                             (40)         (12)         (11)         (13)         (39)         (36)         
      Lymphoma Malignant Histiocytic                                                          1 (8%)                                
      Lymphoma Malignant Lymphocytic                   1 (3%)                                 1 (8%)       1 (3%)       1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (40)         (14)         (11)         (14)         (40)         (39)         
      Squamous Cell Papilloma                                                                 1 (7%)                                
      Sebaceous Gland, Adenoma                                                                1 (7%)                                
      Subcutaneous Tissue, Sarcoma                                                                                      1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (40)         (40)         (39)         (40)         (40)         (38)         
      Lymphoma Malignant Lymphocytic                                                                                    1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (40)         (12)         (11)         (13)         (40)         (38)         
      Meningioma Malignant, Metastatic, Spinal Cord                                                                     1 (3%)      
   Spinal Cord                                        (40)         (40)         (39)         (40)         (39)         (38)         
      Meningioma Malignant                                                                                              1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (40)         (40)         (39)         (40)         (40)         (38)         
      Alveolar/Bronchiolar Adenoma                     2 (5%)       2 (5%)       1 (3%)       4 (10%)      8 (20%)      5 (13%)     
      Alveolar/Bronchiolar Adenoma, Multiple                                                               2 (5%)       4 (11%)     
      Alveolar/Bronchiolar Carcinoma                                                          1 (3%)                    3 (8%)      
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (3%)                   
      Lymphoma Malignant Histiocytic                                                          1 (3%)                                
      Lymphoma Malignant Lymphocytic                                                                                    1 (3%)      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                                     1 (3%)                   
   Nose                                               (40)         (40)         (39)         (40)         (40)         (38)         
      Turbinate, Olfactory Epithelium, Lymphoma                                                                                     
          Malignant                                                                                        1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (40)         (40)         (39)         (40)         (40)         (38)         
      Adenoma                                          2 (5%)       6 (15%)      4 (10%)     13 (33%)     11 (28%)      7 (18%)     
      Adenoma, Multiple                                                                       1 (3%)       2 (5%)       5 (13%)     
      Carcinoma                                                                                            1 (3%)                   
      Lymphoma Malignant                                                                                   1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (40)         (13)         (11)         (14)         (40)         (38)         
      Bilateral, Lymphoma Malignant Lymphocytic                                               1 (7%)       1 (3%)       1 (3%)      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(40)        *(40)        *(40)        *(40)        *(40)        *(40)         
      Lymphoma Malignant                                                                                   1 (3%)                   
      Lymphoma Malignant Histiocytic                                                          1 (3%)                    1 (3%)      
      Lymphoma Malignant Lymphocytic                   1 (3%)                                 1 (3%)       1 (3%)       1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05135-06               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            12          12          11          25          26          25               
     Total Primary Neoplasms                           14          13          15          45          55          59               
                                                                                                                                    
   Total Animals with Benign Neoplasms                  9          11          10          23          25          24               
     Total Benign Neoplasms                             9          12          12          37          45          42               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               5           1           3           8           9          14               
     Total Malignant Neoplasms                          5           1           3           8          10          17               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                              1           1               
     Total Metastatic Neoplasm                                                                          6           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------