TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:38
31 WEEK SSAC FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 04/14/99 - 04/15/99
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 10 NG / 10 UG
Include 003 100 NG /100 UG
Include 005 300 NG /300 UG
Include 007 1000 NG/1000 UG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:38
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SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 98 98
Scheduled Sacrifice 16 10 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10)
Clear Cell Focus 1
Fatty Change, Diffuse 1 [1.0] 10 [2.1]
Inflammation 10 [1.0] 10 [1.0] 10 [1.1] 10 [1.0] 10 [1.6]
Mixed Cell Focus 1 2 3 2
Mixed Cell Focus, Multiple 1 1 1 3 3
Pigmentation 3 [1.0] 10 [1.0] 10 [1.2]
Toxic Hepatopathy 5 [1.0]
Bile Duct, Hyperplasia 1 [1.0] 2 [1.0]
Bile Duct, Inflammation, Chronic Active,
Focal 1 [2.0]
Hepatocyte, Hypertrophy 3 [1.0] 5 [1.0] 10 [1.0] 10 [3.2]
Hepatocyte, Multinucleated 9 [1.2]
Pancreas (10) (10) (10) (10) (10)
Basophilic Focus 1
Inflammation, Chronic Active 1 [1.0] 1 [1.0] 1 [1.0]
Acinus, Atrophy 1 [1.0] 1 [1.0] 1 [1.0]
Acinus, Vacuolization Cytoplasmic 3 [1.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10)
Degeneration, Cystic 1 [1.0] 1 [2.0]
Hyperplasia 1 [1.0] 2 [2.5]
Hypertrophy 3 [1.0] 2 [1.0] 2 [1.5] 4 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:38
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 1 [1.0]
Thyroid Gland (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 5 [1.0] 5 [1.0] 7 [1.0] 8 [1.4]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10)
Atrophy 6 [4.0] 7 [4.0] 9 [4.0] 10 [4.0] 6 [4.0]
Uterus (10) (10) (10) (10) (10)
Inflammation, Suppurative 1 [2.0] 1 [2.0]
Metaplasia, Squamous 6 [1.7] 7 [2.0] 5 [1.8] 9 [2.2] 4 [1.8]
Endometrium, Hyperplasia, Cystic 1 [4.0] 1 [4.0]
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Inflammation, Granulomatous 1 [3.0]
Spleen (10)
Pigmentation 10 [1.0]
Thymus (10) (10) (10) (10) (10)
Atrophy 6 [1.2] 5 [1.2] 6 [1.0] 7 [1.0] 10 [1.9]
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:38
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10)
Hemorrhage 1 [1.0]
Infiltration Cellular, Histiocyte 2 [1.0] 1 [1.0] 1 [1.0] 4 [1.0]
Inflammation 1 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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