TDMS Study 55801-06 Pathology Tables
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
FINAL #1 RATS/48 HOURS DAY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 103-90-2
Lock Date: 09/30/03
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 004 0 MG/KG 48 HR
Include 008 50 MG/KG48 HR
Include 012 150MG/KG48 HR
Include 016 1500MG/K48 HR
Include 020 2000MG/K48 HR
Page 1
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver, Left Lobe | + + + + + + | 6 |
|__________________________________________________________________________|____________|
Liver, Median Lobe | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver, Left Lobe | + + + + + + | 6 |
|__________________________________________________________________________|____________|
Liver, Median Lobe | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
150MG/KG | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver, Left Lobe | + + + + + + | 6 |
|__________________________________________________________________________|____________|
Liver, Median Lobe | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
150MG/KG | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
1500MG/K | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver, Left Lobe | + + + + + + | 6 |
Centrilobular, Infiltration Cellular,| | |
Mononuclear Cell | 2 2 3 1 2 1 | 6 1.8|
Centrilobular, Necrosis | 2 2 2 1 1 1 | 6 1.5|
Hepatocyte, Degeneration | 1 2 2 1 | 4 1.5|
Hepatocyte, Regeneration | 3 1 1 1 2 | 5 1.6|
Sinusoid, Congestion | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Liver, Median Lobe | + + + + + + | 6 |
Centrilobular, Infiltration Cellular,| | |
Mononuclear Cell | 2 2 3 2 1 2 | 6 2.0|
Centrilobular, Necrosis | 3 3 2 2 1 2 | 6 2.2|
Hepatocyte, Degeneration | 1 2 2 1 3 | 5 1.8|
Hepatocyte, Regeneration | 3 1 1 1 3 | 5 1.8|
Sinusoid, Congestion | 3 3 2 2 1 | 5 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
1500MG/K | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + | 6 |
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| | A |
2000MG/K | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver, Left Lobe | + + + + + + | 6 |
Centrilobular, Infiltration Cellular,| | |
Mononuclear Cell | 1 1 2 3 2 2 | 6 1.8|
Centrilobular, Necrosis | 3 2 2 1 2 2 | 6 2.0|
Hepatocyte, Degeneration | 2 1 1 | 3 1.3|
Hepatocyte, Regeneration | 1 3 2 1 3 3 | 6 2.2|
Sinusoid, Congestion | 2 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Liver, Median Lobe | + + + + + + | 6 |
Centrilobular, Infiltration Cellular,| | |
Mononuclear Cell | 1 1 2 3 2 2 | 6 1.8|
Centrilobular, Necrosis | 3 3 2 2 2 3 | 6 2.5|
Hepatocyte, Degeneration | 1 1 1 | 3 1.0|
Hepatocyte, Regeneration | 2 3 2 1 3 3 | 6 2.3|
Sinusoid, Congestion | 2 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 55801-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: ACUTE ACETAMINOPHEN (4-HYDROXYACETANILIDE) Date: 08/18/04
Route: GAVAGE Time: 10:42:52
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| | |
| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| | A |
2000MG/K | 1| 1| 1| 2| 2| 2| | L |
48 HR | 0| 1| 2| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------