TDMS Study 93027-11 Pathology Tables
NTP Experiment-Test: 93027-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (DIBUTYL PHTHALATE) Date: 07/08/99
Route: DOSED FEED Time: 09:48:44
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 84-74-2
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (DIBUTYL PHTHALATE) Date: 07/08/99
Route: DOSED FEED Time: 09:48:44
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SPRAGUE-DAWLEY RATS MALE 0 PPM 1000 2500 5000 10,000 20,000
PPM PPM PPM PPM PPM
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Cytoplasmic Alteration 10 (100%) 10 (100%)
Infiltration Cellular, Mononuclear Cell 5 (50%) 4 (40%) 7 (70%) 4 (40%) 4 (40%) 6 (60%)
Necrosis 1 (10%)
Pancreas (10) (10) (10) (10) (10) (10)
Atrophy, Focal 1 (10%) 1 (10%) 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10)
Infiltration Cellular, Mononuclear Cell 1 (10%)
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Hypertrophy 1 (10%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Preputial Gland (10) (10) (10) (10) (10) (10)
Inflammation, Chronic 10 (100%) 7 (70%) 8 (80%) 9 (90%) 9 (90%) 10 (100%)
Testes (10) (10) (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%) 1 (10%) 3 (30%)
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a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (DIBUTYL PHTHALATE) Date: 07/08/99
Route: DOSED FEED Time: 09:48:44
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 PPM 1000 2500 5000 10,000 20,000
PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage, Focal 1 (10%) 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Nephropathy 9 (90%) 7 (70%) 9 (90%) 5 (50%) 6 (60%) 7 (70%)
a Number of animals examined microscopically at site and number of animals with lesion
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